Interplay between influenza A virus and the innate immune signaling

Microbes and Infection

Volumn 12, Issue 1, 2010, Pages 81-87

  Ehrhardt, Christina ^a   Seyer, Roman ^a   Hrincius, Eike R ^a   Eierhoff, Thorsten ^a   Wolff, Thorsten ^b   Ludwig, Stephan ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b ROBERT KOCH INSTITUTE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

INTERFERON; MITOGEN ACTIVATED PROTEIN KINASE; MYXOVIRUS RESISTANCE PROTEIN; NONSTRUCTURAL PROTEIN 1; PROTEIN BP1 F2; PROTEIN KINASE R; RETINOIC ACID INDUCIBLE PROTEIN I; UNCLASSIFIED DRUG;

CELL ACTIVATION; CELLULAR IMMUNITY; GENETIC TRANSCRIPTION; INFLUENZA VIRUS A; INNATE IMMUNITY; NONHUMAN; PRIORITY JOURNAL; RNA INTERFERENCE; SHORT SURVEY; VIRUS CELL INTERACTION; VIRUS INHIBITION; VIRUS INTERFERENCE; VIRUS PATHOGENESIS; VIRUS VIRULENCE;

ANIMALS; DEAD-BOX RNA HELICASES; HOST-PATHOGEN INTERACTIONS; HUMANS; IMMUNITY, INNATE; INFLUENZA A VIRUS; INTERFERON TYPE I; SIGNAL TRANSDUCTION; VIRAL NONSTRUCTURAL PROTEINS; VIRULENCE FACTORS;

INFLUENZA A VIRUS;

EID: 72949109523     PISSN: 12864579     EISSN: 1769714X     Source Type: Journal    
DOI: 10.1016/j.micinf.2009.09.007     Document Type: Short Survey

References (60)

