메뉴 건너뛰기




Volumn 163, Issue 2, 2005, Pages 174-185

Behavioral, cognitive and biochemical responses to different environmental conditions in male Ts65Dn mice, a model of Down syndrome

Author keywords

Aggression; Biochemical stress response; Down syndrome; Environmental enrichment; Learning; Ts65Dn mice

Indexed keywords

CORTICOTROPIN; TESTOSTERONE;

EID: 23744473479     PISSN: 01664328     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbr.2005.04.016     Document Type: Article
Times cited : (75)

References (62)
  • 1
    • 0033978891 scopus 로고    scopus 로고
    • Discovery and genetic localization of Down syndrome cerebellar phenotypes using the Ts65Dn mouse
    • L. Baxter, T.H. Moran, J.T. Richtsmeier, J. Troncoso, and R.H. Reeves Discovery and genetic localization of Down syndrome cerebellar phenotypes using the Ts65Dn mouse Hum Mol Gen 9 2000 195 202
    • (2000) Hum Mol Gen , vol.9 , pp. 195-202
    • Baxter, L.1    Moran, T.H.2    Richtsmeier, J.T.3    Troncoso, J.4    Reeves, R.H.5
  • 5
    • 0025246314 scopus 로고
    • Neonatal stress and long-term modulation of GABA receptors in rat brain
    • S.W. Bolden, J.W. Hambley, Johnston GAR, and L.J. Rogers Neonatal stress and long-term modulation of GABA receptors in rat brain Neurosci Lett 111 1990 258 262
    • (1990) Neurosci Lett , vol.111 , pp. 258-262
    • Bolden, S.W.1    Hambley, J.W.2    Gar, J.3    Rogers, L.J.4
  • 6
    • 0004794879 scopus 로고    scopus 로고
    • Postnatal handling/maternal separation alters responses to startle and central benzodiazepine receptor level subtypes in adult rats
    • C. Caldji, D. Francis, S. Sharma, P.M. Plostky, and M.J. Meaney Postnatal handling/maternal separation alters responses to startle and central benzodiazepine receptor level subtypes in adult rats Soc Neurosci Abstr 23 1997 1083
    • (1997) Soc Neurosci Abstr , vol.23 , pp. 1083
    • Caldji, C.1    Francis, D.2    Sharma, S.3    Plostky, P.M.4    Meaney, M.J.5
  • 7
    • 0030045921 scopus 로고    scopus 로고
    • Behavioral assessment of the Ts65Dn mouse, a model for Down syndrome: Altered behavioral in the elevated plus maze and open field
    • M.E. Cousons-Read, and L.S. Crnic Behavioral assessment of the Ts65Dn mouse, a model for Down syndrome: altered behavioral in the elevated plus maze and open field Behav Genet 26 1996 7 13
    • (1996) Behav Genet , vol.26 , pp. 7-13
    • Cousons-Read, M.E.1    Crnic, L.S.2
  • 8
    • 0003043137 scopus 로고    scopus 로고
    • Down syndrome: Neuropsychology and animal models
    • L.S. Crnic, and B.F. Pennington Down syndrome: neuropsychology and animal models Prog Infancy Res 1 2000 69 111
    • (2000) Prog Infancy Res , vol.1 , pp. 69-111
    • Crnic, L.S.1    Pennington, B.F.2
  • 9
    • 0026337337 scopus 로고
    • Antinociceptive action of opiates and opioid peptides after unilateral microinjection into area tempestas in rats
    • A. D'Amore, P. Lorenzini, and M. Massotti Antinociceptive action of opiates and opioid peptides after unilateral microinjection into area tempestas in rats J Pharmacol Exp Ther 259 1991 1308 1315
    • (1991) J Pharmacol Exp Ther , vol.259 , pp. 1308-1315
    • D'Amore, A.1    Lorenzini, P.2    Massotti, M.3
  • 10
    • 0029046318 scopus 로고
    • Long-term changes induced by neonatal handling in the nociceptive threshold and body weight in mice
    • A. D'Amore, A. Mazzucchelli, and A. Koizzo Long-term changes induced by neonatal handling in the nociceptive threshold and body weight in mice Physiol Behav 57 1995 1195 1197
    • (1995) Physiol Behav , vol.57 , pp. 1195-1197
    • D'Amore, A.1    Mazzucchelli, A.2    Koizzo, A.3
  • 11
    • 0023071678 scopus 로고
    • An improved method for preparing G-banded chromosomes from mouse peripheral blood
    • M.T. Davisson, and E.C. Akeson An improved method for preparing G-banded chromosomes from mouse peripheral blood Cyt Cell Genet 45 1987 70 74
    • (1987) Cyt Cell Genet , vol.45 , pp. 70-74
    • Davisson, M.T.1    Akeson, E.C.2
  • 12
    • 0033215376 scopus 로고    scopus 로고
    • Stress and cognition: Are corticosteroids good or bad guys?
