Total synthesis and evaluation of C26-hydroxyepothilone D derivatives for photoaffinity labeling of β-tubulin

Journal of Organic Chemistry

Volumn 75, Issue 1, 2010, Pages 86-94

  Reiff, Emily A ^a   Nair, Sajiv K ^a   Henri, John T ^a   Greiner, Jack F ^a   Reddy, Bollu S ^a   Chakrasali, Ramappa ^a   David, Sunil A ^a   Chiu, Ting Lan ^b   Amin, Elizabeth A ^b   Himes, Richard H ^a   Vander Velde, David G ^a   Georg, Gunda I ^b  

^a UNIVERSITY OF KANSAS   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACID DERIVATIVE; ASYMMETRIC SYNTHESIS; CANCER CELL LINES; CELLULAR CYTOTOXICITY; CHEMICAL EQUATIONS; EPOTHILONES; HYDROGEN BONDINGS; HYDROXYL GROUPS; KETOESTER; KETONE REDUCTION; OXAZABOROLIDINE; PEPTIDE FRAGMENTS; PHOTOAFFINITY; PHOTOAFFINITY ANALOGUES; PHOTOAFFINITY LABELING; PROTEIN BINDING; SIDE CHAINS; SYNTHETIC BUILDING BLOCKS; TERT-BUTYLDIMETHYLSILYL; TOTAL SYNTHESIS; TUBULIN ASSEMBLY;

ACIDS; ASSAYS; BINDING ENERGY; BINDING SITES; BIOCHEMISTRY; CELL CULTURE; CYTOTOXICITY; ELECTRON TRANSITIONS; ESTERS; HYDROGEN BONDS; KETONES; LABELING;

SYNTHESIS (CHEMICAL);

10,14 DIHYDROXY 9,11,13,13 TETRAMETHYL 2 [1 (2 METHYLTHIAZOL 4 YL)PROP 1 EN 2 YL] 12,16 DIOXOOXACYCLOHEXADEC 4 EN 5 YL)METHYL 3 AZIDOBENZOATE; 10,14 DIHYDROXY 9,11,13,13 TETRAMETHYL 2 [1 (2 METHYLTHIAZOL 4 YL)PROP 1 EN 2 YL] 12,16 DIOXOOXACYCLOHEXADEC 4 EN 5 YL)METHYL 4 AZIDOBENZOATE; 10,14 DIHYDROXY 9,11,13,13 TETRAMETHYL 2 [1 (2 METHYLTHIAZOL 4 YL)PROP 1 EN 2 YL] 12,16 DIOXOOXACYCLOHEXADEC 4 EN 5 YL)METHYL 4 BENZOYLBENZOATE; BETA TUBULIN; EPOTHILONE B; EPOTHILONE DERIVATIVE; HYDROXYL GROUP; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CANCER CELL; CELL MEDIATED CYTOTOXICITY; CONTROLLED STUDY; DRUG SCREENING; HUMAN; HUMAN CELL; HYDROGEN BOND; MICROTUBULE ASSEMBLY; PHOTOAFFINITY LABELING; PROTEIN BINDING; REDUCTION;

EPOTHILONES; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR PROBES; MOLECULAR STRUCTURE; PHOTOAFFINITY LABELS; TUBULIN; TUBULIN MODULATORS;

EID: 73449112626     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo901752v     Document Type: Article

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