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Volumn 28, Issue 24, 2009, Pages 3879-3892

The target of rapamycin complex 2 controls dendritic tiling of Drosophila sensory neurons through the Tricornered kinase signalling pathway

Author keywords

Dendritic fields; Sensory neuron; Tiling; TORC2; Tricornered kinase

Indexed keywords

PROTEIN KINASE; TARGET OF RAPAMYCIN COMPLEX 2; TARGET OF RAPAMYCIN KINASE; TRICORNERED KINASE; UNCLASSIFIED DRUG;

EID: 72449168825     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/emboj.2009.312     Document Type: Article
Times cited : (62)

References (62)
  • 1
    • 63749117393 scopus 로고    scopus 로고
    • TORC2 plasma membrane localization is essential for cell viability and restricted to a distinct domain
    • Berchtold D, Walther TC (2009) TORC2 plasma membrane localization is essential for cell viability and restricted to a distinct domain. Mol Biol Cell 20: 1565-1575
    • (2009) Mol Biol Cell , vol.20 , pp. 1565-1575
    • Berchtold, D.1    Walther, T.C.2
  • 2
    • 34047095297 scopus 로고    scopus 로고
    • The two TORCs and Akt
    • Bhaskar PT, Hay N (2007) The two TORCs and Akt. Dev Cell 12: 487-502
    • (2007) Dev Cell , vol.12 , pp. 487-502
    • Bhaskar, P.T.1    Hay, N.2
  • 3
    • 0023111193 scopus 로고
    • Morphological differentiation of the embryonic peripheral neurons in Drosophila
    • Bodmer R, Jan YN (1987) Morphological differentiation of the embryonic peripheral neurons in Drosophila. Rouxs Arch Dev Biol 196: 69-77
    • (1987) Rouxs Arch Dev Biol , vol.196 , pp. 69-77
    • Bodmer, R.1    Jan, Y.N.2
  • 4
    • 0344630216 scopus 로고    scopus 로고
    • Time-restricted role for dendritic activation of the mTOR-p70S6K pathway in the induction of late-phase long-term potentiation in the CA1
    • Cammalleri M, Lutjens R, Berton F, King AR, Simpson C, Francesconi W, Sanna PP (2003) Time-restricted role for dendritic activation of the mTOR-p70S6K pathway in the induction of late-phase long-term potentiation in the CA1. Proc Natl Acad Sci USA 100: 14368-14373
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 14368-14373
    • Cammalleri, M.1    Lutjens, R.2    Berton, F.3    King, A.R.4    Simpson, C.5    Francesconi, W.6    Sanna, P.P.7
  • 5
    • 5144222766 scopus 로고    scopus 로고
    • Control of dendritic branching and tiling by the Tricornered-Kinase/Furry signaling pathway in Drosophila sensory neurons
    • Emoto K, He Y, Ye B, Grueber WB, Adler PN, Jan LY, Jan YN (2004) Control of dendritic branching and tiling by the Tricornered-Kinase/Furry signaling pathway in Drosophila sensory neurons. Cell 119: 245-256
    • (2004) Cell , vol.119 , pp. 245-256
    • Emoto, K.1    He, Y.2    Ye, B.3    Grueber, W.B.4    Adler, P.N.5    Jan, L.Y.6    Jan, Y.N.7
  • 6
    • 33748664773 scopus 로고    scopus 로고
    • The tumour suppressor Hippo acts with the NDR kinases in dendritic tiling and maintenance
    • Emoto K, Parrish JZ, Jan LY, Jan YN (2006) The tumour suppressor Hippo acts with the NDR kinases in dendritic tiling and maintenance. Nature 443: 210-213
    • (2006) Nature , vol.443 , pp. 210-213
    • Emoto, K.1    Parrish, J.Z.2    Jan, L.Y.3    Jan, Y.N.4
  • 7
    • 37549021098 scopus 로고    scopus 로고
    • Molecular and cellular mechanisms of dendrite morphogenesis
    • Gao FB (2007) Molecular and cellular mechanisms of dendrite morphogenesis. Curr Opin Neurobiol 17: 525-532
    • (2007) Curr Opin Neurobiol , vol.17 , pp. 525-532
    • Gao, F.B.1
  • 8
    • 5144222592 scopus 로고    scopus 로고
    • Mechanosensory neurite termination and tiling depends on SAX-2 and the SAX-1 kinase