    • E.R. De Kloet, M.S. Oitzl, and M. Joëls Stress and cognition: are corticosteroids good or bad guys? Trends Neurosci 22 1999 422 426
    • (1999) Trends Neurosci , vol.22 , pp. 422-426
    • De Kloet, E.R.1    Oitzl, M.S.2    Joëls, M.3
  • 15
    • 78651165544 scopus 로고
    • The effects of an enriched environment on the histology of the rat cerebral cortex
    • M.C. Diamond, D. Krech, and M.R. Rosenzweig The effects of an enriched environment on the histology of the rat cerebral cortex J Comp Neurol 123 1964 111 120
    • (1964) J Comp Neurol , vol.123 , pp. 111-120
    • Diamond, M.C.1    Krech, D.2    Rosenzweig, M.R.3
  • 16
    • 0037662885 scopus 로고    scopus 로고
    • Alterations of neocortical pyramidal cell phenotype in the Ts65Dn mouse model of Down syndrome: Effects of environmental enrichment
    • M. Dierssen, R. Benavides-Piccione, C. Martínez-Cué, X. Estivill, J. Flórez, and G.N. Elston Alterations of neocortical pyramidal cell phenotype in the Ts65Dn mouse model of Down syndrome: effects of environmental enrichment Cereb Cortex 13 2003 758 764
    • (2003) Cereb Cortex , vol.13 , pp. 758-764
    • Dierssen, M.1    Benavides-Piccione, R.2    Martínez-Cué, C.3    Estivill, X.4    Flórez, J.5    Elston, G.N.6
  • 19
    • 9644274134 scopus 로고    scopus 로고
    • Impaired sustained attention and error-induced stereotypy in the aged Ts65Dn mouse: A mouse model of Down syndrome and Alzheimer's disease
    • L.J. Driscoll, J.C. Carroll, J. Moon, L.S. Crnic, D.A. Levitsky, and B.J. Strupp Impaired sustained attention and error-induced stereotypy in the aged Ts65Dn mouse: a mouse model of Down syndrome and Alzheimer's disease Behav Neurosci 118 2004 1196 1205
    • (2004) Behav Neurosci , vol.118 , pp. 1196-1205
    • Driscoll, L.J.1    Carroll, J.C.2    Moon, J.3    Crnic, L.S.4    Levitsky, D.A.5    Strupp, B.J.6
  • 21
    • 0029170921 scopus 로고
    • Environmental enrichment and postnatal handling prevent spatial learning deficits in aged hypoemotional and hyperemotional rats
    • R.M. Escorihuela, A. Tobeña, and A. Fernández-Teruel Environmental enrichment and postnatal handling prevent spatial learning deficits in aged hypoemotional and hyperemotional rats Learn Mem 2 1995 40 48
    • (1995) Learn Mem , vol.2 , pp. 40-48
    • Escorihuela, R.M.1    Tobeña, A.2    Fernández-Teruel, A.3
  • 23
    • 0031425147 scopus 로고    scopus 로고
    • Neonatal handling and environmental enrichment effects on emotionality, novelty/reward seeking, and age-related cognitive and hippocampal impairments: Focus on the roman rat lines
    • A. Fernández-Teruel, R.M. Escorihuela, B. Castellano, B. González, and A. Tobeña Neonatal handling and environmental enrichment effects on emotionality, novelty/reward seeking, and age-related cognitive and hippocampal impairments: focus on the roman rat lines Behav Genet 27 1997 513 526
    • (1997) Behav Genet , vol.27 , pp. 513-526
    • Fernández-Teruel, A.1    Escorihuela, R.M.2    Castellano, B.3    González, B.4    Tobeña, A.5
  • 24
    • 0035022091 scopus 로고    scopus 로고
    • On the cause of mental retardation in Down syndrome: Extrapolation from full and segmental trisomy 16 mouse models
    • Z. Galdzicki, R. Siarey, R. Pearce, J. Stoll, and S.I. Rapoport On the cause of mental retardation in Down syndrome: extrapolation from full and segmental trisomy 16 mouse models Brain Res Revs 35 2001 115 145
