메뉴 건너뛰기




Volumn 44, Issue , 2010, Pages 201-216

Environmental enrichment and gene-environment interactions in mouse models of brain disorders

Author keywords

Alzheimer's disease; Amyotrophic lateral sclerosis; Gene environment interactions; Huntington's disease; Knockout mice; Mental activity; Physical exercise; Rett syndrome; Transgenic mice

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; BRAIN DERIVED NEUROTROPHIC FACTOR; COPPER ZINC SUPEROXIDE DISMUTASE; FLUOXETINE; NEUROTROPHIC FACTOR;

EID: 73849142340     PISSN: 08932336     EISSN: 19406045     Source Type: Book Series    
DOI: 10.1007/978-1-60761-474-6_11     Document Type: Review
Times cited : (3)

References (66)
  • 1
    • 33747613561 scopus 로고    scopus 로고
    • Enriched environments, experience-dependent plasticity and disorders of the nervous system
    • Nithianantharajah J, Hannan AJ (2006) Enriched environments, experience-dependent plasticity and disorders of the nervous system. Nat Rev Neurosci 7:697-709
    • (2006) Nat Rev Neurosci , vol.7 , pp. 697-709
    • Nithianantharajah, J.1    Hannan, A.J.2
  • 3
    • 33947689271 scopus 로고    scopus 로고
    • Regulators of adult neurogenesis in the healthy and diseased brain
    • Grote HE, Hannan AJ (2007) Regulators of adult neurogenesis in the healthy and diseased brain. Clin Exp Pharmacol Physiol 34:533-545
    • (2007) Clin Exp Pharmacol Physiol , vol.34 , pp. 533-545
    • Grote, H.E.1    Hannan, A.J.2
  • 4
    • 47149083991 scopus 로고    scopus 로고
    • Effects of enriched environment on animal models of neurodegenerative and psychiatric disorders
    • Laviola G, Hannan AJ, Macri S, Solinas M, Jaber M (2008) Effects of enriched environment on animal models of neurodegenerative and psychiatric disorders. Neurobiol Dis 31:159-168
    • (2008) Neurobiol Dis , vol.31 , pp. 159-168
    • Laviola, G.1    Hannan, A.J.2    MacRi, S.3    Solinas, M.4    Jaber, M.5
  • 5
    • 34250208181 scopus 로고    scopus 로고
    • Dynamic mutations as digital genetic modulators of brain development, function and dysfunction
    • Nithianantharajah J, Hannan AJ (2007) Dynamic mutations as digital genetic modulators of brain development, function and dysfunction. Bioessays 29:525-535
    • (2007) Bioessays , vol.29 , pp. 525-535
    • Nithianantharajah, J.1    Hannan, A.J.2
  • 6
    • 0013218415 scopus 로고    scopus 로고
    • Bates G, Harper PS, Jones L (eds) 3rd edn. Oxford University Press, Oxford, England
    • Bates G, Harper PS, Jones L (eds) (2002) Huntington's disease, 3rd edn. Oxford University Press, Oxford, England
    • (2002) Huntington's Disease
  • 8
    • 0034643362 scopus 로고    scopus 로고
    • Delaying the onset of Huntington's in mice
    • Van Dellen A, Blakemore C, Deacon R et al (2000) Delaying the onset of Huntington's in mice. Nature 404:721-722
    • (2000) Nature , vol.404 , pp. 721-722
    • Van Dellen, A.1    Blakemore, C.2    Deacon, R.3
  • 9
    • 0036152343 scopus 로고    scopus 로고
    • Environmental enrichment slows disease progression in R6/2 Huntington's disease mice
    • Hockly E, Cordery P, Woodman B et al (2002) Environmental enrichment slows disease progression in R6/2 Huntington's disease mice. Ann Neurol 51:235-242
    • (2002) Ann Neurol , vol.51 , pp. 235-242
    • Hockly, E.1    Cordery, P.2    Woodman, B.3
  • 10
    • 1542286877 scopus 로고    scopus 로고
    • EE rescues protein deficits in a mouse model of Huntington's disease, indicating a possible disease mechanism
