Upregulated expression of interleukin-8, RANTES and chemokine receptors in human astrocytic cells infected with HIV-1

Journal of NeuroVirology

Volumn 6, Issue 1, 2000, Pages 75-83

  Cota, Manuela ^a,f   Kleinschmidt, Andrea ^d   Ceccherini Silberstein, Francesca ^d   Aloisi, Francesca ^e   Mengozzi, Manuela ^a   Mantovani, Alberto ^b,c   Brack Werner, Ruth ^d   Poli, Guido ^a  

^a SAN RAFFAELE HOSPITAL   (Italy)

^b MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^c UNIVERSITY OF BRESCIA   (Italy)

^d INSTITUTE OF EPIDEMIOLOGY   (Germany)

^e ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^f P2 P3 Laboratories   (Italy)

Author keywords

Astrocytes; Chemokine receptors; Chemokines; Cytokines; HIV

Indexed keywords

CHEMOKINE; CHEMOKINE RECEPTOR; CHEMOKINE RECEPTOR CXCR4; CYTOKINE; INTERLEUKIN 8; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; RANTES; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; ASTROCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DNA TRANSFECTION; GENE ACTIVATION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0034068785     PISSN: 13550284     EISSN: None     Source Type: Journal    
DOI: 10.3109/13550280009006384     Document Type: Article

References (46)