    • (2001) Brain Res Revs , vol.35 , pp. 115-145
    • Galdzicki, Z.1    Siarey, R.2    Pearce, R.3    Stoll, J.4    Rapoport, S.I.5
  • 25
    • 0042025826 scopus 로고    scopus 로고
    • Understanding mental retardation in Down syndrome using trisomy 16 mouse models
    • Z. Galdzicki, and R. Siarey Understanding mental retardation in Down syndrome using trisomy 16 mouse models Genes Brain Behav 2 2003 167 178
    • (2003) Genes Brain Behav , vol.2 , pp. 167-178
    • Galdzicki, Z.1    Siarey, R.2
  • 26
    • 0242348738 scopus 로고    scopus 로고
    • Mouse models of Down syndrome: How useful can they be? Comparison of the gene content of human chromosome 21 with orthologous mouse genomic regions
    • K. Gardiner, A. Fortna, L. Bechtel, and M.T. Davisson Mouse models of Down syndrome: how useful can they be? Comparison of the gene content of human chromosome 21 with orthologous mouse genomic regions Gene 318 2003 137 147
    • (2003) Gene , vol.318 , pp. 137-147
    • Gardiner, K.1    Fortna, A.2    Bechtel, L.3    Davisson, M.T.4
  • 27
    • 0034097607 scopus 로고    scopus 로고
    • Loss of cholinergic phenotype in basal forebrain coincides with cognitive decline in a mouse model of Down's syndrome
    • Granholm A-CE, L.A. Sanders, and L.S. Crnic Loss of cholinergic phenotype in basal forebrain coincides with cognitive decline in a mouse model of Down's syndrome Exp Neurol 161 2000 647 663
    • (2000) Exp Neurol , vol.161 , pp. 647-663
    • A-Ce, G.1    Sanders, L.A.2    Crnic, L.S.3
  • 28
    • 0028143161 scopus 로고
    • Effects of environmental enrichment on aggresive behavior, dominance hierarchies, and endocrine states in male DBA/2J mice
    • A. Haemisch, T. Voss, and K. Gärtner Effects of environmental enrichment on aggresive behavior, dominance hierarchies, and endocrine states in male DBA/2J mice Physiol Behav 56 1994 1041 1048
    • (1994) Physiol Behav , vol.56 , pp. 1041-1048
    • Haemisch, A.1    Voss, T.2    Gärtner, K.3
  • 29
    • 0031302607 scopus 로고    scopus 로고
    • Effects of cage enrichment on territorial aggression
    • A. Haemisch, and K. Gärtner Effects of cage enrichment on territorial aggression Acta Physiol Scand Suppl 640 1997 73 76
    • (1997) Acta Physiol Scand Suppl , vol.640 , pp. 73-76
    • Haemisch, A.1    Gärtner, K.2
  • 30
    • 0020329371 scopus 로고
    • The relation of social to biological processes in disease
    • J.P. Henri The relation of social to biological processes in disease Soc Sci Med 16 1982 369 380
    • (1982) Soc Sci Med , vol.16 , pp. 369-380
    • Henri, J.P.1
  • 34
    • 0032864548 scopus 로고    scopus 로고
    • Primate models to understand human aggression
    • N.H. Kalin Primate models to understand human aggression J Clin Psychiatry 60 Suppl. 15 1999 29 32
    • (1999) J Clin Psychiatry , vol.60 , Issue.15 SUPPL. , pp. 29-32
    • Kalin, N.H.1
  • 35
    • 4644250821 scopus 로고    scopus 로고
    • Hippocampal long-term potentiation suppressed by increased inhibition in the Ts65Dn mouse, a genetic model of Down syndrome
    • A.M. Kleschevnikov, P.V. Belichenko, A.J. Villar, C.J. Epstein, R.C. Malenka, and W.C. Mobley Hippocampal long-term potentiation suppressed by increased inhibition in the Ts65Dn mouse, a genetic model of Down syndrome J Neurosci 24 2004 8153 8160
    • (2004) J Neurosci , vol.24 , pp. 8153-8160
