메뉴 건너뛰기




Volumn 36, Issue 12, 2009, Pages 1139-1143

Peroxisome proliferator-activated receptor-γ coactivator-1α in muscle links metabolism to inflammation

Author keywords

Exercise; Inflammation; Metabolism; Muscle; Peroxisome proliferator activated receptor coactivator 1 (PGC 1 )

Indexed keywords

INTERLEUKIN 6; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; TUMOR NECROSIS FACTOR ALPHA;

EID: 72149099919     PISSN: 03051870     EISSN: 14401681     Source Type: Journal    
DOI: 10.1111/j.1440-1681.2009.05275.x     Document Type: Review
Times cited : (34)

References (66)
  • 2
    • 56749164791 scopus 로고    scopus 로고
    • Nutrient sensing and inflammation in metabolic diseases
    • Hotamisligil GS, Erbay E. Nutrient sensing and inflammation in metabolic diseases. Nat. Rev. Immunol. 2008 8 : 923 934.
    • (2008) Nat. Rev. Immunol. , vol.8 , pp. 923-934
    • Hotamisligil, G.S.1    Erbay, E.2
  • 3
    • 33744547493 scopus 로고    scopus 로고
    • Energy cost of infection burden. An approach to understanding the dynamics of host-pathogen interactions
    • Romanyukha AA, Rudnev SG, Sidorov IA. Energy cost of infection burden. An approach to understanding the dynamics of host-pathogen interactions. J. Theor. Biol. 2006 241 : 1 13.
    • (2006) J. Theor. Biol. , vol.241 , pp. 1-13
    • Romanyukha, A.A.1    Rudnev, S.G.2    Sidorov, I.A.3
  • 4
    • 33845866857 scopus 로고    scopus 로고
    • Inflammation and metabolic disorders
    • Hotamisligil GS. Inflammation and metabolic disorders. Nature 2006 444 : 860 867.
    • (2006) Nature , vol.444 , pp. 860-867
    • Hotamisligil, G.S.1
  • 6
    • 33846422032 scopus 로고    scopus 로고
    • Obesity and diabetes in the developing world: A growing challenge
    • Hossain P, Kawar B, El NahasM. Obesity and diabetes in the developing world: A growing challenge. N. Engl. J. Med. 2007 356 : 213 215.
    • (2007) N. Engl. J. Med. , vol.356 , pp. 213-215
    • Hossain, P.1    Kawar, B.2    El, N.M.3
  • 7
    • 34247857663 scopus 로고    scopus 로고
    • Obesity, inflammation, and insulin resistance
    • Shoelson SE, Herrero L, Naaz A. Obesity, inflammation, and insulin resistance. Gastroenterology 2007 132 : 2169 2180.
    • (2007) Gastroenterology , vol.132 , pp. 2169-2180
    • Shoelson, S.E.1    Herrero, L.2    Naaz, A.3
  • 8
    • 35348874911 scopus 로고    scopus 로고
    • Developmental origin of fat: Tracking obesity to its source
    • Gesta S, Tseng YH, Kahn CR. Developmental origin of fat: Tracking obesity to its source. Cell 2007 131 : 242 256.
    • (2007) Cell , vol.131 , pp. 242-256
    • Gesta, S.1    Tseng, Y.H.2    Kahn, C.R.3
  • 9
    • 33947430960 scopus 로고    scopus 로고
    • Endocrine functions of adipose tissue
    • Waki H, Tontonoz P. Endocrine functions of adipose tissue. Annu. Rev. Pathol. 2007 2 : 31 56.
    • (2007) Annu. Rev. Pathol. , vol.2 , pp. 31-56
    • Waki, H.1    Tontonoz, P.2
  • 10
    • 33845592201 scopus 로고    scopus 로고
    • Adipose tissue-derived factors: Impact on health and disease
    • Trujillo ME, Scherer PE. Adipose tissue-derived factors: Impact on health and disease. Endocr. Rev. 2006 27 : 762 778.
    • (2006) Endocr. Rev. , vol.27 , pp. 762-778
    • Trujillo, M.E.1    Scherer, P.E.2
  • 11
    • 33748992313 scopus 로고    scopus 로고
    • Adipocytokines: Mediators linking adipose tissue, inflammation and immunity
    • Tilg H, Moschen AR. Adipocytokines: Mediators linking adipose tissue, inflammation and immunity. Nat. Rev. Immunol. 2006 6 : 772 783.
