Combined effects of hyperglycemic conditions and HIV-1 Nef: A potential model for induced HIV neuropathogenesis

Virology Journal

Volumn 6, Issue , 2009, Pages

  Acheampong, Edward A ^a   Roschel, Cassandra ^b   Mukhtar, Muhammad ^c   Srinivasan, Alagarsamy ^d   Rafi, Mohammad ^a   Pomerantz, Roger J ^e   Parveen, Zahida ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

^c PMAS ARID AGRICULTURE UNIVERSITY   (Pakistan)

^d NanoBio Diagnostics   (United States)

^e Tibotec Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

8 ISOPROSTAGLANDIN F2 ALPHA; CASPASE 3; COMPLEMENT COMPONENT C3; NEF PROTEIN; NITRATE; AUTACOID; NEF PROTEIN, HUMAN IMMUNODEFICIENCY VIRUS 1; VIRULENCE FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BRAIN TISSUE; CELL DEATH; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HYPERGLYCEMIA; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NEUROPATHOLOGY; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; STREPTOZOCIN DIABETES; ANIMAL; APOPTOSIS; C57BL MOUSE; DIABETES MELLITUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; METABOLISM; NONOBESE DIABETIC MOUSE; PATHOGENICITY; PATHOLOGY; PHYSIOLOGY;

ANIMALIA; HUMAN IMMUNODEFICIENCY VIRUS 1; MUS;

ANIMALS; APOPTOSIS; ASTROCYTES; DIABETES COMPLICATIONS; HIV INFECTIONS; HIV-1; INFLAMMATION MEDIATORS; MICE; MICE, INBRED C57BL; MICE, INBRED NOD; NEF GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; VIRULENCE FACTORS;

EID: 73449121430     PISSN: None     EISSN: 1743422X     Source Type: Journal    
DOI: 10.1186/1743-422X-6-183     Document Type: Article

References (60)

