Iron metabolism: Microbes, mouse, and man

BioEssays

Volumn 31, Issue 12, 2009, Pages 1309-1317

  Latunde Dada, Gladys O ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Iron; Mammals; Man; Metabolism; Microbes

Indexed keywords

CD71 ANTIGEN; CERULOPLASMIN; CYTOCHROME B; FERRITIN; FERROPORTIN; HEME OXYGENASE 1; HEMOJUVELIN; HEPCIDIN; HEPHAESTIN; HFE PROTEIN; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; IRON REGULATORY FACTOR; LACTOFERRIN; NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN; SIDEROPHORE; TRANSFERRIN RECEPTOR 2; TUMOR NECROSIS FACTOR ALPHA;

ACUTE PHASE RESPONSE; BACTERIAL GROWTH; BACTERIAL INFECTION; ENDOCYTOSIS; ERYTHROPOIESIS; HOST RESISTANCE; HUMAN; INNATE IMMUNITY; INTESTINE ABSORPTION; IRON ABSORPTION; IRON METABOLISM; IRON RESPONSIVE ELEMENT; IRON TRANSPORT; LYSOSOME; NONHUMAN; PHAGOCYTOSIS; REGULATORY MECHANISM; REVIEW;

ANIMALS; BACTERIA; CELL PROLIFERATION; HEME; HUMANS; IRON; MICE;

MAMMALIA;

EID: 73149095597     PISSN: 02659247     EISSN: None     Source Type: Journal    
DOI: 10.1002/bies.200900101     Document Type: Review

References (99)