    • (2006) Nat. Rev. Immunol. , vol.6 , pp. 772-783
    • Tilg, H.1    Moschen, A.R.2
  • 12
    • 0027459878 scopus 로고
    • Adipose expression of tumor necrosis factor-α: Direct role in obesity-linked insulin resistance
    • Hotamisligil GS, Shargill NS, Spiegelman BM. Adipose expression of tumor necrosis factor-α: Direct role in obesity-linked insulin resistance. Science 1993 259 : 87 91.
    • (1993) Science , vol.259 , pp. 87-91
    • Hotamisligil, G.S.1    Shargill, N.S.2    Spiegelman, B.M.3
  • 13
    • 33646572904 scopus 로고    scopus 로고
    • The metabolic syndrome and adipocytokines
    • Matsuzawa Y. The metabolic syndrome and adipocytokines. FEBS Lett. 2006 580 : 2917 2921.
    • (2006) FEBS Lett. , vol.580 , pp. 2917-2921
    • Matsuzawa, Y.1
  • 14
    • 0030028606 scopus 로고    scopus 로고
    • The expression of TNFα by human muscle. Relationship to insulin resistance
    • Saghizadeh M, Ong JM, Garvey WT, Henry RR, Kern PA. The expression of TNFα by human muscle. Relationship to insulin resistance. J. Clin. Invest. 1996 97 : 1111 1116.
    • (1996) J. Clin. Invest. , vol.97 , pp. 1111-1116
    • Saghizadeh, M.1    Ong, J.M.2    Garvey, W.T.3    Henry, R.R.4    Kern, P.A.5
  • 15
    • 34548824200 scopus 로고    scopus 로고
    • Molecular mechanisms of skeletal muscle insulin resistance in Type 2 diabetes
    • Bouzakri K, Koistinen HA, Zierath JR. Molecular mechanisms of skeletal muscle insulin resistance in Type 2 diabetes. Curr. Diab. Rev. 2005 1 : 167 174.
    • (2005) Curr. Diab. Rev. , vol.1 , pp. 167-174
    • Bouzakri, K.1    Koistinen, H.A.2    Zierath, J.R.3
  • 16
    • 33644846005 scopus 로고    scopus 로고
    • Skeletal muscle lipid metabolism in exercise and insulin resistance
    • Kiens B. Skeletal muscle lipid metabolism in exercise and insulin resistance. Physiol. Rev. 2006 86 : 205 243.
    • (2006) Physiol. Rev. , vol.86 , pp. 205-243
    • Kiens, B.1
  • 17
    • 0035985859 scopus 로고    scopus 로고
    • Waging war on physical inactivity: Using modern molecular ammunition against an ancient enemy
    • Booth FW, Chakravarthy MV, Gordon SE, Spangenburg EE. Waging war on physical inactivity: Using modern molecular ammunition against an ancient enemy. J. Appl. Physiol. 2002 93 : 3 30.
    • (2002) J. Appl. Physiol. , vol.93 , pp. 3-30
    • Booth, F.W.1    Chakravarthy, M.V.2    Gordon, S.E.3    Spangenburg, E.E.4
  • 19
    • 0037034257 scopus 로고    scopus 로고
    • Reduction in the incidence of Type 2 diabetes with lifestyle intervention or metformin
    • Knowler WC, Barrett-Connor E, Fowler SE et al. Reduction in the incidence of Type 2 diabetes with lifestyle intervention or metformin. N. Engl. J. Med. 2002 346 : 393 403.
    • (2002) N. Engl. J. Med. , vol.346 , pp. 393-403
    • Knowler, W.C.1    Barrett-Connor, E.2    Fowler, S.E.3
  • 21
    • 22244477735 scopus 로고    scopus 로고
    • Contraction-induced myokine production and release: Is skeletal muscle an endocrine organ?
    • Febbraio MA, Pedersen BK. Contraction-induced myokine production and release: Is skeletal muscle an endocrine organ? Exerc. Sport Sci. Rev. 2005 33 : 114 119.
    • (2005) Exerc. Sport Sci. Rev. , vol.33 , pp. 114-119
    • Febbraio, M.A.1    Pedersen, B.K.2
  • 22
    • 4143148710 scopus 로고    scopus 로고
    • Interleukin-6 and insulin sensitivity: Friend or foe?
