메뉴 건너뛰기




Volumn 8, Issue 18, 2009, Pages 1691-1698

Cancer stem cells and hepatocellular carcinoma

Author keywords

2 SPECTRIN; Hepatocellular cancer; Signal transduction; Stem progenitor cells; TGF

Indexed keywords

NOTCH RECEPTOR; SONIC HEDGEHOG PROTEIN; STAT3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; WNT PROTEIN;

EID: 73249127416     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.8.18.9843     Document Type: Review
Times cited : (78)

References (100)
  • 1
    • 60549108333 scopus 로고    scopus 로고
    • The STAT3 inhibitor NSC 74859 is effective in hepatocellular cancers with disrupted TGFbeta signaling
    • Lin L, Amin R, Gallicano GI, Glasgow E, Jogunoori W, Jessup JM, et al. The STAT3 inhibitor NSC 74859 is effective in hepatocellular cancers with disrupted TGFbeta signaling. Oncogene 2009; 28:961-72.
    • (2009) Oncogene , vol.28 , pp. 961-972
    • Lin, L.1    Amin, R.2    Gallicano, G.I.3    Glasgow, E.4    Jogunoori, W.5    Jessup, J.M.6
  • 4
    • 26444585020 scopus 로고    scopus 로고
    • Transforming growth factor-beta signaling in stem cells and cancer
    • Mishra L, Derynck R, Mishra B. Transforming growth factor-beta signaling in stem cells and cancer. Science 2005; 310:68-71.
    • (2005) Science , vol.310 , pp. 68-71
    • Mishra, L.1    Derynck, R.2    Mishra, B.3
  • 5
    • 40649116943 scopus 로고    scopus 로고
    • Progenitor/stem cells give rise to liver cancer due to aberrant TGFbeta and IL-6 signaling
    • Tang Y, Kitisin K, Jogunoori W, Li C, Deng CX, Mueller SC, et al. Progenitor/stem cells give rise to liver cancer due to aberrant TGFbeta and IL-6 signaling. Proc Natl Acad Sci USA 2008; 105:2445-50.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 2445-2450
    • Tang, Y.1    Kitisin, K.2    Jogunoori, W.3    Li, C.4    Deng, C.X.5    Mueller, S.C.6
  • 6
    • 34250740943 scopus 로고    scopus 로고
    • The immortal strand hypothesis: Segregation and reconstruction
    • Rando TA. The immortal strand hypothesis: segregation and reconstruction. Cell 2007; 129:1239-43.
    • (2007) Cell , vol.129 , pp. 1239-1243
    • Rando, T.A.1
  • 8
    • 1542358839 scopus 로고    scopus 로고
    • A molecular view of stem cell and cancer cell self-renewal
    • Tsai RY. A molecular view of stem cell and cancer cell self-renewal. Int J Biochem Cell Biol 2004; 36:684-94.
    • (2004) Int J Biochem Cell Biol , vol.36 , pp. 684-694
    • Tsai, R.Y.1
  • 9
    • 39149086121 scopus 로고    scopus 로고
    • Stems cells and the pathways to aging and cancer
    • Rossi DJ, Jamieson CH, Weissman IL. Stems cells and the pathways to aging and cancer. Cell 2008; 132:681-96.
    • (2008) Cell , vol.132 , pp. 681-696
    • Rossi, D.J.1    Jamieson, C.H.2    Weissman, I.L.3
  • 10
    • 33745600820 scopus 로고    scopus 로고
    • Asymmetric and symmetric stem-cell divisions in development and cancer
    • Morrison SJ, Kimble J. Asymmetric and symmetric stem-cell divisions in development and cancer. Nature 2006; 441:1068-74.
    • (2006) Nature , vol.441 , pp. 1068-1074
    • Morrison, S.J.1    Kimble, J.2
  • 11
    • 39149144034 scopus 로고    scopus 로고
    • Stem cells and niches: Mechanisms that promote stem cell maintenance throughout life
    • Morrison SJ, Spradling AC. Stem cells and niches: mechanisms that promote stem cell maintenance throughout life. Cell 2008; 132:598-611.
    • (2008) Cell , vol.132 , pp. 598-611
    • Morrison, S.J.1    Spradling, A.C.2
  • 12
    • 0345059767 scopus 로고    scopus 로고
    • Applying the principles of stem-cell biology to cancer
    • Pardal R, Clarke MF, Morrison SJ. Applying the principles of stem-cell biology to cancer. Nat Rev Cancer 2003; 3:895-902.
    • (2003) Nat Rev Cancer , vol.3 , pp. 895-902
    • Pardal, R.1    Clarke, M.F.2    Morrison, S.J.3
  • 14
    • 33747195353 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
    • Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006; 126:663-76.
    • (2006) Cell , vol.126 , pp. 663-676
    • Takahashi, K.1    Yamanaka, S.2
  • 15
    • 55849117368 scopus 로고    scopus 로고
    • Generation of mouse induced pluripotent stem cells without viral vectors
    • Okita K, Nakagawa M, Hyenjong H, Ichisaka T, Yamanaka S. Generation of mouse induced pluripotent stem cells without viral vectors. Science 2008; 322:949-53.
