메뉴 건너뛰기




Volumn 107, Issue 5, 2009, Pages 1479-1485

Insulin resistance without elevated mammalian target of rapamycin complex 1 activity in muscles of mice fed a high-fat diet

Author keywords

Signal transduction; Skeletal muscle

Indexed keywords

INSULIN; INSULIN RECEPTOR SUBSTRATE 1; MAMMALIAN TARGET OF RAPAMYCIN; MTORC1 ENZYME; S6 KINASE; SERINE; THREONINE; UNCLASSIFIED DRUG;

EID: 72749110489     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.00574.2009     Document Type: Article
Times cited : (10)

References (30)
  • 2
    • 0036298262 scopus 로고    scopus 로고
    • Rapamycin partially prevents insulin resistance induced by chronic insulin treatment
    • DOI 10.1016/S0006-291X(02)00333-9, PII S0006291X02003339
    • Berg CE, Lavan BE, Rondinone CM. Rapamycin partially prevents insulin resistance induced by chronic insulin treatment. Biochem Biophys Res Commun 293: 1021-1027, 2002. (Pubitemid 34694144)
    • (2002) Biochemical and Biophysical Research Communications , vol.293 , Issue.3 , pp. 1021-1027
    • Berg, C.E.1    Lavan, B.E.2    Rondinone, C.M.3
  • 3
    • 33750735034 scopus 로고    scopus 로고
    • mTOR signaling and the molecular adaptation to resistance exercise
    • Bodine SC. mTOR signaling and the molecular adaptation to resistance exercise. Med Sci Sports Exerc 38: 1950-1957, 2006.
    • (2006) Med Sci Sports Exerc , vol.38 , pp. 1950-1957
    • Bodine, S.C.1
  • 4
    • 1542616960 scopus 로고    scopus 로고
    • Mammalian target of rapamycin regulates IRS-1 serine 307 phosphorylation
    • Carlson CJ, White MF, Rondinone CM. Mammalian target of rapamycin regulates IRS-1 serine 307 phosphorylation. Biochem Biophys Res Commun 316: 533-539, 2004.
    • (2004) Biochem Biophys Res Commun , vol.316 , pp. 533-539
    • Carlson, C.J.1    White, M.F.2    Rondinone, C.M.3
  • 5
    • 21844468767 scopus 로고    scopus 로고
    • Phosphorylation of mammalian target of rapamycin (mTOR) at Ser-2448 is mediated by p70S6 kinase
    • DOI 10.1074/jbc.M501707200
    • Chiang GG, Abraham RT. Phosphorylation of mammalian target of rapamycin (mTOR) at Ser-2448 is mediated by p70S6 kinase. J Biol Chem 280: 25485-25490, 2005. (Pubitemid 40962253)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.27 , pp. 25485-25490
    • Chiang, G.G.1    Abraham, R.T.2
  • 6
    • 33746488875 scopus 로고    scopus 로고
    • Chronic inhibition of mammalian target of rapamycin signaling downregulates insulin receptor substrates 1 and 2 and AKT activation: A crossroad between cancer and diabetes?
    • DOI 10.1681/ASN.2006030196
    • Di Paolo S, Teutonico A, Leogrande D, Capobianco C, Schena PF. Chronic inhibition of mammalian target of rapamycin signaling downregulates insulin receptor substrates 1 and 2 and Akt activation: a crossroad between cancer and diabetes? J Am Soc Nephrol 17: 2236-2244, 2006. (Pubitemid 44141914)
    • (2006) Journal of the American Society of Nephrology , vol.17 , Issue.8 , pp. 2236-2244
    • Di Paolo, S.1    Teutonico, A.2    Leogrande, D.3    Capobianco, C.4    Schena, P.F.5
  • 7
    • 0037073679 scopus 로고    scopus 로고
    • Serine phosphorylation of insulin receptor substrate 1 by inhibitor κB kinase complex
    • DOI 10.1074/jbc.M209459200
    • Gao Z, Hwang D, Bataille F, Lefevre M, York D, Quon MJ, Ye J. Serine phosphorylation of insulin receptor substrate 1 by inhibitor-κB kinase complex. J Biol Chem 277: 48115-48121, 2002. (Pubitemid 35470759)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.50 , pp. 48115-48121
    • Gao, Z.1    Hwang, D.2    Bataille, F.3    Lefevre, M.4    York, D.5    Quon, M.J.6    Ye, J.7