1. Use of human immunodeficiency virus-1 protease inhibitors is associated with atherogenic lipoprotein changes and endothelial dysfunction. JH Stein MA Klein JL Bellehumeur PE McBride DA Wiebe JD Otvos JM Sosman, Circulation 2001 104 257 262 11457741
2. Severe hyperglycemia in an HIV clinic: preexisting versus drug-associated diabetes mellitus. JM Kilby PB Tabereaux, J Acquir Immune Defic Syndr Hum Retrovirol 1998 17 46 50 9436758
3. Metabolic complications associated with the use of highly active antiretroviral therapy in HIV-1-infected adults. PL Monier R Wilcox, Am J Med Sci 2004 328 48 56 15254441
4. Impaired glucose tolerance, beta cell function and lipid metabolism in HIV patients under treatment with protease inhibitors. G Behrens A Dejam H Schmidt HJ Balks G Brabant T Korner M Stoll RE Schmidt, Aids 1999 13 63 70 10416516
5. Brain anaerobic lactate production: a suicide note or a survival kit? A Schurr BM Rigor, Dev Neurosci 1998 20 348 357 9778571
6. Pathophysiology of central nervous system complications in diabetes mellitus. AD Mooradian, Clin Neurosci 1997 4 322 326 9358975
7. Central nervous system impairment in diabetic patients. OI Kolev I Milanov, Electromyogr Clin Neurophysiol 1999 39 479 484 10627933
8. Central nervous system complications of diabetes mellitus - a perspective from the blood-brain barrier. AD Mooradian, Brain Res Brain Res Rev 1997 23 210 218 9164671
9. Pathogenesis of HIV-1 associated neurodegeneration. E Masliah N Ge L Mucke, Crit Rev Neurobiol 1996 10 57 67 8853954
10. Insulin, C-peptide, hyperglycemia, and central nervous system complications in diabetes. AA Sima H Kamiya ZG Li, Eur J Pharmacol 2004 490 187 197 15094085
11. Hyperglycemic condition disturbs the proliferation and cell death of neural progenitors in mouse embryonic spinal cord. Q Gao YM Gao, Int J Dev Neurosci 2007 25 349 357 17888615
12. Immune and inflammatory responses in the CNS: modulation by astrocytes. M Aschner, Toxicol Lett 1998 102-103 283 287 10022267 (Pubitemid 29021234)
13. Hyperglycemia-induced activation of human T-lymphocytes with de novo emergence of insulin receptors and generation of reactive oxygen species. FB Stentz AE Kitabchi, Biochem Biophys Res Commun 2005 335 491 495 16084832
14. Human Immunodeficiency virus type 1 Nef potently induces apoptosis in primary human brain microvascular endothelial cells via the activation of caspases. EA Acheampong Z Parveen LW Muthoga M Kalayeh M Mukhtar RJ Pomerantz, J Virol 2005 79 4257 4269 15767427
15. HIV type 1 Nef protein is a viral factor for leukocyte recruitment into the central nervous system. U Koedel B Kohleisen B Sporer F Lahrtz V Ovod A Fontana V Erfle HW Pfister, J Immunol 1999 163 1237 1245 10415019
16. HIV-1 Vpr potently induces programmed cell death in the CNS in vivo. X Cheng M Mukhtar EA Acheampong A Srinivasan M Rafi RJ Pomerantz Z Parveen, DNA Cell Biol 2007 26 116 131 17328670
17. Interactions of HIV-1 NEF with cellular signal transducing proteins. GH Renkema K Saksela, Front Biosci 2000 5 268 283 10704155
18. Modulation of different human immunodeficiency virus type 1 Nef functions during progression to AIDS. S Carl TC Greenough M Krumbiegel M Greenberg J Skowronski JL Sullivan F Kirchhoff, J Virol 2001 75 3657 3665 11264355
19. HIV and SIV Nef modulate signal transduction and protein sorting in T cells. J Skowronski ME Greenberg M Lock R Mariani S Salghetti T Swigut AJ Iafrate, Cold Spring Harb Symp Quant Biol 1999 64 453 463 11232322
20. HIV-1 induces complement factor C3 synthesis in astrocytes and neurons by modulation of promoter activity. C Bruder M Hagleitner G Darlington I Mohsenipour R Wurzner I Hollmuller H Stoiber C Lass-Florl MP Dierich C Speth, Mol Immunol 2004 40 949 961 14725791
21. Human immunodeficiency virus type 1 induces expression of complement factors in human astrocytes. C Speth G Stockl I Mohsenipour R Wurzner H Stoiber C Lass-Florl MP Dierich, J Virol 2001 75 2604 2615 11222683