    • (2008) Science , vol.322 , pp. 949-953
    • Okita, K.1    Nakagawa, M.2    Hyenjong, H.3    Ichisaka, T.4    Yamanaka, S.5
  • 16
    • 55849115999 scopus 로고    scopus 로고
    • Induced pluripotent stem cells generated without viral integration
    • Stadtfeld M, Nagaya M, Utikal J, Weir G, Hochedlinger K. Induced pluripotent stem cells generated without viral integration. Science 2008; 322:945-9.
    • (2008) Science , vol.322 , pp. 945-949
    • Stadtfeld, M.1    Nagaya, M.2    Utikal, J.3    Weir, G.4    Hochedlinger, K.5
  • 17
    • 0037462502 scopus 로고    scopus 로고
    • Disruption of transforming growth factor-beta signaling in ELFbeta-spectrin-deficient mice
    • Tang Y, Katuri V, Dillner A, Mishra B, Deng CX, Mishra L. Disruption of transforming growth factor-beta signaling in ELFbeta-spectrin-deficient mice. Science 2003; 299:574-7.
    • (2003) Science , vol.299 , pp. 574-577
    • Tang, Y.1    Katuri, V.2    Dillner, A.3    Mishra, B.4    Deng, C.X.5    Mishra, L.6
  • 18
    • 2542601615 scopus 로고    scopus 로고
    • Liver regeneration and repair: Hepatocytes, progenitor cells and stem cells
    • Fausto N. Liver regeneration and repair: hepatocytes, progenitor cells and stem cells. Hepatology 2004; 39:1477-87.
    • (2004) Hepatology , vol.39 , pp. 1477-1487
    • Fausto, N.1
  • 20
    • 33745533559 scopus 로고    scopus 로고
    • Liver stem cells and their implication in hepatocellular and cholangiocarcinoma
    • Roskams T. Liver stem cells and their implication in hepatocellular and cholangiocarcinoma. Oncogene 2006; 25:3818-22.
    • (2006) Oncogene , vol.25 , pp. 3818-3822
    • Roskams, T.1
  • 21
    • 0034951680 scopus 로고    scopus 로고
    • Smad proteins and hepatocyte growth factor control parallel regulatory pathways that converge on beta1-integrin to promote normal liver development
    • Weinstein M, Monga SP, Liu Y, Brodie SG, Tang Y, Li C, et al. Smad proteins and hepatocyte growth factor control parallel regulatory pathways that converge on beta1-integrin to promote normal liver development. Mol Cell Biol 2001; 21:5122-31.
    • (2001) Mol Cell Biol , vol.21 , pp. 5122-5131
    • Weinstein, M.1    Monga, S.P.2    Liu, Y.3    Brodie, S.G.4    Tang, Y.5    Li, C.6
  • 22
    • 33745924696 scopus 로고    scopus 로고
    • Side population purified from hepatocellular carcinoma cells harbors cancer stem cell-like properties
    • Chiba T, Kita K, Zheng YW, Yokosuka O, Saisho H, Iwama A, et al. Side population purified from hepatocellular carcinoma cells harbors cancer stem cell-like properties. Hepatology 2006; 44:240-51.
    • (2006) Hepatology , vol.44 , pp. 240-251
    • Chiba, T.1    Kita, K.2    Zheng, Y.W.3    Yokosuka, O.4    Saisho, H.5    Iwama, A.6
  • 23
    • 0033617522 scopus 로고    scopus 로고
    • Notch Signaling: Cell Fate Control and Signal Integration in Development
    • Artavanis-Tsakonas S, Rand MD, Lake RJ. Notch Signaling: Cell Fate Control and Signal Integration in Development. Science 1999; 284:770-6.
    • (1999) Science , vol.284 , pp. 770-776
    • Artavanis-Tsakonas, S.1    Rand, M.D.2    Lake, R.J.3
  • 27
    • 0842324623 scopus 로고    scopus 로고
    • Multiple niches for Notch in cancer: Context is everything
    • Weng AP, Aster JC. Multiple niches for Notch in cancer: context is everything. Curr Opin Genet Dev 2004; 14:48-54.
    • (2004) Curr Opin Genet Dev , vol.14 , pp. 48-54
    • Weng, A.P.1    Aster, J.C.2
  • 30
    • 33947411967 scopus 로고    scopus 로고
    • Expression of Jagged1 and its association with hepatitis B virus X protein in hepatocellular carcinoma
    • Gao J, Chen C, Hong L, Wang J, Du Y, Song J, et al. Expression of Jagged1 and its association with hepatitis B virus X protein in hepatocellular carcinoma. Biochem Biophys Res Commun 2007; 356:341-7.
    • (2007) Biochem Biophys Res Commun , vol.356 , pp. 341-347
    • Gao, J.1    Chen, C.2    Hong, L.3    Wang, J.4    Du, Y.5    Song, J.6
  • 31
    • 0034738965 scopus 로고    scopus 로고
    • Ras pathway signals are required for notch-mediated oncogenesis
    • Fitzgerald K, Harrington A, Leder P. Ras pathway signals are required for notch-mediated oncogenesis. Oncogene 2000; 19:4191-8.