  • 9
    • 34547102518 scopus 로고    scopus 로고
    • Common inhibitory serine sites phosphorylated by IRS-1 kinases, triggered by insulin and inducers of insulin resistance
    • DOI 10.1074/jbc.M610949200
    • Herschkovitz A, Liu YF, Ilan E, Ronen D, Boura-Halfon S, Zick Y. Common inhibitory serine sites phosphorylated by IRS-1 kinases, triggered by insulin and inducers of insulin resistance. J Biol Chem 282: 18018-18027, 2007. (Pubitemid 47100249)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.25 , pp. 18018-18027
    • Herschkovitz, A.1    Liu, Y.-F.2    Ilan, E.3    Ronen, D.4    Boura-Halfon, S.5    Zick, Y.6
  • 11
    • 14244256097 scopus 로고    scopus 로고
    • Increased activation of the mammalian target of rapamycin pathway in liver and skeletal muscle of obese rats: Possible involvement in obesity-linked insulin resistance
    • DOI 10.1210/en.2004-0921
    • Khamzina L, Veilleux A, Bergeron S, Marette A. Increased activation of the mammalian target of rapamycin pathway in liver and skeletal muscle of obese rats: possible involvement in obesity-linked insulin resistance. Endocrinology 146: 1473-1481, 2005. (Pubitemid 40289337)
    • (2005) Endocrinology , vol.146 , Issue.3 , pp. 1473-1481
    • Khamzina, L.1    Veilleux, A.2    Bergeron, S.3    Marette, A.4
  • 12
    • 0037178786 scopus 로고    scopus 로고
    • MTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery
    • DOI 10.1016/S0092-8674(02)00808-5
    • Kim DH, Sarbassov DD, Ali SM, King JE, Latek RR, Erdjument- Bromage H, Tempst P, Sabatini DM. mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell 110: 163-175, 2002. (Pubitemid 34876545)
    • (2002) Cell , vol.110 , Issue.2 , pp. 163-175
    • Kim, D.-H.1    Sarbassov, D.D.2    Ali, S.M.3    King, J.E.4    Latek, R.R.5    Erdjument-Bromage, H.6    Tempst, P.7    Sabatini, D.M.8
  • 13
    • 57349116906 scopus 로고    scopus 로고
    • Rapamycin does not improve insulin sensitivity despite elevated mammalian target of rapamycin complex 1 activity in muscles of ob/ob mice
    • Miller AM, Brestoff JR, Phelps CB, Berk EZ, Reynolds TH. Rapamycin does not improve insulin sensitivity despite elevated mammalian target of rapamycin complex 1 activity in muscles of ob/ob mice. Am J Physiol Regul Integr Comp Physiol 295: R1431-R1438, 2008.
    • (2008) Am J Physiol Regul Integr Comp Physiol , vol.295
    • Miller, A.M.1    Brestoff, J.R.2    Phelps, C.B.3    Berk, E.Z.4    Reynolds, T.H.5
  • 17
    • 0030740005 scopus 로고    scopus 로고
    • The modular phosphorylation and activation of p70s6k
    • Pullen N, Thomas G. The modular phosphorylation and activation of p70s6k. FEBS Lett 410: 78-82, 1997.
    • (1997) FEBS Lett , vol.410 , pp. 78-82
    • Pullen, N.1    Thomas, G.2
  • 21
    • 13844312400 scopus 로고    scopus 로고
    • Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
    • Sarbassov DD, Guertin DA, Ali SM, Sabatini DM. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 307: 1098-1101, 2005.
    • (2005) Science , vol.307 , pp. 1098-1101
    • Sarbassov, D.D.1    Guertin, D.A.2    Ali, S.M.3    Sabatini, D.M.4
  • 22
    • 4544343980 scopus 로고    scopus 로고
    • Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies
    • DOI 10.1016/j.cub.2004.08.026, PII S0960982204006116
    • Shah OJ, Wang Z, Hunter T. Inappropriate activation of the TSC/Rheb/ mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies. Curr Biol 14: 1650-1656, 2004. (Pubitemid 39239362)
    • (2004) Current Biology , vol.14 , Issue.18 , pp. 1650-1656
    • Shah, O.J.1    Wang, Z.2    Hunter, T.3
  • 23
