RNAi-mediated silencing of estrogen receptor α in the ventromedial nucleus of hypothalamus abolishes female sexual behaviors

Proceedings of the National Academy of Sciences of the United States of America

Volumn 103, Issue 27, 2006, Pages 10456-10460

  Musatov, Sergei ^a,b,c   Chen, Walter ^b   Pfaff, Donald W ^b   Kaplitt, Michael G ^b,c   Ogawa, Sonoko ^b,d  

^a Neurologix Inc   (United States)

^b ROCKEFELLER UNIVERSITY   (United States)

^c WEILL CORNELL MEDICAL COLLEGE   (United States)

^d UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

Adeno associated virus; Lordosis; RNA interference; Viral vector

Indexed keywords

ESTROGEN; ESTROGEN RECEPTOR ALPHA; PARVOVIRUS VECTOR; PROGESTERONE RECEPTOR; SHORT HAIRPIN RNA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN REGION; CONTROLLED STUDY; FEMALE; GENE DELETION; GENE SILENCING; HUMAN; HUMAN CELL; HYPOTHALAMUS VENTROMEDIAL NUCLEUS; KNOCKOUT MOUSE; MOUSE; NEUROENDOCRINE SYSTEM; NONHUMAN; OVARIECTOMY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR BLOCKING; RECEPTOR DOWN REGULATION; RNA INTERFERENCE; SEXUAL BEHAVIOR; VIRUS RECOMBINANT;

ADENOCARCINOMA; ANIMALS; ESTROGEN RECEPTOR ALPHA; FEMALE; GENETIC VECTORS; HUMANS; MALE; MICE; MICE, INBRED C57BL; RNA INTERFERENCE; SEXUAL BEHAVIOR; VENTROMEDIAL HYPOTHALAMIC NUCLEUS;

ADENO-ASSOCIATED VIRUS;

EID: 33745907268     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0603045103     Document Type: Article

References (26)

1. Ogawa, S., Chester, A. E., Hewitt, S. C., Walker, V. R., Gustafsson, J. A., Smithies, O., Korach, K. S. & Pfaff, D. W. (2000) Proc. Natl. Acad. Sci. USA 97, 14737-14741.
2. Mosselman, S., Polman, J. & Dijkema, R. (1996) FEBS Lett. 392, 49-53.
3. Ogawa, S., Chan, J., Chester, A. E., Gustafsson, J. A., Korach, K. S. & Pfaff, D. W. (1999) Proc. Natl. Acad. Sci. USA 96, 12887-12892.
4. Pfaff, D. W. & Sakuma, Y. (1979) J. Physiol. 288, 189-202.
5. Rissman, E. F., Early, A. H., Taylor, J. A., Korach, K. S. & Lubahn, D. B. (1997) Endocrinology 138, 507-510.
6. Ogawa, S., Taylor, J. A., Lubahn, D. B., Korach, K. S. & Pfaff, D. W. (1996) Neuroendocrinology 64, 467-470.
7. Ogawa, S., Eng, V., Taylor, J. A., Lubahn, D. B., Korach, K. S. & Pfaff, D. W. (1998) Endocrinology 139, 5070-5081.
8. Moffatt, C. A., Rissman, E. F., Shupnik, M. A. & Blaustein, J. D. (1998) J. Neurosci. 18, 9556-9563.
9. Doench, J. G., Petersen, C. P. & Sharp, P. A. (2003) Genes Dev. 17, 438-442.
10. Brummelkamp, T. R., Bernards, R. & Agami, R. (2002) Science 296, 550-553.
11. Mani, S. K., Blaustein, J. D., Allen, J. M. C., Law, S. W., O'Malley, B. W. & Clark, J. H. (1994) Endocrinology 135, 1409-1414.
12. Pollio, G., Xue, P., Zanisi, M., Nicolin, A. & Maggi, A. (1993) Mol. Brain Res. 19, 135-139.
13. Ogawa, S., Olazabal, U. E., Parhar, I. S. & Pfaff, D. W. (1994) J. Neurosci. 14, 1766-1774.
14. Pfaff, D. W. (1999) Drive (MIT Press, Cambridge, MA).
15. Shughrue, P. J., Lubahn, D. B., Negro-Vilar, A., Korach, K. S. & Merchenthaler, I. (1997) Proc. Natl. Acad. Sci. USA 94, 11008-11012.
16. Singh, M., Setalo, G., Jr., Guan, X., Frail, D. E. & Toran-Allerand, C. D. (2000) J. Neurosci. 20, 1694-1700.
17. Shughrue, P. J., Askew, G. R., Dellovade, T. L. & Merchenthaler, I. (2002) Endocrinology 143, 1643-1650.
18. Ghosh, D., Taylor, J. A., Green, J. A. & Lubahn, D. B. (1999) Endocrinology 140, 3526-3533.
19. Miyagishi, M. & Taira, K. (2002) Nat. Biotechnol. 20, 497-500.
20. Xia, H., Mao, Q., Paulson, H. L. & Davidson, B. L. (2002) Nat. Biotechnol. 20, 1006-1010.
21. Xia, H., Mao, Q., Eliason, S. L., Harper, S. Q., Martins, I. H., Orr, H. T., Paulson, H. L., Yang, L., Kotin, R. M. & Davidson, B. L. (2004) Nat. Med. 10, 816-820.
22. Hommel, J. D., Sears, R. M., Georgescu, D., Simmons, D. L. & DiLeone, R. J. (2003) Nat. Med. 9, 1539-1544.
23. Babcock, A. M., Standing, D., Bullshields, K., Schwartz, E., Paden, C. M. & Poulsen, D. J. (2005) Mol. Ther. 11, 899-905.
24. McEwen, B. S. (1983) Int. Rev. Physiol. 27, 99-145.
25. Kawasaki, H. & Taira, K. (2003) Nucleic Acids Res. 31, 700-707.
26. Clark, K. R., Liu, X., McGrath, J. P. & Johnson, P. R. (1999) Hum. Gene Ther. 10, 1031-1039.