Steroid hormones modulate expression of cytochrome P450 enzymes in male hamster reproductive tract and leiomyosarcomas

Carcinogenesis

Volumn 22, Issue 5, 2001, Pages 763-770

  Hudson, Chad E ^a   Schulte, Bradley A ^a   Sutter, Thomas R ^b   Norris, James S ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; CYTOCHROME P450; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 1B1; CYTOCHROME P450 3A; ESTRADIOL; ESTROGEN; STEROID HORMONE; TESTOSTERONE PROPIONATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY SPECIFICITY; ARTICLE; BASAL CELL; CANCER CELL; CANCER LOCALIZATION; CARCINOGENESIS; COLUMNAR EPITHELIUM; CONTROLLED STUDY; EPIDIDYMIS; EPITHELIUM CELL; ESTROGEN METABOLISM; EXPOSURE; GENITAL SYSTEM; HORMONAL CARCINOGENESIS; HORMONAL THERAPY; HYPOTHESIS; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LEIOMYOSARCOMA; MALE; MODULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SMOOTH MUSCLE; SYRIAN HAMSTER; TIME; VAS DEFERENS;

EID: 0035026710     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/22.5.763     Document Type: Article

References (33)

1. Kirkman, H. and Algard, F.T. (1965) Characteristics of an androgen-estrogen-induced uterine smooth muscle cell tumor of the Syrian hamster. Cancer Res., 30, 794-800.
2. Norris, J., Schwartz, D., Cooper, T. and Fan, W. (1992) Hormonal carcinogenesis in Syrian hamsters: a hypothesis involving glutathione S-transferase regulation. In Li, J., Nandi, S. and Li, S. (eds) Hormonal Carcinogenesis: Proceedings of the First International Symposium. Springer-Verlag, New York, pp. 33-40.
3. Hudson, C.E., DeHaven, J.E., Schulte, B.A. and Norris, J.S. (1999) Exogenous 17β-estradiol blocks α and μ but not π class glutathione S-transferase immunoreactivity in epithelium of Syrian hamster vas deferens. J. Histochem. Cytochem., 47, 91-98.
4. Kirkman, H. and Bacon, R.L. (1950) Malignant renal tumors in male hamsters (Cricelus auratus) treated with estrogen. Cancer Res., 10, 122.
5. Yager, J.D. and Liehr, J.G. (1996) Molecular mechanisms of estrogen carcinogenesis. Annu. Rev. Pharmacol. Toxicol., 36, 203-232.
6. Bradlow, L., Telang, N.T. and Osborn, M.P. (1996) Estrogen metabolites as bioreactive modulators of tumor initiators and promoters. Adv. Exp. Med. Biol., 387, 285-296.
7. Liehr, J.G. (1990) Genotoxic effects of estrogens. Mutat. Res., 238, 269-276.
8. Ogawa, T., Higashi, S., Kawarada, Y. and Mizumoto, R. (1995) Role of reactive oxygen in synthetic estrogen induction of hepatocellular carcinomas in rats and preventive effect of vitamins. Carcinogenesis. 16, 831-836.
9. Li, J.J. and Li, S.A. (1990) Estrogen carcinogenesis in hamster tissues: a critical review. Endocrine Rev., 11, 524-531.
10. Tsutsui, T., Suzuki, N., Fukuda, S., Sato, M., Maizumi, H., McLachlan, J.A. and Barrett, J.C. (1987) 17 β-Estradiol-induced cell transformation and aneuploidy of Syrian hamster embryo cells in culture. Carcinogenesis, 8, 1715-1719.
11. Epe, B., Hegler, J. and Metzler, M. (1987) Site-specific covalent binding of stilbene-type and steroidal estrogens to tubulin following metabolic activation in vitro. Carcinogenesis, 8, 1271-1275.
12. Li, J.J., Hou, X., Banerjee, S.K., Liao, D.J., Maggouta, F., Norris, J.S. and Li, S.A. (1999) Overexpression and amplification of c-myc in the Syrian hamster kidney during estrogen carcinogenesis: A probable critical role in neoplastic transformation. Cancer Res., 59, 2340-2346.
13. Omiecinski, C.J., Remmel, R.P. and Hosagrahara, V.P. (1999) Concise review of the cytochrome P450s and their roles in toxicology. Toxicol. Sci., 48, 151-156.
14. Martucci, C.P. and Fishman, J. (1993) P450 enzymes of estrogen metabolism. Pharmacol. Ther., 57, 237-257.
15. Savas, U., Bhattacharyya, K.K., Christou, M., Alexander, D.L. and Jefcoate, C.R. (1994) Mouse cytochrome P-450EF, representative of a new 1B subfamily of cytochrome P-450s. Cloning, sequence determination and tissue expression. J. Biol. Chem., 269, 14905-14911.
