Steady and transient fluid shear stress stimulate NO release in osteoblasts through distinct biochemical pathways

Journal of Bone and Mineral Research

Volumn 14, Issue 6, 1999, Pages 930-936

  McAllister, T N ^a   Frangos, J A ^a,b  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM IONOPHORE; GUANINE NUCLEOTIDE BINDING PROTEIN; PERTUSSIS TOXIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BONE REMODELING; CALCIUM HOMEOSTASIS; CALVARIA; CHELATION; HORMONE STRUCTURE; NONHUMAN; OSTEOBLAST; PROTEIN ANALYSIS; PROTEIN STRUCTURE; RAT; SHEAR STRESS;

NASA DISCIPLINE CELL BIOLOGY; NON-NASA CENTER;

ANIMALS; CALCIUM; ENZYME INHIBITORS; GTP-BINDING PROTEINS; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; OSTEOBLASTS; RATS; RATS, SPRAGUE-DAWLEY; STRESS, MECHANICAL; TIME FACTORS; VISCOSITY;

EID: 0033023570     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.1999.14.6.930     Document Type: Article

References (52)

1. Rubin CT, McLeod KJ, Bain SJ 1990 Functional strains and cortical bone adaptation: Epigenetic assurance of skeletal integrity. J Biomech 23:43-54.
2. Frost HM 1964 Laws of Bone Structure. Charles C. Thomas Publishers, Springfield, IL, U.S.A.
3. Hargens AR, Tipton CM, Gollnick PD, Mubarak SJ, Tucker BJ, Akeson WH 1983 Fluid shifts and muscle function in humans during acute simulated weightlessness. J Appl Physiol 54:1003-1009.
4. Roer RD, Dillaman RM 1990 Bone growth and calcium balance during simulated weightlessness in the rat. Appl Physiol 68:13-20.
5. Tilton FE, Degioanni JJ, Schneider VS 1980 Long term follow-up of Skylab bone demineralization. Aviat Space Environ Med 51:1209-1213.
6. Suominen H 1993 Bone mineral density and long term exercise: An overview of cross-sectional athlete studies. Sports Med 16:316-330.
7. Turner CH, Takano Y, Owan I, Murrell GC 1996 Nitric oxide inhibitor L-NAME suppresses mechanically induced bone formation in rats. Am J Physiol 270 (Endocrinol Metab 33):E634-E639.
8. Goldstein SA, Matthews LS, Kuhn JL, Hollister SJ 1991 Trabecular bone remodeling: An experimental model. J Biomech 24:135-150.
9. Chambers TJ, Evans M, Gardner TN, Turner-Smith A, Chow JWM 1993 Induction of bone foration in rat tail vertebrae by mechanical loading. Bone Miner 20:167-178.
10. 2 release: A new experimental method. Calcif Tissue Int 47:35-39.
11. Rubin CT, Lanyon LE 1985 Regulation of bone mass by mechanical strain magnitude. Calcif Tissue Int 37:411-417.
12. McLeod KJ, Bain SD, Rubin CT 1990 Dependence of bone adaptation on the frequency of induced dynamic strains. 36th Annual Meeting of the Orthopedic Research Society (abstract).
13. Piekarski K, Munro M 1977 Transport mechanism operating between blood supply and osteocytes in long bones. Nature 269:80-82.
14. Montgomery RJ, Sutker BD, Bronk JT, Smith SR, Kelly PJ 1988 Interstitial fluid flow in cortical bone. Microvasc Res 35:295-307.
15. Otter MW, Bronk JT, Wu DD, Bieber WA, Kelly PJ, Cochran GVB 1996 Inflatable brace-related streaming potentials in living canine tibias. Clin Orthop 324:283-291.
16. Dillaman RM 1984 Movement of ferritin in the 2-day-old chick femur. Anat Rec 209:445-453.
17. Johnson MW, Chakkalakal DA, Harper RA, Katz JL 1982 Fluid flow in bone in vitro. J Biomech 15:881-885.
18. Dillaman RM, Roer RD, Gay DM 1991 Fluid movement in bone: Theoretical and empirical. J Biomech 24 (Suppl 1):163-177.
19. Weinbaum S, Cowin SC, Zeng Y 1994 A model for the excitation of osteocytes by mechanical loading induced bone fluid shear stresses. J Biomech 27:339-360.
20. 2 in osteoblasts by wall shear stress but not mechanical strain. Am J Physiol 273(4 Part 1):E751-E758.
21. Owan I, Burr DB, Turner CH, Qui J, Tu Y, Onyia JE, Duncan RL 1997 Mechanotransduction in bone: Osteoblasts are more sensitive to fluid forces than mechanical strain. Am J Physiol Cell Physiol 42:C810-C815.
22. Reich KM, Gay CV, Frangos JA 1990 Fluid shear stress as a mediator of osteoblast cyclic adenosine monophosphate production. J Cell Physiol 143:100-104.
23. 2 and inositol trisphosphate levels in osteoblasts. Am J Physiol 261 (Cell Physiol 30):C428-C432.
24. Johnson DL, McAllister TN, Frangos JA 1996 Fluid flow stimulates rapid and continuous release of nitric oxide in osteoblasts. Am J Physiol 271:E205-E208.
25. MacIntyre I, Zaidi M, Towhidul-Alam TS, Datta HK 1991 Osteoclastic inhibition: An action of nitric oxide not mediated by cyclic GMP. Proc Natl Acad Sci USA 88:2936-2940.
26. Kasten TP, Collin-Osdoby P, Patel N, Osdoby P, Krukowski M, Musko MP, Settle SL, Currie MG, Nickols GA 1994 Potentiation of osteoclast bone resorption activity by inhibition of nitric oxide synthase. Proc Natl Acad Sci USA 91:3569-3573.
