Mechanotransduction and functional response of the skeleton to physical stress: The mechanisms and mechanics of bone adaptation

Journal of Orthopaedic Science

Volumn 3, Issue 6, 1998, Pages 346-355

  Turner, Charles H ^a   Pavalko, Fredrick M ^a  

^a INDIANA UNIVERSITY   (United States)

Author keywords

Biomechanics; Bone density; Mechanical stress; Mechanotransduction

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PROSTAGLANDIN; PROSTAGLANDIN SYNTHASE;

ADAPTATION; BIOMECHANICS; BONE; BONE DENSITY; BONE STRUCTURE; CONFERENCE PAPER; MECHANICAL STRESS; OSTEOBLAST; OSTEOCLAST; SIGNAL TRANSDUCTION; SKELETON;

EID: 0031770558     PISSN: 09492658     EISSN: None     Source Type: Journal    
DOI: 10.1007/s007760050064     Document Type: Conference Paper

References (60)

1. Bidwell JP, VanWijnen AJ, Fey EG, et al. Osteocalcin gene promoter-binding factors are tissue-specific nuclear matrix components. Proc Nat Acad Sci USA 1993;90:3162-6.
2. Chakkalakal DA. Mechanoelectric tranduction in bone. J Mater Res 1989;4:1034-6.
3. Chow JW, Chambers TJ. Indomethacin has distinct early and late actions on bone formation induced by mechanical stimulation. Am J Physiol 1994;267:E287-92.
4. Chow JW, Fox S, Jagger CJ, et al. A role for parathroid hormone in the mechanical responsiveness of rat bone. J Bone Miner Res 1997;12:3316.
5. Donahue HJ, McLeod KJ, Rubin CT, et al. Cell-to-cell communication in osteoblastic networks: cell line-dependent hormonal regulation of gap junction function. J Bone Miner Res 1995;10:881-9.
6. Doty SB. Morphological evidence of gap junctions between bone cells. Calcif Tissue Int 1981;33:509-12.
7. Duncan RL, Kizer N, Barry EL, et al. Antisense oligodeoxynucleotide inhibition of a swelling-activated cation channel in osteoblast-like osteosarcoma cells. Proc Nat Acad Sci USA 1996;93:1864-9.
8. Duncan RL, Turner CH. Mechanotransduction and the functional response of bone to mechanical strain. Calcif Tissue Int 1995;57:344-58.
9. Ducy P, Zhang R, Geoffroy V, et al. Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation. Cell 1997;89:747-54.
10. Forwood MR. Inducible cyclo-oxygenase (COX-2) mediates the induction of bone formation by mechanical loading in vivo. J Bone Miner Res 1996;11:1688-93.
11. Fox SW, Chambers TJ, Chow JW. Nitric oxide is an early mediator of the increase in bone formation by mechanical stimulation. Am J Physiol 1996;270:E955-60.
12. Frost HM. The Laws of Bone Structure. Springfield, IL: Charles C. Thomas, 1964.
13. Frost HM. Bone "mass" and the "mechanostat": A proposal. Anat Rec 1987;219:1-9.
14. Frost HM. Structural adaptations to mechanical usage (SATMU): 1. Redefining Wolff's law. The bone modeling problem. Anat Rec 1990;226:403-13.
15. Frost HM. Structural adaptations to mechanical usage (SATMU). 2. Redefining Wolff's law: The bone remodeling problem. Anat Rec 1990;226:414-22.
16. Fyhrie DP, Schaffler MB. The adaptation of bone apparent density to applied load. J Biomech 1995;28:135-46.
17. Hung CT, Allen FD, Pollack SR, et al. What is the role of the connective current density in the real-time calcium response of cultured bone cells to fluid flow? J Biomech 1996;29:1403-9.
18. 2+ response of bone cells experiencing fluid flow. J Biomech 1996;29:1411-17.
19. Inoaka T, Lean JM, Bessho T, et al. Sequential analysis of gene expression after an osteogenic stimulus: c-fos expression is induced in osteocytes. Biochera Biophys Res Comm 1995;217: 264-70.
20. Johnson DL, McAllister TN, Frangos JA. Fluid flow stimulates rapid and continuous release of nitric oxide in osteoblasts. Am J Physiol 1996;271:E205-8.
21. Jones DB, Bingmann D. How do osteoblasts respond to mechanical stimulation? Cells Materials 1991;1:329-40.
22. Klein-Nulend J, van der Plas A, Semeins CM, et al. Sensitivity of osteocytes to biomechanical stress in vitro. FASEB J 1995;9:441-5.
23. Klein-Nulend J, Burger EH, Semeins CM, et al. Pulsating fluid flow stimulates prostaglandin release and inducible prostaglandin G/H synthase mRNA expression in primary mice bone cells. J Bone Miner Res 1997;12:45-51.
24. Komori T, Yagi H, Nomura S, et al. Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturation arrest of osteoblasts. Cell 1997;89:755-64.
25. Korenstein R, Somjen D, Fischler H, et al. Capacitative pulsed electric stimulation of bone cells. Induction of cyclic-AMP changes and DNA synthesis. Biochim Biophys Acta 1984; 803:302-7.
26. Lanyon LE. The success and failure of the adaptive response to functional loading-bearing in averting bone fracture. Bone 1992;13:S17-21.
27. Lanyon LE, Rubin CT. Static vs dynamic loads as an influence on bone remodelling. J Biomechanics 1984;17:897-905.
