CYP1A2, GSTM1, and GSTT1 polymorphisms and diet effects on CYP1A2 activity in a crossover feeding trial

Cancer Epidemiology Biomarkers and Prevention

Volumn 18, Issue 11, 2009, Pages 3118-3125

  Peterson, Sabrina ^a   Schwarz, Yvonne ^b   Li, Shuying S ^b   Li, Lin ^b   King, Irena B ^b   Chen, Chu ^b   Eaton, David L ^b   Potter, John D ^b   Lampe, Johanna W ^b  

^a UNIVERSITY OF MINNESOTA   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CAFFEINE; CYTOCHROME P450 1A2; GLUTATHIONE TRANSFERASE; GLUTATHIONE TRANSFERASE M1; GLUTATHIONE TRANSFERASE T1;

ADULT; APIACEOUS VEGETABLE; ARTICLE; BIOTRANSFORMATION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; CRUCIFEROUS VEGETABLE; DIET; DNA POLYMORPHISM; FEEDING; FEMALE; GENETIC VARIABILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; MODULATION; PHYTOCHEMISTRY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SEX DIFFERENCE; URINE; VEGETABLE;

ADULT; CAFFEINE; CROSS-OVER STUDIES; CYTOCHROME P-450 CYP1A2; DIET; FEMALE; GENOTYPE; GLUTATHIONE TRANSFERASE; HUMANS; MALE; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; PROGNOSIS; RISK FACTORS; YOUNG ADULT;

EID: 72749124459     PISSN: 10559965     EISSN: None     Source Type: Journal    
DOI: 10.1158/1055-9965.EPI-09-0589     Document Type: Article

References (58)

