Human plasma contains cross-reactive Aβ conformer-specific IgG antibodies

Biochemistry

Volumn 47, Issue 47, 2008, Pages 12254-12256

  O'Nuallain, Brian ^a   Acero, Luis ^a   Williams, Angela D ^a   McWilliams Koeppen, Helen P ^a   Weber, Alfred ^b   Schwarz, Hans P ^b   Wall, Jonathan S ^a   Weiss, Deborah T ^a   Solomon, Alan ^a  

^a UNIVERSITY OF TENNESSEE GRADUATE SCHOOL OF MEDICINE   (United States)

^b BAXTER BIOSCIENCE   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

AFFINITY CHROMATOGRAPHY; CHROMATOGRAPHIC ANALYSIS; MONOMERS; OLIGOMERS; PLASMA (HUMAN); PLASMAS; POLYMERS;

ALZHEIMER'S DISEASES; CONFORMATIONAL EPITOPES; HUMAN PLASMAS;

AGGLOMERATION;

AMYLOID BETA PROTEIN; EPITOPE; IMMUNOGLOBULIN; IMMUNOGLOBULIN G ANTIBODY; MONOMER; OLIGOMER;

AFFINITY CHROMATOGRAPHY; ANTIBODY ISOLATION; ANTIBODY SPECIFICITY; ANTIGEN RECOGNITION; ARTICLE; CONFORMATION; CROSS REACTION; FIBER; HUMAN; HUMAN TISSUE; NORMAL HUMAN; PLASMA; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN BINDING;

AMYLOID BETA-PROTEIN; ANTIBODY SPECIFICITY; CROSS REACTIONS; HUMANS; IMMUNOGLOBULIN G; IMMUNOGLOBULINS, INTRAVENOUS; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY;

EID: 56749153276     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi801767k     Document Type: Article

References (23)

