Anatibant®, a selective non-peptide bradykinin B2 receptor antagonist, reduces intracranial hypertension and histopathological damage after experimental traumatic brain injury

Neuroscience Letters

Volumn 454, Issue 2, 2009, Pages 115-117

  Zweckberger, Klaus ^a   Plesnila, Nikolaus ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

Bradykinin; Bradykinin B2 receptor antagonist; Contusion volume; Intracranial pressure; Traumatic brain injury

Indexed keywords

ANATIBANT; BRADYKININ B2 RECEPTOR; NEUROPROTECTIVE AGENT; QUINOLINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BOLUS INJECTION; BRAIN CONTUSION; BRAIN DAMAGE; CONTROLLED STUDY; INTRACRANIAL HYPERTENSION; INTRACRANIAL PRESSURE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRAUMATIC BRAIN INJURY; ANIMAL; BRAIN; BRAIN INJURY; C57BL MOUSE; DRUG ANTAGONISM; DRUG EFFECT; PATHOLOGY; SUBCUTANEOUS DRUG ADMINISTRATION;

ANIMALS; BRAIN; BRAIN INJURIES; INJECTIONS, SUBCUTANEOUS; INTRACRANIAL HYPERTENSION; MALE; MICE; MICE, INBRED C57BL; NEUROPROTECTIVE AGENTS; QUINOLINES; RECEPTOR, BRADYKININ B2;

EID: 62949096976     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2009.02.014     Document Type: Article

References (33)