1. Eaton DL, Gallagher EP, Bammler TK, Kunze KL. Role of cytochrome P4501A2 in chemical carcinogenesis: implications for human variability in expression and enzyme activity. Pharmacogenetics 1995;5:259-274
2. Boobis AR, Lynch AM, Murray S, et al. CYP1A2-catalyzed conversion of dietary heterocyclic amines to their proximate carcinogens is their major route of metabolism in humans. Cancer Res 1994;54:89-94. (Pubitemid 24042093)
3. Guengerich FP, Shimada T, Yun CH, et al. Interactions of ingested food, beverage and tobacco components involving human cytochrome P4501A2, 2A6, 2E1 and 3A4 enzymes. Environ Health Perspect 1994; 102:49-53.
4. Gunes A, Dahl ML. Variation in CYP1A2 activity and its clinical implications: influence of environmental factors and genetic polymorphisms. Pharmacogenomics 2008;9:625-637 (Pubitemid 351803920)
5. Sachse C, Brockmöller J, Bauer S, Roots I. Functional significance of a C>A polymorphism in intron 1 of the cytochrome P450 CYP1A2 gene tested with caffeine. Br J Clin Pharmacol 1999;47:445-449 (Pubitemid 29161279)
6. Lampe JW, King IB, Li S, et al. Brassica vegetables increase and apiaceous vegetables decrease cytochrome P450 1A2 activity in humans: changes in caffeine metabolite ratios in response to controlled vegetable diets. Carcinogenesis 2000;21:1157-1162 (Pubitemid 30389341)
7. Kall MA, Vang O, Clausen J. Effects of dietary broccoli on human in vivo drug metabolising enzymes: evaluation of caffeine, estrone and chlozoxazone metabolism. Carcinogenesis 1996;17:793-799 (Pubitemid 26129695)
8. Gross-Steinmeyer K, Stapleton PL, Liu F, et al. Phytochemical-induced changes in gene expression of carcinogen-metabolizing enzymes in cultured human primary hepatocytes. Xenobiotica 2004;34:619-632 (Pubitemid 39486044)
9. Lake BG, Tredger JM, Renwick AB, Barton PT, Price RJ. 3,3′-Diindolylmethane induces CYP1A2 in cultured precision-cut human liver slices. Xenobiotica 1998;28:803-811
10. Keum YS, Jeong WS, Kong ANT. Chemoprevention by isothiocyanates and their underlying molecular signaling mechanisms. Mutat Res 2004;555:191-202. (Pubitemid 39345404)
11. Slattery ML, Kampman E, Samowitz W, Caan BJ, Potter JD. Interplay between dietary inducers of GST and the GSTM1-genotype in colon cancer. Int J Cancer 2000;87:728-733 (Pubitemid 30620417)
12. London SJ, Yuan JM, Chung FL, et al. Isothiocyanates, glutathione Stransferase M1 and T1 polymorphisms, and lung-cancer risk: a prospective study of men in Shanghai, China. Lancet 2000;356:724-729
13. Seow A, Yuan JM, Sun CL, Van Den Berg D, Lee HP, Yu MC. Dietary isothiocyanates, glutathione S-transferase polymorphisms and colorectal cancer risk in the Singapore Chinese Health Study. Carcinogenesis 2002;23:2055-2061 (Pubitemid 36104958)
14. Brennan P, Hsu CC, Moullan N, et al. Effect of cruciferous vegetables on lung cancer in patients stratified by genetic status: a mendelian randomisation approach. Lancet 2005;366:1558-1560 (Pubitemid 41540114)
15. Wang LI, Giovannucci EL, Hunter D, Neuberg D, Su L, Christiani DC. Dietary intake of cruciferous vegetables, glutathione S-transferase (GST) polymorphisms and lung cancer risk in a Caucasian population. Cancer Causes Control 2004;15:977-985 (Pubitemid 41449278)
16. Joseph MA, Moysich KB, Freudenheim JL, et al. Cruciferous vegetables, genetic polymorphisms in glutathione S-transferases M1 and T1, and prostate cancer risk. Nutr Cancer 2004;50:206-213
17. Ambrosone CB, McCann SE, Freudenheim JL, Marshall JR, Zhang Y, Shields PG. Breast cancer risk in premenopausal women is inversely associated with consumption of broccoli, a source of isothiocyanates, but is not modified by GST genotype. J Nutr 2004;134:1134-1138 (Pubitemid 38619952)
18. Gaudet MM, Olshan AF, Poole C, Weissler MC, Watson M, Bell DA. Diet, GSTM1 and GSTT1 and head and neck cancer. Carcinogenesis 2004;25:735-740