    • Spires TL, Grote HE, Varshney NK et al (2004) EE rescues protein deficits in a mouse model of Huntington's disease, indicating a possible disease mechanism. J Neurosci 24:2270-2276
    • (2004) J Neurosci , vol.24 , pp. 2270-2276
    • Spires, T.L.1    Grote, H.E.2    Varshney, N.K.3
  • 11
    • 2942620844 scopus 로고    scopus 로고
    • Dendritic spine pathology and deficits in experience-dependent dendritic plasticity in R6/1 Huntington's disease transgenic mice
    • Spires TL, Grote HE, Garry S et al (2004) Dendritic spine pathology and deficits in experience-dependent dendritic plasticity in R6/1 Huntington's disease transgenic mice. Eur J Neurosci 19:2799-2807
    • (2004) Eur J Neurosci , vol.19 , pp. 2799-2807
    • Spires, T.L.1    Grote, H.E.2    Garry, S.3
  • 12
    • 0345118102 scopus 로고    scopus 로고
    • Delayed onset of Huntington's disease in mice in an enriched environment correlates with delayed loss of cannabinoid CB1 receptors
    • Glass M, Van Dellen A, Blakemore C et al (2004) Delayed onset of Huntington's disease in mice in an enriched environment correlates with delayed loss of cannabinoid CB1 receptors. Neuroscience 123:207-212
    • (2004) Neuroscience , vol.123 , pp. 207-212
    • Glass, M.1    Van Dellen, A.2    Blakemore, C.3
  • 13
    • 11144358364 scopus 로고    scopus 로고
    • Environmental, pharmacological, and genetic modulation of the HD phenotype in transgenic mice
    • Schilling G et al (2004) Environmental, pharmacological, and genetic modulation of the HD phenotype in transgenic mice. Exp Neurol 187:137-149
    • (2004) Exp Neurol , vol.187 , pp. 137-149
    • Schilling, G.1
  • 14
    • 39249084983 scopus 로고    scopus 로고
    • Gene-environment interactions modulating cognitive function and molecular correlates of synaptic plasticity in Huntington's disease transgenic mice
    • Nithianantharajah AJ, Barkus C, Murphy M, Hannan AJ (2008) Gene-environment interactions modulating cognitive function and molecular correlates of synaptic plasticity in Huntington's disease transgenic mice. Neurobiol Dis 29:490-504
    • (2008) Neurobiol Dis , vol.29 , pp. 490-504
    • Nithianantharajah, A.J.1    Barkus, C.2    Murphy, M.3    Hannan, A.J.4
  • 15
    • 58949085531 scopus 로고    scopus 로고
    • Altered serotonin receptor expression is associated with depression-related behavior in the R6/1 transgenic mouse model of Huntington's disease
    • Pang TYC, Du X, Zajac MS et al (2009) Altered serotonin receptor expression is associated with depression-related behavior in the R6/1 transgenic mouse model of Huntington's disease. Hum Mol Genet 18:753-766
    • (2009) Hum Mol Genet , vol.18 , pp. 753-766
    • Pang, T.Y.C.1    Du, X.2    Zajac, M.S.3
  • 16
    • 1842608950 scopus 로고    scopus 로고
    • Decreased hippocampal cell proliferation in R6/1 Huntington's mice
    • Lazic SE, Grote H, Armstrong RJ et al (2004) Decreased hippocampal cell proliferation in R6/1 Huntington's mice. Neuroreport 15:811-813
    • (2004) Neuroreport , vol.15 , pp. 811-813
    • Lazic, S.E.1    Grote, H.2    Armstrong, R.J.3
  • 17
    • 27644524469 scopus 로고    scopus 로고
    • Cognitive disorders and neurogenesis deficits in Huntington's disease mice are rescued by fluoxetine
    • Grote HE, Bull ND, Howard ML et al (2005) Cognitive disorders and neurogenesis deficits in Huntington's disease mice are rescued by fluoxetine. Eur J Neurosci 22:2081-2088
    • (2005) Eur J Neurosci , vol.22 , pp. 2081-2088
    • Grote, H.E.1    Bull, N.D.2    Howard, M.L.3
  • 18
