Anti-obesity activity of diglyceride containing conjugated linoleic acid in C57BL/6J ob/ob mice

Journal of Veterinary Science

Volumn 10, Issue 3, 2009, Pages 189-195

  Hue, Jin Joo ^a   Lee, Ki Nam ^a   Jeong, Jae Hwang ^b   Lee, Sang Hwa ^c   Lee, Young Ho ^d   Jeong, Seong woon ^d   Nam, Sang Yoon ^a   Yun, Young Won ^a   Lee, Beom Jun ^a  

^a Chungbuk National University   (South Korea)

^b Department of Biotechnology and Biomedicine   (South Korea)

^c Seowon University   (South Korea)

^d Ilshinwells   (South Korea)

Author keywords

C57BL 6J ob ob mouse; Conjugated linoleic acid; Diglyceride; Obesity; PPAR

Indexed keywords

ANTIOBESITY AGENT; CONJUGATED LINOLEIC ACID; DIACYLGLYCEROL; LIPID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA;

ADIPOSE TISSUE; ANIMAL; ARTICLE; BLOOD; BLOOD ANALYSIS; BODY WEIGHT; C57BL MOUSE; DISEASE MODEL; DRUG EFFECT; EATING; GENE EXPRESSION REGULATION; LIVER; MALE; METABOLISM; MOUSE; MOUSE MUTANT; OBESITY; PATHOLOGY; TIME;

ADIPOSE TISSUE; ANIMALS; ANTI-OBESITY AGENTS; BLOOD CHEMICAL ANALYSIS; BODY WEIGHT; DIGLYCERIDES; DISEASE MODELS, ANIMAL; EATING; GENE EXPRESSION REGULATION; LINOLEIC ACIDS, CONJUGATED; LIPIDS; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, OBESE; OBESITY; PPAR GAMMA; TIME FACTORS;

EID: 73349105905     PISSN: 1229845X     EISSN: 1976555X     Source Type: Journal    
DOI: 10.4142/jvs.2009.10.3.189     Document Type: Article

References (41)

