Increased energy metabolism and suppressed body fat accumulation in mice by a low concentration of conjugated linoleic acid

Bioscience, Biotechnology and Biochemistry

Volumn 65, Issue 10, 2001, Pages 2200-2204

  Ohnuki, Koichiro ^a   Haramizu, Satoshi ^a   Ishihara, Kengo ^a   Fushiki, Tohru ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

Body fat accumulation; Conjugated linoleic acid; Energy metabolism; Mouse

Indexed keywords

GLYCOGEN; LINOLEIC ACID; TRIACYLGLYCEROL;

ADIPOSE TISSUE; ANIMAL; ARTICLE; BASAL METABOLIC RATE; BODY WEIGHT; CALORIMETRY; CHEMISTRY; DRUG EFFECT; ENERGY METABOLISM; LIVER; MALE; METABOLISM; MOUSE; NONPARAMETRIC TEST; ORGAN WEIGHT; OXYGEN CONSUMPTION; PHYSIOLOGY; RANDOMIZATION;

ADIPOSE TISSUE; ANIMAL; BASAL METABOLISM; BODY WEIGHT; CALORIMETRY, INDIRECT; ENERGY METABOLISM; GLYCOGEN; LINOLEIC ACID; LIVER; MALE; MICE; ORGAN WEIGHT; OXYGEN CONSUMPTION; RANDOM ALLOCATION; STATISTICS, NONPARAMETRIC; TRIGLYCERIDES;

EID: 0035491367     PISSN: 09168451     EISSN: None     Source Type: Journal    
DOI: 10.1271/bbb.65.2200     Document Type: Article

References (18)

1. Chin, S. F., Liu, W., Storkson, J. M., Ha, Y. L., and Pariza, M. W., Dietary sources of conjugated dienoic isomers of linoleic acid, a newly recognized class of anticarcinogens. J. Food Comp. Anal., 5, 185-197 (1992).
2. Ha, Y. L., Grimm, N. K., and Pariza, M. W., Anticarcinogens from fried ground beef: Heat-altered derivatives of linoleic acid. Carcinogenesis, 8, 1881-1888 (1987).
3. Ha, Y. L., Grimm, N. K., and Pariza, M. W., Newly recognized anticarcinogenic fatty acids: Identification and quantification in natural and processed cheeses. J. Agric. Food Chem., 37, 75-81 (1989).
4. Shantha, N. C., Crum, A. D., and Decker, E. A., Evaluation of conjugated linoleic acid concentrations in cooked beef. J. Agric. Food Chem., 42, 1757-1760 (1994).
5. Miller, C. C., Park, Y., Pariza, M. W., and Cook, M. E. Feeding conjugated linoleic acid to animals partially overcomes catabolic responses due to endotoxin injection. Biochem. Biophys. Res. Commun., 198, 1107-1112 (1994).
6. Hayek, M. G., Han, S. N., Wu, D., Watkins, B. A., Meydani, M., Dorsey, J. L., Smith, D. E., and Meydani, S. N., Dietary conjugated linoleic acid influences the immune response of young and old C57BL/6NCrlBR mice. J. Nutr., 129, 32-38 (1999).
7. Ip, C., Singh, M., Thompson, H. J., and Scimeca, J. A., Conjugated linoleic acid suppresses mammary carcinogenesis and proliferative activity of the mammary gland in the rat. Cancer Res., 54, 1212-1215 (1994).
8. Ip, C., Scimeca, J. A., and Thompson, H. J., Conjugated linoleic acid: A powerful anticarcinogen from animal fat sources. Cancer, 74, 1050-1054 (1994).
9. Shultz, T. D., Chew, B. P., and Seaman, W. R., Differential stimulatory and inhibitory responses of human MCF-7 breast cancer cells to linoleic acid and conjugated linoleic acid in culture. Anticancer Res., 12, 2143-2145 (1992).
10. Chew, B. P., Wong, T. S., Shultz, T. D., and Magnuson, N. S., Effects of conjugated dienoic derivatives of linoleic acid and beta-carotene in modulating lymphocyte and macrophage function. Anticancer Res., 17, 1099-1106 (1997).
11. Visoneau, S., Cesano, A., Tepper, S. A., Scimeca, J. A., Santoli, D., and Kritchevsky, D., Conjugated linoleic acid suppresses the growth of human breast adenocarcinoma cells in SCID mice. Anticancer Res., 17, 969-973 (1997).
12. Lee, K. N., Kritchevsky, D., and Pariza, M. W., Conjugated linoleic acid and atherosclerosis in rabbits. Atherosclerosis, 108, 19-25 (1994).
13. Nicolosi, R. J., Rogers, E. J., Kritchevsky, D., Scimeca, J. A., and Huth, P. J., Dietary conjugated linoleic acid reduces plasma lipoproteins and early aortic atherosclerosis in hypercholesterolemic hamsters. Artery, 22, 266-277 (1997).
14. Park, Y., Albright, K. J., Liu, W., Storkson, J. M., Cook, M. E., and Pariza, M. W., Effect of conjugated linoleic acid on body composition in mice. Lipids, 32, 853-858 (1997).
15. Tsuboyama-Kasaoka, N., Takahashi, M., Tanemura, K., Kim, H. J., Tange, T., Okuyama, H., Kasai, M., Ikemoto, S., and Ezaki, O. Conjugated linoleic acid supplementation reduces adipose tissue by apoptosis and develops lipodystrophy in mice. Diebetes, 49, 1534-1543 (2000).
16. West, D. B., Delany, J. P., Camet, P. M., Blohm, F., Truett, A. A., and Scimeca, J., Effects of conjugated linoleic acid on body fat and energy metabolism in the mouse. Am. J. Physiol., 215, R667-R672 (1998).
17. Ishihara, K., Oyaizu, S., Onuki, K., Lim, K., and Fushiki, T., Chronic (-)-hydroxycitrate administration spares carbohydrate utilization and promotes lipid oxidation during exericise in mice. J. Nutr., 130, 2990-2995 (2000).
18. Belury, M. A., and Kempa, S. A., Conjugated linoleic acid modulates hepatic lipid composition in mice. Lipids, 32, 199-204 (1997).