    • 33745979171 scopus 로고    scopus 로고
    • Differential effects of voluntary physical exercise on behavioral and brain-derived neurotrophic factor expression deficits in Huntington's disease transgenic mice
    • Pang TY, Stam NC, Nithianantharajah J et al (2006) Differential effects of voluntary physical exercise on behavioral and brain-derived neurotrophic factor expression deficits in Huntington's disease transgenic mice. Neuroscience 141:569-584
    • (2006) Neuroscience , vol.141 , pp. 569-584
    • Pang, T.Y.1    Stam, N.C.2    Nithianantharajah, J.3
  • 19
    • 33645452859 scopus 로고    scopus 로고
    • Neurogenesis in the R6/1 transgenic mouse model of Huntington's disease: Effects of environmental enrichment
    • Lazic SE, Grote HE, Blakemore C et al (2006) Neurogenesis in the R6/1 transgenic mouse model of Huntington's disease: effects of environmental enrichment. Eur J Neurosci 23:1829-1838
    • (2006) Eur J Neurosci , vol.23 , pp. 1829-1838
    • Lazic, S.E.1    Grote, H.E.2    Blakemore, C.3
  • 20
    • 67649249884 scopus 로고    scopus 로고
    • Modeling brain reserve: Experience- dependent neuronal plasticity in healthy and Huntington's disease transgenic mice
    • Nithianantharajah J, Vijiaratnam N, Barkus C, et al (2009) Modeling brain reserve: experience- dependent neuronal plasticity in healthy and Huntington's disease transgenic mice. Am J Ger Psychiatry 17:196-209
    • (2009) Am J Ger Psychiatry , vol.17 , pp. 196-209
    • Nithianantharajah, J.1    Vijiaratnam, N.2    Barkus, C.3
  • 21
    • 42549092746 scopus 로고    scopus 로고
    • Wheel running from a juvenile age delays onset of specific motor deficits but does not alter protein aggregate density in a mouse model of Huntington's disease
    • Van Dellen A, Cordery PM, Spires TL et al (2008) Wheel running from a juvenile age delays onset of specific motor deficits but does not alter protein aggregate density in a mouse model of Huntington's disesase. BMC Neurosci 9:34
    • (2008) BMC Neurosci , vol.9 , pp. 34
    • Van Dellen, A.1    Cordery, P.M.2    Spires, T.L.3
  • 22
    • 12144288251 scopus 로고    scopus 로고
    • Venezuelan kindreds reveal that genetic and environmental factors modulate Huntington's disease age of onset
    • U.S.-Venezuela Collaborative Research Project
    • Wexler NS, Lorimer J, Porter J et al (2004) U.S.-Venezuela Collaborative Research Project. Venezuelan kindreds reveal that genetic and environmental factors modulate Huntington's disease age of onset. Proc Natl Acad Sci USA 101:3498-3503
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 3498-3503
    • Wexler, N.S.1    Lorimer, J.2    Porter, J.3
  • 23
    • 33745027879 scopus 로고    scopus 로고
    • Molecular mechanisms for Alzheimer's disease: Implications for neuroimaging and therapeutics
    • DOI 10.1111/j.1471-4159.2006.03989.x
    • Masters CL, Cappai R, Barnham KJ, Villemagne VL (2006) Molecular mechanisms for Alzheimer's disease: implications for neuroimaging and therapeutics. J Neurochem 97:1700-1725 (Pubitemid 43873662)
    • (2006) Journal of Neurochemistry , vol.97 , Issue.6 , pp. 1700-1725
    • Masters, C.L.1    Cappai, R.2    Barnham, K.J.3    Villemagne, V.L.4
  • 24
    • 0042093508 scopus 로고    scopus 로고
    • ApoE4 impairs hippocampal plasticity isoform- specifically and blocks the environmental stimulation of synaptogenesis and memory
    • Levi O, Jongen-Relo AL, Feldon J et al (2003) ApoE4 impairs hippocampal plasticity isoform- specifically and blocks the environmental stimulation of synaptogenesis and memory. Neurobiol Dis 13:273-282