    • (2000) Oncogene , vol.19 , pp. 4191-4198
    • Fitzgerald, K.1    Harrington, A.2    Leder, P.3
  • 32
    • 33846297979 scopus 로고    scopus 로고
    • MAPK regulation of maternal and zygotic Notch transcript stability in early development
    • Gonsalves FC, Weisblat DA. MAPK regulation of maternal and zygotic Notch transcript stability in early development. Proc Natl Acad Sci USA 2007; 104:531-6.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 531-536
    • Gonsalves, F.C.1    Weisblat, D.A.2
  • 33
    • 25844517958 scopus 로고    scopus 로고
    • Regulation of the Notch target gene Hes-1 by TGFalpha induced Ras/MAPK signaling in human neuroblastoma cells
    • Stockhausen MT, Sjolund J, Axelson H. Regulation of the Notch target gene Hes-1 by TGFalpha induced Ras/MAPK signaling in human neuroblastoma cells. Exp Cell Res 2005; 310:218-28.
    • (2005) Exp Cell Res , vol.310 , pp. 218-228
    • Stockhausen, M.T.1    Sjolund, J.2    Axelson, H.3
  • 34
    • 26444467062 scopus 로고    scopus 로고
    • Increased protein expression of the PTEN tumor suppressor in the presence of constitutively active Notch-1
    • Chappell WH, Green TD, Spengeman JD, McCubrey JA, Akula SM, Bertrand FE. Increased protein expression of the PTEN tumor suppressor in the presence of constitutively active Notch-1. Cell Cycle 2005; 4:1389-95.
    • (2005) Cell Cycle , vol.4 , pp. 1389-1395
    • Chappell, W.H.1    Green, T.D.2    Spengeman, J.D.3    McCubrey, J.A.4    Akula, S.M.5    Bertrand, F.E.6
  • 35
    • 0346365362 scopus 로고    scopus 로고
    • Notch1 signaling inhibits growth of human hepatocellular carcinoma through induction of cell cycle arrest and apoptosis
    • Qi R, An H, Yu Y, Zhang M, Liu S, Xu H, et al. Notch1 signaling inhibits growth of human hepatocellular carcinoma through induction of cell cycle arrest and apoptosis. Cancer Res 2003; 63:8323-9.
    • (2003) Cancer Res , vol.63 , pp. 8323-8329
    • Qi, R.1    An, H.2    Yu, Y.3    Zhang, M.4    Liu, S.5    Xu, H.6
  • 36
    • 67650236862 scopus 로고    scopus 로고
    • Notch1 signaling sensitizes tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human hepatocellular carcinoma cells by inhibiting Akt/Hdm2-mediated p53 degradation and upregulating p53-dependent DR5 expression
    • Wang C, Qi R, Li N, Wang Z, An H, Zhang Q, et al. Notch1 signaling sensitizes tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human hepatocellular carcinoma cells by inhibiting Akt/Hdm2-mediated p53 degradation and upregulating p53-dependent DR5 expression. J Biol Chem 2009; 284:16183-90.
    • (2009) J Biol Chem , vol.284 , pp. 16183-16190
    • Wang, C.1    Qi, R.2    Li, N.3    Wang, Z.4    An, H.5    Zhang, Q.6
  • 37
    • 17244376814 scopus 로고    scopus 로고
    • Wnt signalling in stem cells and cancer
    • Reya T, Clevers H. Wnt signalling in stem cells and cancer. Nature 2005; 434:843-50.
    • (2005) Nature , vol.434 , pp. 843-850
    • Reya, T.1    Clevers, H.2
  • 40
    • 0021270667 scopus 로고
    • Mode of proviral activation of a putative mammary oncogene (int-1) on mouse chromosome 15
    • Nusse R, van Ooyen A, Cox D, Fung YK, Varmus H. Mode of proviral activation of a putative mammary oncogene (int-1) on mouse chromosome 15. Nature 1984; 307:131-6.
    • (1984) Nature , vol.307 , pp. 131-136
    • Nusse, R.1    van Ooyen, A.2    Cox, D.3    Fung, Y.K.4    Varmus, H.5
  • 41
    • 33747339465 scopus 로고    scopus 로고
    • Wnt signaling: Multiple pathways, multiple receptors and multiple transcription factors
    • Gordon MD, Nusse R. Wnt signaling: multiple pathways, multiple receptors and multiple transcription factors. J Biol Chem 2006; 281:22429-33.
    • (2006) J Biol Chem , vol.281 , pp. 22429-22433
    • Gordon, M.D.1    Nusse, R.2
  • 42
    • 0030779038 scopus 로고    scopus 로고
    • Serine phosphorylation-regulated ubiquitination and degradation of beta-catenin
    • Orford K, Crockett C, Jensen JP, Weissman AM, Byers SW. Serine phosphorylation-regulated ubiquitination and degradation of beta-catenin. J Biol Chem 1997; 272:24735-8.
    • (1997) J Biol Chem , vol.272 , pp. 24735-24738
    • Orford, K.1    Crockett, C.2    Jensen, J.P.3    Weissman, A.M.4    Byers, S.W.5
  • 43
    • 0029811434 scopus 로고    scopus 로고
    • Wingless inactivates glycogen synthase kinase-3 via an intracellular signalling pathway which involves a protein kinase C
    • Cook D, Fry MJ, Hughes K, Sumathipala R, Woodgett JR, Dale TC. Wingless inactivates glycogen synthase kinase-3 via an intracellular signalling pathway which involves a protein kinase C. EMBO J 1996; 15:4526-36.