1. Carter M.J. A rationale for using steroids in the treatment of severe cases of H5N1 avian influenza. J. Med. Microbiol. 56 (2007) 875-883
2. Randall R.E., and Goodbourn S. Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures. J. Gen. Virol 89 (2008) 1-47
3. Garcia-Sastre A., and Biron C.A. Type 1 interferons and the virus-host relationship: a lesson in detente. Science 312 (2006) 879-882
4. Hornung V., Ellegast J., Kim S., Brzozka K., Jung A., Kato H., Poeck H., Akira S., Conzelmann K.K., Schlee M., Endres S., and Hartmann G. 5′-Triphosphate RNA is the ligand for RIG-I. Science 314 (2006) 994-997
5. Kato H., Sato S., Yoneyama M., Yamamoto M., Uematsu S., Matsui K., Tsujimura T., Takeda K., Fujita T., Takeuchi O., and Akira S. Cell type-specific involvement of RIG-I in antiviral response. Immunity 23 (2005) 19-28
6. Pichlmair A., Schulz O., Tan C.P., Naslund T.I., Liljestrom P., Weber F., and Reis e Sousa C. RIG-I-mediated antiviral responses to single-stranded RNA bearing 5′-phosphates. Science 314 (2006) 997-1001
7. Le Goffic R., Pothlichet J., Vitour D., Fujita T., Meurs E., Chignard M., and Si-Tahar M. Cutting edge: influenza A virus activates TLR3-dependent inflammatory and RIG-I-dependent antiviral responses in human lung epithelial cells. J. Immunol 178 (2007) 3368-3372
8. Weber F., Wagner V., Rasmussen S.B., Hartmann R., and Paludan S.R. Double-stranded RNA is produced by positive-strand RNA viruses and DNA viruses but not in detectable amounts by negative-strand RNA viruses. J. Virol 80 (2006) 5059-5064
9. Akira S. TLR signaling. Curr. Top. Microbiol. Immunol 311 (2006) 1-16
10. Yoneyama M., and Fujita T. RIG-I family RNA helicases: cytoplasmic sensor for antiviral innate immunity, Cytokine Growth. Factor Rev. 18 (2007) 545-551
11. Allen I.C., Scull M.A., Moore C.B., Holl E.K., McElvania-TeKippe E., Taxman D.J., Guthrie E.H., Pickles R.J., and Ting J.P. The NLRP3 inflammasome mediates in vivo innate immunity to influenza A virus through recognition of viral RNA. Immunity 30 (2009) 556-565
12. Albrecht R.A., and Garcia-Sastre A. Suppression of Innate Immunity by Orthomyxoviruses (2009), ASM Press, Washington
13. Kumar H., Kawai T., Kato H., Sato S., Takahashi K., Coban C., Yamamoto M., Uematsu S., Ishii K.J., Takeuchi O., and Akira S. Essential role of IPS-1 in innate immune responses against RNA viruses. J. Exp. Med 203 (2006) 1795-1803
14. Hiscott J., Nguyen T.L., Arguello M., Nakhaei P., and Paz S. Manipulation of the nuclear factor-kappaB pathway and the innate immune response by viruses. Oncogene 25 (2006) 6844-6867
15. Servant M.J., Grandvaux N., and Hiscott J. Multiple signaling pathways leading to the activation of interferon regulatory factor 3. Biochem. Pharmacol 64 (2002) 985-992
16. Ludwig S., Pleschka S., Planz O., and Wolff T. Ringing the alarm bells: signalling and apoptosis in influenza virus infected cells. Cell. Microbiol. 8 (2006) 375-386
17. Martinon F., Mayor A., and Tschopp J. The inflammasomes: guardians of the body. Annu. Rev. Immunol 27 (2009) 229-265
18. Thomas P.G., Dash P., Aldridge Jr. J.R., Ellebedy A.H., Reynolds C., Funk A.J., Martin W.J., Lamkanfi M., Webby R.J., Boyd K.L., Doherty P.C., and Kanneganti T.D. The intracellular sensor NLRP3 mediates key innate and healing responses to influenza A virus via the regulation of caspase-1. Immunity 30 (2009) 566-575
19. Ichinohe T., Lee H.K., Ogura Y., Flavell R., and Iwasaki A. Inflammasome recognition of influenza virus is essential for adaptive immune responses. J. Exp. Med 206 (2009) 79-87
20. Hwang S.Y., Hertzog P.J., Holland K.A., Sumarsono S.H., Tymms M.J., Hamilton J.A., Whitty G., Bertoncello I., and Kola I. A null mutation in the gene encoding a type I interferon receptor component eliminates antiproliferative and antiviral responses to interferons alpha and beta and alters macrophage responses, Proc. Natl. Acad. Sci. U.S.A 92 (1995) 11284-11288
