LF 16-0687 Ms, a new bradykinin B2 receptor antagonist, decreases ex vivo brain tissue prostaglandin E2 synthesis after closed head trauma in rats

Resuscitation

Volumn 56, Issue 2, 2003, Pages 207-213

  Kaplanski, Jakob ^a   Asa, Ilia ^a   Artru, Alan A ^b   Azez, Abed ^a   Ivashkova, Yulia ^a   Rudich, Zvia ^a   Pruneau, Didier ^c   Shapira, Yoram ^a  

^a BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^c Laboratoire de Pharmacochimie   (France)

Author keywords

Brain injury; Inflammatory response; Intracranial pressure; Neurologic dysfunction; Trauma

Indexed keywords

1 [[3 [(2,4 DIMETHYLQUINOLIN 8 YL)OXYMETHYL] 2,4 DICHLOROPHENYL]SULFONYL] N [3 [[4 (AMINOIMINOMETHYL)PHENYL]CARBONYLAMINO]PROPYL] PYRROLIDINECARBOXAMIDE DIMESYLATE; BRADYKININ B2 RECEPTOR ANTAGONIST; LF 160687 MS; PROSTAGLANDIN E2; UNCLASSIFIED DRUG; WATER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN TISSUE; BRAIN WATER; CONTROLLED STUDY; DRUG EFFECT; EXPERIMENTAL MODEL; FATTY ACID ANALYSIS; HEAD INJURY; INCUBATION TIME; LIPOGENESIS; MALE; NEUROLOGIC EXAMINATION; NONHUMAN; PRIORITY JOURNAL; RAT; SAMPLE; SCORING SYSTEM; TISSUE; TREATMENT OUTCOME; WATER CONTENT;

ANIMALS; BRAIN; CULTURE TECHNIQUES; DINOPROSTONE; DISEASE MODELS, ANIMAL; HEAD INJURIES, CLOSED; INTRACRANIAL PRESSURE; MALE; MULTIVARIATE ANALYSIS; PROBABILITY; QUINOLINES; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, BRADYKININ; REFERENCE VALUES; STATISTICS, NONPARAMETRIC;

EID: 12244260771     PISSN: 03009572     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-9572(02)00371-4     Document Type: Article

References (32)