    • Carey AL, Febbraio MA. Interleukin-6 and insulin sensitivity: Friend or foe? Diabetologia 2004 47 : 1135 1142.
    • (2004) Diabetologia , vol.47 , pp. 1135-1142
    • Carey, A.L.1    Febbraio, M.A.2
  • 23
    • 33644755633 scopus 로고    scopus 로고
    • Interleukin-6 and diabetes: The good, the bad, or the indifferent?
    • Kristiansen OP, Mandrup-Poulsen T. Interleukin-6 and diabetes: The good, the bad, or the indifferent? Diabetes 2005 54 (Suppl. 2 S114 24.
    • (2005) Diabetes , vol.54 , Issue.SUPPL. 2
    • Kristiansen, O.P.1    Mandrup-Poulsen, T.2
  • 24
    • 0142187317 scopus 로고    scopus 로고
    • Searching for the exercise factor: Is IL-6 a candidate?
    • Pedersen BK, Steensberg A, Fischer C et al. Searching for the exercise factor: Is IL-6 a candidate? J. Muscle Res. Cell 2003 24 : 113 119.
    • (2003) J. Muscle Res. Cell , vol.24 , pp. 113-119
    • Pedersen, B.K.1    Steensberg, A.2    Fischer, C.3
  • 25
    • 34447619742 scopus 로고    scopus 로고
    • Exercise and inflammation
    • Febbraio MA. Exercise and inflammation. J. Appl. Physiol. 2007 103 : 376 377.
    • (2007) J. Appl. Physiol. , vol.103 , pp. 376-377
    • Febbraio, M.A.1
  • 26
    • 34547626210 scopus 로고    scopus 로고
    • Immune function in sport and exercise
    • Gleeson M. Immune function in sport and exercise. J. Appl. Physiol. 2007 103 : 693 699.
    • (2007) J. Appl. Physiol. , vol.103 , pp. 693-699
    • Gleeson, M.1
  • 27
    • 0037610288 scopus 로고    scopus 로고
    • Molecular basis of skeletal muscle plasticity: From gene to form and function
    • Flück M, Hoppeler H. Molecular basis of skeletal muscle plasticity: From gene to form and function. Rev. Physiol. Biochem. Pharmacol. 2003 146 : 159 216.
    • (2003) Rev. Physiol. Biochem. Pharmacol. , vol.146 , pp. 159-216
    • Flück, M.1    Hoppeler, H.2
  • 28
    • 0033939421 scopus 로고    scopus 로고
    • Calcium ion in skeletal muscle. Its crucial role for muscle function, plasticity, and disease
    • Berchtold MW, Brinkmeier H, Muntener M. Calcium ion in skeletal muscle. Its crucial role for muscle function, plasticity, and disease. Physiol. Rev. 2000 80 : 1215 1265.
    • (2000) Physiol. Rev. , vol.80 , pp. 1215-1265
    • Berchtold, M.W.1    Brinkmeier, H.2    Muntener, M.3
  • 29
    • 0038810035 scopus 로고    scopus 로고
    • An autoregulatory loop controls peroxisome proliferator-activated receptor γ coactivator 1α expression in muscle
    • Handschin C, Rhee J, Lin J, Tarr PT, Spiegelman BM. An autoregulatory loop controls peroxisome proliferator-activated receptor γ coactivator 1α expression in muscle. Proc. Natl Acad. Sci. USA 2003 100 : 7111 7116.
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 7111-7116
    • Handschin, C.1    Rhee, J.2    Lin, J.3    Tarr, P.T.4    Spiegelman, B.M.5
  • 30
    • 0037452677 scopus 로고    scopus 로고
    • Regulation of peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) and mitochondrial function by MEF2 and HDAC5
    • Czubryt MP, McAnally J, Fishman GI, Olson EN. Regulation of peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) and mitochondrial function by MEF2 and HDAC5. Proc. Natl Acad. Sci. USA 2003 100 : 1711 1716.
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 1711-1716
    • Czubryt, M.P.1    McAnally, J.2    Fishman, G.I.3    Olson, E.N.4
  • 31
    • 34547545892 scopus 로고    scopus 로고
    • AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1a
    • Jager S, Handschin C, St-Pierre J, Spiegelman BM. AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1a. Proc. Natl Acad. Sci. USA 2007 104 : 12017 12022.