    • Kleschevnikov, A.M.1    Belichenko, P.V.2    Villar, A.J.3    Epstein, C.J.4    Malenka, R.C.5    Mobley, W.C.6
  • 36
    • 0030271334 scopus 로고    scopus 로고
    • Characterization of sensorimotor performance, reproductive and aggressive behaviors in segmental trisomic 16 (Ts65Dn) mice
    • S.L. Klein, L.J. Kriegsfeld, J.E. Hairston, V. Rau, R.J. Nelson, and P.J. Yarowsky Characterization of sensorimotor performance, reproductive and aggressive behaviors in segmental trisomic 16 (Ts65Dn) mice Physiol Behav 60 1996 1159 1164
    • (1996) Physiol Behav , vol.60 , pp. 1159-1164
    • Klein, S.L.1    Kriegsfeld, L.J.2    Hairston, J.E.3    Rau, V.4    Nelson, R.J.5    Yarowsky, P.J.6
  • 37
    • 0025612695 scopus 로고
    • Animal models for human PFC-related disorders
    • B. Kolb Animal models for human PFC-related disorders Prog Brain Res 85 1990 501 519
    • (1990) Prog Brain Res , vol.85 , pp. 501-519
    • Kolb, B.1
  • 38
    • 0033970177 scopus 로고    scopus 로고
    • Synaptic deficit in the temporal cortex of partial trisomy 16 (Ts65Dn) mice
    • M.A. Kurt, D.C. Davies, M. Kidd, M. Dierssen, and J. Flórez Synaptic deficit in the temporal cortex of partial trisomy 16 (Ts65Dn) mice Brain Res 858 2000 191 197
    • (2000) Brain Res , vol.858 , pp. 191-197
    • Kurt, M.A.1    Davies, D.C.2    Kidd, M.3    Dierssen, M.4    Flórez, J.5
  • 39
    • 4444336568 scopus 로고    scopus 로고
    • Deficits of neuronal density in CA1 and synaptic density in the dentate gyrus, CA3 and CA1, in a mouse model of Down syndrome
    • M.A. Kurt, I. Kaffa, M. Dierssen, and D.C. Davies Deficits of neuronal density in CA1 and synaptic density in the dentate gyrus, CA3 and CA1, in a mouse model of Down syndrome Brain Res 1022 2004 101 109
    • (2004) Brain Res , vol.1022 , pp. 101-109
    • Kurt, M.A.1    Kaffa, I.2    Dierssen, M.3    Davies, D.C.4
  • 40
    • 0027179669 scopus 로고
    • Subchronic MK-801 treatment to juvenile rats attenuates environmental effects on adult spatial learning
    • R. Liljequist, B.G. Henriksson, N. Latif, T. Pham, B. Winblad, and A.H. Mohammed Subchronic MK-801 treatment to juvenile rats attenuates environmental effects on adult spatial learning Behav Brain Res 56 1993 107 114
    • (1993) Behav Brain Res , vol.56 , pp. 107-114
    • Liljequist, R.1    Henriksson, B.G.2    Latif, N.3    Pham, T.4    Winblad, B.5    Mohammed, A.H.6
  • 43
    • 0037306414 scopus 로고    scopus 로고
    • Effects of different forms of environmental enrichment on behavioural, endocrinological, and immunological parameters in male mice
    • V. Marashi, A. Barnekow, E. Ossendorf, and N. Sachser Effects of different forms of environmental enrichment on behavioural, endocrinological, and immunological parameters in male mice Horm Behav 43 2003 281 292
    • (2003) Horm Behav , vol.43 , pp. 281-292
    • Marashi, V.1    Barnekow, A.2    Ossendorf, E.3    Sachser, N.4
  • 45
    • 0037151272 scopus 로고    scopus 로고
    • Differential effects of environmental enrichment on behavior and learning of male and female Ts65Dn mice, a model for Down syndrome
    • C. Martínez-Cué, C. Baamonde, M. Lumbreras, J. Paz, M.T. Davisson, and M. Dierssen Differential effects of environmental enrichment on behavior and learning of male and female Ts65Dn mice, a model for Down syndrome Behav Brain Res 134 2002 185 200
    • (2002) Behav Brain Res , vol.134 , pp. 185-200