27. Collin-Osdoby P, Nickols GA, Osdoby P 1995 Bone cell function, regulation, and communication: A role for nitric oxide. J Cell Biochem 57:399-408.
28. Riancho JA, Zarrabeitia MT, Fernandez-Luna JL, Gonzalez-Macias J 1995 Mechanisms controlling nitric oxide synthesis in osteoblasts. Mol Cell Endrocrinol 107:87-92.
29. Riancho JA, Salas E, Zarrabeitia MT, Olmos JM, Almado JA, Fernandez-Luna JL, Gonzalez-Macias J 1995 Expression and functional role of nitric oxide synthase in osteoblast like cells. J Bone Miner Res 10:439-446.
30. Lowik CW, Van Nibbering PH, de Ruit M, Papapoulos SE 1994 Inducible production of nitric oxide in osteoblast-like cells and in fetal mouse bone explants is associated with suppression of osteoclast ic bone resorption. J Clin Invest 93:1465-1472.
31. Hukkanen M, Hughes FJ, Buttery LDK, Gross SS, Evans TJ, Seddon S, Riveros-Moreno V, MacIntyre I, Polak JM 1995 Cytokine-stimulated expression of inducible nitric oxide synthase by mouse, rat, and human osteoblast-like cells and its functional role in osteoblast metabolic activity. Endocrinology 136:5445-5453.
32. Ralston SH, Todd D, Helfrich M, Benjamin N, Grabowski PS 1994 Human osteoblast-like cells produce nitric oxide and express inducible nitric oxide synthase. Endocrinology 135:330-336.
33. Damoulis PD, Hauschka PV 1994 Cytokines induce nitric oxide production in mouse osteoblasts. Biochem Biophys Res Commun 201:924-931.
34. Pitsillides AA, Rawlinson SCF, Suswillo RFL, Zaman G, Nijweide PI, Lanyon LE 1995 Mechanical strain-induced nitric oxide production by bone cells: A possible role in adaptive bone (re)modeling. FASEB J 9:1614-1622.
35. Sessa WC 1994 Review: The nitric oxide synthase family of proteins. J Vasc Res 31:131-143.
36. Ecarot-Charrier B, Glorieux H, Van der Rest M, Pereira G 1983 Osteoblast isolated from mouse calvaria initiate matrix mineralization in culture. J Cell Biol 96:639-643.
37. Frangos JA, Eskin SG, McIntire LV, Ives CL 1985 Flow effects on prostacyclin production by cultured human endothelial cells. Science 227:1477-1479.
38. Glantz SA 1987 Primer of Biostatistics, 2nd Ed. McGraw-Hill, Inc., New York, NY, U.S.A.
39. Klein-Nulend J, Van der Plas A, Semeins CM, Ajubi NE, Frangos JA, Nijweide PJ, Burger EH 1995 Sensitivity of osteocytes to biomechanical stress in vitro. FASEB J 9:441-445.
40. Hung CT, Pollack SR, Reilly TM, Brighton CT 1995 Real time calcium response of cultured bone cells to fluid flow. Clin Orthop 313:256-259.
41. Hung CT, Allen FD, Pollack SR, Brighton CT 1996 What is the role of the convective current density in the real time calcium response of cultured bone cells to fluid flow? J Biomech 29:1403-1409.
42. McDonald F, Yettram AL, McLeod K 1994 The response of bone to external loading regimens. Med Eng Phys 16:384-397.
43. Rubin C, Gross T, Qin Y, Fritton S, Guilak F, McLeod K 1996 Differentiation of the bone-tissue remodeling response to axial and torsional loading in the turkey ulna. J Bone Joint Surg 78A:1523-1533.
44. Gross TS, Edwards JL, McLeod KJ, Rubin CT 1997 Strain gradients correlate with sites of periosteal bone formation. J Bone Miner Res 12:982-988.
45. Berthiaume F 1992 Model of flow-induced convection of ATP. In: Mechanism of Flow-Induced Stimulation of Endothelial Cells. The Pennsylvania State University, PA, U.S.A., pp. 134-138.
46. Ferrier J, Ross SM, Kanehisa J 1986 Osteoclasts and osteoblasts migrate in opposite directions in response to a constant electric field. J Cell Physiol 129:283-288.
47. Williams JL, Iannotti JP, Ham A, Bleuit J, Chen JH 1994 Effects of fluid shear stress on bone cells. Biorheology 31:163-170.
48. 2 production in osteoblasts. Endocrinology 138:1014-1018.
49. Gudi SP, Clark CB, Frangos JA 1996 Fluid flow rapidly activates G-proteins in human endothelial cells: Involvement of G-proteins in mechanochemical signal transduction. Circ Res 79:834-839.
50. Hellfrich MH, Evans DE, Grabowski PS, Pollock JS, Ohshima H, Ralston SH 1997 Expression of nitric oxide synthase isoforms in bone cell cultures. J Bone Miner Res 12:1108-1115.
51. Kuchan MJ, Frangos JA 1994 Role of calcium and calmodulin in flow-induced nitric oxide production in endothelial cells. Am J Physiol 66 (Cell Physiol 35):C628-C636.
52. Rawlinson SC, Mosley JR, Suswillo RW, Pitsillides AA, Lanyon LE 1995 Calvarial and limb bone cells in organ and monolayer culture do not show the same early responses to dynamic mechanical strain. J Bone Miner Res 10:1225-1232.