Effect of N2-Guanyl Modifications on Early Steps in Catalysis of Polymerization by Sulfolobus solfataricus P2 DNA Polymerase Dpo4 T239W

Journal of Molecular Biology

Volumn 395, Issue 5, 2010, Pages 1007-1018

  Zhang, Huidong ^a   Guengerich, F Peter ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

DNA adducts; DNA polymerase; fluorescence; pre steady state kinetics; translesion DNA synthesis

Indexed keywords

ALKYL GROUP; DEOXYGUANOSINE; DEOXYRIBONUCLEOSIDE TRIPHOSPHATE; DNA POLYMERASE; GUANINE DERIVATIVE; OLIGONUCLEOTIDE; 2'-DEOXYCYTIDINE 5'-TRIPHOSPHATE; ARCHAEAL DNA; ARCHAEAL PROTEIN; DEOXYCYTIDINE PHOSPHATE; DEOXYCYTIDINE TRIPHOSPHATE; DNA DIRECTED DNA POLYMERASE BETA; RECOMBINANT PROTEIN;

ARTICLE; CATALYSIS; CHEMICAL BOND; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DNA ADDUCT; FLUORESCENCE; POLYMERIZATION; PRIORITY JOURNAL; SULFOLOBUS SOLFATARICUS; AMINO ACID SUBSTITUTION; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; DNA REPLICATION; ENZYME ACTIVE SITE; ENZYMOLOGY; GENETICS; KINETICS; METABOLISM; NUCLEOTIDE SEQUENCE; PROTEIN CONFORMATION; SITE DIRECTED MUTAGENESIS; SPECTROFLUOROMETRY;

SULFOLOBUS SOLFATARICUS;

AMINO ACID SUBSTITUTION; ARCHAEAL PROTEINS; BASE SEQUENCE; CATALYTIC DOMAIN; DEOXYCYTOSINE NUCLEOTIDES; DNA ADDUCTS; DNA POLYMERASE BETA; DNA REPLICATION; DNA, ARCHAEAL; KINETICS; MOLECULAR STRUCTURE; MUTAGENESIS, SITE-DIRECTED; NUCLEIC ACID CONFORMATION; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; SPECTROMETRY, FLUORESCENCE; SULFOLOBUS SOLFATARICUS;

EID: 73649091713     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2009.11.071     Document Type: Article

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