Neuroprotective effects of genistein and folic acid on apoptosis of rat cultured cortical neurons induced by β-amyloid 31-35

British Journal of Nutrition

Volumn 102, Issue 5, 2009, Pages 655-662

  Yu, Huan Ling ^a   Li, Li ^a   Zhang, Xiao Hong ^a   Xiang, Li ^a   Zhang, Jie ^a   Feng, Jin Fang ^a   Xiao, Rong ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

Amyloid peptide 31 35; Apoptosis; Cultured cortical neurons; Folic acid; Genistein; Neuroprotection

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[31-35]; CASPASE 3; FOLIC ACID; GENISTEIN; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; BRAIN CELL; CELL PROTECTION; CELL STRUCTURE; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; MITOCHONDRIAL MEMBRANE POTENTIAL; NERVE CELL CULTURE; NEUROPROTECTION; NEWBORN; NONHUMAN; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION;

AMYLOID BETA-PROTEIN; ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CASPASE 3; CELLS, CULTURED; CEREBRAL CORTEX; DOWN-REGULATION; FOLIC ACID; GENISTEIN; NEURONS; NEUROPROTECTIVE AGENTS; PEPTIDE FRAGMENTS; RATS; TUMOR SUPPRESSOR PROTEIN P53;

RATTUS;

EID: 73749088208     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114509243042     Document Type: Article

References (41)