28. Liskova M, Hert J. Reaction of bone to mechanical stimuli. Part 2. Periosteal and endosteal reaction to tibial diaphysis in rabbit to intermittent loading. Folia Morphologica 1971;19:301-17.
29. Merriman HL, VanWijnen AJ, Hiebert S, et al. The tissue-specific nuclear matrix protein, NMP-2, is a member of the AML/CBF/ PEBP2/runt domain transcription factor family interactions with the osteocalcin gene promoter. Biochemistry 1995;34:13125-32.
30. Mosley JR, March BM, Lynch J, et al Strain magnitude related changes in whole bone architecture in growing rats. Bone 1997;20:191-8.
31. Otey CA, Pavalko FM, Burridge K. An interaction between α-actinin and the β1 integrin subunit in vitro. J Cell Biol 1990;111:721-30.
32. Otto F, Thornell AP, Crompton T, et al. Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development. Cell 1997;89:677-80.
33. Parfitt AM. The physiologic and clinical significance of bone histomorphometric data. In: Recker RR editor. Bone histomorphometry. Boca Raton: CRC Press. 1983:143-223.
34. Pauwels F. Biomechanics of the locomotor apparatus. Berlin: Springer-Verlag, 1980.
35. Pavalko FM, Burridge K. Disruption of the actin cytoskeleton after microinjection of proteolytic fragments of alpha-actinin. J Cell Biol 1991;114:481-91.
36. Pavalko FM, LaRoche SM. Activation of human neutrophils induces an interaction between the integrin β2 subunit (CD18) and the actin-binding protein α-actinin. J Immunology 1993;151: 3795-807.
37. Pavalko FM, Otey CA. Role of adhesion molecule cytoplasmic domains in mediating interactions with the cytoskeleton. Proc Soc Exp Biol Med 1994;205:282-93.
38. Pavalko FM, Otey CA, Simon KO, et al. α-Actinin: a direct link between actin and integrins. Biochem Soc Trans 1991;19:1065-9.
39. Pitsillides AA, Rawlinson SC, Suswillo RF, et al. Mechanical strain-induced NO production by boue cells: a possible role in adaptive bone (re)modeling? FASEB J 1995;9:1614-22.
40. Qin Y-X, McLeod KJ, Guilak F, et al. Correlation of bony ingrowth to the distribution of stress and strain parameters surrounding a porous-coated implant. J Orthop Res 1996;14:862-70.
41. Rawlinson SC, Mohan S, Baylink DJ, et al. Exogenous prostacyclin, but not prostaglandin E2, produces similar responses in both G6PD activity and RNA production as mechanical loading, and increases IGF-II release, in adult cancellous bone in culture. Calcif Tissue Int 1993;53:324-9.
42. 2 and inositol triphosphate levels in osteoblasts. Am J Physiol 1991;261:C428-32.
43. Reich KM, Gay CV, Frangos JA. Fluid shear stress as a mediator of osteoblast cyclic adenosine monophosphate production. J Cell Physiol 1990;143:100-4.
44. Reich KM, McAllister TN, Gudi S, et al Activation of G proteins mediates flow-induced prostagandin E2 production in osteoblasts. Endocrinology 1997;138:1014-18.
45. Roux W. Gesammelte Abhandlungen. Vol. 1. Leipzig: Engelmann, 1895.
46. Rubin CT, Lanyon LE. Regulation of bone formation by applied dynamic loads. J Bone Joint Surg Am 1984;66:397-402.
47. Skerry TM, Bitensky L, Chayen J, et al. Early strain-related changes in enzyme activity in osteocytes following bone loading in vivo J Bone Miner Res 1989;4:783-8.
48. 2 mediated. Biochim Biophys Acta 1980;627:91-100.
49. Thompson D. On growth and form. (Abridged edition.) Bonner JT editors. Cambridge, 1961 (originally published in 1917).
50. Turner CH, Owan I, Alvey T, et al. Recruitment and proliferative responses of osteoblasts after mechanical loading in vivo determined using sustained-release bromodeoxyuridine. Bone 1998;22:463-9.
51. Turner CH, Owan I, Takano Y. Mechanotransduction in bone: The role of strain rate. Am J Physiol 1995;269:E438-42.
52. Turner CH, Takano Y, Owan I. Aging changes mechanical loading thresholds for bone formation in rats. J Bone Miner Res 1995;10:1544-9.
53. Turner CH, Takano Y, Owan I, et al. Nitric oxide inhibitor L-NAME suppresses mechanically-induced bone formation in rats. Am J Physiol 1996;270:E634-9.
54. Turner CH Homeostatic control of bone structure: an application of feedback theory. Bone 1991;12:203-17.
55. Turner CH. On Wolff's law of trabecular architecture. J Biomechanics 1992;25:1-9.
56. Turner CH, Anne V, Pidaparti RMV. A uniform strain criterion for trabecular bone adaptation: do continuum-level strain gradients drive adaptation? J Biomechanics 1997;30:555-63.
57. Turner CH, Forwood MR, Otter MW Mechanotransduction in bone: do bone cells act as sensors of fluid flow? FASEB J 1994;8:875-8.
58. Turner CH, Forwood MR, Rho J, et al. Mechanical loading thresholds for lamellar and woven bone formation. J Bone Min Res 1994;9:87-97
59. Umemura Y, Ishiko T, et al. Five jumps per day increase bone mass and breaking force in rats. J Bone Miner Res 1997;12:1480-5.
60. Wolff J. Das Gesetz der Transformation der Knochen. Berlin: Hirschwald, 1892.