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , pp. 12017-12022
    • Jager, S.1    Handschin, C.2    St-Pierre, J.3    Spiegelman, B.M.4
  • 32
    • 61449106744 scopus 로고    scopus 로고
    • AMPK and the biochemistry of exercise. Implications for human health and disease
    • Richter EA, Ruderman NB. AMPK and the biochemistry of exercise. Implications for human health and disease. Biochem. J. 2009 418 : 261 275.
    • (2009) Biochem. J. , vol.418 , pp. 261-275
    • Richter, E.A.1    Ruderman, N.B.2
  • 33
    • 34247259630 scopus 로고    scopus 로고
    • Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1α
    • Gerhart-Hines Z, Rodgers JT, Bare O et al. Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1α. EMBO J. 2007 26 : 1913 1923.
    • (2007) EMBO J. , vol.26 , pp. 1913-1923
    • Gerhart-Hines, Z.1    Rodgers, J.T.2    Bare, O.3
  • 34
    • 33846885684 scopus 로고    scopus 로고
    • Energy sensing and regulation of gene expression in skeletal muscle
    • Freyssenet D. Energy sensing and regulation of gene expression in skeletal muscle. J. Appl. Physiol. 2007 102 : 529 540.
    • (2007) J. Appl. Physiol. , vol.102 , pp. 529-540
    • Freyssenet, D.1
  • 36
    • 18244399631 scopus 로고    scopus 로고
    • Cytokine stimulation of energy expenditure through p38 MAP kinase activation of PPARγ coactivator-1
    • Puigserver P, Rhee J, Lin J et al. Cytokine stimulation of energy expenditure through p38 MAP kinase activation of PPARγ coactivator-1. Mol. Cell 2001 8 : 971 982.
    • (2001) Mol. Cell , vol.8 , pp. 971-982
    • Puigserver, P.1    Rhee, J.2    Lin, J.3
  • 37
    • 0347579845 scopus 로고    scopus 로고
    • Mitochondrial biogenesis in mammals: The role of endogenous nitric oxide
    • Nisoli E, Clementi E, Paolucci C et al. Mitochondrial biogenesis in mammals: The role of endogenous nitric oxide. Science 2003 299 : 896 899.
    • (2003) Science , vol.299 , pp. 896-899
    • Nisoli, E.1    Clementi, E.2    Paolucci, C.3
  • 38
    • 34347237611 scopus 로고    scopus 로고
    • An increase in murine skeletal muscle peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) mRNA in response to exercise is mediated by β-adrenergic receptor activation
    • Miura S, Kawanaka K, Kai Y et al. An increase in murine skeletal muscle peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) mRNA in response to exercise is mediated by β-adrenergic receptor activation. Endocrinology 2007 148 : 3441 3448.
    • (2007) Endocrinology , vol.148 , pp. 3441-3448
    • Miura, S.1    Kawanaka, K.2    Kai, Y.3
  • 39
    • 33751201239 scopus 로고    scopus 로고
    • The orphan nuclear receptor, NOR-1, is a target of β-adrenergic signaling in skeletal muscle
    • Pearen MA, Ryall JG, Maxwell MA, Ohkura N, Lynch GS, Muscat GE. The orphan nuclear receptor, NOR-1, is a target of β-adrenergic signaling in skeletal muscle. Endocrinology 2006 147 : 5217 5227.
    • (2006) Endocrinology , vol.147 , pp. 5217-5227
    • Pearen, M.A.1    Ryall, J.G.2    Maxwell, M.A.3    Ohkura, N.4    Lynch, G.S.5    Muscat, G.E.6
  • 40
    • 34548304285 scopus 로고    scopus 로고
    • Nur77 coordinately regulates expression of genes linked to glucose metabolism in skeletal muscle
    • Chao LC, Zhang Z, Pei L, Saito T, Tontonoz P, Pilch PF. Nur77 coordinately regulates expression of genes linked to glucose metabolism in skeletal muscle. Mol. Endocrinol. 2007 21 : 2152 2163.
