Iron homeostasis: New tales from the crypt

Blood

Volumn 96, Issue 13, 2000, Pages 4020-4027

  Roy, Cindy N ^a   Enns, Caroline A ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; CATION TRANSPORT PROTEIN; DMRT1 PROTEIN; FERRITIN; HEPH PROTEIN, HUMAN; HFE PROTEIN, HUMAN; HLA ANTIGEN; HLA ANTIGEN CLASS 1; IRON; MEMBRANE PROTEIN; METAL TRANSPORTING PROTEIN 1; TRANSCRIPTION FACTOR; TRANSFERRIN; TRANSFERRIN RECEPTOR;

BIOLOGICAL MODEL; CELL DIFFERENTIATION; CELL POLARITY; DUODENUM; EPITHELIUM CELL; GENETICS; HEMOCHROMATOSIS; HOMEOSTASIS; HUMAN; INTESTINE ABSORPTION; INTESTINE MUCOSA; IRON DEFICIENCY ANEMIA; METABOLISM; MICROVILLUS; PROTEIN TRANSPORT; REVIEW; STEM CELL; TRANSPORT AT THE CELLULAR LEVEL; ULTRASTRUCTURE;

ANEMIA, HYPOCHROMIC; BIOLOGICAL TRANSPORT; CARRIER PROTEINS; CATION TRANSPORT PROTEINS; CELL DIFFERENTIATION; CELL POLARITY; DUODENUM; EPITHELIAL CELLS; FERRITINS; HEMOCHROMATOSIS; HISTOCOMPATIBILITY ANTIGENS CLASS I; HLA ANTIGENS; HOMEOSTASIS; HUMANS; INTESTINAL ABSORPTION; INTESTINAL MUCOSA; IRON; MEMBRANE PROTEINS; MICROVILLI; MODELS, BIOLOGICAL; PROTEIN TRANSPORT; RECEPTORS, TRANSFERRIN; STEM CELLS; TRANSCRIPTION FACTORS; TRANSFERRIN;

EID: 0034672236     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v96.13.4020     Document Type: Article

References (14)

1. Daniele B, D'Agostino L. Proliferation and differentiation of the small intestinal epithelium: from petri dish to bedside. Ital J Gastroenterol. 1994; 26:459-470.
2. Hocker M, Weidenmann B. Molecular mechanisms of enteroendocrine differentiation. Ann N Y Acad Sci. 1998:859:160-174.
3. Pothier P, Hugon JS. Characterization of isolated villus and crypt cells from the small intestine of the adult mouse. Cell Tissue Res. 1980:211:405-418.
4. Hodin RA, Chamberlain SM, Meng S. Pattern of rat intestinal brush-border enzyme gene expression changes with epithelial growth state. Am J Physiol. 1995;269:C385-C391.
5. Vulpe CD, Kuo YM, Murphy TL, et al. Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse. Nat Genet. 1999:21:195-199.
6. Canonne-Hergaux F, Gruenheid S, Ponka P, Gros P. Cellular and subcellular localization of the Nramp2 iron transporter in the intestinal brush border and regulation by dietary iron. Blood. 1999:93:4406-4417.
7. Donovan A, Brownlie A, Zhou Y, et al. Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter. Nature. 2000; 403:776-781.
8. Gruenheid S, Cellier M, Vidal S, Gros P. Identification and characterization of a second mouse Nramp gene. Genomics. 1995:25:514-525.
9. Pinner E, Gruenheid S, Raymond M, Gros P. Functional complementation of the yeast divalent cation transporter family SMF by NRAMP2, a member of the mammalian natural resistance-associated macrophage protein family. J Biol Chem. 1997;272:28933-28938.
10. Fleming MD, Trenor CC, Su MA, et al. Microcytic anaemia mice have a mutation in nramp2, a candidate iron transporter gene. Nat Genet. 1997;16: 383-386.
11. Gunshin H, Mackenzie B, Berger UV, et al. Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature. 1997:388: 482-488.
12. Fleming MD, Romano MA, Su MA, Garrick LM, Garrick MD, Andrews NC. Nramp2 is mutated in the anemic Belgrade (b) rat: evidence of a role for Nramp2 in endosomal iron transport. Proc Natl Acad Sci USA. 1998:95:1148-1153.
13. Su MA, Trenor CC, Fleming JC, Fleming MD, Andrews NC. The G185R mutation disrupts function of the Iron transporter Nramp2. Blood. 1998;92: 2157-2163.
14. Gruenheid S, Canonne-Hergaux F, Gauthier S, Hackam DJ, Grinstein S, Gros P. The iron transport protein NRAMP2 is an integral membrane glycoprotein that colocalizes with transferrin in recycling endosomes. J Exp Med. 1999:189:831-841.