    • Gallegos ME, Bargmann CI (2004) Mechanosensory neurite termination and tiling depends on SAX-2 and the SAX-1 kinase. Neuron 44: 239-249
    • (2004) Neuron , vol.44 , pp. 239-249
    • Gallegos, M.E.1    Bargmann, C.I.2
  • 9
    • 0029056604 scopus 로고
    • Interactions between segmental homologs and between isoneuronal branches guide the formation of sensory terminal fields
    • Gan WB, Macagno ER (1995) Interactions between segmental homologs and between isoneuronal branches guide the formation of sensory terminal fields. J Neurosci 15: 3243-3253
    • (1995) J Neurosci , vol.15 , pp. 3243-3253
    • Gan, W.B.1    MacAgno, E.R.2
  • 10
    • 0035914551 scopus 로고    scopus 로고
    • Tiling of the body wall by multidendritic sensory neurons in Manduca sexta
    • Grueber WB, Graubard K, Truman JW (2001) Tiling of the body wall by multidendritic sensory neurons in Manduca sexta. J Comp Neurol 440: 271-283
    • (2001) J Comp Neurol , vol.440 , pp. 271-283
    • Grueber, W.B.1    Graubard, K.2    Truman, J.W.3
  • 11
    • 0037447261 scopus 로고    scopus 로고
    • Dendrites of distinct classes of Drosophila sensory neurons show different capacities for homotypic repulsion
    • Grueber WB, Ye B, Moore A, Jan LY, Jan YN (2003) Dendrites of distinct classes of Drosophila sensory neurons show different capacities for homotypic repulsion. Curr Biol 13: 618-626
    • (2003) Curr Biol , vol.13 , pp. 618-626
    • Grueber, W.B.1    Ye, B.2    Moore, A.3    Jan, L.Y.4    Jan, Y.N.5
  • 12
    • 24344474135 scopus 로고    scopus 로고
    • Human NDR kinases are rapidly activated by MOB proteins through recruitment to plasma membrane and phosphorylation
    • Hergovich A, Bichsel SJ, Hemmings BA (2005) Human NDR kinases are rapidly activated by MOB proteins through recruitment to plasma membrane and phosphorylation. Mol Cell Biol 25: 8259-8272
    • (2005) Mol Cell Biol , vol.25 , pp. 8259-8272
    • Hergovich, A.1    Bichsel, S.J.2    Hemmings, B.A.3
  • 14
    • 33947330747 scopus 로고    scopus 로고
    • Re-evaluating AKT regulation: Role of TOR complex 2 in tissue growth
    • Hietakangas V, Cohen SM (2007) Re-evaluating AKT regulation: role of TOR complex 2 in tissue growth. Genes Dev 21: 632-637
    • (2007) Genes Dev , vol.21 , pp. 632-637
    • Hietakangas, V.1    Cohen, S.M.2
  • 15
    • 47549115586 scopus 로고    scopus 로고
    • Threonine 74 of MOB1 is a putative key phosphorylation site by MST2 to form the scaffold to activate nuclear Dbf2-related kinase 1
    • Hirabayashi S, Nakagawa K, Sumita K, Hidaka S, Kawai T, Ikeda M, Kawata A, Ohno K, Hata Y (2008) Threonine 74 of MOB1 is a putative key phosphorylation site by MST2 to form the scaffold to activate nuclear Dbf2-related kinase 1. Oncogene 27: 4281-4292
    • (2008) Oncogene , vol.27 , pp. 4281-4292
    • Hirabayashi, S.1    Nakagawa, K.2    Sumita, K.3    Hidaka, S.4    Kawai, T.5    Ikeda, M.6    Kawata, A.7    Ohno, K.8    Hata, Y.9
  • 16
    • 3242724040 scopus 로고    scopus 로고
    • Activation of the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin signaling pathway is required for metabotropic glutamate receptor-dependent long-term depression
    • Hou L, Klann E (2004) Activation of the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin signaling pathway is required for metabotropic glutamate receptor-dependent long-term depression. J Neurosci 24: 6352-6361
    • (2004) J Neurosci , vol.24 , pp. 6352-6361
    • Hou, L.1    Klann, E.2
  • 17
    • 28844434558 scopus 로고    scopus 로고
    • MTOR. RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes
