Rapamycin inhibits osteoblast proliferation and differentiation in MC3T3-E1 cells and primary mouse bone marrow stromal cells

Journal of Cellular Biochemistry

Volumn 103, Issue 2, 2008, Pages 434-446

  Singha, Ujjal K ^a,c   Jiang, Yu ^a   Yu, Shibing ^a   Luo, Min ^a   Lu, Yi ^a,b   Zhang, Jian ^a   Xiao, Guozhi ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b TIANJIN MEDICAL UNIVERSITY   (China)

^c UNIVERSITY OF TENNESSEE COLLEGE OF MEDICINE   (United States)

Author keywords

Differentiation; Mammalian target of rapamycin; Osteoblast; Osteocalcin; Proliferation; Rapamycin; Runx2

Indexed keywords

ALKALINE PHOSPHATASE; BONE SIALOPROTEIN; CYCLIN A; CYCLIN D1; MAMMALIAN TARGET OF RAPAMYCIN; MESSENGER RNA; OSTEOCALCIN; RAPAMYCIN; S6 KINASE; TRANSCRIPTION FACTOR OSTERIX; TRANSCRIPTION FACTOR RUNX2;

ANIMAL CELL; ARTICLE; BONE MARROW CELL; BONE MINERALIZATION; CELL DIFFERENTIATION; CELL LINE; CELL PROLIFERATION; CELL TYPE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME INHIBITION; MOUSE; NONHUMAN; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; STROMA CELL;

ANIMALS; BONE MARROW CELLS; CELL DIFFERENTIATION; CELL DIVISION; CELL LINE; CERCOPITHECUS AETHIOPS; CORE BINDING FACTOR ALPHA 1 SUBUNIT; COS CELLS; CYCLIN A; CYCLINS; GENE EXPRESSION REGULATION; MICE; OSTEOBLASTS; OSTEOCALCIN; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; SIALOGLYCOPROTEINS; SIROLIMUS; STROMAL CELLS; TRANSCRIPTION FACTORS;

MAMMALIA;

EID: 38649110155     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.21411     Document Type: Article

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