Prolonged treatment of genetically obese mice with conjugated linoleic acid improves glucose tolerance and lowers plasma insulin concentration: Possible involvement of PPAR activation

Lipids in Health and Disease

Volumn 4, Issue , 2005, Pages

  Wargent, Ed ^a   Sennitt, Matthew V ^a   Stocker, Claire ^a   Mayes, Andrew E ^b   Brown, Louise ^b   O'Dowd, Jacqueline ^a   Wang, Steven ^a   Einerhand, Alexandra W C ^c   Mohede, Inge ^c   Arch, Jonathan R S ^a   Cawthorne, Michael A ^a  

^a UNIVERSITY OF BUCKINGHAM   (United Kingdom)

^b UNILEVER RESEARCH   (United Kingdom)

^c Loders Croklaan BV   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN; CLARINOL; CONJUGATED LINOLEIC ACID; INSULIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; ROSIGLITAZONE; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA;

ADIPOCYTE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CELL COUNT; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DIET; FEMALE; GENETICS; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE; INSULIN BLOOD LEVEL; INSULIN SENSITIVITY; MOUSE; NONHUMAN; OBESITY; PROTEIN BLOOD LEVEL; REPORTER GENE; STIMULATION; TRIACYLGLYCEROL BLOOD LEVEL; WHITE ADIPOSE TISSUE;

ADIPONECTIN; ANIMALS; BIOMETRY; BLOOD GLUCOSE; BODY WEIGHT; CELL LINE; CERCOPITHECUS AETHIOPS; FEMALE; HUMANS; INSULIN; LINOLEIC ACIDS, CONJUGATED; MICE; MICE, INBRED C57BL; MICE, OBESE; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS; TIME FACTORS; TRIGLYCERIDES; TUMOR NECROSIS FACTOR-ALPHA;

RODENTIA;

EID: 20044395616     PISSN: 1476511X     EISSN: 1476511X     Source Type: Journal    
DOI: 10.1186/1476-511X-4-3     Document Type: Article

References (43)