    • Hresko RC, Mueckler M (2005) mTOR. RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes. J Biol Chem 208: 40406-40416
    • (2005) J Biol Chem , vol.208 , pp. 40406-40416
    • Hresko, R.C.1    Mueckler, M.2
  • 18
    • 33749076673 scopus 로고    scopus 로고
    • SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity
    • Jacinto E, Facchinetti V, Liu D, Soto N, Wei S, Jung SY, Huamg Q, Qin J, Su B (2006) SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity. Cell 127: 125-137
    • (2006) Cell , vol.127 , pp. 125-137
    • Jacinto, E.1    Facchinetti, V.2    Liu, D.3    Soto, N.4    Wei, S.5    Jung, S.Y.6    Huamg, Q.7    Qin, J.8    Su, B.9
  • 20
    • 0141918787 scopus 로고    scopus 로고
    • The control of dendrite development
    • Jan YN, Jan LY (2003) The control of dendrite development. Neuron 40: 229-242
    • (2003) Neuron , vol.40 , pp. 229-242
    • Jan, Y.N.1    Jan, L.Y.2
  • 21
    • 33847038824 scopus 로고    scopus 로고
    • The growing role of mTOR in neuronal development and plasticity
    • Jaworski J, Sheng M (2006) The growing role of mTOR in neuronal development and plasticity. Mol Neurobiol 34: 205-219
    • (2006) Mol Neurobiol , vol.34 , pp. 205-219
    • Jaworski, J.1    Sheng, M.2
  • 24
    • 32644480629 scopus 로고    scopus 로고
    • The role of the phosphatidylinositol 3-kinase protein kinase B pathway in schizophrenia
    • Kalkman HO (2006) The role of the phosphatidylinositol 3-kinase protein kinase B pathway in schizophrenia. Pharmacol Ther 11 0: 117-134
    • (2006) Pharmacol Ther , vol.11 , Issue.0 , pp. 117-134
    • Kalkman, H.O.1
  • 25
    • 31944434543 scopus 로고    scopus 로고
    • TOR-mediated cell-cycle activation causes neuro-degeneration in a Drosophila tauopathy model
    • Khurana V, Lu Y, Steinhilb ML, Oldham S, Shulman JM, Feany MB (2006) TOR-mediated cell-cycle activation causes neuro-degeneration in a Drosophila tauopathy model. Curr Biol 16: 230-241
    • (2006) Curr Biol , vol.16 , pp. 230-241
    • Khurana, V.1    Lu, Y.2    Steinhilb, M.L.3    Oldham, S.4    Shulman, J.M.5    Feany, M.B.6
  • 27
    • 0242268407 scopus 로고    scopus 로고
    • MTor is required for hypertrophy of Pten-deficient neuronal soma in vivo
    • Kwon CH, Zhu X, Zhang J, Baker SJ (2003) mTor is required for hypertrophy of Pten-deficient neuronal soma in vivo. Proc Natl Acad Sci USA 100: 12923-12928
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 12923-12928
    • Kwon, C.H.1    Zhu, X.2    Zhang, J.3    Baker, S.J.4
  • 28
    • 0032849043 scopus 로고    scopus 로고
    • A novel Ras-interacting protein required for chemotaxis and cyclic adenosine mono-phosphate signal relay in Dictyostelium
    • Lee S, Parent CA, Insall R, Firtel RA (1999) A novel Ras-interacting protein required for chemotaxis and cyclic adenosine mono-phosphate signal relay in Dictyostelium. Mol Biol Cell 10: 2829-2845
    • (1999) Mol Biol Cell , vol.10 , pp. 2829-2845
    • Lee, S.1    Parent, C.A.2    Insall, R.3    Firtel, R.A.4
  • 29
    • 72449183499 scopus 로고    scopus 로고
    • Mosaic analysis with a repressible cell marker for studies of gene function in neuronal morphogenesis
    • Lee T, Luo L (1999) Mosaic analysis with a repressible cell marker for studies of gene function in neuronal morphogenesis. Neuron 25: 307-316
    • (1999) Neuron , vol.25 , pp. 307-316
    • Lee, T.1    Luo, L.2
  • 30
    • 0035912822 scopus 로고    scopus 로고
    • Protein kinase Cdc15 activates the Dbf2-Mob1 kinase complex
    • Mah AS, Jang J, Deshaies RJ (2001) Protein kinase Cdc15 activates the Dbf2-Mob1 kinase complex. Proc Natl Acad Sci USA 98: 7325-7330
