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Volumn 190, Issue 11, 2004, Pages 1979-1988

Cellular viral rebound after cessation of potent antiretroviral therapy predicted by levels of multiply spliced HIV-1 RNA encoding nef

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; DIDANOSINE; INDINAVIR; LAMIVUDINE; NEF PROTEIN; NELFINAVIR; REV PROTEIN; RITONAVIR; SAQUINAVIR; STAVUDINE; TRANSACTIVATOR PROTEIN; VIRUS RNA; ZIDOVUDINE;

EID: 9444285887     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/425983     Document Type: Article
Times cited : (50)

References (72)
  • 1
    • 0030952479 scopus 로고    scopus 로고
    • Decay characteristics of HIV-1-infected compartments during combination therapy
    • Perelson AS, Essunger P, Cao Y, et al. Decay characteristics of HIV-1-infected compartments during combination therapy. Nature 1997; 387:188-91.
    • (1997) Nature , vol.387 , pp. 188-191
    • Perelson, A.S.1    Essunger, P.2    Cao, Y.3
  • 2
    • 0030869269 scopus 로고    scopus 로고
    • Treatment with indinavir, zidovudine, and lamivudine in adults with human immunodeficiency virus infection and prior antiretroviral therapy
    • Gulick RM, Mellors JW, Havlir D, et al. Treatment with indinavir, zidovudine, and lamivudine in adults with human immunodeficiency virus infection and prior antiretroviral therapy. N Engl J Med 1997; 337:734-9.
    • (1997) N Engl J Med , vol.337 , pp. 734-739
    • Gulick, R.M.1    Mellors, J.W.2    Havlir, D.3
  • 3
    • 0442268112 scopus 로고    scopus 로고
    • A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less
    • AIDS Clinical Trials Group 320 Study Team
    • Hammer SM, Squires KE, Hughes MD, et al. A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less. AIDS Clinical Trials Group 320 Study Team. N Engl J Med 1997; 337:725-33.
    • (1997) N Engl J Med , vol.337 , pp. 725-733
    • Hammer, S.M.1    Squires, K.E.2    Hughes, M.D.3
  • 4
    • 0033550965 scopus 로고    scopus 로고
    • Clinical progression and virological failure on highly active antiretroviral therapy in HIV-1 patients: A prospective cohort study. Swiss HIV Cohort Study
    • Ledergerber B, Egger M, Opravil M, et al. Clinical progression and virological failure on highly active antiretroviral therapy in HIV-1 patients: a prospective cohort study. Swiss HIV Cohort Study. Lancet 1999; 353:863-8.
    • (1999) Lancet , vol.353 , pp. 863-868
    • Ledergerber, B.1    Egger, M.2    Opravil, M.3
  • 5
    • 0030659177 scopus 로고    scopus 로고
    • Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy
    • Chun TW, Stuyver L, Mizell SB, et al. Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy. Proc Natl Acad Sci USA 1997; 94:13193-7.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 13193-13197
    • Chun, T.W.1    Stuyver, L.2    Mizell, S.B.3
  • 6
    • 14444273439 scopus 로고    scopus 로고
    • Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy
    • Finzi D, Hermankova M, Pierson T, et al. Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy. Science 1997; 278:1295-300.
    • (1997) Science , vol.278 , pp. 1295-1300
    • Finzi, D.1    Hermankova, M.2    Pierson, T.3
  • 7
    • 0030712305 scopus 로고    scopus 로고
    • Recovery of replication-competent HIV despite prolonged suppression of plasma viremia
    • Wong JK, Hezareh M, Günthard HF, et al. Recovery of replication-competent HIV despite prolonged suppression of plasma viremia. Science 1997; 278:1291-5.
    • (1997) Science , vol.278 , pp. 1291-1295
    • Wong, J.K.1    Hezareh, M.2    Günthard, H.F.3
  • 8
    • 0032546919 scopus 로고    scopus 로고
    • Toward HIV eradication or remission: The tasks ahead
    • Ho DD. Toward HIV eradication or remission: the tasks ahead. Science 1998; 280:1866-7.
    • (1998) Science , vol.280 , pp. 1866-1867
    • Ho, D.D.1
  • 9
    • 0141676556 scopus 로고    scopus 로고
    • Productive infection maintains a dynamic steady state of residual viremia in human immunodeficiency virus type 1-infected persons treated with suppressive antiretroviral therapy for five years
    • Havlir DV, Strain MC, Clerici M, et al. Productive infection maintains a dynamic steady state of residual viremia in human immunodeficiency virus type 1-infected persons treated with suppressive antiretroviral therapy for five years. J Virol 2003; 77:11212-9.