    • Martínez-Cué, C.1    Baamonde, C.2    Lumbreras, M.3    Paz, J.4    Davisson, M.T.5    Dierssen, M.6
  • 46
    • 0014326508 scopus 로고
    • A review of psychoendocrine research on the pituitary-adrenal-cortical system
    • J.W. Mason A review of psychoendocrine research on the pituitary-adrenal-cortical system Psychosom Med 30 1968 576 607
    • (1968) Psychosom Med , vol.30 , pp. 576-607
    • Mason, J.W.1
  • 47
    • 0025063652 scopus 로고
    • Environmental influence on behaviour and nerve growth factor in the brain
    • A.H. Mohammed, B. Winblad, B. Ebendal, and L. Lärkfors Environmental influence on behaviour and nerve growth factor in the brain Brain Res 528 1990 62 72
    • (1990) Brain Res , vol.528 , pp. 62-72
    • Mohammed, A.H.1    Winblad, B.2    Ebendal, B.3    Lärkfors, L.4
  • 49
    • 0033571336 scopus 로고    scopus 로고
    • Reactive oxygen intermediates during programmed cell death in the thymus of the Ts(1716)65Dn mouse, a murine model for human Down's syndrome
    • J.E. Paz-Miguel, R. Flórez, P. Sanchez-Velasco, G. Ocejo-Vinyals, J. Escribano de Diego, and J. López de Rego Reactive oxygen intermediates during programmed cell death in the thymus of the Ts(1716)65Dn mouse, a murine model for human Down's syndrome J Immunol 163 1999 5399 5410
    • (1999) J Immunol , vol.163 , pp. 5399-5410
    • Paz-Miguel, J.E.1    Flórez, R.2    Sanchez-Velasco, P.3    Ocejo-Vinyals, G.4    Escribano De Diego, J.5    López De Rego, J.6
  • 50
    • 0034283099 scopus 로고    scopus 로고
    • Environmental enrichment from birth enhances visual acuity but not place learning in mice
    • G.T. Prusky, C. Reidel, and R.M. Douglas Environmental enrichment from birth enhances visual acuity but not place learning in mice Behav Brain Res 114 2000 11 15
    • (2000) Behav Brain Res , vol.114 , pp. 11-15
    • Prusky, G.T.1    Reidel, C.2    Douglas, R.M.3
  • 51
    • 0034006822 scopus 로고    scopus 로고
    • Enrichment induces structural changes and recovery from nonspatial memory deficits in CA1 NMDAR1-knockout mice
    • C. Rampon, Y.-P. Tang, J. Goodhouse, E. Shimizu, M. Kyin, and J.Z. Tsien Enrichment induces structural changes and recovery from nonspatial memory deficits in CA1 NMDAR1-knockout mice Nature 3 2000 238 244
    • (2000) Nature , vol.3 , pp. 238-244
    • Rampon, C.1    Tang, Y.-P.2    Goodhouse, J.3    Shimizu, E.4    Kyin, M.5    Tsien, J.Z.6
  • 54
    • 0029083245 scopus 로고
    • Factor analysis of spatiotemporal and ethological measures in the murine elevated plus maze of anxiety
    • R.J. Rodgers, and J.T. Johnson Factor analysis of spatiotemporal and ethological measures in the murine elevated plus maze of anxiety Pharmacol Biochem Behav 52 1995 297 303
    • (1995) Pharmacol Biochem Behav , vol.52 , pp. 297-303
    • Rodgers, R.J.1    Johnson, J.T.2
  • 55
    • 0000572047 scopus 로고
    • Effects of environmental complexity and training on brain chemistry and anatomy: A replication and extension
    • M.R. Rosenzweig, D. Krech, E.L. Bennett, and M.C. Diamond Effects of environmental complexity and training on brain chemistry and anatomy: a replication and extension J Comp Physiol Psychol 55 1962 429 437
    • (1962) J Comp Physiol Psychol , vol.55 , pp. 429-437
    • Rosenzweig, M.R.1    Krech, D.2    Bennett, E.L.3    Diamond, M.C.4
  • 56
    • 0035889445 scopus 로고    scopus 로고
