-
1
-
-
0003004498
-
The cytokines: An overview
-
Thompson A (ed) Academic Press, San Diego
-
Vilcek J (1998) The cytokines: an overview. In: Thompson A (ed) The cytokine handbook. Academic Press, San Diego, pp 1-20
-
(1998)
The Cytokine Handbook
, pp. 1-20
-
-
Vilcek, J.1
-
3
-
-
0026660277
-
Role of cytokines in inducing hyperlipidemia
-
Feingold KR, Grunfeld C (1992) Role of cytokines in inducing hyperlipidemia. Diabetes 41 [Suppl 2]:97-101
-
(1992)
Diabetes
, vol.41
, Issue.2 SUPPL.
, pp. 97-101
-
-
Feingold, K.R.1
Grunfeld, C.2
-
4
-
-
0026689535
-
Evidence for the involvement of interleukin 6 in experimental cancer cachexia
-
Strassmann G, Fong M, Kenney JS, Jacob CO (1992) Evidence for the involvement of interleukin 6 in experimental cancer cachexia. J Clin Invest 89:1681-1684
-
(1992)
J Clin Invest
, vol.89
, pp. 1681-1684
-
-
Strassmann, G.1
Fong, M.2
Kenney, J.S.3
Jacob, C.O.4
-
5
-
-
0024406719
-
Evidence for IL-6 production by and effects on the pancreatic beta-cell
-
Campbell IL, Cutri A, Wilson A, Harrison LC (1989) Evidence for IL-6 production by and effects on the pancreatic beta-cell. J Immunol 143:1188-1191
-
(1989)
J Immunol
, vol.143
, pp. 1188-1191
-
-
Campbell, I.L.1
Cutri, A.2
Wilson, A.3
Harrison, L.C.4
-
6
-
-
0030731621
-
NIDDM as a disease of the innate immune system: Association of acute-phase reactants and interleukin-6 with metabolic syndrome X
-
Pickup JC, Mattock MB, Chusney GD, Burt D (1997) NIDDM as a disease of the innate immune system: association of acute-phase reactants and interleukin-6 with metabolic syndrome X. Diabetologia 40:1286-1292
-
(1997)
Diabetologia
, vol.40
, pp. 1286-1292
-
-
Pickup, J.C.1
Mattock, M.B.2
Chusney, G.D.3
Burt, D.4
-
7
-
-
0032925340
-
Mechanisms of TNF-alpha-induced insulin resistance
-
Hotamisligil GS (1999) Mechanisms of TNF-alpha-induced insulin resistance. Exp Clin Endocrinol Diabetes 107:119-125
-
(1999)
Exp Clin Endocrinol Diabetes
, vol.107
, pp. 119-125
-
-
Hotamisligil, G.S.1
-
8
-
-
0038322493
-
Exercise and IL-6 infusion inhibit endotoxin-induced TNF-alpha production in humans
-
Starkie R, Ostrowski SR, Jauffred S, Febbraio M, Pedersen BK (2003) Exercise and IL-6 infusion inhibit endotoxin-induced TNF-alpha production in humans. FASEB J 17:884-886
-
(2003)
FASEB J
, vol.17
, pp. 884-886
-
-
Starkie, R.1
Ostrowski, S.R.2
Jauffred, S.3
Febbraio, M.4
Pedersen, B.K.5
-
9
-
-
0036720342
-
Muscle-derived interleukin-6: Mechanisms for activation and possible biological roles
-
Febbraio MA, Pedersen BK (2002) Muscle-derived interleukin-6: mechanisms for activation and possible biological roles. FASEB J 16:1335-1347
-
(2002)
FASEB J
, vol.16
, pp. 1335-1347
-
-
Febbraio, M.A.1
Pedersen, B.K.2
-
10
-
-
0019128380
-
Two interferon mRNAs in human fibroblasts: In vitro translation and Escherichia coli cloning studies
-
Weissenbach J, Chernajovsky Y, Zeevi M et al. (1980) Two interferon mRNAs in human fibroblasts: in vitro translation and Escherichia coli cloning studies. Proc Natl Acad Sci USA 77:7152-7156
-
(1980)
Proc Natl Acad Sci USA
, vol.77
, pp. 7152-7156
-
-
Weissenbach, J.1
Chernajovsky, Y.2
Zeevi, M.3
-
11
-
-
0022499547
-
Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin
-