    • (2007) Mol. Endocrinol. , vol.21 , pp. 2152-2163
    • Chao, L.C.1    Zhang, Z.2    Pei, L.3    Saito, T.4    Tontonoz, P.5    Pilch, P.F.6
  • 41
    • 34147109662 scopus 로고    scopus 로고
    • PGC-1α regulates the neuromuscular junction program and ameliorates Duchenne muscular dystrophy
    • Handschin C, Kobayashi YM, Chin S, Seale P, Campbell KP, Spiegelman BM. PGC-1α regulates the neuromuscular junction program and ameliorates Duchenne muscular dystrophy. Genes Dev. 2007 21 : 770 783.
    • (2007) Genes Dev. , vol.21 , pp. 770-783
    • Handschin, C.1    Kobayashi, Y.M.2    Chin, S.3    Seale, P.4    Campbell, K.P.5    Spiegelman, B.M.6
  • 42
    • 33749345519 scopus 로고    scopus 로고
    • Effects of exercise training on α-motoneurons
    • Gardiner P, Dai Y, Heckman CJ. Effects of exercise training on α-motoneurons. J. Appl. Physiol. 2006 101 : 1228 1236.
    • (2006) J. Appl. Physiol. , vol.101 , pp. 1228-1236
    • Gardiner, P.1    Dai, Y.2    Heckman, C.J.3
  • 43
    • 32344447256 scopus 로고    scopus 로고
    • Assembly of the postsynaptic membrane at the neuromuscular junction: Paradigm lost
    • Kummer TT, Misgeld T, Sanes JR. Assembly of the postsynaptic membrane at the neuromuscular junction: Paradigm lost. Curr. Opin. Neurobiol. 2006 16 : 74 82.
    • (2006) Curr. Opin. Neurobiol. , vol.16 , pp. 74-82
    • Kummer, T.T.1    Misgeld, T.2    Sanes, J.R.3
  • 44
    • 24144463983 scopus 로고    scopus 로고
    • Metabolic control through the PGC-1 family of transcription coactivators
    • Lin J, Handschin C, Spiegelman BM. Metabolic control through the PGC-1 family of transcription coactivators. Cell Metab. 2005 1 : 361 370.
    • (2005) Cell Metab. , vol.1 , pp. 361-370
    • Lin, J.1    Handschin, C.2    Spiegelman, B.M.3
  • 45
    • 33845596500 scopus 로고    scopus 로고
    • PGC-1 coactivators, energy homeostasis, and metabolism
    • Handschin C, Spiegelman BM. PGC-1 coactivators, energy homeostasis, and metabolism. Endocr. Rev. 2006 27 : 728 735.
    • (2006) Endocr. Rev. , vol.27 , pp. 728-735
    • Handschin, C.1    Spiegelman, B.M.2
  • 46
    • 0038036024 scopus 로고    scopus 로고
    • Bioenergetic analysis of peroxisome proliferator-activated receptor γ coactivators 1α and 1β (PGC-1α and PGC-1β) in muscle cells
    • St-Pierre J, Lin J, Krauss S et al. Bioenergetic analysis of peroxisome proliferator-activated receptor γ coactivators 1α and 1β (PGC-1α and PGC-1β) in muscle cells. J. Biol. Chem. 2003 278 : 26597 26603.
    • (2003) J. Biol. Chem. , vol.278 , pp. 26597-26603
    • St-Pierre, J.1    Lin, J.2    Krauss, S.3
  • 47
    • 0033977890 scopus 로고    scopus 로고
    • The coactivator PGC-1 cooperates with peroxisome proliferator-activated receptor α in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes
    • Vega RB, Huss JM, Kelly DP. The coactivator PGC-1 cooperates with peroxisome proliferator-activated receptor α in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes. Mol. Cell. Biol. 2000 20 : 1868 1876.
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 1868-1876
    • Vega, R.B.1    Huss, J.M.2    Kelly, D.P.3
  • 48
    • 2342477730 scopus 로고    scopus 로고
    • Errα and Gabpa/b specify PGC-1α-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle
    • Mootha VK, Handschin C, Arlow D et al. Errα and Gabpa/b specify PGC-1α-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle. Proc. Natl Acad. Sci. USA 2004 101 : 6570 6575.