19. Gasper AV, Al-Janobi A, Smith JA, et al. Glutathione S-transferase M1 polymorphism and metabolism of sulforaphane from standard and high-glucosinolate broccoli. Am J Clin Nutr 2005;82:1283-1291 (Pubitemid 43779728)
20. Steck SE, Gammon MD, Hebert JR, Wall DE, Zeisel SH. GSTM1, GSTT1, GSTP1, and GSTA1 polymorphisms and urinary isothiocyanate metabolites following broccoli consumption in humans. J Nutr 2007;137:904-909
21. Dashwood RH, Uyetake L, Fong AT, Hendricks JD, Bailey GS. In vivo disposition of the natural anti-carcinogen indole-3-carbinol after po administration to rainbow trout. Food Chem Toxicol 1989;27:385-392
22. Lombaert GA, Siemens KH, Pellaers P, Mankotia M, Ng W. Furanocoumarins in celery and parsnips: method and multiyear Canadian survey. J AOACInt 2001;84:1135-1143 (Pubitemid 33610545)
23. Beier RC. Natural pesticides and bioactive components in foods. Rev Environ Contam Toxicol 1990;113:47-137.
24. Ono S, Hatanaka T, Hotta H, Satoh T, Gonzalez FJ, Tsutsui M. Specificity of substrate and inhibitor probes for cytochrome P450s: evaluation of in vitro metabolism using cDNA-expressed human P450s and human liver microsomes. Xenobiotica 1996;26:681-693 (Pubitemid 26233022)
25. Mays DC , C amisa C , C heney P, Pacula C M, Nawoot S, Gerber N. Methoxsalen is a potent inhibitor of the metabolism of caffeine in humans. Clin Pharmacol Ther 1987;42:621-626
26. Bendriss EK, Bechtel Y, Bendriss A, et al. Inhibition of caffeine metabolism by 5-methoxypsoralen in patients with psoriasis. Br J Clin Pharmacol 1996;41:421-424 (Pubitemid 26145024)
27. Kharasch ED, Hankins DC, Taraday JK. Single-dose methoxsalen effects on human cytochrome P-450 2A6 activity. Drug Metab Dispos 2000;28:28-33. (Pubitemid 30027508)
28. John BA, Chasseaud LF, Wood SG, Forlot P. Metabolism of the antipsoriatic agent 5-methoxypsoralen in humans: comparison with rat and dog. Xenobiotica 1992;22:1339-1351
29. Navarro SL, Peterson S, Chen C, et al. Cruciferous vegetable feeding alters UGT1A1 activity: diet- and genotype-dependent changes in serum bilirubin in a controlled feeding trial. Cancer Prev Res (Phila Pa) 2009;2:345-352
30. Zeman FJ. Clinical Nutrition and Dietetics. New York, NY: Macmillan; 1983.
31. Frankenfeld D, Roth-Yousey L, Compher C. Comparison of predictive equations for resting metabolic rate in healthy nonobese and obese adults: a systematic review. J Am Diet Assoc 2005;105:775-789 (Pubitemid 40754446)
32. Ainsworth BE, Haskell WL, Whitt MC, et al. Compendium of physical activities: an update of activity codes and MET intensities. Med Sci Sports Exerc 2000;32:S498-504.
33. Nyéki Á, Buclin T, Biollaz J, Decosterd LA. NAT2 and CYP1A2 phenotyping with caffeine: head-to-head comparison of AFMU vs. AAMU in the urine metabolite ratios. Br J Clin Pharmacol 2003;55:62-67 (Pubitemid 36110840)
34. Butler MA, Lang NP, Young JF, et al. Determination of CYP1A2 and NAT2 phenotypes in human populations by analysis of caffeine urinary metabolites. Pharmacogenetics 1992;2:116-127
35. Rostami-Hodjegan A, Nurminen S, Jackson PR, Tucker GT. Caffeine urinary metabolite ratios as markers of enzyme activity: a theoretical assessment. Pharmacogenetics 1996;6:121-149 (Pubitemid 26153358)
36. Tucker GT, Rostami-Hodjegan A, Jackson PR. Determination of drugmetabolizing enzyme activity in vivo: pharmacokinetic and statistical issues. Xenobiotica 1998;28:1255-1273 (Pubitemid 29017142)
37. Sinués B. Five caffeine metabolite ratios to measure tobacco-induced CYP1A2 activity and their relationships with urinary mutagenicity and urine flow. Cancer Epidemiol Biomarkers Prev 1999;8:159-166 (Pubitemid 29085383)
38. Chung FL, Jiao D, Getahun SE, Yu MC. A urinary biomarker for uptake of dietary isothiocyanates in humans. Cancer Epidemiol Biomarkers Prev 1998;7:103-108 (Pubitemid 28109840)
