Sorafenib induces preferential apoptotic killing of a drug- and radio-resistant Hep G2 cells through a mitochondria-dependent oxidative stress mechanism

Cancer Biology and Therapy

Volumn 8, Issue 20, 2009, Pages 1904-1913

  Chiou, Jeng Fong ^a,b   Tai, Cheng Jeng ^b   Wang, Yu Huei ^b   Liu, Tsan Zon ^b   Jen, Yee Min ^c   Shiau, Chia Yang ^a  

^a NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^c TRI SERVICE GENERAL HOSPITAL   (Taiwan)

Author keywords

Anti cancer drug; Apoptosis; Confocal; Hepatocellular carcinoma cell; Mitochondria; Oxidative stress mechanism; Sorafenib

Indexed keywords

CALCIUM ION; CASPASE 3; CASPASE 7; CYTOCHROME C; GLUTATHIONE; REACTIVE OXYGEN METABOLITE; SORAFENIB;

APOPTOSIS; ARTICLE; CANCER RADIOTHERAPY; CELL COMPARTMENTALIZATION; CELL DEATH; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOPLASM; CYTOSOL; DRUG MECHANISM; DRUG RESISTANCE; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; MITOCHONDRION; NUCLEUS ACCUMBENS; OXIDATIVE STRESS;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BENZENESULFONATES; CALCIUM; CARCINOMA, HEPATOCELLULAR; CASPASE 3; CASPASE 7; CELL LINE, TUMOR; CELL SURVIVAL; CYTOCHROMES C; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; GLUTATHIONE; HUMANS; IN SITU NICK-END LABELING; INHIBITORY CONCENTRATION 50; INTRACELLULAR SPACE; LIVER NEOPLASMS; MICROSCOPY, CONFOCAL; MITOCHONDRIA; OXIDATIVE STRESS; PYRIDINES; REACTIVE OXYGEN SPECIES;

EID: 73549094006     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.8.20.9436     Document Type: Article

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