    • (2003) Neurobiol Dis , vol.13 , pp. 273-282
    • Levi, O.1    Jongen-Relo, A.L.2    Feldon, J.3
  • 25
    • 0344305380 scopus 로고    scopus 로고
    • Environmental enrichment exacerbates amyloid plaque formation in a transgenic mouse model of Alzheimer disease
    • Jankowsky JL, Xu G, Fromholt D et al (2003) Environmental enrichment exacerbates amyloid plaque formation in a transgenic mouse model of Alzheimer disease. J Neuropathol Exp Neurol 62:1220-1227
    • (2003) J Neuropathol Exp Neurol , vol.62 , pp. 1220-1227
    • Jankowsky, J.L.1    Xu, G.2    Fromholt, D.3
  • 26
    • 4043147336 scopus 로고    scopus 로고
    • Environmental enrichment improves cognition in aged Alzheimer's transgenic mice despite stable beta-amyloid deposition
    • Arendash GW, Garcia MF, Costa DA et al (2004) Environmental enrichment improves cognition in aged Alzheimer's transgenic mice despite stable beta-amyloid deposition. Neuroreport 15:1751-1754
    • (2004) Neuroreport , vol.15 , pp. 1751-1754
    • Arendash, G.W.1    Garcia, M.F.2    Costa, D.A.3
  • 27
    • 21144456098 scopus 로고    scopus 로고
    • Environmental enrichment mitigates cognitive deficits in a mouse model of Alzheimer's disease
    • Jankowsky JL, Melnikova T, Fadale DJ et al (2005) Environmental enrichment mitigates cognitive deficits in a mouse model of Alzheimer's disease. J Neurosci 25:5217-5224
    • (2005) J Neurosci , vol.25 , pp. 5217-5224
    • Jankowsky, J.L.1    Melnikova, T.2    Fadale, D.J.3
  • 28
    • 20044377403 scopus 로고    scopus 로고
    • Environmental enrichment reduces Abeta levels and amyloid deposition in transgenic mice
    • Lazarov O, Robinson J, Tang YP et al (2005) Environmental enrichment reduces Abeta levels and amyloid deposition in transgenic mice. Cell 120:701-713
    • (2005) Cell , vol.120 , pp. 701-713
    • Lazarov, O.1    Robinson, J.2    Tang, Y.P.3
  • 29
    • 33846798475 scopus 로고    scopus 로고
    • Molecular mechanisms mediating pathological plasticity in Huntington's disease and Alzheimer's disease
    • Spires TL, Hannan AJ (2007) Molecular mechanisms mediating pathological plasticity in Huntington's disease and Alzheimer's disease. J Neurochem 100:874-882
    • (2007) J Neurochem , vol.100 , pp. 874-882
    • Spires, T.L.1    Hannan, A.J.2
  • 30
    • 18244391974 scopus 로고    scopus 로고
    • Deficient neurogenesis in forebrain-specific presenilin-1 knockout mice is associated with reduced clearance of hippocampal memory traces
    • Feng R et al (2001) Deficient neurogenesis in forebrain-specific presenilin-1 knockout mice is associated with reduced clearance of hippocampal memory traces. Neuron 32:911-926
    • (2001) Neuron , vol.32 , pp. 911-926
    • Feng, R.1
  • 31
    • 18244384051 scopus 로고    scopus 로고
    • Voluntary exercise decreases amyloid load in a transgenic model of Alzheimer's disease
    • Adlard PA, Perreau VM, Pop V, Cotman CW (2005) Voluntary exercise decreases amyloid load in a transgenic model of Alzheimer's disease. J Neurosci 25:4217-4221
    • (2005) J Neurosci , vol.25 , pp. 4217-4221
    • Adlard, P.A.1    Perreau, V.M.2    Pop, V.3    Cotman, C.W.4
  • 32
    • 0041856595 scopus 로고    scopus 로고
    • Epidemiology of neurodegeneration
    • Mayeux R (2003) Epidemiology of neurodegeneration. Annu Rev Neurosci 26:81-104
    • (2003) Annu Rev Neurosci , vol.26 , pp. 81-104
    • Mayeux, R.1
  • 33
    • 18944393305 scopus 로고    scopus 로고