1. Smedman A, Vessby B: Conjugated linoleic acid supplementation in humans-metabolic effects. Lipids 2001, 36:773-781.
2. Gaullier JM, Halse J, Hoye K, Kristiansen K, Fagertun H, Vik H, Gudmundsen O: Conjugated linoleic acid supplementation for 1 y reduces body fat mass in healthy overweight humans. Am J Clin Nutr 2004, 79:1118-1125.
3. Thom E, Wadstein J, Gudmundsen O: Conjugated linoleic acid reduces body fat in healthy exercising humans. J Int Med Res 2001, 29:392-396.
4. Blankson H, Stakkestad JA, Fagertun H, Thom E, Wadstein J, Gudmundsen O: Conjugated linoleic acid reduces body fat mass in overweight and obese humans. J Nutr 2000, 130:2943-2948.
5. Belury MA, Mahon A, Banni S: The conjugated linoleic acid (CLA) isomer, t10c12-CLA, is inversely associated with changes in body weight and serum leptin in subjects with type 2 diabetes mellitus. J Nutr 2003, 133:257S-260S.
6. Wang YW, Jones PJ: Conjugated linoleic acid and obesity control: efficacy and mechanisms. Int J Obes Relat Metab Disord 2004, 28:941-955.
7. DeLany JP, Blohm F, Truett AA, Scimeca JA, West DB: Conjugated linoleic acid rapidly reduces body fat content in mice without affecting energy intake. Am J Physiol 1999, 276:R1172-1179.
8. Tsuboyama-Kasaoka N, Takahashi M, Tanemura K, Kim HJ, Tange T, Okuyama H, Kasai M, Ikemoto S, Ezaki O: Conjugated linoleic acid supplementation reduces adipose tissue by apoptosis and develops lipodystrophy in mice. Diabetes 2000, 49:1534-1542.
9. Roche HM, Noone E, Sewter C, Mc Bennett S, Savage D, Gibney MJ, O'Rahilly S, Vidal-Puig AJ: Isomer-dependent metabolic effects of conjugated linoleic acid: insights from molecular markers sterol regulatory element-binding protein-1c and LXRalpha. Diabetes 2002, 51:2037-2044.
10. Clement L, Poirier H, Niot I, Bocher V, Guerre-Millo M, Krief S, Staels B, Besnard P: Dietary trans-10, cis-12 conjugated linoleic acid induces hyperinsulinemia and fatty liver in the mouse. J Lipid Res 2002, 43:1400-1409.
11. Riserus U, Arner P, Brismar K, Vessby B: Treatment with dietary trans10cis12 conjugated linoleic acid causes isomer-specific insulin resistance in obese men with the metabolic syndrome. Diabetes Care 2002, 25:1516-1521.
12. Riserus U, Vessby B, Arnlov J, Basu S: Effects of cis-9, trans-11 conjugated linoleic acid supplementation on insulin sensitivity, lipid peroxidation, and proinflammatory markers in obese men. Am J Clin Nutr 2004, 80:279-283.
13. Moloney F, Yeow TP, Mullen A, Nolan JJ, Roche HM: Conjugated linoleic acid supplementation, insulin sensitivity, and lipoprotein metabolism in patients with type 2 diabetes mellitus. Am J Clin Nutr 2004, 80:887-895.
14. Tricon S, Burdge GC, Kew S, Banerjee T, Russell JJ, Jones EL, Grimble RF, Williams CM, Yaqoob P, Calder PC: Opposing effects of cis-9, trans-11 and trans-10, cis-12 conjugated linoleic acid on blood lipids in healthy humans. Am J Clin Nutr 2004, 80:614-620.
15. Kamphuis MM, Lejeune MP, Saris WH, Westerterp-Plantenga MS: The effect of conjugated linoleic acid supplementation after weight loss on body weight regain, body composition, and resting metabolic rate in overweight subjects. Int J Obes Relat Metab Disord 2003, 27:840-847.
16. Whigham LD, O'Shea M, Mohede IC, Walaski HP, Atkinson RL: Safety profile of conjugated linoleic acid in a 12-month trial in obese humans. Food Chem Toxicol 2004, 42:1701-1709.
17. Noone EJ, Roche HM, Nugent AP, Gibney MJ: The effect of dietary supplementation using isomeric blends of conjugated linoleic acid on lipid metabolism in healthy human subjects. Br J Nutr 2002, 88:243-251.
18. Houseknecht KL, Vanden Heuvel JP, Moya-Camarena SY, Portocarrero CP, Peck LW, Nickel KP, Belury MA: Dietary conjugated linoleic acid normalizes impaired glucose tolerance in the Zucker diabetic fatty fa/fa rat. Biochem Biophys Res Commun 1998, 244:678-682.
19. Ryder JW, Portocarrero CP, Song XM, Cui L, Yu M, Combatsiaris T, Galuska D, Bauman DE, Barbano DM, Charron MJ, Zierath JR, Houseknecht KL: Isomer-specific antidiabetic properties of conjugated linoleic acid. Improved glucose tolerance, skeletal muscle insulin action, and UCP-2 gene expression. Diabetes 2001, 50:1149-1157.
20. Henriksen EJ, Teachey MK, Taylor ZC, Jacob S, Ptock A, Kramer K, Hasselwander O: Isomer-specific actions of conjugated linoleic acid on muscle glucose transport in the obese Zucker rat. Am J Physiol Endocrinol Metab 2003, 285:E98-E105.
21. Nagao K, Inoue N, Wang YM, Yanagita T: Conjugated linoleic acid enhances plasma adiponectin level and alleviates hyperinsulinemia and hypertension in Zucker diabetic fatty (fa/fa) rats. Biochem Biophys Res Commun 2003, 310:562-566.