    • (1996) EMBO J , vol.15 , pp. 4526-4536
    • Cook, D.1    Fry, M.J.2    Hughes, K.3    Sumathipala, R.4    Woodgett, J.R.5    Dale, T.C.6
  • 44
    • 0034625355 scopus 로고    scopus 로고
    • Wnt signaling to beta-catenin involves two interactive components. Glycogen synthase kinase-3beta inhibition and activation of protein kinase C
    • Chen RH, Ding WV, McCormick F. Wnt signaling to beta-catenin involves two interactive components. Glycogen synthase kinase-3beta inhibition and activation of protein kinase C. J Biol Chem 2000; 275:17894-9.
    • (2000) J Biol Chem , vol.275 , pp. 17894-17899
    • Chen, R.H.1    Ding, W.V.2    McCormick, F.3
  • 45
    • 34447122100 scopus 로고    scopus 로고
    • A hidden oncogenic positive feedback loop caused by crosstalk between Wnt and ERK pathways
    • Kim D, Rath O, Kolch W, Cho KH. A hidden oncogenic positive feedback loop caused by crosstalk between Wnt and ERK pathways. Oncogene 2007; 26:4571-9.
    • (2007) Oncogene , vol.26 , pp. 4571-4579
    • Kim, D.1    Rath, O.2    Kolch, W.3    Cho, K.H.4
  • 46
    • 33646581038 scopus 로고    scopus 로고
    • 3-phosphoinositide- dependent protein kinase-1 (PDK1) promotes invasion and activation of matrix metalloproteinases
    • Xie Z, Yuan H, Yin Y, Zeng X, Bai R, Glazer RI. 3-phosphoinositide- dependent protein kinase-1 (PDK1) promotes invasion and activation of matrix metalloproteinases. BMC Cancer 2006; 6:77.
    • (2006) BMC Cancer , vol.6 , pp. 77
    • Xie, Z.1    Yuan, H.2    Yin, Y.3    Zeng, X.4    Bai, R.5    Glazer, R.I.6
  • 47
    • 0037096904 scopus 로고    scopus 로고
    • Transformation of mammary epithelial cells by 3-phosphoinositide-dependent protein kinase-1 (PDK1) is associated with the induction of protein kinase Calpha
    • Zeng X, Xu H, Glazer RI. Transformation of mammary epithelial cells by 3-phosphoinositide-dependent protein kinase-1 (PDK1) is associated with the induction of protein kinase Calpha. Cancer Res 2002; 62:3538-43.
    • (2002) Cancer Res , vol.62 , pp. 3538-3543
    • Zeng, X.1    Xu, H.2    Glazer, R.I.3
  • 48
    • 9144269759 scopus 로고    scopus 로고
    • Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells
    • Li Y, Welm B, Podsypanina K, Huang S, Chamorro M, Zhang X, et al. Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells. Proc Natl Acad Sci USA 2003; 100:15853-8.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 15853-15858
    • Li, Y.1    Welm, B.2    Podsypanina, K.3    Huang, S.4    Chamorro, M.5    Zhang, X.6
  • 49
    • 0035902140 scopus 로고    scopus 로고
    • The Hedgehog and Wnt signalling pathways in cancer
    • Taipale J, Beachy PA. The Hedgehog and Wnt signalling pathways in cancer. Nature 2001; 411:349-54.
    • (2001) Nature , vol.411 , pp. 349-354
    • Taipale, J.1    Beachy, P.A.2
  • 50
    • 33845351678 scopus 로고    scopus 로고
    • Wnt signalling in the mouse intestine
    • Clarke AR. Wnt signalling in the mouse intestine. Oncogene 2006; 25:7512-21.
    • (2006) Oncogene , vol.25 , pp. 7512-7521
    • Clarke, A.R.1
  • 51
    • 0034995765 scopus 로고    scopus 로고
    • Genetic alterations associated with hepatocellular carcinomas define distinct pathways of hepatocarcinogenesis
    • Laurent-Puig P, Legoix P, Bluteau O, Belghiti J, Franco D, Binot F, et al. Genetic alterations associated with hepatocellular carcinomas define distinct pathways of hepatocarcinogenesis. Gastroenterology 2001; 120:1763-73.
    • (2001) Gastroenterology , vol.120 , pp. 1763-1773
    • Laurent-Puig, P.1    Legoix, P.2    Bluteau, O.3    Belghiti, J.4    Franco, D.5    Binot, F.6
  • 52
    • 0037130449 scopus 로고    scopus 로고
    • Mutational spectrum of beta-catenin, AXIN1 and AXIN2 in hepatocellular carcinomas and hepatoblastomas
    • Taniguchi K, Roberts LR, Aderca IN, Dong X, Qian C, Murphy LM, et al. Mutational spectrum of beta-catenin, AXIN1 and AXIN2 in hepatocellular carcinomas and hepatoblastomas. Oncogene 2002; 21:4863-71.
    • (2002) Oncogene , vol.21 , pp. 4863-4871
    • Taniguchi, K.1    Roberts, L.R.2    Aderca, I.N.3    Dong, X.4    Qian, C.5    Murphy, L.M.6
  • 53
    • 6944250147 scopus 로고    scopus 로고
    • Immunohistochemical analysis and mutational analyses of beta-catenin, Axin family and APC genes in hepatocellular carcinomas
    • Ishizaki Y, Ikeda S, Fujimori M, Shimizu Y, Kurihara T, Itamoto T, et al. Immunohistochemical analysis and mutational analyses of beta-catenin, Axin family and APC genes in hepatocellular carcinomas. Int J Oncol 2004; 24:1077-83.