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , pp. 6570-6575
    • Mootha, V.K.1    Handschin, C.2    Arlow, D.3
  • 49
    • 42949083922 scopus 로고    scopus 로고
    • Modest PGC-1α overexpression in muscle in vivo is sufficient to increase insulin sensitivity and palmitate oxidation in subsarcolemmal, not intermyofibrillar, mitochondria
    • Benton CR, Nickerson JG, Lally J et al. Modest PGC-1α overexpression in muscle in vivo is sufficient to increase insulin sensitivity and palmitate oxidation in subsarcolemmal, not intermyofibrillar, mitochondria. J. Biol. Chem. 2008 283 : 4228 4240.
    • (2008) J. Biol. Chem. , vol.283 , pp. 4228-4240
    • Benton, C.R.1    Nickerson, J.G.2    Lally, J.3
  • 50
    • 0037102256 scopus 로고    scopus 로고
    • Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres
    • Lin J, Wu H, Tarr PT et al. Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres. Nature 2002 418 : 797 801.
    • (2002) Nature , vol.418 , pp. 797-801
    • Lin, J.1    Wu, H.2    Tarr, P.T.3
  • 51
    • 33750825245 scopus 로고    scopus 로고
    • PGC-1α protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription
    • Sandri M, Lin J, Handschin C et al. PGC-1α protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription. Proc. Natl Acad. Sci. USA 2006 103 : 16260 16265.
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 16260-16265
    • Sandri, M.1    Lin, J.2    Handschin, C.3
  • 52
    • 37549025047 scopus 로고    scopus 로고
    • A role for the transcriptional coactivator PGC-1α in muscle refueling
    • Wende AR, Schaeffer PJ, Parker GJ et al. A role for the transcriptional coactivator PGC-1α in muscle refueling. J. Biol. Chem. 2007 282 : 36642 36651.
    • (2007) J. Biol. Chem. , vol.282 , pp. 36642-36651
    • Wende, A.R.1    Schaeffer, P.J.2    Parker, G.J.3
  • 53
    • 36849045916 scopus 로고    scopus 로고
    • The muscle-specific ubiquitin ligase atrogin-1/MAFbx mediates statin-induced muscle toxicity
    • Hanai JI, Cao P, Tanksale P et al. The muscle-specific ubiquitin ligase atrogin-1/MAFbx mediates statin-induced muscle toxicity. J. Clin. Invest. 2007 117 : 3940 3951.
    • (2007) J. Clin. Invest. , vol.117 , pp. 3940-3951
    • Hanai, J.I.1    Cao, P.2    Tanksale, P.3
  • 54
    • 50049118173 scopus 로고    scopus 로고
    • Activation of the PPAR/PGC-1α pathway prevents a bioenergetic deficit and effectively improves a mitochondrial myopathy phenotype
    • Wenz T, Diaz F, Spiegelman BM, Moraes CT. Activation of the PPAR/PGC-1α pathway prevents a bioenergetic deficit and effectively improves a mitochondrial myopathy phenotype. Cell Metab. 2008 8 : 249 256.
    • (2008) Cell Metab. , vol.8 , pp. 249-256
    • Wenz, T.1    Diaz, F.2    Spiegelman, B.M.3    Moraes, C.T.4
  • 55
    • 10744228606 scopus 로고    scopus 로고
    • Endurance training in humans leads to fiber type-specific increases in levels of peroxisome proliferator-activated receptor-γ coactivator-1 and peroxisome proliferator-activated receptor-α in skeletal muscle
    • Russell AP, Feilchenfeldt J, Schreiber S et al. Endurance training in humans leads to fiber type-specific increases in levels of peroxisome proliferator-activated receptor-γ coactivator-1 and peroxisome proliferator-activated receptor-α in skeletal muscle. Diabetes 2003 52 : 2874 2881.
    • (2003) Diabetes , vol.52 , pp. 2874-2881
    • Russell, A.P.1    Feilchenfeldt, J.2    Schreiber, S.3
  • 56
    • 0037322888 scopus 로고    scopus 로고
    • Exercise induces transient transcriptional activation of the PGC-1α gene in human skeletal muscle
    • Pilegaard H, Saltin B, Neufer PD. Exercise induces transient transcriptional activation of the PGC-1α gene in human skeletal muscle. J. Physiol. 2003 546 : 851 858.
    • (2003) J. Physiol. , vol.546 , pp. 851-858
    • Pilegaard, H.1    Saltin, B.2    Neufer, P.D.3
  • 57
    • 0038054341 scopus 로고    scopus 로고
    • PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes
    • Mootha VK, Lindgren CM, Eriksson KF et al. PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat. Genet. 2003 34 : 267 273.
