Inherent anti-amyloidogenic activity of human immunoglobulin γ heavy chains

Journal of Biological Chemistry

Volumn 285, Issue 2, 2010, Pages 1066-1074

  Adekar, Sharad P ^a   Klyubin, Igor ^b   Macy, Sally ^c   Rowan, Michael J ^b   Solomon, Alan ^c   Dessain, Scott K ^a   O'Nuallain, Brian ^c,d  

^a LANKENAU INSTITUTE FOR MEDICAL RESEARCH   (United States)

^b TRINITY COLLEGE DUBLIN   (Ireland)

^c UNIVERSITY OF TENNESSEE GRADUATE SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY COLLEGE DUBLIN   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER DISEASE; AMYLOID FIBRIL; AMYLOID FIBRIL GROWTH; BIOLOGICAL MOLECULE; CELLULAR MECHANISMS; CONFORMATIONAL EPITOPES; FIBRIL GROWTH; HEAVY CHAIN; HUMAN IMMUNOGLOBULIN; IN-VITRO; IN-VIVO; LEARNING AND MEMORY; LONG-TERM POTENTIATIONS; MOLECULAR BASIS; NANOMOLAR; NATURALLY OCCURRING; POLYCLONAL; TISSUE SECTIONS;

BINDING ENERGY; GLYCOPROTEINS; OLIGOMERS;

CONFORMATIONS;

AMYLOID; AMYLOID BETA PROTEIN; IMMUNOGLOBULIN HEAVY CHAIN; MONOMER; OLIGOMER;

ALZHEIMER DISEASE; AMYLOID NEUROPATHY; ANIMAL CELL; ANIMAL TISSUE; ANTIGEN BINDING; ARTICLE; BINDING COMPETITION; BINDING SITE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CROSS REACTION; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; LONG TERM DEPRESSION; MALE; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; RAT;

ALZHEIMER DISEASE; AMYLOID; AMYLOID BETA-PROTEIN; ANIMALS; CELLS, CULTURED; FEMALE; HUMANS; IMMUNOGLOBULIN GAMMA-CHAINS; MICE;

RODENTIA;

EID: 74049152516     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.044321     Document Type: Article

References (68)