1. Azain MJ, Hausman DB, Kasser TR, Martin RJ. Effect of somatotropin and feed restriction on body composition and adipose metabolism in obese Zucker rats. Am J Physiol 1995, 269, E137-144.
2. Banni S, Carta G, Angioni E, Murru E, Scanu P, Melis MP, Bauman DE, Fischer SM, Ip C. Distribution of conjugated Linoleic acid and metabolites in different lipid fractions in the rat liver. J Lipid Res 2001, 42, 1056-1061.
3. Bedoucha M, Atzpodien E, Boelsterli UA. Diabetic KKAy mice exhibit increased hepatic PPARgamma1 gene expression and develop hepatic steatosis upon chronic treatment with antidiabetic thiazolidinediones. J Hepatol 2001, 35, 17-23.
4. Bocher V, Pineda-Torra I, Fruchart JC, Staels B. PPARs: transcription factors controlling lipid and lipoprotein metabolism. Ann N Y Acad Sci 2002, 967, 7-18.
5. Blond JP, Henchiri C, Bézard J. Delta 6 and delta 5 desaturase activities in liver from obese Zucker rats at different ages. Lipids 1989, 24, 389-395.
6. Brown JM, McIntosh MK. Conjugated linoleic acid in humans: regulation of adiposity and insulin sensitivity. J Nutr 2003, 133, 3041-3046.
7. Burant CF, Sreenan S, Hirano K, Tai TA, Lohmiller J, Lukens J, Davidson NO, Ross S, Graves RA. Troglitazone action is independent of adipose tissue. J Clin Invest 1997, 100, 2900-2908.
8. Chao L, Marcus-Samuels B, Mason MM, Moitra J, Vinson C, Arioglu E, Gavrilova O, Reitman ML. Adipose tissue is required for the antidiabetic, but not for the hypolipidemic, effect of thiazolidinediones. J Clin Invest 2000, 106, 1221-1228.
9. Chawla A, Schwarz EJ, Dimaculangan DD, Lazar MA. Peroxisome proliferator-activated receptor (PPAR) gamma: adipose-predominant expression and induction early in adipocyte differentiation. Endocrinology 1994, 135, 798-800.
10. Chin SF, Liu W, Storkson JM, Ha YL, Pariza MW. Dietary sources of conjugated dienoic isomers of linoleic acid, a newly recognized class of anticarcinogens. J Food Comp Anal 1992, 5, 185-197.
11. DeLany JP, Blohm F, Truett AA, Scimeca JA, West DB. Conjugated Linoleic acid rapidly reduces body fat content in mice without affecting energy intake. Am J Physiol 1999, 276, R1172-1179.
12. Fajas L, Auboeuf D, Raspé E, Schoonjans K, Lefebvre AM, Saladin R, Najib J, Laville M, Fruchart JC, Deeb S, Vidal-Puig A, Flier J, Briggs MR, Staels B, Vidal H, Auwerx J. The organization, promoter analysis, and expression of the human PPARgamma gene. J Biol Chem 1997, 272, 18779-18789.
13. Flegal KM. Epidemiologic aspects of overweight and obesity in the United States. Physiol Behav 2005, 86, 599-602.
14. Granlund L, Pedersen JI, Nebb HI. Impaired lipid accumulation by trans10, cis12 CLA during adipocyte differentiation is dependent on timing and length of treatment. Biochim Biophys Acta 2005, 1687, 11-22.
15. Hihi AK, Michalik L, Wahli W. PPARs: transcriptional effectors of fatty acids and their derivatives. Cell Mol Life Sci 2002, 59, 790-798.
16. Houseknecht KL, Vanden Heuvel JP, Moya-Camarena SY, Portocarrero CP, Peck LW, Nickel KP, Belury MA. Dietary conjugated linoleic acid normalizes impaired glucose tolerance in the Zucker diabetic fatty fa/fa rat. Biochem Biophys Res Commun 1998, 244, 678-682.
17. Kissebah AH, Krakower GR. Regional adiposity and morbidity. Physiol Rev 1994, 74, 761-811.
18. Lambert PD, Anderson KD, Sleeman MW, Wong V, Tan J, Hijarunguru A, Corcoran TL, Murray JD, Thabet KE, Yancopoulos GD, Wiegand SJ. Ciliary neurotrophic factor activates leptin-like pathways and reduces body fat, without cachexia or rebound weight gain, even in leptin-resistant obesity. Proc Natl Acad Sci USA 2001, 98, 4652-4657.
19. Lee KN, Kritchevsky D, Pariza MW. Conjugated linoleic acid and atherosclerosis in rabbits. Atherosclerosis 1994, 108, 19-25.
20. Lee KN, Pariza MW, Ntambi JM. Conjugated linoleic acid decreases hepatic stearoyl-CoA desaturase mRNA expression. Biochem Biophys Res Commun 1998, 248, 817-821.
21. Lefebvre AM, Chen I, Desreumaux P, Najib J, Fruchart JC, Geboes K, Briggs M, Heyman R, Auwerx J. Activation of the peroxisome proliferator-activated receptorgamma promotes the development of colon tumors in C57BL/6J-APCMin/+ mice. Nat Med 1998, 4, 1053-1057.