    • Nature, nurture and neurology: Gene-environment interactions in neurodegeneration
    • Spires TL, Hannan AJ (2005) Nature, nurture and neurology: gene-environment interactions in neurodegeneration. FEBS J 272:2347-2361
    • (2005) FEBS J , vol.272 , pp. 2347-2361
    • Spires, T.L.1    Hannan, A.J.2
  • 34
    • 33644919176 scopus 로고    scopus 로고
    • Brain reserve and dementia: A systematic review
    • Valenzuela MJ, Sachdev P (2006) Brain reserve and dementia: a systematic review. Psychol Med 36:441-454
    • (2006) Psychol Med , vol.36 , pp. 441-454
    • Valenzuela, M.J.1    Sachdev, P.2
  • 35
    • 42249102078 scopus 로고    scopus 로고
    • Transgenics, toxicity and therapeutics in rodent models of mutant SOD1-mediated familial ALS
    • Turner BJ, Talbot K (2008) Transgenics, toxicity and therapeutics in rodent models of mutant SOD1-mediated familial ALS. Prog Neurobiol 85:94-134
    • (2008) Prog Neurobiol , vol.85 , pp. 94-134
    • Turner, B.J.1    Talbot, K.2
  • 36
    • 0038103806 scopus 로고    scopus 로고
    • Regular exercise is beneficial to a mouse model of amyotrophic lateral sclerosis
    • Kirkinezos IG, Hernandez D, Bradley WG, Moraes CT (2003) Regular exercise is beneficial to a mouse model of amyotrophic lateral sclerosis. Ann Neurol 53:804-807
    • (2003) Ann Neurol , vol.53 , pp. 804-807
    • Kirkinezos, I.G.1    Hernandez, D.2    Bradley, W.G.3    Moraes, C.T.4
  • 37
    • 0141997900 scopus 로고    scopus 로고
    • Sexual differences in onset of disease and response to exercise in a transgenic model of ALS
    • Veldink JH et al (2003) Sexual differences in onset of disease and response to exercise in a transgenic model of ALS. Neuromuscul Disord 13:737-743
    • (2003) Neuromuscul Disord , vol.13 , pp. 737-743
    • Veldink, J.H.1
  • 38
    • 2442497548 scopus 로고    scopus 로고
    • Effects of high-intensity endurance exercise training in the G93A mouse model of amyotrophic lateral sclerosis
    • Mahoney DJ, Rodriguez C, Devries M et al (2004) Effects of high-intensity endurance exercise training in the G93A mouse model of amyotrophic lateral sclerosis. Muscle Nerve 29:656-662
    • (2004) Muscle Nerve , vol.29 , pp. 656-662
    • Mahoney, D.J.1    Rodriguez, C.2    Devries, M.3
  • 39
    • 18244390714 scopus 로고    scopus 로고
    • Synergy of insulin-like growth factor-1 and exercise in amyotrophic lateral sclerosis
    • Kaspar BK, Frost LM, Christian L et al (2005) Synergy of insulin-like growth factor-1 and exercise in amyotrophic lateral sclerosis. Ann Neurol 57:649-655
    • (2005) Ann Neurol , vol.57 , pp. 649-655
    • Kaspar, B.K.1    Frost, L.M.2    Christian, L.3
  • 40
    • 10844284618 scopus 로고    scopus 로고
    • Extensive exercise is not harmful in amyotrophic lateral sclerosis
    • Liebetanz D, Hagemann K, Von Lewinski F et al (2004) Extensive exercise is not harmful in amyotrophic lateral sclerosis. Eur J Neurosci 20:3115-3120
    • (2004) Eur J Neurosci , vol.20 , pp. 3115-3120
    • Liebetanz, D.1    Hagemann, K.2    Von Lewinski, F.3
  • 41
    • 49249123273 scopus 로고    scopus 로고
    • Sex-specific behavioural effects of environmental enrichment in a transgenic mouse model of amyotrophic lateral sclerosis
    • Stam N, Nithianantharajah J, Howard ML et al (2008) Sex-specific behavioural effects of environmental enrichment in a transgenic mouse model of amyotrophic lateral sclerosis. Eur J Neurosci 28:717-723
    • (2008) Eur J Neurosci , vol.28 , pp. 717-723
    • Stam, N.1    Nithianantharajah, J.2    Howard, M.L.3