16. Sutter, T.R., Tang, Y.M., Hayes, C.L., Wo, Y.Y. Jabs, E.W., Li, X., Yin, H., Cody, C.W. and Greenlee, W.F. (1994) Complete cDNA sequence of a human dioxin-inducible mRNA identifies a new gene subfamily of cytochrome P450 that maps to chromosome 2. J. Biol. Chem., 269, 13092-13099.
17. Spink, D.C., Hayes, C.L., Young, N.R., Christou, M., Sutter, T.R., Jefcoate, C.R. and Gierthy, J.F. (1994) The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on estrogen metabolism in MCF-7 breast cancer cells: evidence for induction of a novel 17 β-estradiol 4-hydroxylase. J. Steroid Biochem. Mol. Biol., 51, 251-258.
18. Hayes, C.L., Spink, D.C., Spink, B.C., Cao, J.Q., Walker, N.J. and Sutter, T.R. (1996) 17 β-estradiol hydroxylation catalyzed by human cytochrome P450 1B1. Proc. Natl Acad. Sci. USA, 93, 9776-9781.
19. Liehr, J.G., Ricci, M.J., Jefcoate, C.R., Hannigan, E.V., Hokanson, J.A. and Zhu, B.T. (1995) 4-Hydroxylation of estradiol by human uterine myometrium and myoma microsomes: implications for the mechanism of uterine tumorigenesis. Proc. Natl Acad. Sci. USA, 92, 9220-9224.
20. Hammond, D.K., Zhu, B.T., Wang, M.Y., Ricci, M.J. and Liehr, J.G. (1997) Cytochrome P450 metabolism of estradiol in hamster liver and kidney. Toxicol. Appl. Pharmacol., 145, 54-60.
21. Bhattacharyya, K.K., Brake, P.B., Eltom, S.E., Otto, S.A. and Jefcoate, C.R. (1995) Identification of a rat adrenal cytochrome P450 active in polycyclic hydrocarbon metabolism as rat CYP1BI. Demonstration of a unique tissue-specific pattern of hormonal and aryl hydrocarbon receptor-linked regulation. J. Biol. Chem., 270, 11595-11602.
22. Walker, N.J., Crofts, F.G., Li, Y., Lax, S.F., Hayes, C.L., Strickland, P.T., Lucier, G.W. and Sutter, T.R. (1998) Induction and localization of cytochrome P450 1B1 (CYP1B1) protein in the livers of TCDD-treated rats: detection using polyclonal antibodies raised to histidine-tagged fusion proteins produced and purified from bacteria. Carcinogenesis, 19, 395-402.
23. Otto, S., Bhattacharyya, K.K. and Jefcoate, C.R. (1992) Polycyclic aromatic hydrocarbon metabolism in rat adrenal, ovary and testis microsomes is catalyzed by the same novel cytochrome P450 (P450RAP). Endocrinology, 131, 3067-3076.
24. Thomas, P.E., Bandiera, S., Reik, L.M., Maines, S.L., Ryan, D.E. and Levin, W. (1987) Polyclonal and monoclonal antibodies as probes of rat hepatic cytochrome P-450 isozymes. Fed. Proc., 46, 2563-2566.
25. Black, S.D. and Coon, M.J. (1987) P-450 cytochromes: structure and function. Adv. Enzymol., 60, 35-87.
26. Nelson, D.R., Kamataki, T., Waxman, D.J. et al. (1993) The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes and nomenclature. DM4 Cell Biol., 12, 1-51.
27. Edward, R.J., Singleton, A.M., Murray, B.P., Davies, D.S. and Boobis, A.R. (1995) Short synthetic peptides exploited for reliable and specific targeting of antibodies to the C-termini of cytochrome P450 enzymes. Biochem. Pharmacol., 49, 39-47.
28. Halvorson, M., Greenway, D., Eberhart, D., Fitzgerald, K. and Parkinson, A. (1990) Reconstitution of testosterone oxidation by purified rat cytochrome P450p (IIIA1). Arch. Biochem. Biophys., 211, 166-180.
29. Eberhart, D., Fitzgerald, K. and Parkinson, A. (1992) Evidence for the involvement of a distinct form of cytochrome P450 3A in the oxidation of digitoxin by rat liver microsomes. J. Biochem. Toxicol., 7, 53-64.
30. Gemzik, B., Greenway, D., Nevins, C. and Parkinson, A. (1992) Regulation of two electrophoretically distinct proteins recognized by antibody against rat liver cytochrome P450 3A1. J. Biochem. Toxicol., 7, 43-52.
31. MacIndoe, J.H. and Etre, L.A. (1981) An antiestrogenic action of androgens in human breast cancer cells. J. Clin. Endocrinol. Metab., 53, 836-842.
32. Hung, T.T. and Gibbons, W.E. (1983) Evaluation of androgen antagonism of estrogen by dihydrotestosterone. J. Steroid Biochem., 19, 1513-1520.
33. Croston, G.E., Milan, L.B., Marschke, K.B., Reichman, M. and Briggs, M.R. (1997) Androgen receptor-mediated antagonism of estrogen-dependent low density lipoprotein receptor transcription in cultured hepatocytes. Endocrinology, 138, 3779-3786.