Immune function in sport and exercise

Journal of Applied Physiology

Volumn 103, Issue 2, 2007, Pages 693-699

  Gleeson, Michael ^a  

^a LOUGHBOROUGH UNIVERSITY   (United Kingdom)

Author keywords

Cytokines; Infection; Inflammation; Leukocytes; Toll like receptors

Indexed keywords

ALPHA TOCOPHEROL; ASCORBIC ACID; C REACTIVE PROTEIN; CORTICOTROPIN; CYTOKINE; GAMMA INTERFERON; HYDROCORTISONE; IMMUNOGLOBULIN A; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 6; MACROPHAGE INFLAMMATORY PROTEIN 1; TUMOR NECROSIS FACTOR ALPHA;

ANTIGEN PRESENTATION; ATHLETE; CD4+ CD25+ T LYMPHOCYTE; CELLULAR IMMUNITY; EXERCISE; FOOD INTAKE; HUMAN; IMMUNE DEFICIENCY; IMMUNE DYSREGULATION; IMMUNE RESPONSE; INCIDENCE; INFECTION; LYMPHOCYTE PROLIFERATION; MONOCYTE; NATURAL KILLER CELL; NEUTROPHIL; OXYGEN CONSUMPTION; PRIORITY JOURNAL; RESPIRATORY BURST; REVIEW; SITTING; SPORT; UPPER RESPIRATORY TRACT INFECTION;

DEPRESSION; EXERCISE; HUMANS; IMMUNE SYSTEM; INFLAMMATION; PHARYNGITIS; RISK FACTORS; SPORTS;

EID: 34547626210     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.00008.2007     Document Type: Review

References (56)