    • (2003) Nat. Genet. , vol.34 , pp. 267-273
    • Mootha, V.K.1    Lindgren, C.M.2    Eriksson, K.F.3
  • 58
    • 0037477855 scopus 로고    scopus 로고
    • Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1
    • Patti ME, Butte AJ, Crunkhorn S et al. Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1. Proc. Natl Acad. Sci. USA 2003 100 : 8466 8471.
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 8466-8471
    • Patti, M.E.1    Butte, A.J.2    Crunkhorn, S.3
  • 59
    • 35648937073 scopus 로고    scopus 로고
    • Skeletal muscle fiber-type switching, exercise intolerance, and myopathy in PGC-1α muscle-specific knock-out animals
    • Handschin C, Chin S, Li P et al. Skeletal muscle fiber-type switching, exercise intolerance, and myopathy in PGC-1α muscle-specific knock-out animals. J. Biol. Chem. 2007 282 : 30014 30021.
    • (2007) J. Biol. Chem. , vol.282 , pp. 30014-30021
    • Handschin, C.1    Chin, S.2    Li, P.3
  • 60
    • 36048931015 scopus 로고    scopus 로고
    • Abnormal glucose homeostasis in skeletal muscle-specific PGC-1α knockout mice reveals skeletal muscle-pancreatic β cell crosstalk
    • Handschin C, Choi CS, Chin S et al. Abnormal glucose homeostasis in skeletal muscle-specific PGC-1α knockout mice reveals skeletal muscle-pancreatic β cell crosstalk. J. Clin. Invest. 2007 117 : 3463 3474.
    • (2007) J. Clin. Invest. , vol.117 , pp. 3463-3474
    • Handschin, C.1    Choi, C.S.2    Chin, S.3
  • 61
    • 47949104798 scopus 로고    scopus 로고
    • The role of exercise and PGC1α in inflammation and chronic disease
    • Handschin C, Spiegelman BM. The role of exercise and PGC1α in inflammation and chronic disease. Nature 2008 454 : 463 469.
    • (2008) Nature , vol.454 , pp. 463-469
    • Handschin, C.1    Spiegelman, B.M.2
  • 63
    • 5444262078 scopus 로고    scopus 로고
    • IKKb/NF-κB activation causes severe muscle wasting in mice
    • Cai D, Frantz JD, Tawa NE Jr. et al. IKKb/NF-κB activation causes severe muscle wasting in mice. Cell 2004 119 : 285 298.
    • (2004) Cell , vol.119 , pp. 285-298
    • Cai, D.1    Frantz, J.D.2    Tawa Jr., N.E.3
  • 64
    • 28844451913 scopus 로고    scopus 로고
    • Tumor necrosis factor-α gene transfer induces cachexia and inhibits muscle regeneration
    • Coletti D, Moresi V, Adamo S, Molinaro M, Sassoon D. Tumor necrosis factor-α gene transfer induces cachexia and inhibits muscle regeneration. Genesis 2005 43 : 120 128.
    • (2005) Genesis , vol.43 , pp. 120-128
    • Coletti, D.1    Moresi, V.2    Adamo, S.3    Molinaro, M.4    Sassoon, D.5
  • 65
    • 42449092519 scopus 로고    scopus 로고
    • Gene expression-based screening identifies microtubule inhibitors as inducers of PGC-1α and oxidative phosphorylation
    • Arany Z, Wagner BK, Ma Y, Chinsomboon J, Laznik D, Spiegelman BM. Gene expression-based screening identifies microtubule inhibitors as inducers of PGC-1α and oxidative phosphorylation. Proc. Natl Acad. Sci. USA 2008 105 : 4721 4726.
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 4721-4726
    • Arany, Z.1    Wagner, B.K.2    Ma, Y.3    Chinsomboon, J.4    Laznik, D.5    Spiegelman, B.M.6
  • 66
    • 40449112930 scopus 로고    scopus 로고
    • Large-scale chemical dissection of mitochondrial function
    • Wagner BK, Kitami T, Gilbert TJ et al. Large-scale chemical dissection of mitochondrial function. Nat. Biotechnol. 2008 26 : 343 351.
    • (2008) Nat. Biotechnol. , vol.26 , pp. 343-351
    • Wagner, B.K.1    Kitami, T.2    Gilbert, T.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.