Hirano T, Yasukawa K, Harada H et al. (1986) Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin. Nature 324:73-76
-
(1986)
Nature
, vol.324
, pp. 73-76
-
-
Hirano, T.1
Yasukawa, K.2
Harada, H.3
-
12
-
-
0023425699
-
Structure and expression of human B cell stimulatory factor-2 (BSF-2/IL-6) gene
-
Yasukawa K, Hirano T, Watanabe Y et al. (1987) Structure and expression of human B cell stimulatory factor-2 (BSF-2/IL-6) gene. EMBO J 6:2939-2945
-
(1987)
EMBO J
, vol.6
, pp. 2939-2945
-
-
Yasukawa, K.1
Hirano, T.2
Watanabe, Y.3
-
14
-
-
0343185888
-
Human B-cell differentiation factor defined by an anti-peptide antibody and its possible role in autoantibody production
-
Hirano T, Taga T, Yasukawa K et al. (1987) Human B-cell differentiation factor defined by an anti-peptide antibody and its possible role in autoantibody production. Proc Natl Acad Sci USA 84:228-231
-
(1987)
Proc Natl Acad Sci USA
, vol.84
, pp. 228-231
-
-
Hirano, T.1
Taga, T.2
Yasukawa, K.3
-
15
-
-
0024586781
-
Bacterial lipopolysaccharide and inflammatory mediators augment IL-6 secretion by human endothelial cells
-
Jirik FR, Podor TJ, Hirano T et al. (1989) Bacterial lipopolysaccharide and inflammatory mediators augment IL-6 secretion by human endothelial cells. J Immunol 142:144-147
-
(1989)
J Immunol
, vol.142
, pp. 144-147
-
-
Jirik, F.R.1
Podor, T.J.2
Hirano, T.3
-
16
-
-
0026753927
-
Regulation of transcription factor mRNA accumulation during 3T3-L1 preadipocyte differentiation by tumour necrosis factor-alpha
-
Stephens JM, Butts MD, Pekala PH (1992) Regulation of transcription factor mRNA accumulation during 3T3-L1 preadipocyte differentiation by tumour necrosis factor-alpha. J Mol Endocrinol 9:61-72
-
(1992)
J Mol Endocrinol
, vol.9
, pp. 61-72
-
-
Stephens, J.M.1
Butts, M.D.2
Pekala, P.H.3
-
17
-
-
0030735542
-
Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-alpha, in vivo
-
Mohamed-Ali V, Goodrick S, Rawesh A et al. (1997) Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-alpha, in vivo. J Clin Endocrinol Metab 82:4196-4200
-
(1997)
J Clin Endocrinol Metab
, vol.82
, pp. 4196-4200
-
-
Mohamed-Ali, V.1
Goodrick, S.2
Rawesh, A.3
-
18
-
-
0642364997
-
Immunohistochemical detection of interleukin-6 in human skeletal muscle fibers following exercise
-
Penkowa M, Keller C, Keller P, Jauffred S, Pedersen BK (2003) Immunohistochemical detection of interleukin-6 in human skeletal muscle fibers following exercise. FASEB J 17:2166-2168
-
(2003)
FASEB J
, vol.17
, pp. 2166-2168
-
-
Penkowa, M.1
Keller, C.2
Keller, P.3
Jauffred, S.4
Pedersen, B.K.5
-
19
-
-
4143052910
-
Skeletal myocytes are the source of interleukin-6 mRNA expression and protein release during contraction: Evidence of fiber type specificity
-
Hiscock N, Chan MHS, Bisucci T, Darby A, Febbraio MA (2004) Skeletal myocytes are the source of interleukin-6 mRNA expression and protein release during contraction: evidence of fiber type specificity. FASEB J 18:992-994
-
(2004)
FASEB J
, vol.18
, pp. 992-994
-
-
Hiscock, N.1
Chan, M.H.S.2
Bisucci, T.3
Darby, A.4
Febbraio, M.A.5
-
20
-
-
0034668926
-
Production of interleukin-6 in contracting human skeletal muscles can account for the exercise-induced increase in plasma interleukin-6
-
