Macrophage colony stimulatory factor and interferon-γ trigger distinct mechanisms for augmentation of β-amyloid-induced microglia-mediated neurotoxicity

Journal of Neurochemistry

Volumn 91, Issue 3, 2004, Pages 623-633

  Li, M ^a   Pisalyaput, K ^a   Galvan, M ^a   Tenner, A J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

amyloid; Alzheimer's disease; Free radicals; MCSF; Microglia; Neurotoxicity

Indexed keywords

AMYLOID BETA PROTEIN; APOCYNIN; COLONY STIMULATING FACTOR 1; COLONY STIMULATING FACTOR RECEPTOR; GAMMA INTERFERON; N 5 (1 IMINOETHYL)ORNITHINE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN; CONTROLLED STUDY; CYTOKINE PRODUCTION; EMBRYO; MICROGLIA; NEUROPATHOLOGY; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

AMYLOID BETA-PROTEIN; ANIMALS; CELLS, CULTURED; COCULTURE TECHNIQUES; CYTOKINES; DRUG SYNERGISM; HUMANS; INTERFERON TYPE II; MACROPHAGE COLONY-STIMULATING FACTOR; MICROGLIA; NEURONS; NITRIC OXIDE; PEPTIDE FRAGMENTS; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 7244257823     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2004.02765.x     Document Type: Article

References (62)