    • (2003) J Virol , vol.77 , pp. 11212-11219
    • Havlir, D.V.1    Strain, M.C.2    Clerici, M.3
  • 10
    • 0242584383 scopus 로고    scopus 로고
    • Heterogeneous clearance rates of long-lived lymphocytes infected with HIV: Intrinsic stability predicts lifelong persistence
    • Strain MC, Günthard HF, Havlir DV, et al. Heterogeneous clearance rates of long-lived lymphocytes infected with HIV: intrinsic stability predicts lifelong persistence. Proc Natl Acad Sci USA 2003; 100:4819-24.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 4819-4824
    • Strain, M.C.1    Günthard, H.F.2    Havlir, D.V.3
  • 11
    • 0033609373 scopus 로고    scopus 로고
    • Quantifying residual HIV-1 replication in patients receiving combination antiretroviral therapy
    • Zhang L, Ramratnam B, Tenner RK, et al. Quantifying residual HIV-1 replication in patients receiving combination antiretroviral therapy. N Engl J Med 1999; 340:1605-13.
    • (1999) N Engl J Med , vol.340 , pp. 1605-1613
    • Zhang, L.1    Ramratnam, B.2    Tenner, R.K.3
  • 12
    • 0242629783 scopus 로고    scopus 로고
    • Evolution of envelope sequences of human immunodeficiency virus type 1 in cellular reservoirs in the setting of potent antiviral therapy
    • Günthard HF, Frost SD, Leigh BA, et al. Evolution of envelope sequences of human immunodeficiency virus type 1 in cellular reservoirs in the setting of potent antiviral therapy. J Virol 1999; 73:9404-12.
    • (1999) J Virol , vol.73 , pp. 9404-9412
    • Günthard, H.F.1    Frost, S.D.2    Leigh, B.A.3
  • 13
    • 0034092682 scopus 로고    scopus 로고
    • Effect of influenza vaccination on viral replication and immune response in persons infected with human immunodeficiency virus receiving potent antiretroviral therapy
    • Günthard HF, Wong JK, Spina CA, et al. Effect of influenza vaccination on viral replication and immune response in persons infected with human immunodeficiency virus receiving potent antiretroviral therapy. J Infect Dis 2000; 181:522-31.
    • (2000) J Infect Dis , vol.181 , pp. 522-531
    • Günthard, H.F.1    Wong, J.K.2    Spina, C.A.3
  • 14
    • 0037302345 scopus 로고    scopus 로고
    • In a subset of subjects on highly active antiretroviral therapy, human immunodeficiency virus type 1 RNA in plasma decays from 50 to <5 copies per milliliter, with a half-life of 6 months
    • Di Mascio M, Dornadula G, Zhang H, et al. In a subset of subjects on highly active antiretroviral therapy, human immunodeficiency virus type 1 RNA in plasma decays from 50 to <5 copies per milliliter, with a half-life of 6 months. J Virol 2003; 77:2271-5.
    • (2003) J Virol , vol.77 , pp. 2271-2275
    • Di Mascio, M.1    Dornadula, G.2    Zhang, H.3
  • 15
    • 0034946886 scopus 로고    scopus 로고
    • HIV-1 drug resistance profiles in children and adults with viral load of <50 copies/mL receiving combination therapy
    • Hermankova M, Ray SC, Ruff C, et al. HIV-1 drug resistance profiles in children and adults with viral load of <50 copies/mL receiving combination therapy. JAMA 2001; 286:196-207.
    • (2001) JAMA , vol.286 , pp. 196-207
    • Hermankova, M.1    Ray, S.C.2    Ruff, C.3
  • 16
    • 0036616965 scopus 로고    scopus 로고
    • Residual cell-associated unspliced HIV-1 RNA in peripheral blood of patients on potent antiretroviral therapy represents intracellular transcripts
    • Fischer M, Wong JK, Russenberger D, et al. Residual cell-associated unspliced HIV-1 RNA in peripheral blood of patients on potent antiretroviral therapy represents intracellular transcripts. Antivir Ther 2002; 7:91-103.
    • (2002) Antivir Ther , vol.7 , pp. 91-103
    • Fischer, M.1    Wong, J.K.2    Russenberger, D.3
  • 17
    • 15144342918 scopus 로고    scopus 로고
    • Kinetics of response in lymphoid tissues to antiretroviral therapy of HIV-1 infection
    • Cavert W, Notermans DW, Staskus K, et al. Kinetics of response in lymphoid tissues to antiretroviral therapy of HIV-1 infection. Science 1997; 276:960-4.
    • (1997) Science , vol.276 , pp. 960-964
    • Cavert, W.1    Notermans, D.W.2    Staskus, K.3
  • 18
    • 0742324942 scopus 로고    scopus 로고
    • Attenuated and nonproductive viral transcription in the lymphatic tissue of HIV-1-infected patients receiving potent antiretroviral therapy
    • Fischer M, Joos B, Wong JK, et al. Attenuated and nonproductive viral transcription in the lymphatic tissue of HIV-1-infected patients receiving potent antiretroviral therapy. J Infect Dis 2004; 189:273-85.