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 7325-7330
    • Mah, A.S.1    Jang, J.2    Deshaies, R.J.3
  • 31
    • 33750142818 scopus 로고    scopus 로고
    • Sin1 binds to both ATF-2 and p38 and enhances ATF-2-dependent transcription in an SAPK signaling pathway
    • Makino C, Sano Y, Shinagawa T, Miller JBA, Ishii S (2006) Sin1 binds to both ATF-2 and p38 and enhances ATF-2-dependent transcription in an SAPK signaling pathway. Genes Cells 11: 1239-1251
    • (2006) Genes Cells , vol.11 , pp. 1239-1251
    • Makino, C.1    Sano, Y.2    Shinagawa, T.3    Miller, J.B.A.4    Ishii, S.5
  • 32
    • 0033607636 scopus 로고    scopus 로고
    • Ndr protein kinase is regulated by phosphorylation on two conserved sequence motifs
    • Millward TA, Hess D, Hemmings BA (1999) Ndr protein kinase is regulated by phosphorylation on two conserved sequence motifs. J Biol Chem 274: 33847-33850
    • (1999) J Biol Chem , vol.274 , pp. 33847-33850
    • Millward, T.A.1    Hess, D.2    Hemmings, B.A.3
  • 33
    • 3242794878 scopus 로고    scopus 로고
    • Regulation of the MST1 kinase by autophosphorylation, by the growth inhibitory proteins, RASSF1 and NORE1, and by Ras
    • Praskova M, Khoklatchev A, Ortiz-Vega S, Avruch J (2004) Regulation of the MST1 kinase by autophosphorylation, by the growth inhibitory proteins, RASSF1 and NORE1, and by Ras. Biochem J 381: 453-462
    • (2004) Biochem J , vol.381 , pp. 453-462
    • Praskova, M.1    Khoklatchev, A.2    Ortiz-Vega, S.3    Avruch, J.4
  • 34
    • 40149111984 scopus 로고    scopus 로고
    • MOBKL1A/MOBKL1B phospho-rylation by MST1 and MST2 inhibits cell proliferation
    • Praskova M, Xia F, Avruch J (2008) MOBKL1A/MOBKL1B phospho-rylation by MST1 and MST2 inhibits cell proliferation. Curr Biol 18: 311-321
    • (2008) Curr Biol , vol.18 , pp. 311-321
    • Praskova, M.1    Xia, F.2    Avruch, J.3
  • 35
    • 34547674622 scopus 로고    scopus 로고
    • Mechanisms that regulate establishment, maintenance, and remodeling of dendritic fields
    • Parrish JZ, Emoto K, Kim MD, Jan YN (2007) Mechanisms that regulate establishment, maintenance, and remodeling of dendritic fields. Annu Rev Neurosci 30: 399-424
    • (2007) Annu Rev Neurosci , vol.30 , pp. 399-424
    • Parrish, J.Z.1    Emoto, K.2    Kim, M.D.3    Jan, Y.N.4
  • 36
    • 33749639034 scopus 로고    scopus 로고
    • Activity-and mTOR-dependent suppression of Kv1-1 channel mRNA translation in dendrites
    • Raab-Graham KF, Haddick PC, Jan YN, Jan LY (2006) Activity-and mTOR-dependent suppression of Kv1-1 channel mRNA translation in dendrites. Science 314: 144-148
    • (2006) Science , vol.314 , pp. 144-148
    • Raab-Graham, K.F.1    Haddick, P.C.2    Jan, Y.N.3    Jan, L.Y.4
  • 39
    • 0141433278 scopus 로고    scopus 로고
    • Molecular requirements for actin-based lamella formation in Drosophila S2 cells
    • Rogers SL, Weidemann U, Stuurman N, Vale RD (2003) Molecular requirements for actin-based lamella formation in Drosophila S2 cells. J Cell Biol 162: 1079-1088
    • (2003) J Cell Biol , vol.162 , pp. 1079-1088
    • Rogers, S.L.1    Weidemann, U.2    Stuurman, N.3    Vale, R.D.4
  • 40
    • 3342895823 scopus 로고    scopus 로고
    • Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and Raptor-independent pathway that regulates the cytoskeleton
    • Sarbassov DD, Ali SM, Kim DH, Guertin DA, Latek RR, Erdjument-Bromage H, Tempst P, Sabatini DM (2004) Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and Raptor-independent pathway that regulates the cytoskeleton. Curr Biol 14: 1296-1302
    • (2004) Curr Biol , vol.14 , pp. 1296-1302