1. Stefani, M. (2004) Biochim. Biophys. Acta 1739, 5-25
2. Goedert, M., and Spillantini, M. G. (2006) Science 314, 777-781
3. Haass, C., Schlossmacher, M. G., Hung, A. Y., Vigo-Pelfrey, C., Mellon, A., Ostaszewski, B. L., Lieberburg, I., Koo, E. H., Schenk, D., Teplow, D. B., and Selkoe, D. J. (1992) Nature 359, 322-325
4. Hardy, J., and Selkoe, D. J. (2002) Science 297, 353-356
5. Walsh, D. M., and Selkoe, D. J. (2007) J. Neurochem. 101, 1172-1184
6. Gilman, S., Koller, M., Black, R. S., Jenkins, L., Griffith, S. G., Fox, N. C., Eisner, L., Kirby, L., Rovira, M. B., Forette, F., and Orgogozo, J. M. (2005) Neurology 64, 1553-1562
7. Shankar, G. M., Li, S., Mehta, T. H., Garcia-Munoz, A., Shepardson, N. E., Smith, I., Brett, F. M., Farrell, M. A., Rowan, M. J., Lemere, C. A., Regan, C. M., Walsh, D. M., Sabatini, B. L., and Selkoe, D. J. (2008) Nat. Med. 14, 837-842
8. Klyubin, I., Betts, V., Welzel, A. T., Blennow, K., Zetterberg, H., Wallin, A., Lemere, C. A., Cullen, W. K., Peng, Y., Wisniewski, T., Selkoe, D. J., Anwyl, R., Walsh, D. M., and Rowan, M. J. (2008) J. Neurosci. 28, 4231-4237
9. Gong, Y., Chang, L., Viola, K. L., Lacor, P. N., Lambert, M. P., Finch, C. E., Krafft, G. A., and Klein, W. L. (2003) Proc. Natl. Acad. Sci. U.S.A. 100, 10417-10422
10. Moir, R. D., Tseitlin, K. A., Soscia, S., Hyman, B. T., Irizarry, M. C., and Tanzi, R. E. (2005) J. Biol. Chem. 280, 17458-17463
11. Lee, E. B., Leng, L. Z., Zhang, B., Kwong, L., Trojanowski, J. Q., Abel, T., and Lee, V. M. (2006) J. Biol. Chem. 281, 4292-4299
12. Morgan, D., Diamond, D. M., Gottschall, P. E., Ugen, K. E., Dickey, C., Hardy, J., Duff, K., Jantzen, P., DiCarlo, G., Wilcock, D., Connor, K., Hatcher, J., Hope, C., Gordon, M., and Arendash, G. W. (2000) Nature 408, 982-985
13. Solomon, B. (2004) Curr. Alzheimer Res. 1, 149-163
14. Grimm, M. O., Grimm, H. S., Pätzold, A. J., Zinser, E. G., Halonen, R., Duering, M., Tschäpe, J. A., De Strooper, B., Müller, U., Shen, J., and Hartmann, T. (2005) Nat. Cell Biol. 7, 1118-1123
15. Lambert, M. P., Velasco, P. T., Chang, L., Viola, K. L., Fernandez, S., Lacor, P. N., Khuon, D., Gong, Y., Bigio, E. H., Shaw, P., De Felice, F. G., Krafft, G. A., and Klein, W. L. (2007) J. Neurochem. 100, 23-35
16. Kayed, R., Head, E., Thompson, J. L., McIntire, T. M., Milton, S. C., Cotman, C. W., and Glabe, C. G. (2003) Science 300, 486-489
17. O'Nuallain, B., Acero, L., Williams, A. D., Koeppen, H. P., Weber, A., Schwarz, H. P., Wall, J. S., Weiss, D. T., and Solomon, A. (2008) Biochemistry 47, 12254-12256
18. O'Nuallain, B., Hrncic, R., Wall, J. S., Weiss, D. T., and Solomon, A. (2006) J. Immunol. 176, 7071-7078
19. Dodel, R. C., Du, Y., Depboylu, C., Hampel, H., Frölich, L., Haag, A., Hemmeter, U., Paulsen, S., Teipel, S. J., Brettschneider, S., Spottke, A., Nölker, C.,Möller, H. J., Wei, X., Farlow, M., Sommer, N., and Oertel, W. H. (2004) J. Neurol. Neurosurg. Psychiatry 75, 1472-1474
20. Istrin, G., Bosis, E., and Solomon, B. (2006) J. Neurosci. Res. 84, 434-443
