Kinetic analysis of translesion synthesis opposite bulky N2- and O6-alkylguanine DNA adducts by human DNA polymerase REV1

Journal of Biological Chemistry

Volumn 283, Issue 35, 2008, Pages 23645-23655

  Choi, Jeong Yun ^a   Guengerich, F Peter ^b  

^a Ewha Womans University School of Medicine   (South Korea)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; DNA; NUCLEIC ACIDS; OLIGONUCLEOTIDES; ORGANIC ACIDS; POLYMERS; POSITIVE IONS; RANGE FINDING;

BINDING AFFINITIES; BURST KINETICS; CATALYTIC FUNCTIONS; CATALYTIC ROLES; DNA ADDUCTS; DNA LESIONS; DNA POLYMERASES; DNA SYNTHESIS; KINETIC ANALYSES; LESION BYPASSES; POLYMERIZATION RATES; PRODUCT FORMATIONS; PRODUCT RELEASES; PYRIDYL; SCAFFOLD PROTEINS; TRANSLESION; TRANSLESION SYNTHESES;

GENES;

DEOXYCYTIDINE TRIPHOSPHATE; DNA POLYMERASE REV1; GUANINE DERIVATIVE; N 2 ALKYLGUANINE; O 6 ALKYLGUANINDE; UNCLASSIFIED DRUG; 2'-DEOXYCYTIDINE 5'-TRIPHOSPHATE; DEOXYCYTIDINE PHOSPHATE; DRUG DERIVATIVE; GUANINE; NUCLEAR PROTEIN; NUCLEOTIDYLTRANSFERASE; RECOMBINANT PROTEIN; REV1 PROTEIN, HUMAN;

ARTICLE; CATALYSIS; DNA ADDUCT; DNA SYNTHESIS; ENZYME KINETICS; POLYMERIZATION; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN FUNCTION; BIOSYNTHESIS; CHEMISTRY; ENZYME SPECIFICITY; GENETICS; HUMAN; KINETICS; METABOLISM; PHYSIOLOGY;

EUKARYOTA;

DEOXYCYTOSINE NUCLEOTIDES; DNA ADDUCTS; GUANINE; HUMANS; KINETICS; NUCLEAR PROTEINS; NUCLEOTIDYLTRANSFERASES; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY;

EID: 53049095093     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M801686200     Document Type: Article

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