    • (2004) J Infect Dis , vol.189 , pp. 273-285
    • Fischer, M.1    Joos, B.2    Wong, J.K.3
  • 19
    • 0033869954 scopus 로고    scopus 로고
    • Treatment-induced decline of HIV-1 p24 and HIV-1 RNA in lymphoid tissue of patients with early HIV-1 infection
    • Kuster H, Cone RC, Ott P, et al. Treatment-induced decline of HIV-1 p24 and HIV-1 RNA in lymphoid tissue of patients with early HIV-1 infection. Am J Pathol 2000; 156:1973-86.
    • (2000) Am J Pathol , vol.156 , pp. 1973-1986
    • Kuster, H.1    Cone, R.C.2    Ott, P.3
  • 20
    • 0037302334 scopus 로고    scopus 로고
    • Latency in human immunodeficiency virus type 1 infection: No easy answers
    • Persaud D, Zhou Y, Siliciano JM, Siliciano RF. Latency in human immunodeficiency virus type 1 infection: no easy answers. J Virol 2003; 77:1659-65.
    • (2003) J Virol , vol.77 , pp. 1659-1665
    • Persaud, D.1    Zhou, Y.2    Siliciano, J.M.3    Siliciano, R.F.4
  • 21
    • 0037115244 scopus 로고    scopus 로고
    • Approaching eradication of highly active antiretroviral therapy: Persistent human immunodeficiency virus type 1 reservoirs with immune activation therapy
    • Kulkosky J, Pomerantz RJ. Approaching eradication of highly active antiretroviral therapy: persistent human immunodeficiency virus type 1 reservoirs with immune activation therapy. Clin Infect Dis 2002; 35:1520-6.
    • (2002) Clin Infect Dis , vol.35 , pp. 1520-1526
    • Kulkosky, J.1    Pomerantz, R.J.2
  • 22
    • 0034054592 scopus 로고    scopus 로고
    • Transient rebound of plasma HIV-1 RNA is not followed by repopulation of the lymphoid compartment with HIV-1 infected cells
    • Joos B, Fischer M, Opravil M, Ott P, Weber R, Cone RC. Transient rebound of plasma HIV-1 RNA is not followed by repopulation of the lymphoid compartment with HIV-1 infected cells. AIDS 2000; 14:752-4.
    • (2000) AIDS , vol.14 , pp. 752-754
    • Joos, B.1    Fischer, M.2    Opravil, M.3    Ott, P.4    Weber, R.5    Cone, R.C.6
  • 24
    • 0031048979 scopus 로고    scopus 로고
    • Accumulation of defective viral genomes in peripheral blood mononuclear cells of human immunodeficiency virus type 1-infected individuals
    • Sanchez G, Xu X, Chermann JC, Hirsch I. Accumulation of defective viral genomes in peripheral blood mononuclear cells of human immunodeficiency virus type 1-infected individuals. J Virol 1997; 71:2233-40.
    • (1997) J Virol , vol.71 , pp. 2233-2240
    • Sanchez, G.1    Xu, X.2    Chermann, J.C.3    Hirsch, I.4
  • 25
    • 0033966504 scopus 로고    scopus 로고
    • Persistence of episomal HIV-1 infection intermediates in patients on highly active anti-retroviral therapy
    • Sharkey ME, Teo I, Greenough T, et al. Persistence of episomal HIV-1 infection intermediates in patients on highly active anti-retroviral therapy. Nat Med 2000; 6:76-81.
    • (2000) Nat Med , vol.6 , pp. 76-81
    • Sharkey, M.E.1    Teo, I.2    Greenough, T.3
  • 26
    • 0038030879 scopus 로고    scopus 로고
    • Shifts in cell-associated HIV-1 RNA but not in episomal HIV-1 DNA correlate with new cycles of HIV-1 infection in vivo
    • Fischer M, Trkola A, Joos B, et al. Shifts in cell-associated HIV-1 RNA but not in episomal HIV-1 DNA correlate with new cycles of HIV-1 infection in vivo. Antivir Ther 2003; 8:97-104.
    • (2003) Antivir Ther , vol.8 , pp. 97-104
    • Fischer, M.1    Trkola, A.2    Joos, B.3
  • 27
    • 0036195928 scopus 로고    scopus 로고
    • Human immunodeficiency virus cDNA metabolism: Notable stability of two-long terminal repeat circles
    • Butler SL, Johnson E, Bushman FD. Human immunodeficiency virus cDNA metabolism: notable stability of two-long terminal repeat circles. J Virol 2002; 76:3739-47.
    • (2002) J Virol , vol.76 , pp. 3739-3747
    • Butler, S.L.1    Johnson, E.2    Bushman, F.D.3
  • 28
    • 0036200163 scopus 로고    scopus 로고
    • Intrinsic stability of episomal circles formed during human immunodeficiency virus type 1 replication
    • Pierson TC, Kieffer TL, Ruff CT, Buck C, Siliciano RF, Siliciano RF. Intrinsic stability of episomal circles formed during human immunodeficiency virus type 1 replication. J Virol 2002; 76:4138-44.