21. Stark G.R., Kerr I.M., Williams B.R., Silverman R.H., and Schreiber R.D. How cells respond to interferons. Annu. Rev. Biochem 67 (1998) 227-264
22. Samuel C.E. Antiviral actions of interferons. Clin. Microbiol. Rev. 14 (2001) 778-809
23. Sadler A.J., and Williams B.R. Interferon-inducible antiviral effectors. Nat. Rev. Immunol 8 (2008) 559-568
24. Pavlovic J., Haller O., and Staeheli P. Human and mouse Mx proteins inhibit different steps of the influenza virus multiplication cycle. J. Virol 66 (1992) 2564-2569
25. Dittmann J., Stertz S., Grimm D., Steel J., Garcia-Sastre A., Haller O., and Kochs G. Influenza A virus strains differ in sensitivity to the antiviral action of Mx-GTPase. J. Virol 82 (2008) 3624-3631
26. Chin K.C., and Cresswell P. Viperin (cig5), an IFN-inducible antiviral protein directly induced by human cytomegalovirus. Proc. Natl. Acad. Sci. USA 98 (2001) 15125-15130
27. Wang X., Hinson E.R., and Cresswell P. The interferon-inducible protein viperin inhibits influenza virus release by perturbing lipid rafts. Cell Host Microbe 2 (2007) 96-105
28. Agrawal N., Dasaradhi P.V., Mohmmed A., Malhotra P., Bhatnagar R.K., and Mukherjee S.K. RNA interference: biology, mechanism, and applications. Microbiol. Mol. Biol. Rev. 67 (2003) 657-685
29. Ding S.W., and Voinnet O. Antiviral immunity directed by small RNAs. Cell 130 (2007) 413-426
30. Kok K.H., and Jin D.Y. Influenza A virus NS1 protein does not suppress RNA interference in mammalian cells. J. Gen. Virol 87 (2006) 2639-2644
31. Matskevich A.A., and Moelling K. Dicer is involved in protection against influenza A virus infection. J. Gen. Virol 88 (2007) 2627-2635
32. Fernandez-Sesma A. The influenza virus NS1 protein: inhibitor of innate and adaptive immunity, Infect. Disord. Drug Targets 7 (2007) 336-343
33. Hale B.G., Randall R.E., Ortin J., and Jackson D. The multifunctional NS1 protein of influenza A viruses. J. Gen. Virol 89 (2008) 2359-2376
34. Garcia-Sastre A., Egorov A., Matassov D., Brandt S., Levy D.E., Durbin J.E., Palese P., and Muster T. Influenza A virus lacking the NS1 gene replicates in interferon-deficient systems. Virology 252 (1998) 324-330
35. Lu Y., Wambach M., Katze M.G., and Krug R.M. Binding of the influenza virus NS1 protein to double-stranded RNA inhibits the activation of the protein kinase that phosphorylates the elF-2 translation initiation factor. Virology 214 (1995) 222-228
36. Talon J., Horvath C.M., Polley R., Basler C.F., Muster T., Palese P., and Garcia-Sastre A. Activation of interferon regulatory factor 3 is inhibited by the influenza A virus NS1 protein. J. Virol 74 (2000) 7989-7996
37. Min J.Y., and Krug R.M. The primary function of RNA binding by the influenza A virus NS1 protein in infected cells: inhibiting the 2′-5′ oligo (A) synthetase/RNase L pathway, Proc. Natl. Acad. Sci. USA 103 (2006) 7100-7105
38. Nisole S., Stoye J.P., and Saib A. TRIM family proteins: retroviral restriction and antiviral defence. Nat. Rev. Microbiol. 3 (2005) 799-808
39. Ozato K., Shin D.M., Chang T.H., and Morse III H.C. TRIM family proteins and their emerging roles in innate immunity. Nat. Rev. Immunol 8 (2008) 849-860
40. Gack M.U., Shin Y.C., Joo C.H., Urano T., Liang C., Sun L., Takeuchi O., Akira S., Chen Z., Inoue S., and Jung J.U. TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity. Nature 446 (2007) 916-920
41. Gack M.U., Albrecht R.A., Urano T., Inn K.S., Huang I.C., Carnero E., Farzan M., Inoue S., Jung J.U., and Garcia-Sastre A. Influenza A virus NS1 targets the ubiquitin ligase TRIM25 to evade recognition by the host viral RNA sensor RIG-I. Cell Host Microbe 5 (2009) 439-449
42. Ehrhardt C., and Ludwig S. A new player in a deadly game: influenza viruses and the PI3K/Akt signalling pathway. Cell. Microbiol. 11 (2009) 863-871
43. Heikkinen L.S., Kazlauskas A., Melen K., Wagner R., Ziegler T., Julkunen I., and Saksela K. Avian and 1918 Spanish influenza a virus NS1 proteins bind to Crk/CrkL Src homology 3 domains to activate host cell signaling. J. Biol. Chem. 283 (2008) 5719-5727