  • 42
    • 33746356840 scopus 로고    scopus 로고
    • Rett syndrome: New clinical and molecular insights
    • Williamson SL, Christodoulou J (2006) Rett syndrome: new clinical and molecular insights. Eur J Hum Genet 14:896-903
    • (2006) Eur J Hum Genet , vol.14 , pp. 896-903
    • Williamson, S.L.1    Christodoulou, J.2
  • 43
    • 0032830639 scopus 로고    scopus 로고
    • Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpGbinding protein 2
    • Amir RE, Van Den Veyver IB, Wan M et al (1999) Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpGbinding protein 2. Nat Genet 23:185-188
    • (1999) Nat Genet , vol.23 , pp. 185-188
    • Amir, R.E.1    Van Den Veyver, I.B.2    Wan, M.3
  • 44
    • 33646893456 scopus 로고    scopus 로고
    • Molecular genetics of Rett syndrome: When DNA methylation goes unrecognized
    • Bienvenu T, Chelly J (2006) Molecular genetics of Rett syndrome: when DNA methylation goes unrecognized. Nat Rev Genet 7:415-426
    • (2006) Nat Rev Genet , vol.7 , pp. 415-426
    • Bienvenu, T.1    Chelly, J.2
  • 45
    • 33847266846 scopus 로고    scopus 로고
    • Reversal of neurological defects in a mouse model of Rett syndrome
    • Guy J, Gan J, Selfridge J et al (2007) Reversal of neurological defects in a mouse model of Rett syndrome. Science 315:1143-1147
    • (2007) Science , vol.315 , pp. 1143-1147
    • Guy, J.1    Gan, J.2    Selfridge, J.3
  • 47
    • 33645080930 scopus 로고    scopus 로고
    • Mecp2 deficiency is associated with learning and cognitive deficits and altered gene activity in the hippocampal region of mice
    • Pelka GJ, Watson CM, Radziewic T et al (2006) Mecp2 deficiency is associated with learning and cognitive deficits and altered gene activity in the hippocampal region of mice. Brain 129:887-898
    • (2006) Brain , vol.129 , pp. 887-898
    • Pelka, G.J.1    Watson, C.M.2    Radziewic, T.3
  • 48
    • 45349089199 scopus 로고    scopus 로고
    • Motor deficits in a Rett syndrome mouse model are ameliorated by environmental enrichment
    • Kondo M, Gray L, Pelka GJ, Christodoulou J, Tam PPL, Hannan AJ (2008) Motor deficits in a Rett syndrome mouse model are ameliorated by environmental enrichment. Eur J Neurosci 27:3342-3350
    • (2008) Eur J Neurosci , vol.27 , pp. 3342-3350
    • Kondo, M.1    Gray, L.2    Pelka, G.J.3    Christodoulou, J.4    Tam, P.P.L.5    Hannan, A.J.6
  • 49
    • 56549105433 scopus 로고    scopus 로고
    • Environmental enrichment alters locomotor behaviour and ventricular volume in Mecp2 1lox mice
    • Nag N, Moriuchi JM, Peitzman CG et al (2009) Environmental enrichment alters locomotor behaviour and ventricular volume in Mecp2 1lox mice. Behav Brain Res 196:44-48
    • (2009) Behav Brain Res , vol.196 , pp. 44-48
    • Nag, N.1    Moriuchi, J.M.2    Peitzman, C.G.3
  • 50
    • 45849092558 scopus 로고    scopus 로고
    • Simple sequence repeats: Genetic modulators of brain function and behavior
    • Fondon JW, Hammock EAD, Hannan AJ, King DJ (2008) Simple sequence repeats: genetic modulators of brain function and behavior. Trends Neurosci 31:328-334
    • (2008) Trends Neurosci , vol.31 , pp. 328-334
    • Fondon, J.W.1    Hammock, E.A.D.2    Hannan, A.J.3    King, D.J.4
  • 51
    • 23844547567 scopus 로고    scopus 로고
    • Enriched environment promotes behavioral and morphological recovery in a mouse model for the fragile X syndrome
    • Restivo L, Ferrari F, Passino E et al (2005) Enriched environment promotes behavioral and morphological recovery in a mouse model for the fragile X syndrome. Proc Natl Acad Sci USA 102:11557-11562