1. Afagh A., Cummings B. J., Cribbs D. H., Cotman C. W. and Tenner A. J. (1996) Localization and cell association of C1q in Alzheimer's disease brain. Exp. Neurol. 138, 22-32.
2. Akiyama H., Nishimura T., Kondo H., Ikeda K., Hayashi Y. and McGeer P. L. (1994) Expression of the receptor for macrophage-colony-stimulating factor by brain microglia and its up-regulation in brains of patients with Alzheimers-disease and amyotrophic-lateral-sclerosis. Brain Res. 639, 171-174.
3. Akiyama H., Barger S., Barnum S. et al. (2000) Inflammation and Alzheimer's disease. Neurobiol. Aging 21, 383-421.
4. Atwood C. S., Martins R. N., Smith M. A. and Perry G. (2002) Senile plaque composition and posttranslational modification of amyloid-beta peptide and associated proteins. Peptides 23, 1343-1350.
5. Benveniste E. N., Nguyen V. T. and O'Keefe G. M. (2001) Immunological aspects of microglia: relevance to Alzheimer's disease. Neurochem. Int. 39, 381-391.
6. Benzing W. C., Wujek J. R., Ward E. K., Shaffer D., Ashe K. H., Younkin S. G. and Brunden K. R. (1999) Evidence for glial-mediated inflammation in aged APP (SW) transgenic mice. Neurobiol. Aging 20, 581-589.
7. Chen Y., Vartiainen N. E., Ying W., Chan P. H., Koistinaho J. and Swanson R. A. (2001) Astrocytes protect neurons from nitric oxide toxicity by a glutathione-dependent mechanism. J. Neurochem. 77, 1601-1610.
8. Chung H., Brazil M. I., Soe T. T. and Maxfield F. R. (1999) Uptake, degregation and release of fibrillar and soluble forms of Alzheimers amyloid β-peptide by microglial cells. J. Biol. Chem. 274, 32 301-32 308.
9. Combs C. K., Johnson D. E., Karlo J. C., Cannady S. B. and Landreth G. E. (2000) Inflammatory mechanisms in Alzheimer's disease: inhibition of beta-amyloid-stimulated proinflammatory responses and neurotoxicity by PPARgamma agonists. J. Neurosci. 20, 558-567.
10. Cotman C. W., Tenner A. J. and Cummings B. J. (1996) β-Amyloid converts an acute phase injury response to chronic injury responses. Neurobiol. Aging 17, 723-731.
11. Cribbs D. H., Velazquez P., Soreghan B., Glabe C. G. and Tenner A. J. (1997) Complement activation by cross-linked truncated and chimeric full-length β-amyloid. Neuroreport 8, 3457-3462.
12. Cummings B. J. and Cotman C. W. (1995) Image analysis of beta-amyloid 'load' in Alzheimer's disease and relation to dementia severity. Lancet 346, 1524-1528.
13. Desai G., Nassar F., Brummer E. and Stevens D. A. (1995) Killing of Histoplasma capsulatum by macrophage colony stimulating factor-treated human monocyte-derived macrophages: role for reactive oxygen intermediates. J. Med. Microbiol. 43, 224-229.
14. Du Yan S., Zhu H., Fu J., Yan S. F., Roher A., Tourtellotte W. W., Rajavashisth T., Chen X., Godman G. C., Stern D. and Schmidt A. M. (1997) Amyloid-beta peptide-receptor for advanced glycation endproduct interaction elicits neuronal expression of macrophage-colony stimulating factor: a proinflammatory pathway in Alzheimer disease. Proc. Natl Acad. Sci. USA 94, 5296-5301.
15. Gallo P., De Rossi A., Sivieri S., Chieco-Bianchi L. and Tavolato B. (1994) M-CSF production by HTV-1-infected monocytes and its intrathecal synthesis implications for neurological HIV-1-related disease. J. Neuroimmunol. 51, 193-198.
16. Ganter S., Northoff H., Mannel D. and Gebicke-Harter P. J. (1992) Growth control of cultured microglia. J. Neurosci. Res. 33, 218-230.
17. Giulian D., Haverkamp L. J., Yu J. H., Karshin W., Tom D., Li J., Kirkpatrick J., Kuo L. M. and Roher A. E. (1996) Specific domains of beta-amyloid from Alzheimer plaque elicit neuron killing in human microglia. J. Neurosci. 16, 6021-6037.
18. Goodwin J. L., Uemura E. and Cunnick J. E. (1995) Microglial release of nitric oxide by the synergistic action of beta-amyloid and IFN-gamma. Brain Res. 692, 207-214.
19. Griffin W. S. and Mrak R. E. (2002) Interleukin-1 in the genesis and progression of and risk for development of neuronal degeneration in Alzheimer's disease. J. Leukoc. Biol. 72, 233-238.
20. Hardy J. and Selkoe D. J. (2002) The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 297, 353-356.
21. Mickey W. F. and Kimura H. (1988) Perivascular microglial cells of the CNS are bone marrow-derived and present antigen in vivo. Science 239, 290-292.
