Synthesis of 16-desmethylepothilone B: Improved methodology for the rapid, highly selective and convergent construction of epothilone B and analogues

Chemical Communications

Volumn , Issue 6, 1999, Pages 519-520

  Nicolaou, K C ^a   Hepworth, David ^a   Finlay, M Ray V ^a   King, N Paul ^a   Werschkun, Barbara ^a   Bigot, Antony ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

EPOTHILONE B;

ARTICLE; METHODOLOGY; STEREOCHEMISTRY; SYNTHESIS;

EID: 0033590797     PISSN: 13597345     EISSN: None     Source Type: Journal    
DOI: 10.1039/a809954e     Document Type: Article

References (13)

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2. For recent syntheses see: (a) S. A. May and P. Grieco, Chem. Commun., 1998, 1597;
3. (b) D. Schinzer, A. Bauer and J. Scheiber, Synlett, 1998, 861;
4. (c) A. Balog, C. Harris, K. Savin, X.-G. Zhang, T. C. Chou and S. J. Danishefsky, Angew. Chem., Int. Ed., 1998, 37, 2675;
5. (d) J. Mulzer, A. Mantoulidis and E. Öhler, Tetrahedron Lett., 1998, 39, 8633;
6. (e) S. C. Sinha, C. F. Barbas III and R. A. Lerner, Proc. Natl. Acad. Sci. U.S.A., 1998, 95, 14603.
7. (a) K. C. Nicolaou, M. R. V. Finlay, S. Ninkovic and F. Sarabia, Tetrahedron, 1998, 54, 7127;
8. (b) K. C. Nicolaou, M. R. V. Finlay, S. Ninkovic, N. P. King, Y. He, T. Li, F. Sarabia and D. Vourloumis, Chem. Biol., 1998, 5, 365;
9. K. C. Nicolaou, N. P. King, M. R. V. Finlay, Y. He, F. Roschangar, D. Vourloumis, H. Vallberg, F. Sarabia, S. Ninkovic and D. Hepworth, Bioorg. Med. Chem., 1998, in the press.
10. M. Tamura and J. Kochi, Synthesis, 1971, 303.
11. Y. Morimoto and H. Shirahama, Tetrahedron, 1996, 52, 10631.
12. C. H. Heathcock, in Comprehensive Organic Synthesis, ed. B. M. Trost and I Fleming, Pergamon, Oxford, 1991, vol. 2. pp. 181-235.
13. R. O. Hutchins, D. Kandasamy, C. A. Maryanoff, D. Masilamani and B. E. Maryanoff, J. Org. Chem., 1977, 42, 82.