22. Upregulated expression of interleukin-8, RANTES and chemokine receptors in human astrocytic cells infected with HIV-1. M Cota A Kleinschmidt F Ceccherini-Silberstein F Aloisi M Mengozzi A Mantovani R Brack-Werner G Poli, J Neurovirol 2000 6 75 83 10786999
23. HIV-1 Nef inhibits ASK1-dependent death signalling providing a potential mechanism for protecting the infected host cell. R Geleziunas W Xu K Takeda H Ichijo WC Greene, Nature 2001 410 834 838 11298454
24. Streptozotocin-induced diabetes can be reversed by hepatic oval cell activation through hepatic transdifferentiation and pancreatic islet regeneration. S Kim JS Shin HJ Kim RC Fisher MJ Lee CW Kim, Lab Invest 2007 87 702 712 17483848
25. In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector. L Naldini U Blomer P Gallay D Ory R Mulligan FH Gage IM Verma D Trono, Science 1996 272 263 267 8602510
26. Upregulation of F-actin and alpha-actinin in reactive astrocytes. EM Abd-El-Basset S Fedoroff, J Neurosci Res 1997 49 608 616 9302082
27. Cell-type-specific gene delivery into neuronal cells in vitro and in vivo. Z Parveen M Mukhtar M Rafi DA Wenger KM Siddiqui CA Siler B Dietzschold RJ Pomerantz MJ Schnell R Dornburg, Virology 2003 314 74 83 14517061
28. HIV Nef-mediated cellular phenotypes are differentially expressed as a function of intracellular Nef concentrations. X Liu JA Schrager GD Lange JW Marsh, J Biol Chem 2001 276 32763 32770 11438519
29. Spleen necrosis virus-derived C-type retroviral vectors for gene transfer to quiescent cells. Z Parveen A Krupetsky M Engelstadter K Cichutek RJ Pomerantz R Dornburg, Nat Biotechnol 2000 18 623 629 10835599
30. Ethanol strongly potentiates apoptosis induced by HIV-1 proteins in primary human brain microvascular endothelial cells. E Acheampong M Mukhtar Z Parveen N Ngoubilly N Ahmad C Patel RJ Pomerantz, Virology 2002 304 222 234 12504564
31. Hyperglycemia and reactive oxygen species mediate apoptosis in aortic endothelial cells through Janus kinase 2. A Tawfik L Jin AK Banes-Berceli RB Caldwell S Ogbi A Shirley D Barber JD Catravas DM Stern D Fulton, et al. Vascul Pharmacol 2005 43 320 326 16257269
32. Hyperglycemia and the pathobiology of diabetic complications. D Aronson, Adv Cardiol 2008 45 1 16 18230953
33. HIV-1-induced pulmonary oxidative and nitrosative stress: exacerbated response to endotoxin administration in HIV-1 transgenic mouse model. BA Jacob KM Porter SC Elms PY Cheng DP Jones RL Sutliff, Am J Physiol Lung Cell Mol Physiol 2006 291 811 819 16728526
34. Apoptosis enhancement by the HIV-1 Nef protein. A Rasola D Gramaglia C Boccaccio PM Comoglio, J Immunol 2001 166 81 88 11123279
35. Mitochondrial localization of non-histone protein HMGB1 during human endothelial cell-Toxoplasma gondii infection. AC Stumbo E Cortez CA Rodrigues MG Henriques LC Porto HS Barbosa L Carvalho, Cell Biol Int 2008 32 235 238 17936030
36. Normal mitochondrial DNA and respiratory chain activity in familial dysautonomia fibroblasts. P Strasberg P Bridge F Merante H Yeger J Pereira, Biochem Mol Med 1996 59 20 27 8902189
37. A structural view of mitochondria-mediated apoptosis. Y Shi, Nat Struct Biol 2001 8 394 401 11323712
38. Overexpression of nef as a marker for restricted HIV-1 infection of astrocytes in postmortem pediatric central nervous tissues. Y Saito LR Sharer LG Epstein J Michaels M Mintz M Louder K Golding TA Cvetkovich BM Blumberg, Neurology 1994 44 474 481 8145918
39. Management of metabolic complications associated with antiretroviral therapy for HIV-1 infection: recommendations of an International AIDS Society-USA panel. M Schambelan CA Benson A Carr JS Currier MP Dube JG Gerber SK Grinspoon C Grunfeld DP Kotler K Mulligan, et al. J Acquir Immune Defic Syndr 2002 31 257 275 12439201
40. HAART drugs induce oxidative stress in human endothelial cells and increase endothelial recruitment of mononuclear cells: exacerbation by inflammatory cytokines and amelioration by antioxidants. D Mondal L Pradhan M Ali KC Agrawal, Cardiovasc Toxicol 2004 4 287 302 15470276