    • 32844474879 scopus 로고    scopus 로고
    • Glucose metabolism in renal transplant recipients: Effect of calcineurin inhibitor withdrawal and conversion to sirolimus
    • DOI 10.1681/ASN.2005050487
    • Teutonico A, Schena PF, Di Paolo S. Glucose metabolism in renal transplant recipients: effect of calcineurin inhibitor withdrawal and conversion to sirolimus. J Am Soc Nephrol 16: 3128-3135, 2005. (Pubitemid 44743511)
    • (2005) Journal of the American Society of Nephrology , vol.16 , Issue.10 , pp. 3128-3135
    • Teutonico, A.1    Schena, P.F.2    Di Paolo, S.3
  • 24
    • 14244252683 scopus 로고    scopus 로고
    • Activation of the mammalian target of rapamycin pathway acutely inhibits insulin signaling to Akt and glucose transport in 3T3-L1 and human adipocytes
    • DOI 10.1210/en.2004-0777
    • Tremblay F, Gagnon A, Veilleux A, Sorisky A, Marette A. Activation of the mammalian target of rapamycin pathway acutely inhibits insulin signaling to Akt and glucose transport in 3T3-L1 and human adipocytes. Endocrinology 146: 1328-1337, 2005. (Pubitemid 40289320)
    • (2005) Endocrinology , vol.146 , Issue.3 , pp. 1328-1337
    • Tremblay, F.1    Gagnon, A.2    Veilleux, A.3    Sorisky, A.4    Marette, A.5
  • 25
    • 0035851205 scopus 로고    scopus 로고
    • Amino acid and insulin signaling via the mTOR/p70 S6 kinase pathway. a negative feedback mechanism leading to insulin resistance in skeletal muscle cells
    • Tremblay F, Marette A. Amino acid and insulin signaling via the mTOR/p70 S6 kinase pathway. A negative feedback mechanism leading to insulin resistance in skeletal muscle cells. J Biol Chem 276: 38052-38060, 2001. (Pubitemid 37384057)
    • (2001) Journal of Biological Chemistry , vol.276 , Issue.41 , pp. 38052-38060
    • Tremblay, F.1    Marette, A.2
  • 26
    • 33644886769 scopus 로고    scopus 로고
    • Nutrients suppress phosphatidylinositol 3-kinase/ Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation
    • Tzatsos A, Kandror KV. Nutrients suppress phosphatidylinositol 3-kinase/ Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation. Mol Cell Biol 26: 63-76, 2006.
    • (2006) Mol Cell Biol , vol.26 , pp. 63-76
    • Tzatsos, A.1    Kandror, K.V.2
  • 28
    • 33847397874 scopus 로고    scopus 로고
    • Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40
    • DOI 10.1038/ncb1547, PII NCB1547
    • Vander Haar E, Lee SI, Bandhakavi S, Griffin TJ, Kim DH. Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40. Nat Cell Biol 9: 316-323, 2007. (Pubitemid 46344611)
    • (2007) Nature Cell Biology , vol.9 , Issue.3 , pp. 316-323
    • Haar, E.V.1    Lee, S.2    Bandhakavi, S.3    Griffin, T.J.4    Kim, D.-H.5
  • 29
    • 33749431713 scopus 로고    scopus 로고
    • The mTOR pathway in the control of protein synthesis
    • DOI 10.1152/physiol.00024.2006
    • Wang X, Proud CG. The mTOR pathway in the control of protein synthesis. Physiology (Bethesda) 21: 362-369, 2006. (Pubitemid 44511764)
    • (2006) Physiology , vol.21 , Issue.5 , pp. 362-369
    • Wang, X.1    Proud, C.G.2
  • 30
    • 0036149984 scopus 로고    scopus 로고
    • Molecular mechanism of insulin-induced degradation of insulin receptor substrate 1
    • DOI 10.1128/MCB.22.4.1016-1026.2002
    • Zhande R, Mitchell JJ, Wu J, Sun XJ. Molecular mechanism of insulin-induced degradation of insulin receptor substrate 1. Mol Cell Biol 22: 1016-1026, 2002. (Pubitemid 34094839)
    • (2002) Molecular and Cellular Biology , vol.22 , Issue.4 , pp. 1016-1026
    • Zhande, R.1    Mitchell, J.J.2    Wu, J.3    Sun, X.J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.