21. Henkel, A. W., Dittrich, P. S., Groemer, T. W., Lemke, E. A., Klingauf, J., Klafki, H. W., Lewczuk, P., Esselmann, H., Schwille, P., Kornhuber, J., and Wiltfang, J. (2007) Mol. Psychiatry 12, 601-610
22. Du, Y., Wei, X., Dodel, R., Sommer, N., Hampel, H., Gao, F., Ma, Z., Zhao, L., Oertel, W. H., and Farlow, M. (2003) Brain 126, 1935-1939
23. O'Nuallain, B., Thakur, A. K., Williams, A. D., Bhattacharyya, A. M., Chen, S., Thiagarajan, G., and Wetzel, R. (2006) Methods Enzymol. 413, 34-74
24. Teplow, D. B. (2006) Methods Enzymol. 413, 20-33
25. Wall, J., Schell, M., Murphy, C., Hrncic, R., Stevens, F. J., and Solomon, A. (1999) Biochemistry 38, 14101-14108
26. Solomon, A. (1985) Methods Enzymol. 116, 101-121
27. McLaughlin, C. L., and Solomon, A. (1974) J. Immunol. 113, 1369-1372
28. Adekar, S. P., Jones, R. M., Elias, M. D., Al-Saleem, F. H., Root, M. J., Simpson, L. L., and Dessain, S. K. (2008) Hybridoma 27, 11-17
29. Adekar, S. P., Jones, R. M., Elias, M. D., Al-Saleem, F. H., Root, M. J., Simpson, L. L., and Dessain, S. K. (2008) J. Immunol. Methods 333, 156-166
30. Galeazzi, L., Ronchi, P., Franceschi, C., and Giunta, S. (1999) Amyloid 6, 7-13
31. Malencik, D. A., and Anderson, S. R. (2003) Amino Acids 25, 233-247
32. O'Nuallain, B., and Wetzel, R. (2002) Proc. Natl. Acad. Sci. U.S.A. 99, 1485-1490
33. Pras, M., Schubert, M., Zucker-Franklin, D., Rimon, A., and Franklin, E. C. (1968) J. Clin. Invest. 47, 924-933
34. Murphy, C. L., Wang, S., Williams, T., Weiss, D. T., and Solomon, A. (2006) Methods Enzymol. 412, 48-62
35. O'Nuallain, B., Allen, A., Kennel, S. J., Weiss, D. T., Solomon, A., and Wall, J. S. (2007) Biochemistry 46, 1240-1247
36. Dessain, S. K., Adekar, S. P., Stevens, J. B., Carpenter, K. A., Skorski, M. L., Barnoski, B. L., Goldsby, R. A., and Weinberg, R. A. (2004) J. Immunol. Methods 291, 109-122
37. Lefranc, M. P., Giudicelli, V., Kaas, Q., Duprat, E., Jabado-Michaloud, J., Scaviner, D., Ginestoux, C., Clément, O., Chaume, D., and Lefranc, G. (2005) Nucleic Acids Res. 33, D593-D597
38. Naiki, H., Higuchi, K., Hosokawa, M., and Takeda, T. (1989) Anal. Biochem. 177, 244-249
39. Klyubin, I., Walsh, D. M., Cullen, W. K., Fadeeva, J. V., Anwyl, R., Selkoe, D. J., and Rowan, M. J. (2004) Eur. J. Neurosci. 19, 2839-2846
40. Carroll, W. L., Mendel, E., and Levy, S. (1988) Mol. Immunol. 25, 991-995
41. Solomon, A., Murphy, C. L., Weaver, K., Weiss, D. T., Hrncic, R., Eulitz, M., Donnell, R. L., Sletten, K., Westermark, G., and Westermark, P. (2003) J. Lab. Clin. Med. 142, 348-355
42. Kaminksy, W., Jin, L. W., Powell, S., Maezawa, I., Claborn, K., Branham, C., and Kahr, B. (2006) Micron 37, 324-338
43. Wetzel, R. (2006) Acc. Chem. Res. 39, 671-679
44. Giacomelli, C. E., and Norde, W. (2005) Macromol. Biosci. 5, 401-407
45. Cullen, W. K., Suh, Y. H., Anwyl, R., and Rowan, M. J. (1997) Neuroreport 8, 3213-3217
46. Rowan, M. J., Klyubin, I., Wang, Q., Hu, N. W., and Anwyl, R. (2007) Biochem. Soc. Trans. 35, 1219-1223
47. Lue, L. F., Kuo, Y. M., Roher, A. E., Brachova, L., Shen, Y., Sue, L., Beach, T., Kurth, J. H., Rydel, R. E., and Rogers, J. (1999) Am. J. Pathol. 155, 853-862