    • (2002) J Virol , vol.76 , pp. 4138-4144
    • Pierson, T.C.1    Kieffer, T.L.2    Ruff, C.T.3    Buck, C.4    Siliciano, R.F.5    Siliciano, R.F.6
  • 29
    • 0242499964 scopus 로고    scopus 로고
    • Longitudinal monitoring of 2-long terminal repeat circles in peripheral blood mononuclear cells from patients with chronic HIV-1 infection
    • Brussel A, Mathez D, Broche-Pierre S, et al. Longitudinal monitoring of 2-long terminal repeat circles in peripheral blood mononuclear cells from patients with chronic HIV-1 infection. AIDS 2003; 17:645-52.
    • (2003) AIDS , vol.17 , pp. 645-652
    • Brussel, A.1    Mathez, D.2    Broche-Pierre, S.3
  • 30
    • 0037471270 scopus 로고    scopus 로고
    • Measuring covert HIV replication during HAART: The abundance of 2-LTR circles is not a reliable marker
    • Bushman F. Measuring covert HIV replication during HAART: the abundance of 2-LTR circles is not a reliable marker. AIDS 2003; 17:749-50.
    • (2003) AIDS , vol.17 , pp. 749-750
    • Bushman, F.1
  • 31
    • 0031572247 scopus 로고    scopus 로고
    • Human immunodeficiency virus type-1 mRNA splicing pattern in infected persons is determined by the proportion of newly infected cells
    • Vesanen M, Markowitz M, Cao Y, Ho DD, Saksela K. Human immunodeficiency virus type-1 mRNA splicing pattern in infected persons is determined by the proportion of newly infected cells. Virology 1997; 236:104-9.
    • (1997) Virology , vol.236 , pp. 104-109
    • Vesanen, M.1    Markowitz, M.2    Cao, Y.3    Ho, D.D.4    Saksela, K.5
  • 32
    • 0033609374 scopus 로고    scopus 로고
    • Persistence of HIV-1 transcription in peripheral-blood mononuclear cells in patients receiving potent antiretroviral therapy
    • Furtado MR, Callaway DS, Phair JP, et al. Persistence of HIV-1 transcription in peripheral-blood mononuclear cells in patients receiving potent antiretroviral therapy. N Engl J Med 1999; 340:1614-22.
    • (1999) N Engl J Med , vol.340 , pp. 1614-1622
    • Furtado, M.R.1    Callaway, D.S.2    Phair, J.P.3
  • 33
    • 0030730288 scopus 로고    scopus 로고
    • Reduction of HIV-1 in blood and lymph nodes following potent antiretroviral therapy and the virologic correlates of treatment failure
    • Wong JK, Günthard HF, Havlir DV, et al. Reduction of HIV-1 in blood and lymph nodes following potent antiretroviral therapy and the virologic correlates of treatment failure. Proc Natl Acad Sci USA 1997; 94:12574-9.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 12574-12579
    • Wong, J.K.1    Günthard, H.F.2    Havlir, D.V.3
  • 34
    • 2642704250 scopus 로고    scopus 로고
    • Human immunodeficiency virus replication and genotypic resistance in blood and lymph nodes after a year of potent antiretroviral therapy
    • Günthard HF, Wong JK, Ignacio CC, et al. Human immunodeficiency virus replication and genotypic resistance in blood and lymph nodes after a year of potent antiretroviral therapy. J Virol 1998; 72:2422-8.
    • (1998) J Virol , vol.72 , pp. 2422-2428
    • Günthard, H.F.1    Wong, J.K.2    Ignacio, C.C.3
  • 36
    • 0036893346 scopus 로고    scopus 로고
    • Selectively reduced tat mRNA heralds the decline in productive human immunodeficiency virus type 1 infection in monocyte-derived macrophages
    • Sonza S, Mutimer HP, O'Brien K, et al. Selectively reduced tat mRNA heralds the decline in productive human immunodeficiency virus type 1 infection in monocyte-derived macrophages. J Virol 2002; 76:12611-21.
    • (2002) J Virol , vol.76 , pp. 12611-12621
    • Sonza, S.1    Mutimer, H.P.2    O'Brien, K.3
  • 37
    • 0021967217 scopus 로고
    • Trans-activator gene of human T-lymphotropic virus type III (HTLV-III)
    • Arya SK, Guo C, Josephs SF, Wong SF. Trans-activator gene of human T-lymphotropic virus type III (HTLV-III). Science 1985; 229:69-73.