    • (2004) Int J Oncol , vol.24 , pp. 1077-1083
    • Ishizaki, Y.1    Ikeda, S.2    Fujimori, M.3    Shimizu, Y.4    Kurihara, T.5    Itamoto, T.6
  • 54
    • 14544270262 scopus 로고    scopus 로고
    • Mutations of beta-catenin and AXIN I genes are a late event in human hepatocellular carcinogenesis
    • Park JY, Park WS, Nam SW, Kim SY, Lee SH, Yoo NJ, et al. Mutations of beta-catenin and AXIN I genes are a late event in human hepatocellular carcinogenesis. Liver Int 2005; 25:70-6.
    • (2005) Liver Int , vol.25 , pp. 70-76
    • Park, J.Y.1    Park, W.S.2    Nam, S.W.3    Kim, S.Y.4    Lee, S.H.5    Yoo, N.J.6
  • 55
    • 0034088858 scopus 로고    scopus 로고
    • AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1
    • Satoh S, Daigo Y, Furukawa Y, Kato T, Miwa N, Nishiwaki T, et al. AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1. Nat Genet 2000; 24:245-50.
    • (2000) Nat Genet , vol.24 , pp. 245-250
    • Satoh, S.1    Daigo, Y.2    Furukawa, Y.3    Kato, T.4    Miwa, N.5    Nishiwaki, T.6
  • 56
    • 5144226941 scopus 로고    scopus 로고
    • Functional consequences of frizzled-7 receptor overexpression in human hepatocellular carcinoma
    • Merle P, de la Monte S, Kim M, Herrmann M, Tanaka S, Von Dem Bussche A, et al. Functional consequences of frizzled-7 receptor overexpression in human hepatocellular carcinoma. Gastroenterology 2004; 127:1110-22.
    • (2004) Gastroenterology , vol.127 , pp. 1110-1122
    • Merle, P.1    de la Monte, S.2    Kim, M.3    Herrmann, M.4    Tanaka, S.5    Von Dem Bussche, A.6
  • 57
    • 0141961143 scopus 로고    scopus 로고
    • Beta-catenin accumulation in the progression of human hepatocarcinogenesis correlates with loss of E-cadherin and accumulation of p53, but not with expression of conventional WNT-1 target genes
    • Prange W, Breuhahn K, Fischer F, Zilkens C, Pietsch T, Petmecky K, et al. Beta-catenin accumulation in the progression of human hepatocarcinogenesis correlates with loss of E-cadherin and accumulation of p53, but not with expression of conventional WNT-1 target genes. J Pathol 2003; 201:250-9.
    • (2003) J Pathol , vol.201 , pp. 250-259
    • Prange, W.1    Breuhahn, K.2    Fischer, F.3    Zilkens, C.4    Pietsch, T.5    Petmecky, K.6
  • 58
    • 0036190930 scopus 로고    scopus 로고
    • Expression and prognostic roles of beta-catenin in hepatocellular carcinoma: Correlation with tumor progression and postoperative survival
    • Inagawa S, Itabashi M, Adachi S, Kawamoto T, Hori M, Shimazaki J, et al. Expression and prognostic roles of beta-catenin in hepatocellular carcinoma: correlation with tumor progression and postoperative survival. Clin Cancer Res 2002; 8:450-6.
    • (2002) Clin Cancer Res , vol.8 , pp. 450-456
    • Inagawa, S.1    Itabashi, M.2    Adachi, S.3    Kawamoto, T.4    Hori, M.5    Shimazaki, J.6
  • 59
    • 0141830987 scopus 로고    scopus 로고
    • Expression of beta-catenin in hepatocellular carcinoma in relation to tumor cell proliferation and cyclin D1 expression
    • Joo M, Lee HK, Kang YK. Expression of beta-catenin in hepatocellular carcinoma in relation to tumor cell proliferation and cyclin D1 expression. J Korean Med Sci 2003; 18:211-7.
    • (2003) J Korean Med Sci , vol.18 , pp. 211-217
    • Joo, M.1    Lee, H.K.2    Kang, Y.K.3
  • 60
    • 0037737728 scopus 로고    scopus 로고
    • A role for Wnt signalling in self-renewal of haematopoietic stem cells
    • Reya T, Duncan AW, Ailles L, Domen J, Scherer DC, Willert K, et al. A role for Wnt signalling in self-renewal of haematopoietic stem cells. Nature 2003; 423:409-14.
    • (2003) Nature , vol.423 , pp. 409-414
    • Reya, T.1    Duncan, A.W.2    Ailles, L.3    Domen, J.4    Scherer, D.C.5    Willert, K.6
  • 61
    • 0037452998 scopus 로고    scopus 로고
    • Wnt-5A augments repopulating capacity and primitive hematopoietic development of human blood stem cells in vivo
    • Murdoch B, Chadwick K, Martin M, Shojaei F, Shah KV, Gallacher L, et al. Wnt-5A augments repopulating capacity and primitive hematopoietic development of human blood stem cells in vivo. Proc Natl Acad Sci USA 2003; 100:3422-7.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 3422-3427
    • Murdoch, B.1    Chadwick, K.2    Martin, M.3    Shojaei, F.4    Shah, K.V.5    Gallacher, L.6
  • 62
    • 48349102037 scopus 로고    scopus 로고
    • Developmental biology: Our fly cousins' gut
    • Pitsouli C, Perrimon N. Developmental biology: Our fly cousins' gut. Nature 2008; 454:592-3.