22. Imai Y. and Kohsaka S. (2002) Intracellular signaling in M-CSF-induced microglia activation: role of Iba1. Glia 40, 164-174.
23. Ishii K., Muelhauser F., Liebl U. et al. (2000) Subacute NO generation induced by Alzheimer's beta-amyloid in the living brain: reversal by inhibition of the inducible NO synthase. FASEB J. 14, 1485-1489.
24. Kayed R., Head E., Thompson J. L., McIntire T. M., Milton S. C., Cotman C. W. and Glabe C. G. (2003) Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis. Science 300, 486-489.
25. Koller H., Siebler M., Schmalenbach C. and Muller H. W. (1990) GABA and glutamate receptor development of cultured neurons from rat hippocampus, septal region, and neocortex. Synapse 5, 59-64.
26. Lawson L. J., Perry V. H., Dri P. and Gordon S. (1990) Heterogeneity in the distribution and morphology of microglia in the normal adult mouse brain. Neuroscience 39, 151-170.
27. Lee S. C., Liu W., Roth P., Dickson D. W., Berman J. W. and Brosnan C. F. (1993) Macrophage colony-stimulating factor in human fetal astrocytes and microglia: differential regulation by cytokines and lipopolysaccharide, and modulation of class II MHC on microglia. J. Immunol. 150, 594-604.
28. Lorton D., Kocsis J. M., King L., Madden K. and Brunden K. R. (1996) beta-Amyloid induces increased release of interleukin-1 beta from lipopolysaccharide-activated human monocytes. J. Neuroimmunol. 67, 21-29.
29. Lue L. F., Walker D. G., Brachova L., Beach T. G., Rogers J., Schmidt A. M., Stern D. M. and Yan S. D. (2001a) Involvement of microglial receptor for advanced glycation endproducts (RAGE) in Alzheimer's disease: identification of a cellular activation mechanism. Exp. Neurol. 171, 29-45.
30. Lue L. F., Walker D. G. and Rogers J. (2001b) Modeling microglial activation in Alzheimer's disease with human postmortem microglial cultures. Neurobiol. Aging 22, 945-956.
31. Matsuoka Y., Picciano M., Malester B., LaFrancois J., Zehr C., Daeschner J. M., Olschowka J. A., Fonseca M. I., O'Banion M. K., Tenner A. J., Lemere C. A. and Duff K. (2001) Inflammatory responses to amyloidosis in a transgenic mouse model of Alzheimer's disease. Am. J. Pathol. 158, 1345-1354.
32. McGeer P. L. and McGeer E. G. (1999) Inflammation of the brain in Alzheimer's disease: implications for therapy. J. Leuk. Biol. 65, 409-415.
33. McGeer E. G. and McGeer P. L. (2003) Inflammatory processes in Alzheimer's disease. Prog. Neuropsychopharmacol. Biol. Psychiatry 27, 741-749.
34. McGeer P. L., Akiyama H., Itagaki S. and McGeer E. G. (1989) Activation of the classical complement pathway in brain tissue of Alzheimer patients. Neurosci. Lett. 107, 341-346.
35. Meda L., Cassatella M. A., Szendrel G. I., Otvos L., Jr, Baron P., Villalba M., Ferrari D. and Rossi F. (1995) Activation of microglial cells by β-amyloid protein and interferon-gamma. Nature 374, 647-650.
36. Mitrasinovic O. M. and Murphy G. M. Jr (2002) Accelerated phagocytosis of amyloid-beta by mouse and human microglia overexpressing the macrophage colony-stimulating factor receptor. J. Biol. Chem. 277, 29 889-29 896.
37. Mitrasinovic O. M., Perez G. V., Zhao F., Lee Y. L., Poon C. and Murphy G. M. Jr (2001) Overexpression of macrophage colony-stimulating factor receptor on microglial cells induces an inflammatory response. J. Biol. Chem. 276, 30 142-30 149.
38. Mrak R. E. and Griffin W. S. (2001) Interleukin-1, neuroinflammation, and Alzheimer's disease. Neurobiol. Aging 22, 903-908.
39. Muehlhauser F., Liebl U., Kuehl S., Walter S., Bertsch T. and Fassbender K. (2001) Aggregation-dependent interaction of the Alzheimer's beta-amyloid and microglia. Clin. Chem. Lab. Med. 39, 313-316.
40. Murphy G. M., Yang L. and Cordell B. (1998) Macrophage colony-stimulating factor augments β-amyloid-induced interleukin-1, interleukin-6, and nitric oxide production by microglial cells. J. Biol. Chem. 273, 20 967-20 971.
41. Murphy G. M. Jr, Zhao F., Yang L. and Cordell B. (2000) Expression of macrophage colony-stimulating factor receptor is increased in the AbetaPP (V717F) transgenic mouse model of Alzheimer's disease. Am. J. Pathol. 157, 895-904.
42. Nassar F., Brummer E. and Stevens D. A. (1995) Macrophage colony-stimulating factor (M-CSF) induction of enhanced anticryptococcal activity in human monocyte-derived macrophages: synergy with fluconazole for killing. Cell Immunol. 164, 113-118.