Steensberg A, Hall G van, Osada T, Sacchetti M, Saltin B, Klarlund Pedersen B (2000) Production of interleukin-6 in contracting human skeletal muscles can account for the exercise-induced increase in plasma interleukin-6. J Physiol 529:237-242
-
(2000)
J Physiol
, vol.529
, pp. 237-242
-
-
Steensberg, A.1
Van Hall, G.2
Osada, T.3
Sacchetti, M.4
Saltin, B.5
Klarlund Pedersen, B.6
-
21
-
-
0024393839
-
Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130
-
Taga T, Hibi M, Hirata Y et al. (1989) Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130. Cell 58:573-581
-
(1989)
Cell
, vol.58
, pp. 573-581
-
-
Taga, T.1
Hibi, M.2
Hirata, Y.3
-
22
-
-
0028270409
-
The soluble human IL-6 receptor. Mutational characterization of the proteolytic cleavage site
-
Mullberg J, Oberthur W, Lottspeich F et al. (1994) The soluble human IL-6 receptor. Mutational characterization of the proteolytic cleavage site. J Immunol 152:4958-4968
-
(1994)
J Immunol
, vol.152
, pp. 4958-4968
-
-
Mullberg, J.1
Oberthur, W.2
Lottspeich, F.3
-
23
-
-
0027398766
-
The soluble interleukin-6 receptor is generated by shedding
-
Mullberg J, Schooltink H, Stoyan T et al. (1993) The soluble interleukin-6 receptor is generated by shedding. Eur J Immunol 23:473-480
-
(1993)
Eur J Immunol
, vol.23
, pp. 473-480
-
-
Mullberg, J.1
Schooltink, H.2
Stoyan, T.3
-
25
-
-
0033864798
-
Gene expression of receptors for IL-6, LIF, and CNTF in regenerating skeletal muscles
-
Kami K, Morikawa Y, Sekimoto M, Senba E (2000) Gene expression of receptors for IL-6, LIF, and CNTF in regenerating skeletal muscles. J Histochem Cytochem 48:1203-1213
-
(2000)
J Histochem Cytochem
, vol.48
, pp. 1203-1213
-
-
Kami, K.1
Morikawa, Y.2
Sekimoto, M.3
Senba, E.4
-
26
-
-
0028089162
-
Trophic effect of ciliary neurotrophic factor on denervated skeletal muscle
-
Helgren ME, Squinto SP, Davis HL et al. (1994) Trophic effect of ciliary neurotrophic factor on denervated skeletal muscle. Cell 76:493-504
-
(1994)
Cell
, vol.76
, pp. 493-504
-
-
Helgren, M.E.1
Squinto, S.P.2
Davis, H.L.3
-
27
-
-
0037064539
-
Molecular basis of the cell specificity of cytokine action
-
Ishihara K, Hirano T (2002) Molecular basis of the cell specificity of cytokine action. Biochim Biophys Acta 1592:281-296
-
(2002)
Biochim Biophys Acta
, vol.1592
, pp. 281-296
-
-
Ishihara, K.1
Hirano, T.2
-
28
-
-
0037064542
-
The role of soluble receptors in cytokine biology: The agonistic properties of the sIL-6R/IL-6 complex
-
Jones SA, Rose-John S (2002) The role of soluble receptors in cytokine biology: the agonistic properties of the sIL-6R/IL-6 complex. Biochem Biophys Acta 1592:251-263
-
(2002)
Biochem Biophys Acta
, vol.1592
, pp. 251-263
-
-
Jones, S.A.1
Rose-John, S.2
-
29
-
-
0032168152
-
Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway
-
Heinrich PC, Behrmann I, Muller-Newen G, Schaper F, Graeve L (1998) Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway. Biochem J 334:297-314
-
(1998)
Biochem J
, vol.334
, pp. 297-314
-
-
Heinrich, P.C.1
Behrmann, I.2
Muller-Newen, G.3
Schaper, F.4
Graeve, L.5
-
30
-
-
0030792590
-
A family of cytokine-inducible inhibitors of signalling
-
Starr R, Willson TA, Viney EM et al. (1997) A family of cytokine-inducible inhibitors of signalling. Nature 387:917-921
