Kinetic evidence for inefficient and error-prone bypass across bulky N 2-guanine DNA adducts by human DNA polymerase

Journal of Biological Chemistry

Volumn 281, Issue 18, 2006, Pages 12315-12324

  Choi, Jeong Yun ^a,b   Guengerich, F Peter ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Ewha Womans University School of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; CARCINOGENS; DNA; HYDROPHOBICITY; POLYMERIZATION;

HOOGSTEEN BASE PAIRING; MISINSERTION FREQUENCY; STEADY-STATE KINETIC ANALYSIS; TRANSLESION SYNTHESIS;

ENZYMES;

DEOXYCYTIDINE TRIPHOSPHATE; DNA POLYMERASE; GUANINE DERIVATIVE; THYMIDINE TRIPHOSPHATE;

ARTICLE; CONTROLLED STUDY; DNA ADDUCT; DNA BINDING; HUMAN; KINETICS; POLYMERIZATION; PRIORITY JOURNAL; STEADY STATE;

BACULOVIRIDAE; BASE PAIRING; BINDING SITES; DNA; DNA ADDUCTS; DNA PRIMERS; DNA, COMPLEMENTARY; DNA-DIRECTED DNA POLYMERASE; GUANINE; HUMANS; KINETICS; MODELS, CHEMICAL; OLIGONUCLEOTIDES; TIME FACTORS;

EID: 33744954680     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M600112200     Document Type: Article

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