1. Almeida A, Bolaños JP & Medina JM (1999) Nitric oxide mediates glutamate-induced mitochondrial depolarization in rat cortical neurons. Brain Res 816, 580-586.
2. Butterfield DA, Perluigi M & Sultana R (2006) Oxidative stress in Alzheimer's disease brain: New insights from redox proteomics. Eur J Pharmacol 545, 39-50.
3. Frey C, Bonert A, Kratzsch T, et al. (2006) Apolipoprotein E epsilon 4 is associated with an increased vulnerability to cell death in Alzheimer's disease. J Neural Transm 113, 1753-1761.
4. Chin SF, Hamid NA, Latiff AA, et al. (2008) Reduction of DNA damage in older healthy adults by Tri E Tocotrienol supplementation. Nutrition 24, 1-10.
5. Clementi ME, Marini S, Coletta M, et al. (2005) Ab (31-35) and Ab (25-35) fragments of amyloid b-protein induce cellular death through apoptotic signals: Role of the redox state of methionine-35. FEBS Lett 579, 2913-2918.
6. Patterson C, Feightner JW, Garcia A, et al. (2008) Diagnosis and treatment of dementia: 1. Risk assessment and primary prevention of Alzheimer disease. CMAJ 178, 548-556.
7. Usui T (2006) Pharmaceutical prospects of phytoestrogens. Endocr J 53, 7-20.
8. Lee YB, Lee HJ & Sohn HS (2005) Soy isoflavones and cognitive function. J Nutr Biochem 16, 641-649.
9. Zhu JL, Yang GL & Huang YM (2004) Effect of soybean isoflavone on the cognitive function in ovariectomized mice. Zhong Nan Da Xue Xue Bao Yi Xue Ban 29, 81-83.
10. Azcoitia I, Moreno A, Carrero P, et al. (2006) Neuroprotective effects of soy phytoestrogens in the rat brain. Gynecol Endocrinol 22, 63-69.
11. Das UN (2008) Folic acid and polyunsaturated fatty acids improve cognitive function and prevent depression, dementia, and Alzheimer's disease-but how and why? Prostaglandins Leukot Essent Fatty Acids 78, 11-19.
12. Tassino M, Campos TF & Guerra RO (2009) Homocysteine (Hcy) and cognitive performance in a population sample of elderly Brazilians. Arch Gerontol Geriatr 48, 142-145.
13. Durga J, van Boxtel MP, Schouten EG, et al. (2007) Effect of 3-year folic acid supplementation on cognitive function in older adults in the FACIT trial: A randomised, double blind, controlled trial. Lancet 369, 208-216.
14. Xiao R, Yu HL, Zhao HF, et al. (2007) Developmental neurotoxicity role of cyclophosphamide on post-neural tube closure of rodents in vitro and in vivo. Int J Dev Neurosci 25, 531-537.
15. Xiao R, Qiao JT, Zhao HF, et al. (2006) Sodium selenite induces apoptosis in cultured cortical neurons with special concomitant changes in expression of the apoptosis-related genes. Neurotoxicology 27, 478-484.
16. Matsui T, Ramasamy K, Ingelsson M, et al. (2006) Coordinated expression of caspase 8, 3 and 7 mRNA in temporal cortex of Alzheimer disease: Relationship to formic acid extractable Ab 42 levels. J Neuropathol Exp Neurol 65, 508-515.
17. Misiti F, Clementi ME, Tringali G, et al. (2006) Fragment 31-35 of b-amyloid peptide induces neurodegeneration in rat cerebellar granule cells via bax gene expression and caspase-3 activation. A crucial role for the redox state of methionine-35 residue. Neurochem Int 49, 525-532.
18. Misiti F, Sampaolese B, Pezzotti M, et al. (2005) Ab(31-35) peptide induces apoptosis in PC 12 cells: Contrast with Ab(25-35) peptide and examination of underlying mechanisms. Neurochem Int 46, 575-583.
19. Zhao L, Qian ZM, Zhang C, et al. (2008) Amyloid b-peptide 31-35-induced neuronal apoptosis is mediated by caspasedependent pathways via cAMP-dependent protein kinase A activation. Aging Cell 7, 47-57.
20. Schmidt F, Knobbe CB, Frank B, et al. (2008) The topoisomerase II inhibitor, genistein, induces G2/M arrest and apoptosis in human malignant glioma cell lines. Oncol Rep 19, 1061-1066.
21. Kim EK, Kwon KB, Song MY, et al. (2007) Genistein protects pancreatic b cells against cytokine-mediated toxicity. Mol Cell Endocrinol 278, 18-28.
22. Kajta M, Domin H, Grynkiewicz G, et al. (2007) Genistein inhibits glutamate-induced apoptotic processes in primary neuronal cell cultures: An involvement of aryl hydrocarbon receptor and estrogen receptor/glycogen synthase kinase-3b intracellular signaling pathway. Neuroscience 145, 592-604.
23. Wu HJ & Chan WH (2007) Genistein protects methylglyoxalinduced oxidative DNA damage and cell injury in human mononuclear cells. Toxicol In Vitro 21, 335-342.
24. Sonee M, Sum T, Wang C, et al. (2004) The soy isoflavone, genistein, protects human cortical neuronal cells from oxidative stress. Neurotoxicology 25, 885-891.
25. Jin Y, Wu H, Cohen EM, et al. (2007) Genistein and daidzein induce neurotoxicity at high concentrations in primary rat neuronal cultures. J Biomed Sci 14, 275-284.
26. Tjiattas L, Ortiz DO, Dhivant S, et al. (2004) Folate deficiency and homocysteine induce toxicity in cultured dorsal root ganglion neurons via cytosolic calcium accumulation. Aging Cell 3, 71-76.
27. Lin Y, Desbois A, Jiang S, et al. (2004) Group B vitamins protect murine cerebellar granule cells from glutamate/NMDA toxicity. Neuroreport 15, 2241-2244.
28. Ho PI, Ashline D, Dhitavat S, et al. (2003) Folate deprivation induces neurodegeneration: Roles of oxidative stress and increased homocysteine. Neurobiol Dis 14, 32-42.
29. Rottkamp CA, Raina AK, Zhu X, et al. (2001) Redox-active iron mediates amyloid-b toxicity. Free Radic Biol Med 30, 447-450.
30. Butterfield BK (2005) The critical role of methionine 35 in Alzheimer's amyloid b-peptide (1-42)-induced oxidative stress and neurotoxicity. Biochim Biophys Acta 1703, 149-156.
31. McBride HM, Neuspiel M & Wasiak S (2006) Mitochondria: More than just a powerhouse. Curr Biol 16, 551-560.
32. Knudson CM & Brown NM (2008) Mitochondria potential, bax 'activation', and programmed cell death. Methods Mol Biol 414, 95-108.
33. Kroemer G, Galluzzi L & Brenner C (2007) Mitochondrial membrane permeabilization in cell death. Physiol Rev 87, 99-163. (Pubitemid 46209992)
34. Naderi J, Somayajulu-Nitu M, Mukerji A, et al. (2006) Watersoluble formulation of coenzyme Q(10) inhibits Bax-induced destabilization of mitochondria in mammalian cells. Apoptosis 11, 1359-1369.
35. Yan XZ, Qiao JT, Dou Y, et al. (1999) b-Amyloid fragment 31-35 induces apoptosis in cultured cortical neurons. Chin J Neurosci 92, 177-184.
36. Raisova M, Hossini AM, Eberle J, et al. (2001) The Bax/Bcl-2 ratio determines the susceptibility of human melanoma cells to CD95/Fas-mediated apoptosis. J Invest Dermatol 117, 333-340.
37. Zhang Y, McLaughlin R, Goodyer C, et al. (2002) Selective cytotoxicity of intracellular amyloid b peptide 1-42 through p53 and Bax in cultured primary human neurons. J Cell Biol 156, 519-529.
38. Inamura N, Araki T, Enokido Y, et al. (2000) Role of p53 in DNA strand break-induced apoptosis in organotypic slice culture from the mouse cerebellum. J Neurosci Res 60, 450-457.
39. Baluchnejadmojarad T, Roghani M, Nadoushan MR, et al. (2009) Neuroprotective effect of genistein in 6-hydroxydopamine Hemi-parkinsonian rat model. Phytother Res 23, 132-135.
40. Occhiuto F, Palumbo DR, Samperi S, et al. (2009) The isoflavones mixture from Trifolium pratense L. protects HCN 1-A neurons from oxidative stress. Phytother Res 23, 192-196.
41. Sánchez Y, Amrán D, Fernández C, et al. (2008) Genistein selectively potentiates arsenic trioxide-induced apoptosis in human leukemia cells via reactive oxygen species generation and activation of reactive oxygen species-inducible protein kinases (p38-MAPK, AMPK). Int J Cancer 123, 1205-1214.