-
(1997)
Nature
, vol.387
, pp. 917-921
-
-
Starr, R.1
Willson, T.A.2
Viney, E.M.3
-
31
-
-
0033139237
-
Circulating levels of interleukin-6, its soluble receptor and interleukin-6/interleukin-6 receptor complexes in patients with type 2 diabetes mellitus
-
Kado S, Nagase T, Nagata N (1999) Circulating levels of interleukin-6, its soluble receptor and interleukin-6/interleukin-6 receptor complexes in patients with type 2 diabetes mellitus. Acta Diabetol 36:67-72
-
(1999)
Acta Diabetol
, vol.36
, pp. 67-72
-
-
Kado, S.1
Nagase, T.2
Nagata, N.3
-
32
-
-
0035403205
-
Circulating interleukin-6 in relation to adiposity, insulin action, and insulin secretion
-
Vozarova B, Weyer C, Hanson K, Tataranni PA, Bogardus C, Pratley RE (2001) Circulating interleukin-6 in relation to adiposity, insulin action, and insulin secretion. Obes Res 9:414-417
-
(2001)
Obes Res
, vol.9
, pp. 414-417
-
-
Vozarova, B.1
Weyer, C.2
Hanson, K.3
Tataranni, P.A.4
Bogardus, C.5
Pratley, R.E.6
-
33
-
-
0033678516
-
Elevated levels of interleukin 6 are reduced in serum and subcutaneous adipose tissue of obese women after weight loss
-
Bastard JP, Jardel C, Bruckert E et al. (2000) Elevated levels of interleukin 6 are reduced in serum and subcutaneous adipose tissue of obese women after weight loss. J Clin Endocrinol Metab 85:3338-3342
-
(2000)
J Clin Endocrinol Metab
, vol.85
, pp. 3338-3342
-
-
Bastard, J.P.1
Jardel, C.2
Bruckert, E.3
-
34
-
-
0034625547
-
Plasma interleukin-6, tumour necrosis factor alpha and blood cytokine production in type 2 diabetes
-
Pickup JC, Chusney GD, Thomas SM, Burt D (2000) Plasma interleukin-6, tumour necrosis factor alpha and blood cytokine production in type 2 diabetes. Life Sci 67:291-300
-
(2000)
Life Sci
, vol.67
, pp. 291-300
-
-
Pickup, J.C.1
Chusney, G.D.2
Thomas, S.M.3
Burt, D.4
-
35
-
-
0035006714
-
Circulating monocytes are not the source of elevations in plasma IL-6 and TNF-alpha levels after prolonged running
-
Starkie RL, Rolland J, Angus DJ, Anderson MJ, Febbraio MA (2001) Circulating monocytes are not the source of elevations in plasma IL-6 and TNF-alpha levels after prolonged running. Am J Physiol Cell Physiol 280:C769-C774
-
(2001)
Am J Physiol Cell Physiol
, vol.280
-
-
Starkie, R.L.1
Rolland, J.2
Angus, D.J.3
Anderson, M.J.4
Febbraio, M.A.5
-
36
-
-
0034325909
-
Effect of prolonged, submaximal exercise and carbohydrate ingestion on monocyte intracellular cytokine production in humans
-
Starkie RL, Angus DJ, Rolland J, Hargreaves M, Febbraio MA (2000) Effect of prolonged, submaximal exercise and carbohydrate ingestion on monocyte intracellular cytokine production in humans. J Physiol 528:647-655
-
(2000)
J Physiol
, vol.528
, pp. 647-655
-
-
Starkie, R.L.1
Angus, D.J.2
Rolland, J.3
Hargreaves, M.4
Febbraio, M.A.5
-
37
-
-
0038745434
-
Acute interleukin-6 administration does not impair muscle glucose uptake or whole-body glucose disposal in healthy humans
-
Steensberg A, Fischer CP, Sacchetti M et al. (2003) Acute interleukin-6 administration does not impair muscle glucose uptake or whole-body glucose disposal in healthy humans. J Physiol 548:631-638
-
(2003)
J Physiol
, vol.548
, pp. 631-638
-
-
Steensberg, A.1
Fischer, C.P.2