    • Sarbassov, D.D.1    Ali, S.M.2    Kim, D.H.3    Guertin, D.A.4    Latek, R.R.5    Erdjument-Bromage, H.6    Tempst, P.7    Sabatini, D.M.8
  • 42
    • 13844312400 scopus 로고    scopus 로고
    • Phospho-rylation and regulation of Akt/PKB by the Rictor-mTOR complex
    • Sarbassov DD, Guertin DA, Ali SM, Sabatini DM (2005b) Phospho-rylation and regulation of Akt/PKB by the Rictor-mTOR complex. Science 307: 1098-1101
    • (2005) Science , vol.307 , pp. 1098-1101
    • Sarbassov, D.D.1    Guertin, D.A.2    Ali, S.M.3    Sabatini, D.M.4
  • 44
    • 0030479340 scopus 로고    scopus 로고
    • TOR2 is required for organization of the actin cytoskeleton in yeast
    • Schmidt A, Kunz J, Hall MN (1996) TOR2 is required for organization of the actin cytoskeleton in yeast. Proc Natl Acad Sci USA 93: 13780-13785
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 13780-13785
    • Schmidt, A.1    Kunz, J.2    Hall, M.N.3
  • 45
    • 0030906569 scopus 로고    scopus 로고
    • The yeast phos-phatidylinositol kinase homolog TOR2 activates RHO1 and RHO2 via the exchange factor ROM2
    • Schmidt A, Bickle M, Beck T, Hall MN (1997) The yeast phos-phatidylinositol kinase homolog TOR2 activates RHO1 and RHO2 via the exchange factor ROM2. Cell 88: 531-542
    • (1997) Cell , vol.88 , pp. 531-542
    • Schmidt, A.1    Bickle, M.2    Beck, T.3    Hall, M.N.4
  • 46
    • 13844294205 scopus 로고    scopus 로고
    • The human stress-activated kinase interacting gene 1 encodes JNK-binding proteins
    • Schroder W, Bushell G, Sculley T (2005) The human stress-activated kinase interacting gene 1 encodes JNK-binding proteins. Cell Signal 17: 761-767
    • (2005) Cell Signal , vol.17 , pp. 761-767
    • Schroder, W.1    Bushell, G.2    Sculley, T.3
  • 48
    • 33748334318 scopus 로고    scopus 로고
    • The STE20/ germinal center kinase POD6 interacts with the NDR kinase COT1 and is involved in polar tip extension in Neurospora crassa
    • Seiler AE, Buesen R, Visan A, Spielmann H (2006) The STE20/ germinal center kinase POD6 interacts with the NDR kinase COT1 and is involved in polar tip extension in Neurospora crassa. Mol Biol Cell 17: 4080-4092
    • (2006) Mol Biol Cell , vol.17 , pp. 4080-4092
    • Seiler, A.E.1    Buesen, R.2    Visan, A.3    Spielmann, H.4
  • 49
    • 0033595679 scopus 로고    scopus 로고
    • Contact-dependent inhibition of cortical neurite growth mediated by Notch signaling
    • Sestan N, Artavanis-Tsakonas S, Rakic P (1999) Contact-dependent inhibition of cortical neurite growth mediated by Notch signaling. Science 286: 741-746
    • (1999) Science , vol.286 , pp. 741-746
    • Sestan, N.1    Artavanis-Tsakonas, S.2    Rakic, P.3
  • 50
    • 33748950810 scopus 로고    scopus 로고
    • Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability
    • Shiota C, Woo JT, Lindner J, Shelton KD, Magnuson MA (2006) Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability. Dev Cell 11: 583-589
    • (2006) Dev Cell , vol.11 , pp. 583-589
    • Shiota, C.1    Woo, J.T.2    Lindner, J.3    Shelton, K.D.4    Magnuson, M.A.5
  • 51
    • 28544435761 scopus 로고    scopus 로고
    • Regulation of NDR protein kinase by hydrophobic motif phosphorylation mediated by the mammalian Ste20-like kinase MST3
    • Stegert MR, Hergovich A, Tamaskovic R, Bichsel SJ, Hemmings BA (2005) Regulation of NDR protein kinase by hydrophobic motif phosphorylation mediated by the mammalian Ste20-like kinase MST3. Mol Cell Biol 25: 11019-11029
    • (2005) Mol Cell Biol , vol.25 , pp. 11019-11029
    • Stegert, M.R.1    Hergovich, A.2    Tamaskovic, R.3    Bichsel, S.J.4    Hemmings, B.A.5
  • 52
    • 0037086001 scopus 로고    scopus 로고