48. Kayed, R., Head, E., Sarsoza, F., Saing, T., Cotman, C. W., Necula, M., Margol, L., Wu, J., Breydo, L., Thompson, J. L., Rasool, S., Gurlo, T., Butler, P., and Glabe, C. G. (2007) Mol. Neurodegener. 2, 18
49. Davies, D. R., Padlan, E. A., and Segal, D. M. (1975) Annu. Rev. Biochem. 44, 639-667
50. Grey, H. M., and Mannik, M. (1965) J. Exp. Med. 122, 619-632
51. Gruschus, J. M. (2008) Amyloid 15, 160-165
52. De Genst, E., Silence, K., Decanniere, K., Conrath, K., Loris, R., Kinne, J., Muyldermans, S., and Wyns, L. (2006) Proc. Natl. Acad. Sci. U.S.A. 103, 4586-4591
53. O'Nuallain, B., Allen, A., Ataman, D., Weiss, D. T., Solomon, A., and Wall, J. S. (2007) Biochemistry 46, 13049-13058
54. Barthelemy, P. A., Raab, H., Appleton, B. A., Bond, C. J., Wu, P., Wiesmann, C., and Sidhu, S. S. (2008) J. Biol. Chem. 283, 3639-3654
55. Weksler, M. E., Gouras, G., Relkin, N. R., and Szabo, P. (2005) Immunol. Rev. 205, 244-256
56. Relkin, N. R., Szabo, P., Adamiak, B., Burgut, T., Monthe, C., Lent, R. W., Younkin, S., Younkin, L., Schiff, R., and Weksler, M. E. (2009) Neurobiol. Aging 30, 1728-1736
57. Nicoll, J. A., Barton, E., Boche, D., Neal, J. W., Ferrer, I., Thompson, P., Vlachouli, C., Wilkinson, D., Bayer, A., Games, D., Seubert, P., Schenk, D., and Holmes, C. (2006) J. Neuropathol. Exp. Neurol. 65, 1040-1048
58. Solomon, B. (2007) Expert Opin. Invest. Drugs 16, 819-828
59. Dodart, J. C., Bales, K. R., Gannon, K. S., Greene, S. J., DeMattos, R. B., Mathis, C., DeLong, C. A., Wu, S., Wu, X., Holtzman, D. M., and Paul, S. M. (2002) Nat. Neurosci. 5, 452-457
60. DeMattos, R. B., Bales, K. R., Cummins, D. J., Dodart, J. C., Paul, S. M., and Holtzman, D. M. (2001) Proc. Natl. Acad. Sci. U.S.A. 98, 8850-8855
61. Robert, R., Dolezal, O., Waddington, L., Hattarki, M. K., Cappai, R., Masters, C. L., Hudson, P. J., and Wark, K. L. (2009) Protein Eng. Des. Sel. 22, 199-208
62. Zameer, A., Kasturirangan, S., Emadi, S., Nimmagadda, S. V., and Sierks, M. R. (2008) J. Mol. Biol. 384, 917-928
63. Yoshihara, T., Takiguchi, S., Kyuno, A., Tanaka, K., Kuba, S., Hashiguchi, S., Ito, Y., Hashimoto, T., Iwatsubo, T., Tsuyama, S., Nakashima, T., and Sugimura, K. (2008) J. Biochem. 143, 475-486
64. Fukuchi, K., Accavitti-Loper, M. A., Kim, H. D., Tahara, K., Cao, Y., Lewis, T. L., Caughey, R. C., Kim, H., and Lalonde, R. (2006) Biochem. Biophys. Res. Commun. 344, 79-86
65. Bacskai, B. J., Kajdasz, S. T., McLellan, M. E., Games, D., Seubert, P., Schenk, D., and Hyman, B. T. (2002) J. Neurosci. 22, 7873-7878
66. Tamura, Y., Hamajima, K., Matsui, K., Yanoma, S., Narita, M., Tajima, N., Xin, K. Q., Klinman, D., and Okuda, K. (2005) Neurobiol. Dis. 20, 541-549
67. Lafaye, P., Achour, I., England, P., Duyckaerts, C., and Rougeon, F. (2009) Mol. Immunol. 46, 695-704
68. Solórzano-Vargas, R. S., Vasilevko, V., Acero, G., Ugen, K. E., Martinez, R., Govezensky, T., Vazquez-Ramirez, R., Kubli-Garfias, C., Cribbs, D. H., Manoutcharian, K., and Gevorkian, G. (2008) Mol. Immunol. 45, 881-886