1. Aloisi F, Carè A, Borsellino G, Gallo P, Rosa S, Bassani A, Cabibbo A, Testa U, Levi G, Peschle C (1992). Production of hemolymphopoietic cytokines (IL-6, IL-8, colony-stimulating factors) by normal human astrocytes in response to IL-1b and tumor necrosis factor-α. J Immunol 149: 2358-2366.
2. Barna BP, Pettay J, Barnett GH, Zhou P, Iwasaki K, Estes ML (1994). Regulation of monocyte chemoattractant protein-1 expression in adult human non-neoplastic astrocytes is sensitive to tumor necrosis factor (TNF) or antibody to the 55-kDa TNF receptor. J Neuroimmunol 50: 101-107.
3. Barnes DA, Huston M, Holmes R, Benveniste EN, Yong VW, Scholz P, Perez HD (1996). Induction of RANTES expression by astrocytes and astrocytoma cell lines. J Neuroimmunol 71: 207-214.
4. Bell JE (1999). The neuropathology of adult HIV infection. Res Neurol 154: 816-829.
5. Bernasconi S, Cinque P, Peri G, Sozzani S, Crociati A, Torri W, Vicenzi E, Vago L, Lazzarin A, Poli G, Mantovani A (1996). Selective elevation of monocyte chemotactic protein-1 in the cerebrospinal fluid of AIDS patients with cytomegalovirus encephalitis. J Infect Dis 174: 1098-1101.
6. Biswas P, Delfanti F, Bernasconi S, Mengozzi M, Cota M, Polentarutti N, Mantovani A, Lazzarin A, Sozzani S, Poli G (1998). Interleukin-6 induces monocyte chemotactic protein-1 in peripheral blood mononuclear cells and in the U937 cell line. Blood 91: 258-265.
7. Brack-Werner R, Kleinschmidt A, Ludvigsen A, Mellert W, Neumann M, Herrmann R, Khim MCL, Burny A, Muller-Lantzsch N, Stavrou D, Erfle V (1992). Infection of human brain cells by HIV-1: restricted virus production in chronically infected human glial cell lines. AIDS 6: 273-285.
8. Brack-Werner R (1999). Astrocytes: HIV cellular reservoirs and important participants in neuropathogenesis. AIDS 13: 1-22.
9. Chesebro B, Buller R, Portis J, Wehrly K (1990). Failure of human immunodeficiency virus entry and infection in CD4-positive human brain and skin cells. J Virol 64: 215-221.
10. Cinque P, Vago L, Mengozzi M, Torri W, Ceresa D, Vicenzi E, Transidico P, Vagani A, Sozzani S, Mantovani A, Lazzarin A, Poli G (1998). Elevated cerebrospinal fluid levels of monocyte chemotactic protein-1 correlate with HIV-1 encephalitis and local viral replication. AIDS 12: 1327-1332.
11. Cocchi F, DeVico AL, Garzino-Demo A, Arya SK, Gallo RC, Lusso P (1995). Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells. Science 270: 1811-1815.
12. Conant K, Garzino-Demo A, Nath A, McArthur JC, Halliday W, Power C, Gallo R, Major EO (1998). Induction of monocyte chemoattractant protein-1 in HIV-1 Tat-stimulated astrocytes and elevation in AIDS dementia. Proc Natl Acad Sci USA 95: 3117-3121.
13. da Cunha A, Jackson RW, Vitkovic L (1995). HIV-1 non-specifically stimulates production of transforming growth factor-β1 transfer in primary astrocytes. J Neuroimmunol 60: 125-133.
14. Desbaillets I, Tada M, De Tribolet N, Deserens AC, Hamou MF, Van Meir EG (1994). Human astrocytomas and gliomas express monocyte chemoattractant protein-1 (MCP-1) in vivo and in vitro. Int J Cancer 58: 249-247.
15. Graziosi C, Gantt KR, Vaccarezza M, Demarest JF, Daucher M, Saag MS, Shaw GM, Quinn TC, Cohen OJ, Welbon CC, Pantaleo G, Fauci AS (1996). Kinetics of cytokine expression during primary human immunodeficiency virus type 1 infection. Proc Natl Acad Sci USA 93: 4386-4391.
16. Hahn BH, Shaw GM, Arya SK, Popovic M, Gallo RC, Wong-Staal F (1984). Molecular cloning and characterization of the HTLV-III virus associated with AIDS. Nature 312: 166-169.
17. Hayashi M, Lou Y, Laning J, Strieter RM, Dorf ME (1995). Production and function of monocyte chemoattractant protein-1 and other β-chemokines in murine glial cells. J Neuroimmunol 60: 143-150.
18. He HL, Chen YZ, Farzan M, Choe HY, Ohagen A, Gartner S, Busciglio J, Yang XY, Hofmann W, Newman W, Mackay CR, Sodroski J, Gabuzda D (1997). CCR3 and CCR5 are co-receptors for HIV-1 infection of microglia. Nature 385: 645-649.
19. Hesselgesser J, Horuk R (1999). Chemokine and chemokine receptor expression in the central nervous system. J Neurovirol 5: 13-26.
20. Hurwitz AA, Lyman WD, Berman JW (1995). Tumor necrosis factor α and transforming growth factor β upregulate astrocyte expression of monocyte chemoattractant protein-1. J Neuroimmunol 57: 193-198.
21. Kasahara T, Mukaida N, Yamashita K, Yagisawa H, Akahoshi T, Matsushima K (1991). IL-1 and TNF-alpha induction of IL-8 and monocyte chemotactic and activating factor (MCAF) mRNA expression in a human astrocytoma cell line. Immunology 74: 60-67.
22. Kelder W, McArthur JC, Nance-Sproson T, McClernon D, Griffin DE (1998). Beta-chemokines MCP-1 and RANTES are selectively increased in cerebrospinal fluid of patients with human immunodeficiency virus-associated dementia. Ann Neurol 44: 831-835.
23. Kleinschmidt A, Neumann M, Moller C, Erfle V, Brack-Werner R (1994). Restricted expression of HIV-1 in human astrocytes: molecular basis for viral persistence in the CNS. Res Virol 145: 147-153.