    • (2008) Nature , vol.454 , pp. 592-593
    • Pitsouli, C.1    Perrimon, N.2
  • 63
    • 33751251034 scopus 로고    scopus 로고
    • Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer
    • Bardeesy N, Cheng KH, Berger JH, Chu GC, Pahler J, Olson P, et al. Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer. Genes Dev 2006; 20:3130-46.
    • (2006) Genes Dev , vol.20 , pp. 3130-3146
    • Bardeesy, N.1    Cheng, K.H.2    Berger, J.H.3    Chu, G.C.4    Pahler, J.5    Olson, P.6
  • 64
    • 0034023371 scopus 로고    scopus 로고
    • Functions of mammalian Smad genes as revealed by targeted gene disruption in mice
    • Weinstein M, Yang X, Deng C. Functions of mammalian Smad genes as revealed by targeted gene disruption in mice. Cytokine Growth Factor Rev 2000; 11:49-58.
    • (2000) Cytokine Growth Factor Rev , vol.11 , pp. 49-58
    • Weinstein, M.1    Yang, X.2    Deng, C.3
  • 65
    • 0036904895 scopus 로고    scopus 로고
    • Genetic analysis of the mammalian transforming growth factor-beta superfamily
    • Chang H, Brown CW, Matzuk MM. Genetic analysis of the mammalian transforming growth factor-beta superfamily. Endocr Rev 2002; 23:787-823.
    • (2002) Endocr Rev , vol.23 , pp. 787-823
    • Chang, H.1    Brown, C.W.2    Matzuk, M.M.3
  • 66
    • 0034644472 scopus 로고    scopus 로고
    • TGFbeta signaling in growth control, cancer and heritable disorders
    • Massague J, Blain SW, Lo RS. TGFbeta signaling in growth control, cancer and heritable disorders. Cell 2000; 103:295-309.
    • (2000) Cell , vol.103 , pp. 295-309
    • Massague, J.1    Blain, S.W.2    Lo, R.S.3
  • 67
    • 0033552955 scopus 로고    scopus 로고
    • β2-Spectrin3 encodes a novel 200-kD beta-spectrin: Role in liver development
    • Mishra L, Cai T, Yu P, Monga SP, Mishra B. β2-Spectrin3 encodes a novel 200-kD beta-spectrin: role in liver development. Oncogene 1999; 18:353-64.
    • (1999) Oncogene , vol.18 , pp. 353-364
    • Mishra, L.1    Cai, T.2    Yu, P.3    Monga, S.P.4    Mishra, B.5
  • 68
    • 0035079328 scopus 로고    scopus 로고
    • Expansion of hepatic and hematopoietic stem cells utilizing mouse embryonic liver explants
    • Monga SP, Tang Y, Candotti F, Rashid A, Wildner O, Mishra B, et al. Expansion of hepatic and hematopoietic stem cells utilizing mouse embryonic liver explants. Cell Transplant 2001; 10:81-9.
    • (2001) Cell Transplant , vol.10 , pp. 81-89
    • Monga, S.P.1    Tang, Y.2    Candotti, F.3    Rashid, A.4    Wildner, O.5    Mishra, B.6
  • 69
    • 85036775442 scopus 로고    scopus 로고
    • Blake T, Ganesan N, Shetty K, Mishra L. TGFbeta Signaling in Gastrointestinal Stem Cells. Sci STKE (Connections Map, as seen September 2005; http://stke.sciencemag.org/cgi/cm/stkecm;CMP-17699).
    • Blake T, Ganesan N, Shetty K, Mishra L. TGFbeta Signaling in Gastrointestinal Stem Cells. Sci STKE (Connections Map, as seen September 2005; http://stke.sciencemag.org/cgi/cm/stkecm;CMP-17699).
  • 70
    • 23044466047 scopus 로고    scopus 로고
    • Specificity and versatility in TGFbeta signaling through Smads
    • Feng XH, Derynck R. Specificity and versatility in TGFbeta signaling through Smads. Annu Rev Cell Dev Biol 2005; 21:659-93.
    • (2005) Annu Rev Cell Dev Biol , vol.21 , pp. 659-693
    • Feng, X.H.1    Derynck, R.2
  • 71
    • 26444443944 scopus 로고    scopus 로고
    • Role of TGFbeta in stem cells and cancer
    • Roberts A, Mishra L. Role of TGFbeta in stem cells and cancer. Oncogene 2005; 24:5667.
    • (2005) Oncogene , vol.24 , pp. 5667
    • Roberts, A.1    Mishra, L.2
  • 72
    • 10044243604 scopus 로고    scopus 로고
    • Genomic specification and epigenetic regulation of eukaryotic DNA replication origins
    • Antequera F. Genomic specification and epigenetic regulation of eukaryotic DNA replication origins. EMBO J 2004; 23:4365-70.