    • (1985) Science , vol.229 , pp. 69-73
    • Arya, S.K.1    Guo, C.2    Josephs, S.F.3    Wong, S.F.4
  • 38
    • 0022470729 scopus 로고
    • The trans-activator gene of HTLV-III is essential for virus replication
    • Fisher AG, Feinberg MB, Josephs SF, et al. The trans-activator gene of HTLV-III is essential for virus replication. Nature 1986; 320:367-71.
    • (1986) Nature , vol.320 , pp. 367-371
    • Fisher, A.G.1    Feinberg, M.B.2    Josephs, S.F.3
  • 39
    • 0024518918 scopus 로고
    • The HIV-1 rev trans-activator acts through a structured target sequence to activate nuclear export of unspliced viral mRNA
    • Malim MH, Hauber J, Le SY, Maizel JV, Cullen BR. The HIV-1 rev trans-activator acts through a structured target sequence to activate nuclear export of unspliced viral mRNA. Nature 1989; 338:254-7.
    • (1989) Nature , vol.338 , pp. 254-257
    • Malim, M.H.1    Hauber, J.2    Le, S.Y.3    Maizel, J.V.4    Cullen, B.R.5
  • 40
    • 0028325203 scopus 로고
    • Human immunodeficiency virus type 1 RNA expression by four chronically infected cell lines indicates multiple mechanisms of latency
    • Butera ST, Roberts BD, Lam L, Hodge T, Folks TM. Human immunodeficiency virus type 1 RNA expression by four chronically infected cell lines indicates multiple mechanisms of latency. J Virol 1994; 68:2726-30.
    • (1994) J Virol , vol.68 , pp. 2726-2730
    • Butera, S.T.1    Roberts, B.D.2    Lam, L.3    Hodge, T.4    Folks, T.M.5
  • 41
    • 0023025035 scopus 로고
    • Effects of mutations within the 3′ orf open reading frame region of human T-cell lymphotropic virus type III (HTLV-III/LAV) on replication and cytopathogenicity
    • Terwilliger E, Sodroski JG, Rosen CA, Haseltine WA. Effects of mutations within the 3′ orf open reading frame region of human T-cell lymphotropic virus type III (HTLV-III/LAV) on replication and cytopathogenicity. J Virol 1986; 60:754-60.
    • (1986) J Virol , vol.60 , pp. 754-760
    • Terwilliger, E.1    Sodroski, J.G.2    Rosen, C.A.3    Haseltine, W.A.4
  • 42
    • 0037441996 scopus 로고    scopus 로고
    • HIV-1 Nef induces the release of inflammatory factors from human monocyte/macrophages: Involvement of Nef endocytotic signals and NF-κB activation
    • Olivetta E, Percario Z, Fiorucci G, et al. HIV-1 Nef induces the release of inflammatory factors from human monocyte/macrophages: involvement of Nef endocytotic signals and NF-κB activation. J Immunol 2003; 170:1716-27.
    • (2003) J Immunol , vol.170 , pp. 1716-1727
    • Olivetta, E.1    Percario, Z.2    Fiorucci, G.3
  • 43
    • 0038342442 scopus 로고    scopus 로고
    • HIV-1 Nef intersects the macrophage CD40L signalling pathway to promote resting-cell infection
    • Swingler S, Brichacek B, Jacque JM, Ulich C, Zhou J, Stevenson M. HIV-1 Nef intersects the macrophage CD40L signalling pathway to promote resting-cell infection. Nature 2003; 424:213-9.
    • (2003) Nature , vol.424 , pp. 213-219
    • Swingler, S.1    Brichacek, B.2    Jacque, J.M.3    Ulich, C.4    Zhou, J.5    Stevenson, M.6
  • 44
    • 0034602776 scopus 로고    scopus 로고
    • The Nef protein of HIV-1 associates with rafts and primes T cells for activation
    • Wang JK, Kiyokawa E, Verdin E, Trono D. The Nef protein of HIV-1 associates with rafts and primes T cells for activation. Proc Natl Acad Sci USA 2000; 97:394-9.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 394-399
    • Wang, J.K.1    Kiyokawa, E.2    Verdin, E.3    Trono, D.4
  • 45
    • 0024316873 scopus 로고
    • Lack of a negative influence on viral growth by the nef gene of human immunodeficiency virus type 1
    • Kim S, Ikeuchi K, Byrn R, Groopman J, Baltimore D. Lack of a negative influence on viral growth by the nef gene of human immunodeficiency virus type 1. Proc Natl Acad Sci USA 1989; 86:9544-8.
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 9544-9548
    • Kim, S.1    Ikeuchi, K.2    Byrn, R.3    Groopman, J.4    Baltimore, D.5
  • 46
    • 0028006247 scopus 로고
    • The human immunodeficiency virus-1 nef gene product: A positive factor for viral infection and replication in primary lymphocytes and macrophages
    • Miller MD, Warmerdam MT, Gaston I, Greene WC, Feinberg MB. The human immunodeficiency virus-1 nef gene product: a positive factor for viral infection and replication in primary lymphocytes and macrophages. J Exp Med 1994; 179:101-13.
