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Journal of Enzyme Inhibition and Medicinal Chemistry

Volumn 24, Issue 6, 2009, Pages 1245-1252

Dipeptide-derived nitriles containing additional electrophilic sites: Potentially irreversible inhibitors of cysteine proteases

(2) Löser, Reik a Gütschow, Michael a

a UNIVERSITY OF BONN (Germany)

Author keywords

Cascade reactions; Cyclizations; Cysteine proteases; Mechanism based inactivators; Nitriles

Indexed keywords

CATHEPSIN K; CATHEPSIN L; CATHEPSIN S; CYSTEINE PROTEINASE; CYSTEINE PROTEINASE INHIBITOR; DIPEPTIDE DERIVATIVE; IMIDE; N (TERT BUTOXYCARBONYL)PHENYLALANYL METHYLMETHIONINE NITRILE IODIDE; N (TERT BUTOXYCARBONYL)PHENYLALANYLCYANOALANINE NITRILE; NITRILE; NITROGEN; PAPAIN; PHENYLALANINE DERIVATIVE; THIOIMIDATE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL MODIFICATION; CONTROLLED STUDY; CYCLIZATION; DRUG INHIBITION; DRUG POTENCY; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; PRIORITY JOURNAL;

CATALYTIC DOMAIN; CATHEPSIN K; CATHEPSIN L; CATHEPSINS; CYCLIZATION; CYSTEINE PROTEINASE INHIBITORS; DIPEPTIDES; NITRILES; PAPAIN; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 73949087937 PISSN: 14756366 EISSN: 14756374 Source Type: Journal
DOI: 10.3109/14756360902797328 Document Type: Article

Times cited : (4)

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