Sacchetti, M.3
-
38
-
-
0038372035
-
Interleukin-6 stimulates lipolysis and fat oxidation in humans
-
Hall G van, Steenberg A, Sacchetti M et al. (2003) Interleukin-6 stimulates lipolysis and fat oxidation in humans. J Clin Endocrinol Metab 88:3005-3010
-
(2003)
J Clin Endocrinol Metab
, vol.88
, pp. 3005-3010
-
-
Van Hall, G.1
Steenberg, A.2
Sacchetti, M.3
-
39
-
-
0035576798
-
Interleukin-6 production in contracting human skeletal muscle is influenced by pre-exercise muscle glycogen content
-
Steensberg A, Febbraio MA, Osada T et al. (2001) Interleukin-6 production in contracting human skeletal muscle is influenced by pre-exercise muscle glycogen content. J Physiol 537:633-639
-
(2001)
J Physiol
, vol.537
, pp. 633-639
-
-
Steensberg, A.1
Febbraio, M.A.2
Osada, T.3
-
40
-
-
0028926159
-
Role of corticosterone in TNF and IL-6 production in isolated perfused rat liver
-
Liao J, Keiser JA, Scales WE, Kunkel SL, Kluger MJ (1995) Role of corticosterone in TNF and IL-6 production in isolated perfused rat liver. Am J Physiol Regul Integr Comp Physiol 268:R699-R706
-
(1995)
Am J Physiol Regul Integr Comp Physiol
, vol.268
-
-
Liao, J.1
Keiser, J.A.2
Scales, W.E.3
Kunkel, S.L.4
Kluger, M.J.5
-
41
-
-
0028939926
-
Role of epinephrine in TNF and IL-6 production from isolated perfused rat liver
-
Liao J, Keiser JA, Scales WE, Kunkel SL, Kluger MJ (1995) Role of epinephrine in TNF and IL-6 production from isolated perfused rat liver. Am J Physiol Regul Integr Comp Physiol 268:R896-R901
-
(1995)
Am J Physiol Regul Integr Comp Physiol
, vol.268
-
-
Liao, J.1
Keiser, J.A.2
Scales, W.E.3
Kunkel, S.L.4
Kluger, M.J.5
-
42
-
-
0035819241
-
Increased secretion of tumour necrosis factor and interleukin 6 from isolated, perfused liver of rats after partial hepatectomy
-
Iwai M, Cui TX, Kitamura H, Saito M, Shimazu T (2001) Increased secretion of tumour necrosis factor and interleukin 6 from isolated, perfused liver of rats after partial hepatectomy. Cytokine 13:60-64
-
(2001)
Cytokine
, vol.13
, pp. 60-64
-
-
Iwai, M.1
Cui, T.X.2
Kitamura, H.3
Saito, M.4
Shimazu, T.5
-
43
-
-
0035930349
-
The effects of infection of thermal injury by Pseudomonas aeruginosa PAO1 on the murine cytokine response
-
Rumbaugh KP, Colmer JA, Griswold JA, Hamood AN (2001) The effects of infection of thermal injury by Pseudomonas aeruginosa PAO1 on the murine cytokine response. Cytokine 16:160-168
-
(2001)
Cytokine
, vol.16
, pp. 160-168
-
-
Rumbaugh, K.P.1
Colmer, J.A.2
Griswold, J.A.3
Hamood, A.N.4
-
45
-
-
0035293048
-
Proteolysis-inducing factor regulates hepatic gene expression via the transcription factors NF-(kappa)B and STAT3
-
Watchorn TM, Waddell I, Dowidar N, Ross JA (2001) Proteolysis-inducing factor regulates hepatic gene expression via the transcription factors NF-(kappa)B and STAT3. FASEB J 15:562-564
-
(2001)
FASEB J
, vol.15
, pp. 562-564
-
-
Watchorn, T.M.1
Waddell, I.2
Dowidar, N.3
Ross, J.A.4
-
47
-
-
3142710172
-
Interleukin-6 and tumor necrosis factor-alpha are not increased in patients with Type 2 diabetes: Evidence that plasma interleukin-6 is related to fat mass and not insulin responsiveness
-