39. Laird NM, Skinner J, Kenward M. An analysis of two-period crossover designs with carry-over effects. Stat Med 1992;11:1967-1979 (Pubitemid 23015642)
40. Little RJ. Modeling the drop-out mechanism in repeated-measures studies. J Am Stat Assoc 1995;90.
41. Shin A, Shrubsole MJ, Rice JM, et al. Meat intake, heterocyclic amine exposure, and metabolizing enzyme polymorphisms in relation to colorectal polyp risk. Cancer Epidemiol Biomarkers Prev 2008;17:320-329 (Pubitemid 351272782)
42. Crump C, Chen C, Appelbaum FR, et al. Glutathione S-transferase theta 1 gene deletion and risk of acute myeloid leukemia. Cancer Epidemiol Biomarkers Prev 2000;9:457-460 (Pubitemid 30313887)
43. Kadlubar FF, Young JF, Lang NP, Caporaso NE, Sinha R, Landi MT. Correspondence re: letter to the editor by BK Tang and W Kalow on CYP1A2 phenotyping using caffeine. Cancer Epidemiol Biomarkers Prev 5: 231, 1996.
44. Cancer Epidemiol Biomarkers Prev 1996;5:757-758
45. Lampe JW, Chen C, Li S, et al. Modulation of human glutathione Stransferases by botanically defined vegetable diets. Cancer Epidemiol Biomarkers Prev 2000;9:787-793 (Pubitemid 30660051)
46. Hudson CE, Schulte BA, Sutter TR, Norris JS. Steroid hormones modulate expression of cytochrome P450 enzymes in male hamster reproductive tract and leiomyosarcomas. Carcinogenesis 2001;22:763-770
47. Scandlyn MJ, Stuart EC, Rosengren RJ. Sex-specific differences in CYP450 isoforms in humans. Expert Opin Drug Metab Toxicol 2008;4:413-424
48. Aklillu E, Carrillo JA, Makkonnen E, et al. Genetic polymorphism of CYP1A2 in Ethiopians affecting induction and expression: characterization of novel haplotypes with single-nucleotide polymorphisms in intron 1. Mol Pharmacol 2003;64:659-669 (Pubitemid 37048569)
49. Larsen JT, Brosen K. Consumption of charcoal-broiled meat as an experimental tool for discerning CYP1A2-mediated drug metabolism in vivo. Basic Clin Pharmacol Toxicol 2005;97:141-148 (Pubitemid 41291210)
50. Ghotbi R, Christensen M, Roh HK, Ingelman-Sundberg M, Aklillu E, Bertilsson L. Comparisons of CYP1A2 genetic polymorphisms, enzyme activity and the genotype-phenotype relationship in Swedes and Koreans. Eur J Clin Pharmacol 2007;63:537-546 (Pubitemid 46684487)
51. Sachse C, Bhambra U, Smith G, et al. Polymorphisms in the cytochrome P450 CYP1A2 gene (CYP1A2) in colorectal cancer patients and controls: allele frequencies, linkage disequilibrium and influence on caffeine metabolism. Br J Clin Pharmacol 2003;55:68-76. (Pubitemid 36110841)
52. Jiang Z, Dragin N, Jorge-Nebert LF, et al. Search for an association between the human CYP1A2 genotype and CYP1A2 metabolic phenotype. Pharmacogenet Genomics 2006;16:359-367
53. Zhang Y, Kolm RH, Mannervik B, Talalay P. Reversible conjugation of isothiocyanates with glutathione catalyzed by human glutathione transferases. Biochem Biophys Res Commun 1995;206:748-755
54. Moyer AM, Salavaggione OE, Hebbring SJ, et al. Glutathione Stransferase T1 and M1: gene sequence variation and functional genomics. Clin Cancer Res 2007;13:7207-7216
55. Koenigs LL, Trager WF. Mechanism-based inactivation of P450 2A6 by furanocoumarins. Biochemistry 1998;37:10047-10061
56. Koenigs LL, Trager WF. Mechanism-based inactivation of cytochrome P450 2B1 by 8-methoxypsoralen and several other furanocoumarins. Biochemistry 1998;37:13184-13193
57. von Weymarn LB, Zhang QY, Ding X, Hollenberg PF. Effects of 8-methoxypsoralen on cytochrome P450 2A13. Carcinogenesis 2005;26:621-629 (Pubitemid 41214152)
58. Shapiro TA, Fahey JW, Wade KL, Stephenson KK, Talalay P. Human metabolism and excretion of cancer chemoprotective glucosinolates and isothiocyanates of cruciferous vegetables. Cancer Epidemiol Biomarkers Prev 1998;7:1091-1100 (Pubitemid 29001665)