41. Hyperglycemia associated with protease inhibitors in HIV-1-infected patients. J Gomez-Vera A de Alarcon ME Jimenez-Mejias D Acosta D Prados P Viciana, Clin Microbiol Infect 2000 6 391 394 11168157
42. Acute hyperglycemia induces an oxidative stress in healthy subjects. R Marfella L Quagliaro F Nappo A Ceriello D Giugliano, J Clin Invest 2001 108 635 636 11518739
43. Cellular viral rebound after cessation of potent antiretroviral therapy predicted by levels of multiply spliced HIV-1 RNA encoding nef. M Fischer B Joos B Hirschel G Bleiber R Weber HF Gunthard, J Infect Dis 2004 190 1979 1988 15529263
44. HIV-1 Nef increases T cell activation in a stimulus-dependent manner. JA Schrager JW Marsh, Proc Natl Acad Sci USA 1999 96 8167 8172 10393966
45. Alcohol, astroglia, and brain development. C Guerri J Renau-Piqueras, Mol Neurobiol 1997 15 65 81 9396005
46. Regulation of HIV-1 infection in astrocytes: expression of Nef, TNF-alpha and IL-6 is enhanced in coculture of astrocytes with macrophages. M Fiala RH Rhodes P Shapshak I Nagano O Martinez-Maza A Diagne G Baldwin M Graves, J Neurovirol 1996 2 158 166 8799208
47. Evidence of oxidative stress in the brains of fetuses with CNS anomalies and islet cell hyperplasia. PK Hockett SC Emery L Hansen E Masliah, Pediatr Dev Pathol 2004 7 370 379 15383932
48. Novel markers of oxidative stress in actively progressive HIV dementia. N Sacktor N Haughey R Cutler A Tamara J Turchan C Pardo D Vargas A Nath, J Neuroimmunol 2004 157 176 184 15579295
49. Oxidative stress in HIV demented patients and protection ex vivo with novel antioxidants. J Turchan CB Pocernich C Gairola A Chauhan G Schifitto DA Butterfield S Buch O Narayan A Sinai J Geiger, et al. Neurology 2003 60 307 314 12552050
50. Effect of HIV-1-related protein expression on cardiac and skeletal muscles from transgenic rats. JS Otis YI Ashikhmin LA Brown DM Guidot, AIDS Res Ther 2008 5 8 18439274
51. HIV-1 viral proteins gp120 and Tat induce oxidative stress in brain endothelial cells. TO Price N Ercal R Nakaoke WA Banks, Brain Res 2005 1045 57 63 15910762
52. Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas. T Brunner RJ Mogil D LaFace NJ Yoo A Mahboubi F Echeverri SJ Martin WR Force DH Lynch CF Ware, et al. Nature 1995 373 441 444 7530336
53. Ex vivo induction of apoptosis in lymphocytes is mediated by oxidative stress: role for lymphocyte loss in HIV infection. TS Dobmeyer S Findhammer JM Dobmeyer SA Klein B Raffel D Hoelzer EB Helm D Kabelitz R Rossol, Free Radic Biol Med 1997 22 775 785 9119245
54. Prostaglandin E2 induces interleukin-6 synthesis in human astrocytoma cells. BL Fiebich M Hull K Lieb K Gyufko M Berger J Bauer, J Neurochem 1997 68 704 709 9003059
55. Region specific increases in oxidative stress and superoxide dismutase in the hippocampus of diabetic rats subjected to stress. CA Grillo GG Piroli DR Rosell EK Hoskin BS McEwen LP Reagan, Neuroscience 2003 121 133 140 12946706
56. Elevated CSF prostaglandin E2 levels in patients with probable AD. TJ Montine KR Sidell BC Crews WR Markesbery LJ Marnett LJ Roberts JD Morrow, Neurology 1999 53 1495 1498 10534257
57. Regulation of nitric oxide synthase activity in human immunodeficiency virus type 1 (HIV-1)-infected monocytes: implications for HIV-associated neurological disease. MI Bukrinsky HS Nottet H Schmidtmayerova L Dubrovsky CR Flanagan ME Mullins SA Lipton HE Gendelman, J Exp Med 1995 181 735 745 7530762
58. Role of free radicals in viral pathogenesis and mutation. T Akaike, Rev Med Virol 2001 11 87 101 11262528
59. A role for actin in aging and apoptosis. CW Gourlay KR Ayscough, Biochem Soc Trans 2005 33 1260 1264 16246093
60. Nef induces apoptosis by activating JNK signaling pathway and inhibits NF-kappaB-dependent immune responses in Drosophila. SB Lee J Park JU Jung J Chung, J Cell Sci 2005 118 1851 1859 15827086