24. Koka P, He K, Zack JA, Kitchen S, Peacock W, Fried I, Tran T, Yashar SS, Merrill JE (1995). Human immunodeficiency virus 1 envelope proteins induce interleukin 1, tumor necrosis factor α, and nitric oxide in glial cultures derived from fetal, neonatal, and adult human brain. J Exp Med 182: 941-952.
25. Kunsch C, Hartle HT, Wigdahl B (1989). Infection of human fetal dorsal root ganglion glial cells with human immunodeficiency virus type 1 involves an entry mechanism independent of the CD4 T4A Epitope. J Virol 63: 5054-5061.
26. Littman DR (1998). Chemokine receptors keys to AIDS pathogenesis. Cell 93: 677-680.
27. Liu J, Zhao ML, Brosnan CF, Lee SC (1996). Expression of type II nitric oxide synthetase in primary human astrocytes and microglia: role of IL-1beta and IL-1 receptor antagonist. J Immunol 157: 3569-3576.
28. Ludwig E, Ceccherini-Siberstein F, van Empel J, Erfle V, Neumann M, Brack-Werner R (1999). Diminished Revmediated stimulation of HIV-1 protein synthesis is a hallmark of human astrocytes. J Virol 73: 8279-8289.
29. Mellert W, Kleinschmidt A, Schmidt J, Festl H, Emler S, Roth WK, Erfle V(1990). Infection of human fibroblasts and osteoblast-like cells with HIV-1. AIDS 4: 527-535.
30. Mengozzi M. De Filippi C, Transidico P, Biswas P, Cota M, Ghezzi S, Vicenzi E, Mantovani A, Sozzani S, Poli G (1999). Human immunodeficiency virus replication induces monocyte chemotactic protein-1 in human macrophages and U937 promonocytic cells. Blood 93: 1851-1857.
31. Miyamoto Y, Kim SU (1999). Cytokine-induced production of macrophage inflammatory protein-1 alpha (MIP-1alpha) in cultured astrocytes. J Neurosci Res 55: 245-251.
32. Neumann M, Felber BK, Kleinschmidt A, Froese B, Erfle V, Pavlakis GN, Brack-Werner R (1995). Restriction of human immunodeficiency virus type 1 production in a human astrocytoma cell line is associated with a cellular block in rev function. J Virol 69: 2159-2167.
33. Oh JW, Schwiebert LM, Benveniste EN (1999). Cytokine regulation of CC and CXC chemokine expression by human astrocytes. J Neurovirol 5: 82-94.
34. Palma C, Minghetti L, Astolfi M, Ambrosini E, Ceccherini Silberstein F, Manzini S, Levi G, Aloisi F (1997). Functional characterization of substance P receptors on cultured human spinal cord astrocytes: Synergism of substance P with cytokines in inducing interleukin-6 and prostaglandin E2 production. Glia 21: 183-193.
35. Peterson PK, Hu S, Salak-Johnson J, Molitor TW, Chao CC (1997). Differential production of and migratory response to β chemokines by human microglia and astrocytes. J Infect Dis 175: 478-481.
36. Poli G, Fauci AS (1995). The role of cytokines in the pathogenesis of HIV disease. In: Human Cytokines: Their Role in Health and Human Disease Aggarwal BB and Puri RK (eds), Blackwell Scientific Publications, Inc. Cambridge, MA, USA pp 421-449.
37. Saito Y, Sharer LR, Epstein LG, Michaels J, Mintz M, Louder M, Golding K, Cvetkovich TA, Blumberg BM (1994). Overexpression of nef as a marker for restricted HIV-1 infection of astrocytes in postmortem pediatric central nervous system. Neurology 44: 481-487.
38. Stauber RH, Horie K, Carney P, Hudson EA, Tarasova NI, Gaitanaris GA, Pavlakis GN (1998). Development and applications of enhanced green fluorescent protein mutants. Biotechniques 24: 462-466, 468-471.
39. Tornatore C, Nath A, Amemiya K, Major EO (1991). Persistent human immunodeficiency virus type 1 infection in human fetal glial cells reactivated by T-cell factor(s) or by the cytokines tumor necrosis factor alpha and interleukin 1beta. J Virol 65: 6094-6100.
40. Tornatore C, Meyers K, Atwood W, Conant K, Major E (1994a). Temporal patterns of human immunodeficiency virus type 1 transcripts in human fetal astrocytes. J Virol 68: 93-102.
41. Tornatore C, Chandra R, Berger JR, Major EO (1994b). HIV-1 infection of subcortical astrocytes in the pediatric central nervous system. Neurology 44: 481-487.
42. Van Meir E, Ceska M, Effenberger F, Walz A, Grouzmann E, Desbaillets I, Frei K, Fontana A, de Tribolet N (1992). Interleukin-8 is produced in neoplastic and infectious diseases of the human central nervous system. Cancer Research 52: 4297-4305.
43. Vicenzi E, Biswas P, Mengozzi M, Poli G (1997). Role of pro-inflammatory cytokines and β-chemokines in controlling HIV replication. J Leuk Biol 62: 34-40.
44. Wagner L, Yang OO, Garcia-Zepeda EA, Ge Y. Kalams SA, Walker BD, Pasternack MS, Luster AD (1998). Beta-chemokines are released from HIV-1-specific cytolitit T-cell granules complexed to proteoglycans. Nature 391: 908-911.
45. Weiss JM, Downie SA, Lyman WD, Berman JW (1998). Astrocyte-derived monocyte-chemoattractant protein-1 directs the transmigration of leukocytes across a model of the human blood brain barrier. J Immunol 161: 6898-6903.
46. Yeung M, Pulliam L, Lau AS (1995). The HIV envelope protein gp120 is toxic to human brain-cell cultures through the induction of interleukin-6 and tumor necrosis factor-α. AIDS 9: 137-143.