    • (1994) J Exp Med , vol.179 , pp. 101-113
    • Miller, M.D.1    Warmerdam, M.T.2    Gaston, I.3    Greene, W.C.4    Feinberg, M.B.5
  • 47
    • 0027952787 scopus 로고
    • The importance of nef in the induction of human immunodeficiency virus type 1 replication from primary quiescent CD4 lymphocytes
    • Spina CA, Kwoh TJ, Chowers MY, Guatelli JC, Richman DD. The importance of nef in the induction of human immunodeficiency virus type 1 replication from primary quiescent CD4 lymphocytes. J Exp Med 1994; 179:115-23.
    • (1994) J Exp Med , vol.179 , pp. 115-123
    • Spina, C.A.1    Kwoh, T.J.2    Chowers, M.Y.3    Guatelli, J.C.4    Richman, D.D.5
  • 48
    • 4344709657 scopus 로고    scopus 로고
    • Humoral immunity to HIV-1: Kinetics of antibody responses in chronic infection reflect capacity of immune system to improve viral set point
    • Trkola A, Kuster H, Leemann C, et al. Humoral immunity to HIV-1: kinetics of antibody responses in chronic infection reflect capacity of immune system to improve viral set point. Blood 2004; 104:1784-92.
    • (2004) Blood , vol.104 , pp. 1784-1792
    • Trkola, A.1    Kuster, H.2    Leemann, C.3
  • 49
    • 10744223424 scopus 로고    scopus 로고
    • Emergence of minor populations of human immunodeficiency virus type 1 carrying the M184V and L90M mutations in subjects undergoing structured treatment interruptions
    • Metzner KJ, Bonhoeffer S, Fischer M, et al. Emergence of minor populations of human immunodeficiency virus type 1 carrying the M184V and L90M mutations in subjects undergoing structured treatment interruptions. J Infect Dis 2003; 188:1433-43.
    • (2003) J Infect Dis , vol.188 , pp. 1433-1443
    • Metzner, K.J.1    Bonhoeffer, S.2    Fischer, M.3
  • 50
    • 0037108925 scopus 로고    scopus 로고
    • Stimulation of HIV-specific cellular immunity by structured treatment interruption fails to enhance viral control in chronic HIV infection
    • Oxenius A, Price DA, Günthard HF, et al. Stimulation of HIV-specific cellular immunity by structured treatment interruption fails to enhance viral control in chronic HIV infection. Proc Natl Acad Sci USA 2002; 99:13747-52.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 13747-13752
    • Oxenius, A.1    Price, D.A.2    Günthard, H.F.3
  • 51
    • 0037462632 scopus 로고    scopus 로고
    • HIV RNA in plasma rebounds within days during structured treatment interruptions
    • Fischer M, Hafner R, Schneider C, et al. HIV RNA in plasma rebounds within days during structured treatment interruptions. AIDS 2003; 17:195-9.
    • (2003) AIDS , vol.17 , pp. 195-199
    • Fischer, M.1    Hafner, R.2    Schneider, C.3
  • 52
    • 0038025296 scopus 로고    scopus 로고
    • A prospective trial of structured treatment interruptions in human immunodeficiency virus infection
    • Fagard C, Lebraz M, Günthard HF, et al. A prospective trial of structured treatment interruptions in human immunodeficiency virus infection. Arch Intern Med 2003; 163:1220-6.
    • (2003) Arch Intern Med , vol.163 , pp. 1220-1226
    • Fagard, C.1    Lebraz, M.2    Günthard, H.F.3
  • 53
    • 0036784585 scopus 로고    scopus 로고
    • + T-cell responses do not predict viral growth and clearance rates during structured intermittent antiretroviral therapy
    • + T-cell responses do not predict viral growth and clearance rates during structured intermittent antiretroviral therapy. J Virol 2002; 76:10169-76.
    • (2002) J Virol , vol.76 , pp. 10169-10176
    • Oxenius, A.1    McLean, A.R.2    Fischer, M.3
  • 54
    • 10744220378 scopus 로고    scopus 로고
    • Human immunodeficiency virus 1 fitness is a determining factor of viral rebound and set point in chronic infection
    • Trkola A, Kuster H, Leemann C, et al. Human immunodeficiency virus 1 fitness is a determining factor of viral rebound and set point in chronic infection. J Virol 2003; 77:13146-55.
    • (2003) J Virol , vol.77 , pp. 13146-13155
    • Trkola, A.1    Kuster, H.2    Leemann, C.3
  • 55
    • 0034632742 scopus 로고    scopus 로고
    • Residual HIV-RNA levels persist for up to 2.5 years in PBMC of patients on potent antiretroviral therapy
    • Fischer M, Günthard HF, Opravil M, et al. Residual HIV-RNA levels persist for up to 2.5 years in PBMC of patients on potent antiretroviral therapy. AIDS Res Hum Retroviruses 2000; 16:1135-40.