1. Schaible UE, Kaufmann SH. 2004. Iron and microbial infection. Nat Rev Microbiol 12: 946-53.
2. Tong Y, Guo M. 2009. Bacterial heme-transport proteins and their hemecoordination modes. Arch Biochem Biophys 481: 1-15.
3. Ratledge C. 2007. Iron metabolism and infection. Food Nutr Bull (4 Suppl): S515-23.
4. Collins HL. 2003. The role of iron in infections with intracellular bacteria. Immunol Lett 85: 193-5.
5. Latunde-Dada GO, Young SP. 1992. Iron deficiency and immune responses. Scand J Immunol Suppl 11: 207-9.
6. Markel TA, Crisostomo PR, Wang M, et al. 2007. The struggle for iron: gastrointestinal microbes modulate the host immune response during infection. J Leukoc Biol 81: 393-400.
7. Weinberg ED. 2009. Iron availability and infection. Biochim Biophys Acta 1790: 600-5.
8. Archibald FS, Fridovich I. 1983. Oxygen radicals, oxygen toxicity and the life of microorganisms. Acta Med Port 4: 101-12.
9. Posey JE, Gherardini FC. 2000. Lack of a role for iron in the Lyme disease pathogen. Science 288: 1651-3.
10. Porto G, de SM. 2007. Iron overload and immunity. World J Gastroenterol 13: 4707-15.
11. de Sousa M, Breedvelt F, Dynesius-TrenthamR, et al. 1988. Iron, ironbinding proteins and immune system cells. Ann NY Acad Sci 526: 310-22.
12. Hahn P, Bale W, Ross J, et al. 1943. Radioactive iron absorption by gastrointestinal tract: influence of anemia, anoxia and antecedent feeding: distribution in growing dogs. J Exp Med 78: 169-88.
13. Frazer DM, Wilkins SJ, Becker EM, et al. 2003. A rapid decrease in the expression of DMT1 and Dcytb but not Ireg1 or hephaestin explains the mucosal block phenomenon of iron absorption. Gut 52: 340-6.
14. Zwilling BS, Kuhn DE, Wikoff L, et al. 1999. Role of iron in Nramp1-mediated inhibition of mycobacterial growth. Infect Immunol 67: 1386-92.
15. Canonne-Hergaux F, Gruenheid S, Govoni G, et al. 1999. The Nramp1 protein and its role in resistance to infection and macrophage function. Proc Assoc Am Physicians 111: 283-9.
16. Soe-Lin S, Apte SS, Andriopoulos B, Jr., et al. 2009. Nramp1 promotes efficient macrophage recycling of iron following erythrophagocytosis in vivo. Proc Natl Acad Sci 106: 5960-5.
17. Jabado N, Jankowski A, Dougaparsad S, et al. 2009. Natural resistance to intracellular infections: natural resistance-associated macrophage protein 1 (Nramp1) functions as a pH-dependent manganese transporter at the phagosomal membrane. J Exp Med 192: 1237-48.
18. Gunshin H, Mackenzie B, Berger UV, et al. 1997. Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature 388: 482-8.
19. Mims MP, Prchal JT. 2005. Divalent metal transporter 1. Hematology 10: 339-45.
20. Tchernitchko D, BourgeoisM, Martin ME, et al. 2002. Expression of the two mRNA isoforms of the iron transporter Nramp2/DMTI in mice and function of the iron responsive element. Biochem J 363: 449-55.
21. Yeh KY, Yeh M, Watkins JA, et al. 2000. Dietary iron induces rapid changes in rat intestinal divalent metal transporter expression. Am J Physiol Gastrointest Liver Physiol 279: G1070-9.
22. Foot NJ, Dalton HE, Shearwin-Whyatt LM, et al. 2008. Regulation of the divalent metal ion transporter DMT1 and iron homeostasis by a ubiquitindependent mechanism involving Ndfips and WWP2. Blood 112: 4268-75.
23. Ilback NG, Frisk P, Tallkvist J, et al. 2008. Gastrointestinal uptake of trace elements are changed during the course of a common human viral (Coxsackievirus B3) infection in mice. J Trace Elem Med Biol 22: 120-30.
24. McKie AT, Barrow D, Latunde-Dada GO, et al. 2001. An iron-regulated ferric reductase associated with the absorption of dietary iron. Science 291: 1755-9. 25. Collins HL. 2008. W14ithholding iron as a cellular defence mechanism - friend or foe? Eur J Immunol 38: 1803-6.