    • Living with lethal PIP3 levels: Viability of flies lacking PTEN restored by a PH domain mutation in Akt/PKB
    • Stocker H, Andjelkovic M, Oldham S, Laffargue M, Wymann MP, Hemmings BA, Hafen E (2002) Living with lethal PIP3 levels: viability of flies lacking PTEN restored by a PH domain mutation in Akt/PKB. Science 295: 2088-2091
    • (2002) Science , vol.295 , pp. 2088-2091
    • Stocker, H.1    Andjelkovic, M.2    Oldham, S.3    Laffargue, M.4    Wymann, M.P.5    Hemmings, B.A.6    Hafen, E.7
  • 53
    • 0037531200 scopus 로고    scopus 로고
    • Distinct developmental modes and lesion-induced reactions of dendrites of two classes of Drosophila sensory neurons
    • Sugimura K, Yamamoto M, Niwa R, Satoh D, Goto S, Taniguchi M, Hayashi S, Uemura T (2003) Distinct developmental modes and lesion-induced reactions of dendrites of two classes of Drosophila sensory neurons. J Neurosci 23: 3752-3760
    • (2003) J Neurosci , vol.23 , pp. 3752-3760
    • Sugimura, K.1    Yamamoto, M.2    Niwa, R.3    Satoh, D.4    Goto, S.5    Taniguchi, M.6    Hayashi, S.7    Uemura, T.8
  • 54
    • 7744224557 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor induces mammalian target of rapamycin-dependent local activation of translation machinery and protein synthesis in neuron dendrites
    • Takei N, Inamura N, Kawamura M, Namba H, Hara K, Yonezawa K, Niwa H (2004) Brain-derived neurotrophic factor induces mammalian target of rapamycin-dependent local activation of translation machinery and protein synthesis in neuron dendrites. J Neurosci 24: 9760-9769
    • (2004) J Neurosci , vol.24 , pp. 9760-9769
    • Takei, N.1    Inamura, N.2    Kawamura, M.3    Namba, H.4    Hara, K.5    Yonezawa, K.6    Niwa, H.7
  • 56
    • 0037039358 scopus 로고    scopus 로고
    • A rapamycin-sensitive signaling pathway contributes to long-term synaptic plasticity in the hippocampus
    • Tang SJ, Reis G, Kang H, Gingras AC, Sonenberg N, Schuman EM (2002) A rapamycin-sensitive signaling pathway contributes to long-term synaptic plasticity in the hippocampus. Proc Natl Acad Sci USA 99: 467-472
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 467-472
    • Tang, S.J.1    Reis, G.2    Kang, H.3    Gingras, A.C.4    Sonenberg, N.5    Schuman, E.M.6
  • 58
    • 0025822368 scopus 로고
    • Functional architecture of the mammalian retina
    • Wassle H, Boycott BB (1991) Functional architecture of the mammalian retina. Physiol Rev 71: 447-480
    • (1991) Physiol Rev , vol.71 , pp. 447-480
    • Wassle, H.1    Boycott, B.B.2
  • 59
    • 34247182696 scopus 로고    scopus 로고
    • Mob as tumor suppressor is activated by Hippo kinase for growth inhibition in Drosophila
    • Wei X, Shimizu T, Lai ZC (2007) Mob as tumor suppressor is activated by Hippo kinase for growth inhibition in Drosophila. EMBO J 26: 1772-1781
    • (2007) EMBO J , vol.26 , pp. 1772-1781
    • Wei, X.1    Shimizu, T.2    Lai, Z.C.3
  • 61
    • 32044465506 scopus 로고    scopus 로고
    • TOR signaling in growth and metabolism
    • Wullschleger S, Loewith R, Hall MN (2006) TOR signaling in growth and metabolism. Cell 124: 471-484
    • (2006) Cell , vol.124 , pp. 471-484
    • Wullschleger, S.1    Loewith, R.2    Hall, M.N.3
  • 62
    • 33751079895 scopus 로고    scopus 로고
    • Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity
    • Yang Q, Inoki K, Ikenoue T, Guan KL (2008) Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity. Genes Dev 20: 2820-2832
    • (2008) Genes Dev , vol.20 , pp. 2820-2832
    • Yang, Q.1    Inoki, K.2    Ikenoue, T.3    Guan, K.L.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.