    • (2004) EMBO J , vol.23 , pp. 4365-4370
    • Antequera, F.1
  • 73
    • 0038505671 scopus 로고    scopus 로고
    • Epigenomic replication: Linking epigenetics to DNA replication
    • McNairn AJ, Gilbert DM. Epigenomic replication: linking epigenetics to DNA replication. Bioessays 2003; 25:647-56.
    • (2003) Bioessays , vol.25 , pp. 647-656
    • McNairn, A.J.1    Gilbert, D.M.2
  • 74
    • 0035430416 scopus 로고    scopus 로고
    • DNA replication origins: From sequence specificity to epigenetics
    • Méchali M. DNA replication origins: from sequence specificity to epigenetics. Nat Rev Genet 2001; 2:640-5.
    • (2001) Nat Rev Genet , vol.2 , pp. 640-645
    • Méchali, M.1
  • 75
    • 0036791653 scopus 로고    scopus 로고
    • Single-molecule analysis reveals clustering and epigenetic regulation of replication origins at the yeast rDNA locus
    • Pasero P, Bensimon A, Schwob E. Single-molecule analysis reveals clustering and epigenetic regulation of replication origins at the yeast rDNA locus. Genes Dev 2002; 16:2479-84.
    • (2002) Genes Dev , vol.16 , pp. 2479-2484
    • Pasero, P.1    Bensimon, A.2    Schwob, E.3
  • 76
    • 7644241815 scopus 로고    scopus 로고
    • ORC MCM, and histone hyperacetylation at the Kaposi's sarcoma-associated herpesvirus latent replication origin
    • Stedman W, Deng Z, Lu F, Lieberman PM. ORC MCM, and histone hyperacetylation at the Kaposi's sarcoma-associated herpesvirus latent replication origin. J Virol 2004; 78:12566-75.
    • (2004) J Virol , vol.78 , pp. 12566-12575
    • Stedman, W.1    Deng, Z.2    Lu, F.3    Lieberman, P.M.4
  • 78
    • 19644381697 scopus 로고    scopus 로고
    • Differential subnuclear localization and replication timing of histone H3 lysine 9 methylation states
    • Wu R, Terry AV, Singh PB, Gilbert DM. Differential subnuclear localization and replication timing of histone H3 lysine 9 methylation states. Mol Biol Cell 2005; 16:2872-81.
    • (2005) Mol Biol Cell , vol.16 , pp. 2872-2881
    • Wu, R.1    Terry, A.V.2    Singh, P.B.3    Gilbert, D.M.4
  • 79
    • 0037406067 scopus 로고    scopus 로고
    • The methyl-CpG binding domain and the evolving role of DNA methylation in animals
    • Hendrich B, Tweedie S. The methyl-CpG binding domain and the evolving role of DNA methylation in animals. Trends Genet 2003; 19:269-77.
    • (2003) Trends Genet , vol.19 , pp. 269-277
    • Hendrich, B.1    Tweedie, S.2
  • 80
    • 0037376187 scopus 로고    scopus 로고
    • Same origins of DNA replication function on the active and inactive human X chromosomes
    • Cohen SM, Brylawski BP, Cordeiro-Stone M, Kaufman DG. Same origins of DNA replication function on the active and inactive human X chromosomes. J Cell Biochem 2003; 88:923-31.
    • (2003) J Cell Biochem , vol.88 , pp. 923-931
    • Cohen, S.M.1    Brylawski, B.P.2    Cordeiro-Stone, M.3    Kaufman, D.G.4
  • 81
    • 2342468603 scopus 로고    scopus 로고
    • Heterochromatin on the inactive X chromosome delays replication timing without affecting origin usage
    • Gómez M, Brockdorff N. Heterochromatin on the inactive X chromosome delays replication timing without affecting origin usage. Proc Natl Acad Sci USA 2004; 101:6923-7298.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 6923-7298
    • Gómez, M.1    Brockdorff, N.2
  • 82
    • 0345393236 scopus 로고    scopus 로고
    • Differential patterns of histone methylation and acetylation distinguish active and repressed alleles at X-linked genes
    • Goto Y, Gomez M, Brockdorff N, Feil R. Differential patterns of histone methylation and acetylation distinguish active and repressed alleles at X-linked genes Cytogenet Genome Res 2002; 99:66-74.
    • (2002) Cytogenet Genome Res , vol.99 , pp. 66-74
    • Goto, Y.1    Gomez, M.2    Brockdorff, N.3    Feil, R.4
  • 83
    • 0034880162 scopus 로고    scopus 로고
    • Hypomethylation of chromosome 1 heterochromatin DNA correlates with q-arm copy gain in human hepatocellular carcinoma
    • Wong N, Lam WC, Lai PB, Pang E, Lau WY, Johnson PJ. Hypomethylation of chromosome 1 heterochromatin DNA correlates with q-arm copy gain in human hepatocellular carcinoma. Am J Pathol 2001; 159:465-671.
    • (2001) Am J Pathol , vol.159 , pp. 465-671
    • Wong, N.1    Lam, W.C.2    Lai, P.B.3    Pang, E.4    Lau, W.Y.5    Johnson, P.J.6
  • 84
    • 59249106504 scopus 로고    scopus 로고
    • Genomic-wide analysis of lymphatic metastasis-associated genes in human hepatocellular carcinoma
    • Lee CF, Ling ZQ, Zhao T, Fang SH, Chang WC, Lee SC, et al. Genomic-wide analysis of lymphatic metastasis-associated genes in human hepatocellular carcinoma. World J Gastroenterol 2009; 15:356-65.
