HIV and SIV nef modulate signal transduction and protein sorting in T cells

Cold Spring Harbor Symposia on Quantitative Biology

Volumn 64, Issue , 1999, Pages 453-463

  Skowronski, J ^a   Greenberg, M E ^a   Lock, M ^a   Marianit, R ^a   Salghetti, S ^a   Swigut, T ^a   Iafrate, A J ^a  

^a Howard Hughes Medical Institute Cold Spring Harbor Laboratory Cold Spring Harbor   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CLATHRIN; NEF PROTEIN; TRANSCRIPTION FACTOR AP 2; BETA 2 MICROGLOBULIN; CD4 ANTIBODY; CD69 ANTIGEN; CD8 ANTIGEN; PROTEASOME;

CONFERENCE PAPER; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; LYMPHOCYTE DIFFERENTIATION; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN TARGETING; SIGNAL TRANSDUCTION; SIMIAN IMMUNODEFICIENCY VIRUS; T LYMPHOCYTE; TRANSGENIC MOUSE; VIRUS CELL INTERACTION; ARTICLE; CALCIUM SIGNALING; ENDOCYTOSIS; GENETIC TRANSCRIPTION; MAJOR HISTOCOMPATIBILITY COMPLEX; MOLECULAR INTERACTION; MOLECULAR PATHOLOGY; MYRISTYLATION; VIRUS REPLICATION;

HUMAN IMMUNODEFICIENCY VIRUS; MUS MUSCULUS; SIMIAE; SIMIAN IMMUNODEFICIENCY VIRUS;

EID: 0033499148     PISSN: 00917451     EISSN: None     Source Type: Book Series    
DOI: 10.1101/sqb.1999.64.453     Document Type: Conference Paper

References (16)

1. Aiken C., Konner J., Landau N.R., Lenburg M.E., and Trono D. 1994. Nef induces CD4 endocytosis: Requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain. Cell 76: 853.
2. Alexander L., Du Z., Rosenzweig M., Jung J.U., and Desrosiers R.C. 1997. A role for natural simian immunodeficiency virus and human immunodeficiency virus type 1 nef alleles in lymphocyte activation. J. Virol. 71: 6094.
3. Arold S., Franken P., Strub M.P., Hoh F., Benichou S., Benarous R., and Dumas. C. 1997. The crystal structure of HIV-1 Nef protein bound to the Fyn kinase SH3 domain suggests a role for this complex in altered T cell receptor signaling. Structure 5: 1361.
4. Baur A.S., Sass G., Laffert B., Willbold D., Cheng-Mayer C., and Peterlin B.M. 1997. The N-terminus of Nef from HIV-1/SIV associates with a protein complex containing Lck and a serine kinase. Immunity 6: 283.
5. Baur A.S., Sawai E.T., Dazin P., Fantl W.J., Cheng-Mayer C., and Peterlin B.M. 1994. HIV-1 Nef leads to inhibition or activation of T cells depending on its intracellular localization. Immunity 1: 373.
6. Bell I., Ashman C., Maughan J., Hooker E., Cook F., and Rein-hart T.A. 1998. Association of simian immunodeficiency virus Nef with the T-cell receptor (TCR) zeta chain leads to TCR down-modulation. J. Gen. Virol. 79: 2717.
7. Brady H.J., Pennington D.J., Miles C.G., and Dzierzak E.A. 1993. CD4 cell surface down-regulation in HIV-1 Nef transgenic mice is a consequence of intracellular sequestration. EMBO J. 12: 4923.
8. Chowers M.Y., Spina C.A., Kwoh T.J., Fitch N.J., Richman D.D., and Guatelli J.C. 1994. Optimal infectivity in vitro of human immunodeficiency virus type 1 requires an intact nef gene. J. Virol. 68: 2906.
9. Cohen G.B., Gandhi R.T., Davis D.M., Mandelboim O., Chen B.K., Strominger J.L., and Baltimore D. 1999. The selective down-regulation of class I major histocompatibility complex proteins by HIV-1 protects HIV-infected cells from NK cells. Immunity 10: 661.
10. Collette Y., Mawas C., and Olive D. 1996. Evidence for intact CD28 signaling in T cell hyporesponsiveness induced by the HIV-1 nef gene. Eur. J. Immunol. 26: 1788.
11. Collins K.L., Chen B.K., Kalams S.A., Walker B.D., and Baltimore D. 1998. HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes. Nature 391: 397.
12. Cullen B.R. 1998. HIV-1 auxiliary proteins: Making connections in a dying cell. Cell 93: 685.
13. Daniel M.D., Kirchhoff F., Czajak S.C., Sehgal P.K., and Desrosiers R.C. 1992. Protective effects of a live attenuated SIV vaccine with a deletion in the nef gens. Science 258: 1938.
14. Deacon N.J., Tsykin A., Solomon A., Smith K., Ludford-Menting M., Hooker D.J., McPhee D.A., Greenway A.L., Ellett A., Chatfield C., Lawson V.A., Crowe S., Maerz A., Sonza S., Learmont J., Sullivan J.S., Cunningham A., Dwyer D., Dowton D., and Mills J. 1995. Genomic structure of an attenuated quasi species of HIV-1 from a blood transfusion donor and recipients. Science 270: 988.
15. Desrosiers, R.C.1999. Strategies used by human immunodeficiency virus that allow persistent viral replication. Nat. Med. 5: 723.
16. Desrosiers R.C., Lifson J.D., Gibbs J.S., Czajak S.C., Howe A.Y., Arthur L.O., and Johnson R.P. 1998. Identification of highly attenuated mutants of simian immunodeficiency virus. J. Virol. 72: 1431.