44. Nemeroff M.E., Barabino S.M., Li Y., Keller W., and Krug R.M. Influenza virus NS1 protein interacts with the cellular 30 kDa subunit of CPSF and inhibits 3′end formation of cellular pre-mRNAs, Mol. Cell 1 (1998) 991-1000
45. Stasakova J., Ferko B., Kittel C., Sereinig S., Romanova J., Katinger H., and Egorov A. Influenza A mutant viruses with altered NS1 protein function provoke caspase-1 activation in primary human macrophages, resulting in fast apoptosis and release of high levels of interleukins 1beta and 18. J. Gen. Virol 86 (2005) 185-195
46. Xing Z., Cardona C.J., Adams S., Yang Z., Li J., Perez D., and Woolcock P.R. Differential regulation of antiviral and proinflammatory cytokines and suppression of Fas-mediated apoptosis by NS1 of H9N2 avian influenza virus in chicken macrophages. J. Gen. Virol 90 (2009) 1109-1118
47. Pauli E.K., Schmolke M., Wolff T., Viemann D., Roth J., Bode J.G., and Ludwig S. Influenza A virus inhibits type I IFN signaling via NF-kappaB-dependent induction of SOCS-3 expression. PLoS Pathog 4 (2008) e1000196
48. Mazur I., Wurzer W.J., Ehrhardt C., Pleschka S., Puthavathana P., Silberzahn T., Wolff T., Planz O., and Ludwig S. Acetylsalicylic acid (ASA) blocks influenza virus propagation via its NF-kappaB-inhibiting activity. Cell. Microbiol. 9 (2007) 1683-1694
49. Chen W., Calvo P.A., Malide D., Gibbs J., Schubert U., Bacik I., Basta S., O'Neill R., Schickli J., Palese P., Henklein P., Bennink J.R., and Yewdell J.W. A novel influenza A virus mitochondrial protein that induces cell death, Nat. Med 7 (2001) 1306-1312
50. Conenello G.M., and Palese P. Influenza A virus PB1-F2: a small protein with a big punch. Cell Host Microbe 2 (2007) 207-209
51. Zamarin D., Garcia-Sastre A., Xiao X., Wang R., and Palese P. Influenza virus PB1-F2 protein induces cell death through mitochondrial ANT3 and VDAC1. PLoS Pathog 1 (2005) e4
52. Zamarin D., Ortigoza M.B., and Palese P. Influenza A virus PB1-F2 protein contributes to viral pathogenesis in mice. J. Virol 80 (2006) 7976-7983
53. McAuley J.L., Hornung F., Boyd K.L., Smith A.M., McKeon R., Bennink J., Yewdell J.W., and McCullers J.A. Expression of the 1918 influenza A virus PB1-F2 enhances the pathogenesis of viral and secondary bacterial pneumonia. Cell Host Microbe 2 (2007) 240-249
54. Mitzner D., Dudek S.E., Studtrucker N., Anhlan D., Mazur I., Wissing J., Jansch L., Wixler L., Bruns K., Sharma A., Wray V., Henklein P., Ludwig S., and Schubert U. Phosphorylation of the influenza A virus protein PB1-F2 by PKC is crucial for apoptosis promoting functions in monocytes. Cell. Microbiol. 11 10 (2009) 1502-1516
55. Ludwig S., Planz O., Pleschka S., and Wolff T. Signaling to life and death: influenza viruses and intracellular signal transduction cascades, Monogr. Virol. Basel, Karger 27 (2008) 210-224
56. Ludwig S. Exploited defense: how influenza viruses take advantage of antiviral signaling responses. Future Virol 2 (2007) 91-100
57. Kakugawa S., Shimojima M., Goto H., Horimoto T., Oshimori N., Neumann G., Yamamoto T., and Kawaoka Y. Mitogen-activated protein kinase-activated kinase RSK2 plays a role in innate immune responses to influenza virus infection. J. Virol 83 (2009) 2510-2517
58. Goodman A.G., Fornek J.L., Medigeshi G.R., Perrone L.A., Peng X., Dyer M.D., Proll S.C., Knoblaugh S.E., Carter V.S., Korth M.J., Nelson J.A., Tumpey T.M., and Katze M.G. P58(IPK): a novel "CIHD" member of the host innate defense response against pathogenic virus infection. PLoS Pathog 5 (2009) e1000438
59. Steel J., Lowen A.C., Pena L., Angel M., Solorzano A., Albrecht R., Perez D.R., Garcia-Sastre A., and Palese P. Live attenuated influenza viruses containing NS1 truncations as vaccine candidates against H5N1 highly pathogenic avian influenza. J. Virol 83 (2009) 1742-1753
60. Basu D., Walkiewicz M.P., Frieman M., Baric R.S., Auble D.T., and Engel D.A. Novel influenza virus NS1 antagonists block replication and restore innate immune function. J. Virol 83 (2009) 1881-1891