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 11557-11562
    • Restivo, L.1    Ferrari, F.2    Passino, E.3
  • 52
    • 0037151272 scopus 로고    scopus 로고
    • Differential effects of environmental enrichment on behavior and learning of male and female Ts65Dn mice, a model for Down syndrome
    • Martinez-Cue C, Baamonde C, Lumbreras M et al (2002) Differential effects of environmental enrichment on behavior and learning of male and female Ts65Dn mice, a model for Down syndrome. Behav Brain Res 134:185-200
    • (2002) Behav Brain Res , vol.134 , pp. 185-200
    • Martinez-Cue, C.1    Baamonde, C.2    Lumbreras, M.3
  • 53
    • 0037662885 scopus 로고    scopus 로고
    • Alterations of neocortical pyramidal cell phenotype in the Ts65Dn mouse model of Down syndrome: Effects of EE
    • Dierssen M, Benavides-Piccione R, Martinez- Cue C et al (2003) Alterations of neocortical pyramidal cell phenotype in the Ts65Dn mouse model of Down syndrome: effects of EE. Cereb Cortex 13:758-764
    • (2003) Cereb Cortex , vol.13 , pp. 758-764
    • Dierssen, M.1    Benavides-Piccione, R.2    Martinez- Cue, C.3
  • 54
    • 23744473479 scopus 로고    scopus 로고
    • Behavioral, cognitive and biochemical responses to different environmental conditions in male Ts65Dn mice, a model of Down syndrome
    • Martinez-Cue C, Rueda N, Garcia E et al (2005) Behavioral, cognitive and biochemical responses to different environmental conditions in male Ts65Dn mice, a model of Down syndrome. Behav Brain Res 163:174-185
    • (2005) Behav Brain Res , vol.163 , pp. 174-185
    • Martinez-Cue, C.1    Rueda, N.2    Garcia, E.3
  • 55
    • 40049097817 scopus 로고    scopus 로고
    • Progressive changes in the development toward schizophrenia: Studies in subjects at increased symptomatic risk
    • Wood SJ, Pantelis C, Velakoulis D et al (2008) Progressive changes in the development toward schizophrenia: studies in subjects at increased symptomatic risk. Schizophr Bull 34:322-329
    • (2008) Schizophr Bull , vol.34 , pp. 322-329
    • Wood, S.J.1    Pantelis, C.2    Velakoulis, D.3
  • 56
    • 33845329226 scopus 로고    scopus 로고
    • Susceptibility genes for schizophrenia: Characterisation of mutant mouse models at the level of phenotypic behaviour
    • O'Tuathaigh CM, Babovic D, O'Meara G et al (2007) Susceptibility genes for schizophrenia: characterisation of mutant mouse models at the level of phenotypic behaviour. Neurosci Biobehav Rev 31:60-78
    • (2007) Neurosci Biobehav Rev , vol.31 , pp. 60-78
    • O'Tuathaigh, C.M.1    Babovic, D.2    O'Meara, G.3
  • 57
    • 0034745927 scopus 로고    scopus 로고
    • PLC-beta1, activated via mGluRs, mediates activity-dependent differentiation in cerebral cortex
    • Hannan AJ, Blakemore C, Katsnelson A et al (2001) PLC-beta1, activated via mGluRs, mediates activity-dependent differentiation in cerebral cortex. Nat Neurosci 4:282-288
    • (2001) Nat Neurosci , vol.4 , pp. 282-288
    • Hannan, A.J.1    Blakemore, C.2    Katsnelson, A.3
  • 58
    • 15244351734 scopus 로고    scopus 로고
    • Activitydependent regulation of synapse and dendritic spine morphology in developing barrel cortex requires phospholipase C-beta1 signalling
    • Spires TL, Molnar Z et al (2005) Activitydependent regulation of synapse and dendritic spine morphology in developing barrel cortex requires phospholipase C-beta1 signalling. Cereb Cortex 15:385-393
    • (2005) Cereb Cortex , vol.15 , pp. 385-393