Carey AL, Bruce CR, Sacchetti M et al. (2004) Interleukin-6 and tumor necrosis factor-alpha are not increased in patients with Type 2 diabetes: evidence that plasma interleukin-6 is related to fat mass and not insulin responsiveness. Diabetologia 47:1029-1037
-
(2004)
Diabetologia
, vol.47
, pp. 1029-1037
-
-
Carey, A.L.1
Bruce, C.R.2
Sacchetti, M.3
-
48
-
-
0141570562
-
Interleukin-6 production by contracting human skeletal muscle: Autocrine regulation by IL-6
-
Keller P, Keller C, Carey AL et al. (2003) Interleukin-6 production by contracting human skeletal muscle: autocrine regulation by IL-6. Biochem Biophys Res Commun 310:550-554
-
(2003)
Biochem Biophys Res Commun
, vol.310
, pp. 550-554
-
-
Keller, P.1
Keller, C.2
Carey, A.L.3
-
49
-
-
0037617454
-
Interleukin (IL)-6 mRNA expression is stimulated by insulin, isoproterenol, tumour necrosis factor alpha, growth hormone, and IL-6 in 3T3-L1 adipocytes
-
Fasshauer M, Klein J, Lossner U, Paschke R (2003) Interleukin (IL)-6 mRNA expression is stimulated by insulin, isoproterenol, tumour necrosis factor alpha, growth hormone, and IL-6 in 3T3-L1 adipocytes. Horm Metab Res 35:147-152
-
(2003)
Horm Metab Res
, vol.35
, pp. 147-152
-
-
Fasshauer, M.1
Klein, J.2
Lossner, U.3
Paschke, R.4
-
50
-
-
0027459878
-
Adipose expression of tumor necrosis factor-alpha: Direct role in obesity-linked insulin resistance
-
Hotamisligil GS, Shargill NS, Spiegelman BM (1993) Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 259:87-91
-
(1993)
Science
, vol.259
, pp. 87-91
-
-
Hotamisligil, G.S.1
Shargill, N.S.2
Spiegelman, B.M.3
-
51
-
-
0028031569
-
Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes. Central role of tumor necrosis factor-alpha
-
Hotamisligil GS, Budavari A, Murray D, Spiegelman BM (1994) Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes. Central role of tumor necrosis factor-alpha. J Clin Invest 94:1543-1549
-
(1994)
J Clin Invest
, vol.94
, pp. 1543-1549
-
-
Hotamisligil, G.S.1
Budavari, A.2
Murray, D.3
Spiegelman, B.M.4
-
53
-
-
0035908632
-
C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus
-
Pradhan AD, Manson JE, Rifai N, Buring JE, Ridker PM (2001) C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus. JAMA 286:327-334
-
(2001)
JAMA
, vol.286
, pp. 327-334
-
-
Pradhan, A.D.1
Manson, J.E.2
Rifai, N.3
Buring, J.E.4
Ridker, P.M.5
-
54
-
-
0031766093
-
Circulating interleukin 6 concentrations and insulin resistance in patients with cancer
-
Makino T, Noguchi Y, Yoshikawa T, Doi C, Nomura K (1998) Circulating interleukin 6 concentrations and insulin resistance in patients with cancer. Br J Surg 85:1658-1662
-
(1998)
Br J Surg
, vol.85
, pp. 1658-1662
-
-
Makino, T.1
Noguchi, Y.2
Yoshikawa, T.3
Doi, C.4
Nomura, K.5
-
55
-
-
0242580711
-
Interleukin-6 (IL-6) induces insulin resistance in 3T3-L1 adipocytes and is, like IL-8 and TNFalpha, overexpressed in human fat cells from insulin-resistant subjects
-
Rotter V, Nagaev I, Smith U (2003) Interleukin-6 (IL-6) induces insulin resistance in 3T3-L1 adipocytes and is, like IL-8 and TNFalpha, overexpressed in human fat cells from insulin-resistant subjects. J Biol Chem 278:45777-45785
-
(2003)
J Biol Chem
, vol.278
, pp. 45777-45785
-
-
Rotter, V.1
Nagaev, I.2
Smith, U.3
-
56
-
-
0035023128
-
Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance
-