    • (2000) AIDS Res Hum Retroviruses , vol.16 , pp. 1135-1140
    • Fischer, M.1    Günthard, H.F.2    Opravil, M.3
  • 56
    • 0042237921 scopus 로고    scopus 로고
    • RANTES (CCL5) utilizes the proteoglycan CD44 as an auxiliary receptor to mediate cellular activation signals and HIV-1 enhancement
    • Roscic-Mrkic B, Fischer M, Leemann C, et al. RANTES (CCL5) utilizes the proteoglycan CD44 as an auxiliary receptor to mediate cellular activation signals and HIV-1 enhancement. Blood 2003; 102:1169-77.
    • (2003) Blood , vol.102 , pp. 1169-1177
    • Roscic-Mrkic, B.1    Fischer, M.2    Leemann, C.3
  • 57
    • 0025335833 scopus 로고
    • Cloning and functional analysis of multiply spliced mRNA species of human immunodeficiency virus type 1
    • Schwartz S, Felber BK, Benko DM, Fenyo EM, Pavlakis GN. Cloning and functional analysis of multiply spliced mRNA species of human immunodeficiency virus type 1. J Virol 1990; 64:2519-29.
    • (1990) J Virol , vol.64 , pp. 2519-2529
    • Schwartz, S.1    Felber, B.K.2    Benko, D.M.3    Fenyo, E.M.4    Pavlakis, G.N.5
  • 58
    • 0027524505 scopus 로고
    • High viral load in lymph nodes and latent human immunodeficiency virus (HIV) in peripheral blood cells of HIV-1-infected chimpanzees
    • Saksela K, Muchmore E, Girard M, Fultz P, Baltimore D. High viral load in lymph nodes and latent human immunodeficiency virus (HIV) in peripheral blood cells of HIV-1-infected chimpanzees. J Virol 1993; 67:7423-7.
    • (1993) J Virol , vol.67 , pp. 7423-7427
    • Saksela, K.1    Muchmore, E.2    Girard, M.3    Fultz, P.4    Baltimore, D.5
  • 59
    • 0032928123 scopus 로고    scopus 로고
    • Highly sensitive HIV-1 RNA quantitation from plasma, cells and tissues
    • Fischer M, Huber W, Kallivroussis A, et al. Highly sensitive HIV-1 RNA quantitation from plasma, cells and tissues. J Clin Microbiol 1999; 37:1260-4.
    • (1999) J Clin Microbiol , vol.37 , pp. 1260-1264
    • Fischer, M.1    Huber, W.2    Kallivroussis, A.3
  • 60
    • 10544241554 scopus 로고    scopus 로고
    • Quantitative image analysis of HIV-1 infection in lymphoid tissue
    • Haase AT, Henry K, Zupancic M, et al. Quantitative image analysis of HIV-1 infection in lymphoid tissue. Science 1996; 274:985-9.
    • (1996) Science , vol.274 , pp. 985-989
    • Haase, A.T.1    Henry, K.2    Zupancic, M.3
  • 61
    • 0242331608 scopus 로고    scopus 로고
    • HIV-1 in genital tract and plasma of women: Compartmentalization of viral sequences, coreceptor usage, and glycosylation
    • Kemal KS, Foley B, Burger H, et al. HIV-1 in genital tract and plasma of women: compartmentalization of viral sequences, coreceptor usage, and glycosylation. Proc Natl Acad Sci USA 2003; 100:12972-7.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 12972-12977
    • Kemal, K.S.1    Foley, B.2    Burger, H.3
  • 62
    • 0034048862 scopus 로고    scopus 로고
    • Antiretroviral resistance mutations in human immunodeficiency virus type 1 reverse transcriptase and protease from paired cerebrospinal fluid and plasma samples
    • Venturi G, Catucci M, Romano L, et al. Antiretroviral resistance mutations in human immunodeficiency virus type 1 reverse transcriptase and protease from paired cerebrospinal fluid and plasma samples. J Infect Dis 2000; 181:740-5.
    • (2000) J Infect Dis , vol.181 , pp. 740-745
    • Venturi, G.1    Catucci, M.2    Romano, L.3
  • 63
    • 0242300160 scopus 로고    scopus 로고
    • Genetic and functional analysis of full-length human immunodeficiency virus type 1 env genes derived from brain and blood of patients with AIDS
    • Ohagen A, Devitt A, Kunstman KJ, et al. Genetic and functional analysis of full-length human immunodeficiency virus type 1 env genes derived from brain and blood of patients with AIDS. J Virol 2003; 77:12336-45.