1. Ellis E.F., Chao J., Heizer M.L. Brain kininogen following experimenta brain injury: evidence for a secondary event. J. Neurosurg. 71:1989;437-442.
2. Hsu C.Y., Hu Z.Y., Doster S.K. Cell-mediated injury. Narayan R.K., Wilberger J.E. jr., Povlishock J.T. Neurotrauma. 1996;1433-1444 McGraw-Hill, New York, NY.
3. 2 receptor antagonist, reduces brain edema and improves long-term neurological function recovery after closed head trauma in rats. J. Neurotrauma. 19:2002;953-964.
4. Clark R.A.F., Henson P.M. The molecular and cellular biology of wound repair. 1988;MTP Press, Boston.
5. Narotam P.K., Rodell T.C., Nadvi S.S., Bhoola K.D., Troha J.M., Parbhoosingh R., et al. Traumatic brain contusions: a clinical role for the kinin antagonist CP-0127. Acta Neurochir. (Wien). 140:1998;793-802.
6. Marmarou A., Nichols J., Burgess J., Newell D., Troha J., Burnham D., et al. Effects of the bradykinin antagonist Bradycor (deltibant, CP-1027) in severe traumatic brain injury: results of a multi-center, randomized, placebo-controlled trial. American brain injury consortium study group. J. Neurotrauma. 16:1999;431-444.
7. Stover J.F., Dohse N.K., Unterberg A.W. Significant reduction in brain swelling by administraion fo nonpeptide kinin B2 receptor antagonist LF 16-0687 Ms after controlled cortical impact injury in rats. J. Neurosurg. 92:2000;853-859.
8. Verrecchia C., Messenge C., Plotkine M. Neuroprotective effect of LF 16-0687 Ms, a bradykinin B2 receptor antagonist, on a model of traumatic brain injury in mice. Restorative Neurol. Neurosci. 16:2000;177-178.
9. Pruneau D., Chorny I., Benkovitz V., Artru A., Roitblat L., Shapira Y. Effect of LF 16-0687MS, a new nonpeptide bradykinin B2 receptor antagonist, in a rat model of closed head trauma. J. Neurotrauma. 16:1999;1057-1065.
10. Relton J.K., Beckey V.E., Hanson W.L., Whalley E.T. CP-0597, a selective bradykinin B2 receptor antagonist, inhibits brain injury in a rat model of reversible middle cerebral artery occlusion. Stroke. 28:1997;1430-1436.
11. Gorlach C., Hortobagyi T., Hortobagyi S., Benyo Z., Relton J., Whalley E.T., et al. Bradykinin B2, but not B1, receptor antagonism has a neuroprotective effect after brain injury. J. Neurotrauma. 18:2001;833-838.
12. Plesnila N., Schulz J., Stoffel M., Eriskat J., Pruneau D., Baethamann A. Role of bradykinin B2 receptors in the formation of vasogenic brain edema in rats. J. Neurotrauma. 18:2001;1049-1058.
13. Shapira Y., Shohami E., Sidi A., Soffer D., Freeman S., Cotev S. Experimental closed head injury in rats: mechanical, pathophysiologic, and neurologic properties. Crit. Care Med. 16:1988;258-265.
14. Dixon C.E., Hayes R.L. Fluid percussion and cortical impact models of traumatic brain injury. Narayan R.K., Wilberger J.E. jr., Povlishock J.T. Neurotrauma. 1996;1337-1346 McGraw-Hill, New York, NY.
15. Gamache D.A., Ellis E.F. Effect of dexamethasone, indomethacin, ibuprofen, and probenecid on carrageenan-induced brain inflammation. J. Neurosurg. 65:1986;686-692.
16. Demopoulous H.B., Milvy P., Kakari S., Ranaohoff J. Molecular aspects of membrane structure in cerebral edema. Reulen H.J., Schurmann K. Steroids and brain edema. 1972;29-39 Springer, Berlin.
17. Feldman Z., Gurevitch B., Artru A.A., Shapira Y., Reichenthal E. Neurologic outcome with hemorrhagic hypotension after closed head trauma in rats: effect of early versus delayed conservative fluid therapy. J. Trauma. 43:1997;667-672.
18. Pruneau D., Paquet J.L., Luccarini J.M., Defrêne E., Franck R.M., Loillier B., et al. Pharmacological profile of LF 16-0687, a new potent non peptide bradykinin B2 receptor antagonist. Immunopharmacology. 43:1999;187-194.
19. Feletou M., Germain M., Thurieau C., Fauchere J.L., Canet E. Agonistic and antagonistic properties of the bradykinin B2 receptor antagonist, Hoe 140, in isolated blood vessels from different species. Br. J. Pharmacol. 112:1994;683-689.
20. Smith D.H., McIntosh T.K. Traumatic brain injury and excitatory amino acids. Narayan R.K., Wilberger J.E. jr., Povlishock J.T. Neurotrauma. 1996;1445-1458 McGraw-Hill, New York, NY.
21. Xing M., Tao L., Insel P.A. Role of extracellular signal-regulated kinase and PKC alpha in cytosolic PLA2 activation by bradykinin in MDCK-D1 cells. Am. J. Physiol. 272:1997;1380-1387.
22. Shapira Y., Davidson E., Weidenfeld Y., Cotev S., Shohami E. Dexamethasone and indomethacin do not affect brain edema following head injury in rats. J. Cereb. Blood Flow Metab. 8:1988;395-402.
23. Shapira Y., Artru A.A., Yadid G., Shohami E. Methylprednisolone does not decrease eicosanoid concentrations or edema in brain tissue or improve neurologic outcome after head trauma in rats. Anesth. Analg. 75:1992;238-244.
24. Koyfman L., Kaplanski J., Artru A.A., Talmor D., Rubin M., Shapira Y. Inhibition of cyclooxygenase 2 by nimesulide decreases prostaglandin E2 formation but does not alter brain edema or clinical recovery after closed head injury in rats. J. Neurosurg. Anesthesiol. 12:2000;44-50.
25. Biestro A.A., Alberti R.A., Soca A.E., Cancela M., Puppo C.B., Borovich B. Use of indomethacin in brain-injured patients with cerebral perfusion pressure impairment: preliminary report. J. Neurosurg. 83:1995;627-630.
26. Doppenberg E.M., Choi S.C., Bullock R. Clinical trials in traumatic brain injury. What can we learn from previous studies? Ann. N.Y. Acad. Sci. 825:1997;305-322.
27. Dash P.K., Mach S.A., Moore A.N. Regional expression and role of cyclooxygenase-2 following experimental traumatic brain injury. J. Neurotrauma. 17:2000;69-81.
28. Parpura V., Basarsky T.A., Liu F., Jeftinija K., Jeftinija S., Haydon P.G. Glutamate-mediated astrocyte-neuron signalling. Nature. 369:1994;744-747.
29. Jeftinija S.D., Jeftinija K.V., Stefanovic G., Liu F. Neuroligand-evoked calcium-dependent release of excitatory amino acids from cultured astrocytes. J. Neurochem. 66:1996;676-684.
30. Jones S., Brown D.A., Milligan G., Willer E., Buckley N.J., Caufield M.P. Bradykinin excites rat sympathetic neurons by inhibition of M current through a mechanism involving B2 receptors and Gαq/11. Neuron. 14:1995;399-405.
31. Wang Q., Patton W.F., Hechtman H.B., Shepro D. A novel anti-inflammatory peptide inhibits endothelial cell cytoskeletal rearrangement, nitric oxide synthase translocation, and paracellular permeability increases. J. Cell Physiol. 172:1997;171-182.
32. Gecse A., Mezei Z., Telegdy G. The effect of bradykinin and its fragments on the arachidonate cascade of brain microvessels. Adv. Exp. Med. Biol. 247A:1989;249-254.