1. Hardy, J., and Selkoe, D. J. (2002) The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics. Science 297, 353-356.
2. Walsh, D. M., and Selkoe, D. J. (2007) Aβ oligomers: A decade of discovery. J. Neurochem. 101, 1172-1184.
3. Moir, R. D., Tseitlin, K. A., Soscia, S., Hyman, B. T., Irizarry, M. C., and Tanzi, R. E. (2005) Autoantibodies to redox-modified oligomeric Aβ are attenuated in the plasma of Alzheimer's disease patients. J. Biol. Chem. 280, 17458-17463.
4. Dodel, R., Hampel, H., Depboylu, C., Lin, S., Gao, F., Schock, S., Jäckel, S., Wei, X., Buerger, K., Höft, C., Hemmer, B., Möller, H.-J., Farlow, M., Oertel, W. H., Sommer, N., and Du, Y. (2002) Human antibodies against amyloid β peptide: A potential treatment for Alzheimer's disease. Ann. Neurol. 52, 253-256.
5. O'Nuallain, B., Hrncic, R., Wall, J. S., Weiss, D. T., and Solomon, A. (2006) Diagnostic and therapeutic potential of amyloid-reactive IgG antibodies contained in human sera. J. Immunol. 176, 7071-7078.
6. Istrin, G., Bosis, E., and Solomon, B. (2006) Intravenous immunoglobulin enhances the clearance of fibrillar amyloid-β peptide. J. Neurosci. Res. 84, 434-444.
7. Weksler, M. E., Relkin, N., Turkenich, R., LaRusse, S., Zhou, L., and Szabo, P. (2002) Patients with Alzheimer disease have lower levels of serum anti-amyloid peptide antibodies than healthy elderly individuals. Exp. Gerontol. 37, 943-948.
8. 1-42 peptide. Biol. Psychiatry 57, 813-816.
9. Dodel, R. C., Du, Y., Depboylu, C., Hampel, H., Frölich, L., Haag, A., Hemmeter, U., Paulsen, S., Teipel, S. J., Brettschneider, S., Spottke, A., Nölker, C., Möller, H. J., Wei, X., Farlow, M., Sommer, N., and Oertel, W. H. (2004) Intravenous immunoglobulins containing antibodies against β-amyloid for the treatment of Alzheimer's disease. J. Neurol., Neurosurg. Psychiatry 75, 1472-1474.
10. Relkin, N. R., Szabo, P., Adamiak, B., Burgut, T., Monthe, C., Lent, R. W., Younkin, S., Younkin, L., Schiff, R., and Weksler, M. E. (2008) 18-month study of intravenous immunoglobulin for treatment of mild Alzheimer disease. Neurobiol. Aging (in press).
11. Grimm, M. O., Grimm, H. S., Pätzold, A. J., Zinser, E. G., Halonen, R., Dueling, M., Tschäpe, J. A., DeStrooper, B., Müller, U., Shen, J., and Hartmann, T. (2005) Regulation of cholesterol and sphingomyelin metabolism by amyloid-β and presenilin. Nat. Cell Biol. 7, 1118-1123.
12. Diamandis, E. P. (1988) Immunoassays with time-resolved fluorescence spectroscopy: Principles and applications. Clin. Biochem. 21, 139-150.
13. Wood, S. J., Wetzel, R., Martin, J. D., and Hurle, M. R. (1995) Prolines and amyloidogenicity in fragments of the Alzheimer's peptide β/A4. Biochemistry 34, 724-730.
14. Barghorn, S., Nimmrich, V., Striebinger, A., Krantz, C., Keller, P., Janson, B., Bahr, M., Schmidt, M., Bitner, R. S., Harlan, J., Barlow, E., Ebert, U., and Hillen, H. (2005) Globular amyloid β-peptide oligomer: A homogenous and stable neuropathological protein in Alzheimer's disease. J. Neurochem. 95, 834-847.
15. Gharibyan, A. L., Zamotin, V., Yanamandra, K., Moskaleva, O. S., Margulis, B. A., Kostanyan, I. A., and Morozova-Roche, L. A. (2007) Lysozyme amyloid oligomers and fibrils induce cellular death via different apoptotic/necrotic pathways. J. Mol. Biol. 35, 1337-1339.
16. Giacomelli, C. E., and Norde, W. (2005) Conformational changes of the amyloid β-peptide (1-40) adsorbed on solid surfaces. Macromol. Biosci. 5, 401-407.
17. Grant, M. A., Lazo, N. D., Lomakin, A., Condron, M. M., Arai, H., Yamin, G., Rigby, A. C., and Teplow, D. B. (2007) Familial Alzheimer's disease mutations alter the stability of the amyloid β-protein monomer folding nucleus. Proc. Natl. Acad. Sci. U.S.A. 104, 16522-16527.
18. Dumoulin, M., and Dobson, C. M. (2004) Probing the origins, diagnosis and treatment of amyloid diseases using antibodies. Biochimie 86, 589-600.
19. Glabe, C. G. (2004) Conformation-dependent antibodies target diseases of protein misfolding. Trends Biochem. Sci. 29, 542-547.
20. Richardson, J. S., and Richardson, D. C. (2002) Natural β-sheet proteins use negative design to avoid edge-to-edge aggregation. Proc. Natl. Acad. Sci. U.S.A. 99, 2754-2759.
21. Enqvist, S., Peng, S., Persson, A., and Westermark, P. (2003) Senile amyloidoses-diseases of increasing importance. Acta Histochem. 105, 377-378.
22. Pearce, F. G., Mackintosh, S. H., and Gerrard, J. A. (2007) Formation of amyloid-like fibrils by ovalbumin and related proteins under conditions relevant to food processing. J. Agric. Food Chem. 55, 318-322.
23. Gebbink, M. F., Claessen, D., Bouma, B., Dijkhuizen, L., and Wösten, H. A. (2005) Amyloids: A functional coat for microorganisms. Nat. Rev. Microbiol. 3, 333-341.