    • Reduced phospholipase C-β activity and isoform expression in the cerebellum of Ts65Dn mouse: A model of Down syndrome
    • I. Ruiz de Azúa, M.A. Lumbreras, C. Baamonde, M. Dierssen, J. Flórez, and J. Sallés Reduced phospholipase C-β activity and isoform expression in the cerebellum of Ts65Dn mouse: a model of Down syndrome J Neurosci Res 66 2001 540 550
    • (2001) J Neurosci Res , vol.66 , pp. 540-550
    • Ruiz De Azúa, I.1    Lumbreras, M.A.2    Baamonde, C.3    Dierssen, M.4    Flórez, J.5    Sallés, J.6
  • 57
    • 0031414807 scopus 로고    scopus 로고
    • Altered long-term potentiation in the young and old Ts65Dn mouse, a model for Down syndrome
    • R.J. Siarey, J. Stoll, S.I. Rapoport, and Z. Galdzicki Altered long-term potentiation in the young and old Ts65Dn mouse, a model for Down syndrome Neuropharmacology 36 1997 1549 1554
    • (1997) Neuropharmacology , vol.36 , pp. 1549-1554
    • Siarey, R.J.1    Stoll, J.2    Rapoport, S.I.3    Galdzicki, Z.4
  • 58
    • 0032729863 scopus 로고    scopus 로고
    • Increased synaptic depression in the Ts65Dn mouse, a model for mental retardation in Down syndrome
    • R.J. Siarey, E.J. Carlson, C.J. Epstein, A. Balbo, S.I. Rapoport, and Z. Galdzicki Increased synaptic depression in the Ts65Dn mouse, a model for mental retardation in Down syndrome Neuropharmacology 38 1999 1917 1920
    • (1999) Neuropharmacology , vol.38 , pp. 1917-1920
    • Siarey, R.J.1    Carlson, E.J.2    Epstein, C.J.3    Balbo, A.4    Rapoport, S.I.5    Galdzicki, Z.6
  • 59
    • 4043159976 scopus 로고    scopus 로고
    • Experimental parameters affecting the Morris water maze performance of a mouse model of Down syndrome
    • M.R. Stasko, and A.C.S. Costa Experimental parameters affecting the Morris water maze performance of a mouse model of Down syndrome Behav Brain Res 154 2004 1 17
    • (2004) Behav Brain Res , vol.154 , pp. 1-17
    • Stasko, M.R.1    Costa, A.C.S.2
  • 60
    • 0030296272 scopus 로고    scopus 로고
    • Expression of neurotrophin-3 mRNA in the rat visual cortex and hippocampus is influenced by environmental conditions
    • M. Torasdotter, M. Metsis, B.G. Henriksson, B. Winblad, and A.H. Mohammed Expression of neurotrophin-3 mRNA in the rat visual cortex and hippocampus is influenced by environmental conditions Neurosci Lett 218 1996 107 110
    • (1996) Neurosci Lett , vol.218 , pp. 107-110
    • Torasdotter, M.1    Metsis, M.2    Henriksson, B.G.3    Winblad, B.4    Mohammed, A.H.5
  • 61
    • 18144440012 scopus 로고    scopus 로고
    • Environmental enrichment results in higher levels of nerve growth factor mRNA in the rat visual cortex and hippocampus
    • M. Torasdotter, M. Metsis, B.G. Henriksson, B. Winblad, and A.H. Mohammed Environmental enrichment results in higher levels of nerve growth factor mRNA in the rat visual cortex and hippocampus Behav Brain Res 93 1998 83 90
    • (1998) Behav Brain Res , vol.93 , pp. 83-90
    • Torasdotter, M.1    Metsis, M.2    Henriksson, B.G.3    Winblad, B.4    Mohammed, A.H.5
  • 62
    • 0942290547 scopus 로고    scopus 로고
    • Operant conditioning in the Ts65Dn mouse: Learning
    • G.R. Wenger, C. Schmidt, and M.T. Davisson Operant conditioning in the Ts65Dn mouse: learning Behav Genet 34 2004 105 119
    • (2004) Behav Genet , vol.34 , pp. 105-119
    • Wenger, G.R.1    Schmidt, C.2    Davisson, M.T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.