25. Hintze KJ, Theil EC. 2006. Cellular regulation and molecular interactions of the ferritins. Cell Mol Life Sci 63: 591-600.
26. Liu X, Hintze K, Lonnerdal B, et al. 2006. Iron at the center of ferritin, metal/oxygen homeostasis and novel dietary strategies. Biol Res 39: 167-71.
27. Arosio P, Ingrassia R, Cavadini P. 2009. Ferritins: a family of molecules for iron storage, antioxidation and more. Biochim Biophys Acta 1790: 589-99.
28. Zandman-Goddard G, Shoenfeld Y. 2007. Ferritin in autoimmune diseases. Autoimmun Rev 6: 457-63.
29. You SA, Wang Q. 2005. Ferritin in atherosclerosis. Clin Chim Acta 357: 1-16.
30. Torti FM, Torti SV. 2002. Regulation of ferritin genes and protein. Blood 99: 3505-16.
31. Olakanmi O, McGowan SE, Hayek MB, et al. 1993. Iron sequestration by macrophages decreases the potential for extracellular hydroxyl radical formation. J Clin Invest 91: 889-99.
32. Todorich B, Zhang X, Slagle-Webb B, et al. 2008. Tim-2 is the receptor for H-ferritin on oligodendrocytes. J Neurochem 107: 1495-505.
33. Recalcati S, Invernizzi P, Arosio P, et al. 2008. New functions for an iron storage protein: the role of ferritin in immunity and autoimmunity. J Autoimmun 30: 84-9.
34. Li JY, Paragas N, Ned RM, et al. 2009. Scara5 is a ferritin receptor mediating non-transferrin iron delivery. Dev Cell 16: 35-46.
35. Abboud S, Haile DJ. 2000. A novel mammalian iron-regulated protein involved in intracellular iron metabolism. J Biol Chem 275: 19906-12.
36. Donovan A, Lima CA, Pinkus JL, et al. 2005. The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis. Cell Metab 1: 191-200.
37. McKie AT, Marciani P, Rolfs A, et al. 2000. A novel duodenal ironregulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation. Mol Cell 5: 299-309.
38. De Domenico I, Ward DM, Nemeth E, et al. 2005. The molecular basis of ferroportin-linked hemochromatosis. Proc Natl Acad Sci 102: 8955-60.
39. Relvas L, Claro MT, Bento MC, et al. 2009. Novel human pathological mutations. Gene symbol: SLC40A1. Disease: haemochromatosis, type 4. Hum Genet 125: 338.
40. Speletas M, Kioumi A, Loules G, et al. 2008. Analysis of SLC40A1 gene at the mRNA level reveals rapidly the causative mutations in patients with hereditary hemochromatosis type IV. Blood Cells Mol Dis 40: 353-9.
41. Wallace DF, Subramaniam VN. 2007. Non-HFE haemochromatosis. World J Gastroenterol 13: 4690-8.
42. Schimanski LM, Drakesmith H, Talbott C, et al. 2008. Ferroportin: lack of evidence for multimers. Blood Cells Mol Dis 40: 360-9.
43. Galy B, Ferring-Appel D, Kaden S, et al. 2008. Iron regulatory proteins are essential for intestinal function and control key iron absorption molecules in the duodenum. Cell Metab 7: 79-85.
44. Peyssonnaux C, Zinkernagel AS, Datta V, et al. 2006. TLR4-dependent hepcidin expression bymyeloid cells in response to bacterial pathogens. Blood 107: 3727-32.
45. De Domenico I, Ward DM, di Patti MC, et al. 2007. Ferroxidase activity is required for the stability of cell surface ferroportin in cells expressing GPI-ceruloplasmin. EMBO J 26: 2823-31.
46. Wang F, Paradkar PN, Custodio AO, et al. 2007. Genetic variation in Mon1a affects protein trafficking and modifies macrophage iron loading in mice. Nat Genet 39: 1025-32.
47. Cherukuri S, Potla R, Sarkar J, et al. 2005. Unexpected role of ceruloplasmin in intestinal iron absorption. Cell Metab 2: 309-19.
48. Floris G, Medda R, Padiglia A, et al. 2000. The physiopathological significance of ceruloplasmin. A possible therapeutic approach. Biochem Pharmacol 60: 1735-41.
49. Attieh ZK, Mukhopadhyay CK, Seshadri V, et al. 1999. Ceruloplasmin ferroxidase activity stimulates cellular iron uptake by a trivalent cationspecific transport mechanism. J Biol Chem 274: 1116-23.