    • Spires, T.L.1    Molnar, Z.2
  • 59
    • 50249118640 scopus 로고    scopus 로고
    • PLC-1 knockout mice as a model of disrupted cortical development and plasticity: Behavioral endophenotypes and dysregulation of RGS4 gene expression
    • McOmish CE, Burrows E, Howard M, Hannan AJ (2008) PLC-1 knockout mice as a model of disrupted cortical development and plasticity: behavioral endophenotypes and dysregulation of RGS4 gene expression. Hippocampus 18:824-834
    • (2008) Hippocampus , vol.18 , pp. 824-834
    • McOmish, C.E.1    Burrows, E.2    Howard, M.3    Hannan, A.J.4
  • 60
    • 69749125063 scopus 로고    scopus 로고
    • Sensitivity to MK-801 in phospholipase C-1 knockout mice reveals a specific NMDA receptor deficit
    • Gray L, McOmish CE, Scarr E et al (2009) Sensitivity to MK-801 in phospholipase C-1 knockout mice reveals a specific NMDA receptor deficit. Int J Neuropsychopharmacol 12:917-928
    • (2009) Int J Neuropsychopharmacol , vol.12 , pp. 917-928
    • Gray, L.1    McOmish, C.E.2    Scarr, E.3
  • 61
    • 45549107762 scopus 로고    scopus 로고
    • Phospholipase C-beta1 knockout mice exhibit endophenotypes modeling schizophrenia which are rescued by environmental enrichment and clozapine administration
    • McOmish CE, Burrows E, Howard M et al (2007) Phospholipase C-beta1 knockout mice exhibit endophenotypes modeling schizophrenia which are rescued by environmental enrichment and clozapine administration. Mol Psychiatry 13:661-672
    • (2007) Mol Psychiatry , vol.13 , pp. 661-672
    • McOmish, C.E.1    Burrows, E.2    Howard, M.3
  • 62
    • 0037624040 scopus 로고    scopus 로고
    • Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene
    • Caspi A, Sugden K, Moffitt TE, Taylor A et al (2003) Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science 301:386-389
    • (2003) Science , vol.301 , pp. 386-389
    • Caspi, A.1    Sugden, K.2    Moffitt, T.E.3    Taylor, A.4
  • 63
    • 0037107176 scopus 로고    scopus 로고
    • EE reverses the effects of maternal separation on stress reactivity
    • Francis DD, Diorio J, Plotsky PM, Meaney MJ (2002) EE reverses the effects of maternal separation on stress reactivity. J Neurosci 22:7840-7843
    • (2002) J Neurosci , vol.22 , pp. 7840-7843
    • Francis, D.D.1    Diorio, J.2    Plotsky, P.M.3    Meaney, M.J.4
  • 64
    • 33947317090 scopus 로고    scopus 로고
    • What's wrong with my mouse model? Advances and strategies in animal modeling of anxiety and depression
    • Kalueff AV, Wheaton M, Murphy DL (2007) What's wrong with my mouse model? Advances and strategies in animal modeling of anxiety and depression. Behav Brain Res 179:1-18
    • (2007) Behav Brain Res , vol.179 , pp. 1-18
    • Kalueff, A.V.1    Wheaton, M.2    Murphy, D.L.3
  • 65
    • 3242756931 scopus 로고    scopus 로고
    • Huntington's disease: Which drugs might help patients?
    • Hannan AJ (2004) Huntington's disease: which drugs might help patients? IDrugs 7:351-358
    • (2004) IDrugs , vol.7 , pp. 351-358
    • Hannan, A.J.1
  • 66
    • 34447337214 scopus 로고    scopus 로고
    • Enviromimetics: Exploring gene-environment interactions to identify therapeutic targets for brain disorders
    • McOmish CE, Hannan AJ (2007) Enviromimetics: exploring gene-environment interactions to identify therapeutic targets for brain disorders. Expert Opin Ther Targets 11:899-913
    • (2007) Expert Opin Ther Targets , vol.11 , pp. 899-913
    • McOmish, C.E.1    Hannan, A.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.