    • (2009) World J Gastroenterol , vol.15 , pp. 356-365
    • Lee, C.F.1    Ling, Z.Q.2    Zhao, T.3    Fang, S.H.4    Chang, W.C.5    Lee, S.C.6
  • 85
    • 33846221516 scopus 로고    scopus 로고
    • Prognostic value of CpG island hypermethylation at PTGS2, RAR-beta, EDNRB, and other gene loci in patients undergoing radical prostatectomy
    • Bastian PJ, Ellinger J, Heukamp LC, Kahl P, Müller SC, von Rücker A. Prognostic value of CpG island hypermethylation at PTGS2, RAR-beta, EDNRB, and other gene loci in patients undergoing radical prostatectomy. Eur Urol 2007; 51:665-74.
    • (2007) Eur Urol , vol.51 , pp. 665-674
    • Bastian, P.J.1    Ellinger, J.2    Heukamp, L.C.3    Kahl, P.4    Müller, S.C.5    von Rücker, A.6
  • 86
    • 33845417885 scopus 로고    scopus 로고
    • The cancer epigenome-components and functional correlates
    • Ting AH, et al. The cancer epigenome-components and functional correlates. Genes Dev 2006; 20:3215-31.
    • (2006) Genes Dev , vol.20 , pp. 3215-3231
    • Ting, A.H.1
  • 87
    • 0032574977 scopus 로고    scopus 로고
    • Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex
    • Nan X, Ng HH, Johnson CA, Laherty CD, Turner BM, Eisenman RN, et al. Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex. Nature 393:386-9.
    • Nature , vol.393 , pp. 386-389
    • Nan, X.1    Ng, H.H.2    Johnson, C.A.3    Laherty, C.D.4    Turner, B.M.5    Eisenman, R.N.6
  • 88
    • 33847065486 scopus 로고    scopus 로고
    • The epigenomics of cancer
    • Jones PA, Baylin SB. The epigenomics of cancer. Cell 2007; 128:683-92.
    • (2007) Cell , vol.128 , pp. 683-692
    • Jones, P.A.1    Baylin, S.B.2
  • 90
    • 0035042611 scopus 로고    scopus 로고
    • SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity
    • Yoshikawa H, Matsubara K, Qian GS, et al. SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity. Nat Genet 2001; 28:29-35.
    • (2001) Nat Genet , vol.28 , pp. 29-35
    • Yoshikawa, H.1    Matsubara, K.2    Qian, G.S.3
  • 91
    • 63049084550 scopus 로고    scopus 로고
    • SALL3 interacts with DNMT3A and shows the ability to inhibit CpG island methylation in hepatocellular carcinoma
    • Shikauchi Y, Saiura A, Kubo T, Niwa Y, Yamamoto J, Murase Y, et al. SALL3 interacts with DNMT3A and shows the ability to inhibit CpG island methylation in hepatocellular carcinoma. Mol Cell Biol 2009; 29:1944-58.
    • (2009) Mol Cell Biol , vol.29 , pp. 1944-1958
    • Shikauchi, Y.1    Saiura, A.2    Kubo, T.3    Niwa, Y.4    Yamamoto, J.5    Murase, Y.6
  • 94
    • 23044491699 scopus 로고    scopus 로고
    • The CD44 receptor interacts with P-glycoprotein to promote cell migration and invasion in cancer
    • Miletti-Gonzalez KE, Chen S, Muthukumaran N, Saglimbeni GN, Wu X, Yang J, et al. The CD44 receptor interacts with P-glycoprotein to promote cell migration and invasion in cancer. Cancer Res 2005; 65:6660-7.
    • (2005) Cancer Res , vol.65 , pp. 6660-6667
    • Miletti-Gonzalez, K.E.1    Chen, S.2    Muthukumaran, N.3    Saglimbeni, G.N.4    Wu, X.5    Yang, J.6
  • 96
    • 50549104322 scopus 로고    scopus 로고
    • Role of Sox-9, ER81 and VE-cadherin in retinoic acid-mediated trans-differentiation of breast cancer cells
    • Endo Y, Deonauth K, Prahalad P, Hoxter B, Zhu Y, Byers SW. Role of Sox-9, ER81 and VE-cadherin in retinoic acid-mediated trans-differentiation of breast cancer cells. PLoS ONE 2008; 3:2714.
    • (2008) PLoS ONE , vol.3 , pp. 2714
    • Endo, Y.1    Deonauth, K.2    Prahalad, P.3    Hoxter, B.4    Zhu, Y.5    Byers, S.W.6
  • 99
    • 0242363225 scopus 로고    scopus 로고
    • Identification of the haematopoietic stem cell niche and control of the niche size
    • Zhang J, Niu C, Ye L, Huang H, He X, Tong WG, et al. Identification of the haematopoietic stem cell niche and control of the niche size. Nature 2003; 425:836-41.
    • (2003) Nature , vol.425 , pp. 836-841
    • Zhang, J.1    Niu, C.2    Ye, L.3    Huang, H.4    He, X.5    Tong, W.G.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.