43. Nohava K., Malipiero U., Frei K. and Fontana A. (1992) Neurons and neuroblastoma as a source of macrophage colony-stimulating factor. Eur. J. Immunol. 22, 2539-2545.
44. Papavasiliou A. K., Mehler M. F., Mabie P. C., Marmur R., Qingbin S., Keating R. F. and Kessler J. A. (1997) Paracrine regulation of colony-stimulating factor-1 in medulloblastoma: implications for pathogenesis and therapeutic interventions. Neurosurgery 41, 916-923.
45. Schmuck G., Ahr H. J. and Schlüter G. (2000) Rat cortical neuron cultures: an in vitro model for differentiating mechanisms of chemically induced neurotoxicity. In Vitro Mol. Toxicol. 13, 37-49.
46. Shimohama S., Tanino H., Kawakami N., Okamura N., Kodama H., Yamaguchi T., Hayakawa T., Nunomura A., Chiba S., Perry G., Smith M. A. and Fujimoto S. (2000) Activation of NADPH oxidase in Alzheimer's disease brains. Biochem. Biophys. Res. Commun. 273, 5-9.
47. Smith M. A., Richey Harris P. L., Sayre L. M., Beckman J. S. and Perry G. (1997) Widespread peroxynitrite-mediated damage in Alzheimer's disease. J. Neurosci. 17, 2653-2657.
48. Smits H. A., van Beelen A. J., de Vos N. M., van der Rijsmus A. B. T., Verhoef J., Van Muiswinkel F. L. and Nottet H. S. (2001) Activation of human macrophages by amyloid-beta is attenuated by astrocytes. J. Immunol. 166, 6869-6876.
49. Stanley E. R., Berg K. L., Einstein D. B., Lee P. S., Pixley F. J., Wang Y. and Yeung Y. G. (1997) Biology and action of colony - stimulating factor-1. Mol. Reprod. Dev. 46, 4-10.
50. Stine W. B. Jr, Dahlgren K. N., Krafft G. A. and LaDu M. J. (2003) In vitro characterization of conditions for amyloid-beta peptide oligomerization and fibrillogenesis. J. Biol. Chem. 278, 11 612-11 622.
51. Sturchler-Pierrat C., Abramowski D., Duke M. et al (1997) Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology. Proc. Natl Acad. Sci. USA 94, 13 287-13 292.
52. Suo Z. M., Tan J., Placzek A., Crawford F., Fang C. H. and Mullan M. (1998) Alzheimer's β-amyloid peptides induce inflammatory cascade in human vascular cells: the roles of cytokines and CD40. Brain Res. 807, 110-117.
53. Tabatabaie T., Vasquez A. M., Moore D. R., Floyd R. A. and Kotake Y. (2001) Direct administration of interleukin-1 and interferon-gamma to rat pancreas leads to the in vivo production of nitric oxide and expression of inducible nitric oxide synthase and inducible cyclooxygenase. Pancreas 23, 316-322.
54. Togo T., Akiyama H., Iseki E., Kondo H., Ikeda K., Kato M., Oda T., Tsuchiya K. and Kosaka K. (2002) Occurrence of T cells in the brain of Alzheimer's disease and other neurological diseases. J. Neuroimmunol. 124, 83-92.
55. Van der Goes A., Brouwer J., Hoekstra K., Roos D., Van den Berg T. K. and Dijkstra C. D. (1998) Reactive oxygen species are required for the phagocytosis of myelin by macrophages. J. Neuroimmunol. 92, 67-75.
56. Veerhuis R., Van Breemen M. J., Hoozemans J. M., Morbin M., Ouladhadj J., Tagliavini F. and Eikelenboom P. (2003) Amyloid beta plaque-associated proteins C1q and SAP enhance the Abeta (1-42) peptide-induced cytokine secretion by adult human microglia in vitro. Acta Neuropathol. (Berl.) 105, 135-144.
57. Vodovotz Y., Lucia M. S., Flanders K. C. et al. (1996) Inducible nitric oxide synthase in tangle-bearing neurons of patients with Alzheimer's disease. J. Exp. Med. 184, 1425-1433.
58. Walsh D. M., Klyubin I., Fadeeva J. V., Cullen W. K., Anwyl R., Wolfe M. S., Rowan M. J. and Selkoe D. J. (2002) Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo. Nature 416, 535-539.
59. Webster S. D., Yang A. J., Margol L., Garzon-Rodriguez W., Glabe C. G. and Tenner A. J. (2000) Complement component C1q modulates the phagocytic behavior of microglia. Exp. Neurol. 161, 127-138.
60. West M. J., Coleman P. D., Flood D. G. and Troncoso J. C. (1994) Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease. Lancet 344, 769-772.
61. Xie Z., Wei M., Morgan T. E., Fabrizio P., Han D., Finch C. E. and Longo V. D. (2002) Peroxynitrite mediates neurotoxicity of amyloid beta-peptide1-42- and lipopolysaccharide-activated microglia. J. Neurosci. 22, 3484-3492.
62. Yankner B. A. (1996) Mechanisms of neuronal degeneration in Alzheimer's disease. Neuron 16, 921-932.