1. Baethmann A., Kempski O., Unterberg A., Maier-Hauff K., Lange M., and Schürer L. Origin and therapy of secondary brain damage. MMW Münchner Med. Wochenschr. 124 (1982) 941-944
2. Baethmann A., Maier-Hauff K., Kempski O., Unterberg A., Wahl M., and Schürer L. Mediators of brain edema and secondary brain damage. Crit. Care Med. 16 10 (1988) 972-978
3. Bouma G.J., Mizelaar J.P., and Fatouros P. Pathogenesis of traumatic brain swelling: role of cerebral blood volume. Acta Neurochir. (Suppl.) 71 (1998) 272-275
4. Bullock R., and Teasdale G. ABC of major trauma. Head injuries. BMJ 300 (1990) 1515-1518
5. Chen E.Y., Emerich D.F., Bartus R.T., and Kordower J.H. B2 bradykinin receptor immunoreactivity in rat brain. J. Comp. Neurol. 427 1 (2000) 1-18
6. Dixon C.E., Clifton G.L., Lighthall J.W., Yaghmail A.A., and Hayes R.L. A controlled cortical impact model of traumatic brain injury in the rat. J. Neurosci. Methods 39 (1991) 253-262
7. 2 receptors in a murine model of diffuse brain injury. J. Neurotrauma 20 9 (2003) 841-851
8. 2 receptor antagonist, reduces brain edema and improves long-term neurological function recovery after closed head trauma in rats. J. Neurotrauma 19 8 (2002) 953-964
9. Kochanek P.M., Marion D.M., Zhang W., Schiding J.K., White M., Palmer A.M., Clark R.S., O'Mally M.E., Styren S.D., and Ho C. Severe controlled cortical impact in rats: assessment of cerebral edema, blood flow, and contusion volume. J. Neurotrauma 12 6 (1995) 1015-1025
10. Lee Y.J., Zachrisson O., Tonge D.A., and Mcnaughton P.A. Upregulation of bradykinin B2 receptors expression by neurotrophic factors and nerve injury in mouse sensory neurons. Mol. Cell Neurosci. 19 2 (2002) 186-200
11. Lynch D.R., and Dawson T.M. Secondary mechanisms in neuronal trauma. Curr. Opin. Neurol. 7 (1994) 510-516
12. Mahabeer R., Naidoo S., and Raidoo D.M. Detection of tissue kallikrein and kinin B1 and B2 receptor mRNAs in human brain by in situ RT-PCR. Metab. Brain Dis. 15 4 (2000) 325-335
13. Marmarou A., Fatouros P., Barzó P., Portella G., Yoshihara M., Tsuji O., Yamamoto T., Laine F., Signoretti S., Ward J.D., Bullock M.R., and Young H.F. Contribution of edema and cerebral blood volume to traumatic brain swelling in head-injured patients. J. Neurosurg. 93 (2000) 183-193
14. Marshall L.F., Toole B.M., and Bowers S.A. The national trauma coma data bank. Part 2: Patient who talk and deteriorate: implications and treatment. J. Neurosurg. 59 (1983) 285-288
15. Mayhan W.G. Role of activation of bradykinin B2 receptors in disruption of the blood-brain barrier during acute hypertension. Brain Res. 738 (1996) 337-341
16. 2 receptors in sheep and spinal cord visualized by in vitro autoradiography. J. Comp. Neurol. 381 2 (1997) 203-218
17. Pela I.R., Rosa A.L., and Silva C.A. Cerebral B2 receptor involvement in the antinociceptive effect of bradykinin in rats. Br. J. Pharmacol. 118 6 (1996) 1488-1492
18. 2 receptors in the formation of vasogenetic brain edema in rats. J. Neurotrauma 18 (2001) 1049-1058
19. Pruneau D., Chorny I., Benkovitz V., Artru A., Roitblat L., and Shapira Y. Effect of LF 16-0687Ms., a new non-peptide Bradykinin B2 receptor antagonist, in a rat model of closed head trauma. J. Neurotrauma 16 11 (1999) 1057-1065
20. 2 receptor antagonist. Immunopharmacology 43 (1999) 187-194
21. Rachinski M., Pruneau D., Artru A.A., Kapuler V., Alonchin A., Smolanezki Y., and Shapira Y. The importance of Kinin antagonist treatment timing in closed head trauma. J. Trauma 51 5 (2001) 944-948
22. Raidoo D.M., and Bhoola K.D. Kinin receptors on human neurons. J. Neuroimmunol. 77 1 (1997) 39-44
23. Regoli D. Neurohumoral regulation of precapillary vessels: The Kallikrein-Kinin system. J. Cardiovasc. Pharmacol. 6 (1984) 401-412
24. Reilly P.L., Graham D.I., Adams J.H., and Jennett B. Patients with head injury who talk and die. Lancet 2 (1975) 375-377
25. 2 Receptor Antagonist Reduces Vasogenetic Brain Edema from a focal Lesion in Rats. Acta Neurochir. Suppl. 76 (2000) 137-139
26. Stover J.F., Dohse N.K., and Unterberg A. Signifiant reduction in brain swelling by administration of non-peptide Kinin B2 receptor antagonist LF 16-0687 Ms. after controlled cortical impact injury in rats. J. Neurosurg. 92 5 (2000) 853-859
27. Stover J.F., Dohse N.K., and Unterberg A. Bradykinin B2 Receptor Antagonist LF 16-0687 reduces posttraumatic brain edema. Acta Neurochir. Suppl. 76 (2000) 171-175
28. Unterberg A., Dautermann C., Baethmann A., and Müller-Esterl W. The Kallikrein-kinin system as mediator in vasogenetic brain swelling. Part. 3. J. Neurosurg. 64 (1986) 269-276
29. Wahl M., Gorlach C., and Hortobagyi T. Effect of bradykinin in the cerebral circulation. Acta Physiol. Hung. 86 2 (1999) 155-160
30. Wahl M., Whally E.T., Unterberg A., Schilling L., Parsons A.A., and Baethmann A. Vasomotor and permeability effects of bradykinin in the cerebral microcirculation. Immunopharmacology 33 (1996) 257-263
31. Walker K., Perkins M., and Dray A. Kinins and kinin receptors in the nervous system. Neurochem. Int. 26 1 (1995) 1-16
32. 2 receptor antagonist, on brain edema formation and tissue damage in a rat model of temporary focal cerebral ischemia. Brain Res. 950 1-2 (2002) 268-278
33. Zweckberger K., Stoffel M., Baethmann A., and Plesnila N. Effect of decompression craniotomy on increase of contusion volume and functional outcome after controlled cortical impact in mice. J. Neurotrauma 12 (2003) 1307-1314