50. Qian ZM, Tsoi YK, Ke Y, et al. 2001. Ceruloplasmin promotes iron uptake rather than release in BT325 cells. Exp Brain Res 140: 369-74.
51. Harris ZL, Durley AP, Man TK, et al. 1999. Targeted gene disruption reveals an essential role for ceruloplasmin in cellular iron efflux. Proc Natl Acad Sci 96: 10812-7.
52. Sarkar J, Seshadri V, Tripoulas NA, et al. 2003. Role of ceruloplasmin in macrophage iron efflux during hypoxia. J Biol Chem 278: 44018-24.
53. Lonnerdal B. 1994. Lactoferrin receptors in intestinal brush border membranes. Adv Exp Med Biol 357: 171-5.
54. Britigan BE, Serody JS, Hayek MB, et al. 1991. Uptake of lactoferrin by mononuclear phagocytes inhibits their ability to form hydroxyl radical and protects them from membrane autoperoxidation. J Immunol 147: 4271-7.
55. Braun V, Braun M. 2002. Active transport of iron and siderophore antibiotics. Curr Opin Microbiol 5: 194-201.
56. Flo TH, Smith KD, Sato S, et al. 2004. Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron. Nature 432: 917-21.
57. Bister B, Bischoff D, Nicholson GJ, et al. 2004. The structure of salmochelins: C-glucosylated enterobactins of Salmonella enterica. Biometals 17: 471-81.
58. Harrison OB, Maiden MC, Rokbi B. 2008. Distribution of transferrin binding protein B gene (tbpB) variants among Neisseria species. BMC Microbiol 8: 66-77.
59. Kingsley RA, Reissbrodt R, Rabsch W, et al. 1999. Ferrioxaminemediated iron(III) utilization by Salmonella enterica. Appl Environ Microbiol 65: 1610-8.
60. Reeder BJ, Wilson MT. 2005. Hemoglobin and myoglobin associated oxidative stress: from molecular mechanisms to disease states. Curr Med Chem 12: 2741-51.
61. Krishnamurthy P, Ross DD, Nakanishi T, et al. 2004. The stem cell marker Bcrp/ABCG2 enhances hypoxic cell survival through interactions with heme. J Biol Chem 279: 24218-25.
62. Quigley JG, Yang Z, Worthington MT, et al. 2004. Identification of a human heme exporter that is essential for erythropoiesis. Cell 118: 757-66.
63. Keel SB, Doty RT, Yang Z, et al. 2008. A heme export protein is required for red blood cell differentiation and iron homeostasis. Science 319: 825-8.
64. Bilban M, Haschemi A, Wegiel B, et al. 2008. Heme oxygenase and carbon monoxide initiate homeostatic signaling. J Mol Med 86: 267-79.
65. Chung SW, Hall SR, Perrella MA. 2009. Role of haem oxygenase-1 in microbial host defence. Cell Microbiol 11: 199-207.
66. Kim S, Ponka P. 2003. Role of nitric oxide in cellular iron metabolism. Biometals 16: 125-35.
67. Cairo G, Recalcati S, Pietrangelo A, et al. 2002. The iron regulatory proteins: targets and modulators of free radical reactions and oxidative damage. Free Radic Biol Med 32: 1237-43.
68. Srai SK, Debnam ES, Boss M, et al. 1988. Age-related changes in the kinetics of iron absorption across the guinea pig proximal intestine in vivo. Biol Neonate 53: 53-9.
69. Nicolas G, Bennoun M, Porteu A, et al. 2002. Severe iron deficiency anemia in transgenic mice expressing liver hepcidin. Proc Natl Acad Sci 99: 4596-601.
70. Weinberg ED. 2008. Survival advantage of the hemochromatosis C282Y mutation. Perspect Biol Med 51: 98-102.
71. Beutler E. 2004. Iron absorption in carriers of the C282Y hemochromatosis mutation. Am J Clin Nutr 80: 799-800.
72. Hunt JR, Zeng H. 2004. Iron absorption by heterozygous carriers of the HFE C282Y mutation associated with hemochromatosis. Am J Clin Nutr 80: 924-31.
73. Williamson SH, Hubisz MJ, Clark AG, et al. 2007. Localizing recent adaptive evolution in the human genome. PLoS Genet 3: 0901-15.
74. Moalem S, Weinberg ED, Percy ME. 2004. Hemochromatosis and the enigma of misplaced iron: implications for infectious disease and survival. Biometals 17: 135-9.