22. Lin H, Boylston TD, Chang MJ, Luedecke LO, Shultz TD. Survey of the conjugated linoleic acid contents of dairy products. J Dairy Sci 1995, 78, 2358-2365.
23. Memon RA, Tecott LH, Nonogaki K, Beigneux A, Moser AH, Grunfeld C, Feingold KR. Up-regulation of peroxisome proliferator-activated receptors (PPAR-alpha) and PPAR-gamma messenger ribonucleic acid expression in the liver in murine obesity: troglitazone induces expression of PPAR-gamma-responsive adipose tissue-specific genes in the liver of obese diabetic mice. Endocrinology 2000, 141, 4021-4031.
24. Miner JL, Cederberg CA, Nielsen MK, Chen X, Baile CA. Conjugated linoleic acid (CLA), body fat, and apoptosis. Obes Res 2001, 9, 129-134.
25. Moore KJ, Fitzgerald ML, Freeman MW. Peroxisome proliferator-activated receptors in macrophage biology: friend or foe? Curr Opin Lipidol 2001, 12, 519-527.
26. Must A, Spadano J, Coakley EH, Field AE, Colditz G, Dietz WH. The disease burden associated with overweight and obesity. JAMA 1999, 282, 1523-1529.
27. Murase T, Aoki M, Wakisaka T, Hase T, Tokimitsu I. Anti-obesity effect of dietary diacylglycerol in C57BL/6J mice: dietary diacylglycerol stimulates intestinal lipid metabolism. J Lipid Res 2002, 43, 1312-1319.
28. Murase T, Mizuno T, Omachi T, Onizawa K, Komine Y, Kondo H, Hase T, Tokimitsu I. Dietary diacylglycerol suppresses high fat and high sucrose diet-induced body fat accumulation in C57BL/6J mice. J Lipid Res 2001, 42, 372-378.
29. Nagao T, Watanabe H, Goto N, Onizawa K, Taguchi H, Matsuo N, Yasukawa T, Tsushima R, Shimasaki H, Itakura H. Dietary diacylglycerol suppresses accumulation of body fat compared to triacylglycerol in men in a double-blind controlled trial. J Nutr 2000, 130, 792-797.
30. Ntambi JM, Kim YC. Adipocyte differentiation and gene expression. J Nutr 2000, 130, 3122S-3126S.
31. Ogden CL, Carroll MD, Curtin LR, McDowell MA, Tabak CJ, Flegal KM. Prevalence of overweight and obesity in the United States, 1999-2004. JAMA 2006, 295, 1549-1555.
32. Ohnuki K, Haramizu S, Ishihara K, Fushiki T. Increased energy metabolism and suppressed body fat accumulation in mice by a low concentration of conjugated linoleic acid. Biosci Biotechnol Biochem 2001, 65, 2200-2204.
33. Pariza MW, Park Y, Cook M. The biologically active isomers of conjugated Linoleic acid. Prog Lipid Res 2001, 40, 283-298.
34. Parodi PW. Cows' milk fat components as potential anticarcinogenic agents. J Nutr 1997, 127, 1055-1060.
35. Park Y, Albright KJ, Storkson JM, Liu W, Cook ME, Pariza MW. Changes in body composition in mice during feeding and withdrawal of conjugated linoleic acid. Lipids 1999, 34, 243-248.
36. Park Y, Storkson JM, Albright KJ, Liu W, Pariza MW. Evidence that the trans-10, cis-12 isomer of conjugated linoleic acid induces body composition changes in mice. Lipids 1999, 34, 235-241.
37. Parker J, Daniel LW, Waite M. Evidence of protein kinase C involvement in phorbol diester-stimulated arachidonic acid release and prostaglandin synthesis. J Biol Chem 1987, 262, 5383-5393.
38. Taguchi H, Nagao T, Watanabe H, Onizawa K, Matsuo N, Tokimitsu I, Itakura H. Energy value and digestibility of dietary oil containing mainly 1,3-diacylglycerol are similar to those of triacylglycerol. Lipids 2001, 36, 379-382.
39. Terpstra AHM, Javadi M, Beynen AC, Kocsis S, Lankhorst AE, Lemmens AG, Mohede ICM. Dietary conjugated linoleic acids as free fatty acids and triacylglycerols similarly affect body composition and energy balance in mice. J Nutr 2003, 133, 3181-3186.
40. Wargent E, Sennitt MV, Stocker C, Mayes AE, Brown L, O'Dowd J, Wang S, Einerhand AW, Mohede I, Arch JR, Cawthorne MA. Prolonged treatment of genetically obese mice with conjugated linoleic acid improves glucose tolerance and lowers plasma insulin concentration: possible involvement of PPAR activation. Lipids Health Dis 2005, 4, 3.
41. West DB, Delany JP, Camet PM, Blohm F, Truett AA, Scimeca J. Effects of conjugated linoleic acid on body fat and energy metabolism in the mouse. Am J Physiol 1998, 275, R667-672.