1. Baj Z, Kantorski J, Majewska E, Zeman K, Pokoca L, Fornalczyk E, Tchorzewski H, Sulowska Z, Lewicki R. Immunological status of competitive cyclists before and after the training season. Int J Sports Med 15: 319-24, 1994.
2. Berk LS, Ton SA, Nieman DC, Eby EC. The suppressive effect of stress from acute exhaustive exercise on T-lymphocyte helper/suppressor ratio in athletes and non-athletes. Med Sci Sports Exerc 18: 706-710, 1986.
3. Blannin AK, Chatwin LJ, Cave R, Gleeson M. Effects of submaximal cycling and long-term endurance training on neutrophil phagocytic activity in middle-aged men. Br J Sports Med 30: 125-129, 1996.
4. Bruunsgaard H, Hartkopp A, Mohr T, Konradsen H, Heron I, Mordhorst CH, Pedersen BK. In vivo cell-mediated immunity and vaccination response following prolonged, intense exercise. Med Sci Sports Exerc 29: 1176-1181, 1997.
5. Bury T, Marechal R, Mahieu P, Pirnay F. Immunological status of competitive football players during the training season. Int J Sports Med 19: 364-368, 1998.
6. Carins J, Booth C. Salivary immunoglobulin-A as a marker of stress during strenuous physical training. Aviat Space Environ Med 73: 1203-1207, 2002.
7. Ekblom B, Ekblom O, Malm C. Infectious episodes before and after a marathon race. Scand J Med Sci Sports 16: 287-293, 2006.
8. Fahlman MM, Engels HJ. Mucosal IgA and URTI in American college football players: a year longitudinal study. Med Sci Sports Exerc 37: 374-380, 2005.
9. Fischer CP, Hiscock NJ, Penkowa M, Basu S, Vessby B, Kallner A, Sjoberg LB, Pedersen BK. Vitamin C and E supplementation inhibits the release of interleukin-6 from contracting human skeletal muscle. J Physiol 558: 633-645, 2004.
10. Friman G, Ilback NG. Acute infection: metabolic responses, effects on performance, interaction with exercise, and myocarditis. Int J Sports Med 19: S172-S182, 1998.
11. Gannon GA, Rhind S, Shek PN, Shephard RJ. Naïve and memory T cell subsets are differentially mobilized during physical stress. Int J Sports Med 23: 223-229, 2002.
12. Gleeson M. Mucosal immune responses and risk of respiratory illness in elite athletes. Exerc Immunol Rev 6: 5-42, 2000.
13. Gleeson M (Editor). Immune Function in Sport and Exercise. Edinburgh: Elsevier, 2005.
14. Gleeson M, McFarlin BK, Flynn MG. Exercise and Toll-like receptors. Exerc Immunol Rev 12: 34-53, 2006.
15. Gleeson M, McDonald WA, Cripps AW, Pyne DB, Clancy RL, Fricker PA. The effect on immunity of long-term intensive training in elite swimmers. Clin Exp Immunol 102: 210-216, 1995.
16. Gleeson M, Nieman DC, Pedersen BK. Exercise, nutrition and immune function. J Sports Sci 22: 115-125, 2004.
17. Gomez-Merino D, Drogou C, Chennaoui M, Tiollier E, Mathieu J, Guezennec CY. Effects of combined stress during intense training on cellular immunity, hormones and respiratory infections. Neuroimmunomodulation 12: 164-172, 2005.
18. Heath GW, Ford ES, Craven TE, Macera CA, Jackson KL, Pate RR. Exercise and the incidence of upper respiratory tract infections. Med Sci Sports Exerc 23: 152-157, 1991.
19. Keil D, Luebke RW, Pruett SB. Quantifying the relationship between multiple immunological parameters and host resistance: probing the limits of reductionism. J Immunol 167: 4543-4552, 2001.
20. Lancaster GI, Halson SL, Khan Q, Drysdale P, Jeukendrup AE, Drayson MT, Gleeson M. Effect of acute exhaustive exercise and a 6-day period of intensified training on immune function in cyclists (Abstract). J Physiol 548P: O96, 2003.
21. Lancaster GI, Halson SL, Khan Q, Drysdale P, Jeukendrup AE, Drayson MT, Gleeson M. The effects of acute exhaustive exercise and intensified training on type 1/type 2 T cell distribution and cytokine production. Exerc Immunol Rev 10: 91-106, 2004.
22. Lancaster GI, Khan Q, Drysdale PT, Wallace F, Jeukendrup AE, Drayson MT, Gleeson M. Effect of prolonged strenuous exercise and carbohydrate ingestion on type 1 and type 2 T lymphocyte distribution and intracellular cytokine production in humans. J Appl Physiol 98: 565-571, 2005.
23. Lancaster GI, Halson SL, Khan Q, Drysdale P, Jeukendrup AE, Drayson MT, Gleeson M. The physiological regulation of toll-like receptor expression and function in humans. J Physiol 563: 945-955, 2005.
24. Mackinnon LT. Advances in Exercise and Immunology. Champaign, IL: Human Kinetics, 1999.
25. Matthews CE, Ockene IS, Freedson PS, Rosal MC, Merriam PA, Hebert JR. Moderate to vigorous physical activity and the risk of upper-respiratory tract infection. Med Sci Sports Exerc 34: 1242-1248, 2002.
26. Moynihan JA, Callahan TA, Kelley SP, Campbell LM. Adrenal hormone modulation of type 1 and type 2 cytokine production by spleen cells: dexamethasone and dehydroepiandrosterone suppress interleukin-2, interleukin-4, and interferon-gamma production in vitro. Cell Immunol 184: 58-64, 1998.
27. Nehlsen-Cannarella SL, Fagoaga OR, Nieman DC, Henson DA, Butterworth DE, Schmitt RL, Bailey EM, Warren BJ, Utter A, Davis JM. Carbohydrate and the cytokine response to 2.5 h of running. J Appl Physiol 82: 1662-1667, 1997.
28. Nieman DC. Exercise, infection and immunity. Int J Sports Med 15: S131-S141, 1994.