75. Roy CN, Enns CA. 2000. Iron homeostasis: new tales from the crypt. Blood 96: 4020-7.
76. Townsend A, Drakesmith H. 2002. Role of HFE in iron metabolism, hereditary haemochromatosis, anaemia of chronic disease, and secondary iron overload. Lancet 359: 786-90.
77. Drakesmith H, Townsend A. 2000. The structure and function of HFE. Bioessays 22: 595-8.
78. Papanikolaou G, Samuels ME, Ludwig EH, et al. 2004. Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis. Nat Genet 36: 77-82.
79. Lee PL, Beutler E, Rao SV, et al. 2004. Genetic abnormalities and juvenile hemochromatosis: mutations of the HJV gene encoding hemojuvelin. Blood 103: 4669-71.
80. Vaulont S, Lou DQ, Viatte L, et al. 2005. Of mice and men: the iron age. J Clin Invest 115: 2079-82.
81. Lin L, Goldberg YP, Ganz T. 2005. Competitive regulation of hepcidin mRNA by soluble and cell-associated hemojuvelin. Blood 106: 2884-9.
82. Malyszko J. 2009. Hemojuvelin: the hepcidin story continues. Kidney Blood Press Res 32: 71-6.
83. Babitt JL, Huang FW, Wrighting DM, et al. 2006. Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression. Nat Genet 38: 531-9.
84. Constante M, Wang D, Raymond VA, et al. 2007. Repression of repulsive guidance molecule C during inflammation is independent of Hfe and involves tumor necrosis factor-alpha. Am J Pathol 170: 497-504.
85. Krijt J, Vokurka M, Chang KT, et al. 2004. Expression of Rgmc, the murine ortholog of hemojuvelin gene, is modulated by development and inflammation, but not by iron status or erythropoietin. Blood 104: 4308-10.
86. Brekelmans P, van SP, Leenen PJ, et al. 1994. Inhibition of proliferation and differentiation during early T cell development by anti-transferrin receptor antibody. Eur J Immunol 24: 2896-902.
87. Gao J, Chen J, Kramer M, et al. 2009. Interaction of the hereditary hemochromatosis protein HFE with transferrin receptor 2 is required for transferrin-induced hepcidin expression. Cell Metab 9: 217-27.
88. Wallace DF, Trinder D, Subramaniam VN. 2009. Hepcidin regulation by HFE and TFR2: is it enough to give a hepatocyte a complex? Gastroenterology 133: 1173-5.
89. Theurl I, Fritsche G, Ludwiczek S, et al. 2005. The macrophage: a cellular factory at the interphase between iron and immunity for the control of infections. Biometals 18: 359-67.
90. Weiss G. 2009. Iron metabolism in the anemia of chronic disease. Biochim Biophys Acta 1790: 682-93.
91. Vogt BA, Alam J, Croatt AJ, et al. 1995. Acquired resistance to acute oxidative stress. Possible role of heme oxygenase and ferritin. Lab Invest 72: 474-83.
92. Cairo G, Bernuzzi F, Recalcati S. 2006. A precious metal: iron, an essential nutrient for all cells. Genes Nutr 1: 25-39.
93. Viatte L, Vaulont S. 2009. Hepcidin, the iron watcher. Biochimie 91: 1223-8.
94. Anderson GJ, Frazer DM, McLaren GD. 2009. Iron absorption and metabolism. Curr Opin Gastroenterol 25: 129-35.
95. Verga Falzacappa MV, Vujic SM, Kessler R, et al. 2007. STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation. Blood 109: 353-8.
96. Truksa J, Lee P, Beutler E. 2007. The role of STAT, AP-1, E-box and TIEG motifs in the regulation of hepcidin by IL-6 and BMP-9: lessons from human HAMP and murine Hamp1 and Hamp2 gene promoters. Blood Cells Mol Dis 39: 255-62.
97. Huang H, Constante M, Layoun A, et al. 2009. Contribution of STAT3 and SMAD4 pathways to the regulation of hepcidin by opposing stimuli. Blood 113: 3593-9.
98. Tanno T, Porayette P, Sripichai O, et al. 2009. Identification of TWSG1 as a second novel erythroid regulator of hepcidin expression in murine and human cells. Blood 114: 181-6.
99. Simpson RJ, McKie AT. 2009. Regulation of intestinal iron absorption: the mucosa takes control? Cell Metab 10: 84-7.