22. Moya-Camarena SY, Belury MA: Species differences in the metabolism and regulation of gene expression by conjugated linoleic acid. Nutr Rev 1999, 57:336-340.
23. Guerre-Millo M, Gervois P, Raspe E, Madsen L, Poulain P, Derudas B, Herbert JM, Winegar DA, Willson TM, Fruchart JC, Berge RK, Staels B: Peroxisome proliferator-activated receptor alpha activators improve insulin sensitivity and reduce adiposity. J Biol Chem 2000, 275:16638-16642.
24. Bassaganya-Riera J, Reynolds K, Martino-Catt S, Cui Y, Hennighausen L, Gonzalez F, Rohrer J, Benninghoff AU, Hontecillas R: Activation of PPAR gamma and delta by conjugated linoleic acid mediates protection from experimental inflammatory bowel disease. Gastroenterology 2004, 127:777-791.
25. Brown JM, Boysen MS, Jensen SS, Morrison RF, Storkson J, Lea-Currie R, Pariza M, Mandrup S, McIntosh MK: Isomer-specific regulation of metabolism and PPARgamma signaling by CLA in human preadipocytes. J Lipid Res 2003, 44:1287-1300.
26. Kang K, Miyazaki M, Ntambi JM, Pariza MW: Evidence that the anti-obesity effect of conjugated linoleic acid is independent of effects on stearoyl-CoA desaturase1 expression and enzyme activity. Biochem Biophys Res Commun 2004, 315:532-537.
27. Granlund L, Juvet LK, Pedersen JI, Nebb HI: Trans10, cis12-conjugated linoleic acid prevents triacylglycerol accumulation in adipocytes by acting as a PPARgamma modulator. J Lipid Res 2003, 44:1441-1452.
28. Zhou X, Sun C, Jiang L, Wang H: [Effect of conjugated linoleic acid on PPAR gamma gene expression and serum leptin in obese rat]. Wei Sheng Yan Jiu 2004, 33:307-309.
29. Kang K, Liu W, Albright KJ, Park Y, Pariza MW: trans-10, cis-12 CLA inhibits differentiation of 3T3-L1 adipocytes and decreases PPAR gamma expression. Biochem Biophys Res Commun 2003, 303:795-799.
30. Takahashi Y, Kushiro M, Shinohara K, Ide T: Dietary conjugated linoleic acid reduces body fat mass and affects gene expression of proteins regulating energy metabolism in mice. Comp Biochem Physiol B Biochem Mol Biol 2002, 133:395-404.
31. Yamasaki M, Ikeda A, Oji M, Tanaka Y, Hirao A, Kasai M, Iwata T, Tachibana H, Yamada K: Modulation of body fat and serum leptin levels by dietary conjugated linoleic acid in Sprague-Dawley rats fed various fat-level diets. Nutrition 2003, 19:30-35.
32. Akahoshi A, Goto Y, Murao K, Miyazaki T, Yamasaki M, Nonaka M, Yamada K, Sugano M: Conjugated linoleic acid reduces body fats and cytokine levels of mice. Biosci Biotechnol Biochem 2002, 66:916-920.
33. Yu Y, Correll PH, Vanden Heuvel JP: Conjugated linoleic acid decreases production of pro-inflammatory products in macrophages: evidence for a PPAR gamma-dependent mechanism. Biochim Biophys Acta 2002, 1581:89-99.
34. db mice. Journal of Oleo Science 2001, 50:889-894.
35. Warren JM, Simon VA, Bartolini G, Erickson KL, Mackey BE, Kelley DS: Trans-10, cis-12 CLA increases liver and decreases adipose tissue lipids in mice: possible roles of specific lipid metabolism genes. Lipids 2003, 38:497-504.
36. Brown M, Bing C, King P, Pickavance L, Heal D, Wilding J: Sibutramine reduces feeding, body fat and improves insulin resistance in dietary-obese male Wistar rats independently of hypothalamic neuropeptide Y. Br J Pharmacol 2001, 132:1898-1904.
37. Wallace TM, Levy JC, Matthews DR: Use and abuse of HOMA modeling. Diabetes Care 2004, 27:1487-1495.
38. Brown JM, McIntosh MK: Conjugated linoleic acid in humans: regulation of adiposity and insulin sensitivity. J Nutr 2003, 133:3041-3046.
39. Pearson SL, Cawthorne MA, Clapham JC, Dunmore SJ, Holmes SD, Moore GB, Smith SA, Tadayyon M: The thiazolidinedione insulin sensitiser, BRL 49653 increases the expression of PPARgamma and aP2 in adipose tissue of high-fat-fed rats. Biochem Biophys Res Commun 1996, 229:752-757.
40. Tiikkainen M, Hakkinen AM, Korsheninnikova E, Nyman T, Makimattila S, Yki-Jarvinen H: Effects of rosiglitazone and metformin on liver fat content, hepatic insulin resistance, insulin clearance, and gene expression in adipose tissue in patients with type 2 diabetes. Diabetes 2004, 53:2169-2176.
41. Moya-Camarena SY, Van den Heuvel JP, Belury MA: Conjugated linoleic acid activates peroxisome proliferator-activated receptor alpha and beta subtypes but does not induce hepatic peroxisome proliferation in Sprague-Dawley rats. Biochim Biophys Acta 1999, 1436:331-342.
42. Peters JM, Park Y, Gonzalez FJ, Pariza MW: Influence of conjugated linoleic acid on body composition and target gene expression in peroxisome proliferator-activated receptor alpha-null mice. Biochim Biophys Acta 2001, 1533:233-242.
43. Beltowski J: Adiponectin and resistin-new hormones of white adipose tissue. Med Sci Monit 2003, 9:RA55-61.