29. Nieman DC. Influence of carbohydrate on the immune responses to intensive, prolonged exercise. Exerc Immunol Rev 4: 64-76, 1998.
30. Nieman DC, Johansen LM, Lee JW, Arabatzis K. Infectious episodes in runners before and after the Los Angeles Marathon. J Sports Med Phys Fitness 30: 316-328, 1990.
31. Niess AM, Dickhuth HH, Northoff H, Fehrenbach E. Free radicals and oxidative stress in exercise-immunological aspects. Exerc Immunol Rev 5: 22-56, 1999.
32. Northoff H, Berg A, Weinstock C. Similarities and differences of the immune response to exercise and trauma: the IFN-γ concept. Can J Physiol Pharmacol 76: 497-504, 1998.
33. Pedersen BK, Bruunsgaard H. How physical exercise influences the establishment of infections. Sports Med 19: 393-400, 1995.
34. Peters EM, Bateman ED. Ultramarathon running and URTI: an epidemiological survey. S Afr Med J 64: 582-584, 1983.
35. Peters EM, Goetzsche JM, Grobbelaar B, Noakes TD. Vitamin C supplementation reduces the incidence of post-race symptoms of upper respiratory tract infection in ultramarathon runners. Am J Clin Nutr 57: 170-174, 1993.
36. Peters EM, Goetzsche JM, Joseph LE, Noakes TD. Vitamin C as effective as combinations of anti-oxidant nutrients in reducing symptoms of upper respiratory tract infections in ultramarathon runners. S A J Sports Med 11: 23-27, 1996.
37. Pilegaard H, Keller C, Steensberg A, Helge JW, Pedersen BK, Saltin B, Neufer PD. Influence of pre-exercise muscle glycogen content on exercise-induced transcriptional regulation of metabolic genes. J Physiol 541: 261-271, 2002.
38. Pyne DB. Regulation of neutrophil function during exercise. Sports Med 17: 245-258, 1994.
39. Rebelo AN, Candeias JR, Fraga MM, Duarte JA, Soares JM, Magalhaes C, Torrinha JA. The impact of soccer training on the immune system. J Sports Med Phys Fitness 38: 258-261, 1998.
40. Roberts JA. Viral illnesses and sports performance. Sports Med 3: 298-303, 1986.
41. Robson PJ, Blannin AK, Walsh NP, Bishop NC, Gleeson M. The effect of an acute period of intense interval training on human neutrophil function and plasma glutamine in endurance-trained male runners. J Physiol 515: 84P-85P, 1999.
42. Robson PJ, Blannin AK, Walsh NP, Castell LM, Gleeson M. Effects of exercise intensity, duration and recovery on in vitro neutrophil function in male athletes. Int J Sports Med 20: 128-135, 1999.
43. Ronsen O, Pedersen BK, Oritsland TR, Bahr R, Kjeldsen-Kragh J. Leukocyte counts and lymphocyte responsiveness associated with repeated bouts of strenuous endurance exercise. J Appl Physiol 91: 425-434, 2001.
44. Schnare M, Barton GM, Holt AC, Takeda K, Akira S, Medzhitov R. Toll-like receptors control activation of adaptive immune responses. Nat Immun 2: 947-950, 2001.
45. Shephard RJ. Physical Activity, Training and the Immune Response. Carmel, IN: Cooper, 1997.
46. Shephard RJ, Shek PN. Effects of exercise and training on natural killer cell counts and cytolytic activity: a meta-analysis. Sports Med 28: 177-195, 1999.
47. Spence L, Nissen MD, Sloots TP, McCormack JG, Locke AS, Pyne DB, Fricker PA, Brown WJ. Upper respiratory illness aetiology and symptomatology in elite and recreationally-competitive athletes. Brain Behav Immun 19: 469-470, 2005.
48. Starkie RL, Ostrowski SR, Jauffred S, Febbraio M, Pedersen BK. Exercise and IL-6 infusion inhibit endotoxin-induced TNF-alpha production in humans. FASEB J 17: 884-886, 2003.
49. Starkie RL, Rolland J, Angus DJ, Anderson MJ, Febbraio M. Circulating monocytes are not the source of elevations in plasma IL-6 and TNF-α levels after prolonged running. Am J Physiol Cell Physiol 280: C769-C774, 2001.
50. Steensberg A, Fischer CP, Keller C, Moller K, Pedersen BK. IL-6 enhances plasma IL-1ra, IL-10, and cortisol in humans. Am J Physiol Endocrinol Metab 285: E433-E437, 2003.
51. Steensberg A, van Hall G, Osada T, Sacchetti M, Saltin B, Pedersen BK. Production of interleukin-6 in contracting human skeletal muscles can account for the exercise-induced increase in plasma interleukin-6. J Physiol 529: 237-242, 2000.
52. Stewart LK, Flynn MG, Campbell WW, Craig BA, Robinson JP, McFarlin BK, Timmerman KL, Coen PM, Felker J, Talbert E. Influence of exercise training and age on CD14-+ cell-surface expression of toll-like receptor 2 and 4. Brain Behav Immun 19: 389-397, 2005.
53. Tiollier E, Gomez-Merino D, Burnat P, Jouanin JC, Bourrilhon C, Filaire E, Guezennec CY, Chennaoui M. Intense training: mucosal immunity and incidence of respiratory infections. Eur J Appl Physiol 93: 421-428, 2005.
54. Tomasi TB, Trudeau FB, Czerwinski D. Immune parameters in athletes before and after strenuous exercise. J Clin Immunol 2: 173-178, 1982.
55. Verde TJ, Thomas SG, Moore RW, Shek P, Shephard RJ. Immune responses and increased training of the elite athlete. J Appl Physiol 73: 1494-1499, 1992.
56. Woods J, Lu Q, Ceddia MA, Lowder T. Special feature for the Olympics: effects of exercise on the immune system: exercise-induced modulation of macrophage function. Immunol Cell Biol 78: 545-553, 2000.