    • (2003) J Virol , vol.77 , pp. 12336-12345
    • Ohagen, A.1    Devitt, A.2    Kunstman, K.J.3
  • 64
    • 0033031005 scopus 로고    scopus 로고
    • Use of real-time PCR and molecular beacons to detect virus replication in human immunodeficiency virus type 1-infected individuals on prolonged effective antiretroviral therapy
    • Lewin SR, Vesanen M, Kostrikis L, et al. Use of real-time PCR and molecular beacons to detect virus replication in human immunodeficiency virus type 1-infected individuals on prolonged effective antiretroviral therapy. J Virol 1999; 73:6099-103.
    • (1999) J Virol , vol.73 , pp. 6099-6103
    • Lewin, S.R.1    Vesanen, M.2    Kostrikis, L.3
  • 65
    • 0037901808 scopus 로고    scopus 로고
    • Stimulation of Tat-independent transcriptional processivity from the HIV-1 LTR promoter by matrix attachment regions
    • Rampalli S, Kulkarni A, Kumar P, et al. Stimulation of Tat-independent transcriptional processivity from the HIV-1 LTR promoter by matrix attachment regions. Nucleic Acids Res 2003; 31:3248-56.
    • (2003) Nucleic Acids Res , vol.31 , pp. 3248-3256
    • Rampalli, S.1    Kulkarni, A.2    Kumar, P.3
  • 66
    • 0033600851 scopus 로고    scopus 로고
    • ERK MAP kinase links cytokine signals to activation of latent HIV-1 infection by stimulating a cooperative interaction of AP-1 and NF-κB
    • Yang X, Chen Y, Gabuzda D. ERK MAP kinase links cytokine signals to activation of latent HIV-1 infection by stimulating a cooperative interaction of AP-1 and NF-κB. J Biol Chem 1999; 274:27981-8.
    • (1999) J Biol Chem , vol.274 , pp. 27981-27988
    • Yang, X.1    Chen, Y.2    Gabuzda, D.3
  • 67
    • 0037458719 scopus 로고    scopus 로고
    • Tat and trans-activation-responsive (TAR) RNA-independent induction of HIV-1 long terminal repeat by human and murine cyclin T1 requires Sp1
    • Yedavalli VS, Benkirane M, Jeang KT. Tat and trans-activation-responsive (TAR) RNA-independent induction of HIV-1 long terminal repeat by human and murine cyclin T1 requires Sp1. J Biol Chem 2003; 278:6404-10.
    • (2003) J Biol Chem , vol.278 , pp. 6404-6410
    • Yedavalli, V.S.1    Benkirane, M.2    Jeang, K.T.3
  • 68
    • 0029846512 scopus 로고    scopus 로고
    • TAR- and Tat-independent replication of human immunodeficiency virus type 1 in human hepatoma cells
    • Zhu M, Duan L, Pomerantz RJ. TAR- and Tat-independent replication of human immunodeficiency virus type 1 in human hepatoma cells. AIDS Res Hum Retroviruses 1996; 12:1093-101.
    • (1996) AIDS Res Hum Retroviruses , vol.12 , pp. 1093-1101
    • Zhu, M.1    Duan, L.2    Pomerantz, R.J.3
  • 69
    • 0032581587 scopus 로고    scopus 로고
    • Early reduction of immune activation in lymphoid tissue following highly active HIV therapy
    • Andersson J, Fehniger TE, Patterson BK, et al. Early reduction of immune activation in lymphoid tissue following highly active HIV therapy. AIDS 1998; 12:F123-9.
    • (1998) AIDS , vol.12
    • Andersson, J.1    Fehniger, T.E.2    Patterson, B.K.3
  • 70
    • 0034298521 scopus 로고    scopus 로고
    • Normalization of immune activation in lymphoid tissue following highly active antiretroviral therapy
    • Behbahani H, Landay A, Patterson BK, et al. Normalization of immune activation in lymphoid tissue following highly active antiretroviral therapy. J Acquir Immune Defic Syndr 2000; 25:150-6.
    • (2000) J Acquir Immune Defic Syndr , vol.25 , pp. 150-156
    • Behbahani, H.1    Landay, A.2    Patterson, B.K.3
  • 71
    • 0030860537 scopus 로고    scopus 로고
    • Macrophages as a source of HIV during opportunistic infections
    • Orenstein JM, Fox C, Wahl SM. Macrophages as a source of HIV during opportunistic infections. Science 1997; 276:1857-61.
    • (1997) Science , vol.276 , pp. 1857-1861
    • Orenstein, J.M.1    Fox, C.2    Wahl, S.M.3
  • 72
    • 0030026189 scopus 로고    scopus 로고
    • + T cells is markedly enhanced in the setting of antigen-specific immune activation
    • + T cells is markedly enhanced in the setting of antigen-specific immune activation. J Exp Med 1996; 183:687-92.
    • (1996) J Exp Med , vol.183 , pp. 687-692
    • Weissman, D.1    Barker, T.D.2    Fauci, A.S.3


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