Kern PA, Ranganathan S, Li C, Wood L, Ranganathan G (2001) Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance. Am J Physiol Endocrinol Metab 280:E745-751
-
(2001)
Am J Physiol Endocrinol Metab
, vol.280
-
-
Kern, P.A.1
Ranganathan, S.2
Li, C.3
Wood, L.4
Ranganathan, G.5
-
57
-
-
0036098188
-
Adipose tissue IL-6 content correlates with resistance to insulin activation of glucose uptake both in vivo and in vitro
-
Bastard JP, Maachi M, Van Nhieu JT et al. (2002) Adipose tissue IL-6 content correlates with resistance to insulin activation of glucose uptake both in vivo and in vitro. J Clin Endocrinol Metab 87:2084-2089
-
(2002)
J Clin Endocrinol Metab
, vol.87
, pp. 2084-2089
-
-
Bastard, J.P.1
Maachi, M.2
Van Nhieu, J.T.3
-
58
-
-
0021994683
-
Effects of insulin on peripheral and splanchnic glucose metabolism in noninsulin-dependent (type II) diabetes mellitus
-
DeFronzo RA, Gunnarsson R, Bjorkman O, Olsson M, Wahren J (1985) Effects of insulin on peripheral and splanchnic glucose metabolism in noninsulin-dependent (type II) diabetes mellitus. J Clin Invest 76:149-155
-
(1985)
J Clin Invest
, vol.76
, pp. 149-155
-
-
DeFronzo, R.A.1
Gunnarsson, R.2
Bjorkman, O.3
Olsson, M.4
Wahren, J.5
-
59
-
-
0345269805
-
Interleukin-6 gene expression is increased in insulin-resistant rat skeletal muscle following insulin stimulation
-
Carey AL, Lamont B, Andrikopoulos S, Koukoulas I, Proietto J, Febbraio MA (2003) Interleukin-6 gene expression is increased in insulin-resistant rat skeletal muscle following insulin stimulation. Biochem Biophys Res Commun 302:837-840
-
(2003)
Biochem Biophys Res Commun
, vol.302
, pp. 837-840
-
-
Carey, A.L.1
Lamont, B.2
Andrikopoulos, S.3
Koukoulas, I.4
Proietto, J.5
Febbraio, M.A.6
-
60
-
-
0042591426
-
Skeletal muscle interleukin-6 and tumor necrosis factor-alpha release in healthy subjects and patients with type 2 diabetes at rest and during exercise
-
Febbraio MA, Steensberg A, Starkie RL, McConell GK, Kingwell BA (2003) Skeletal muscle interleukin-6 and tumor necrosis factor-alpha release in healthy subjects and patients with type 2 diabetes at rest and during exercise. Metabolism 52:939-944
-
(2003)
Metabolism
, vol.52
, pp. 939-944
-
-
Febbraio, M.A.1
Steensberg, A.2
Starkie, R.L.3
McConell, G.K.4
Kingwell, B.A.5
-
61
-
-
0036894360
-
Interleukin-6 induces cellular insulin resistance in hepatocytes
-
Senn JJ, Klover PJ, Nowak IA, Mooney RA (2002) Interleukin-6 induces cellular insulin resistance in hepatocytes. Diabetes 51:3391-3399
-
(2002)
Diabetes
, vol.51
, pp. 3391-3399
-
-
Senn, J.J.1
Klover, P.J.2
Nowak, I.A.3
Mooney, R.A.4
-
62
-
-
0037853260
-
Suppressor of Cytokine Signaling-3 (SOCS-3), a potential mediator of interleukin-6-dependent insulin resistance in hepatocytes
-
Senn JJ, Klover PJ, Nowak IA et al. (2003) Suppressor of Cytokine Signaling-3 (SOCS-3), a potential mediator of interleukin-6-dependent insulin resistance in hepatocytes. J Biol Chem 278:13740-13746
-
(2003)
J Biol Chem
, vol.278
, pp. 13740-13746
-
-
Senn, J.J.1
Klover, P.J.2
Nowak, I.A.3
-
63
-
-
0242299763
-
Chronic interleukin-6 (IL-6) treatment increased IL-6 secretion and induced insulin resistance in adipocyte: Prevention by rosiglitazone
-
Lagathu C, Bastard JP, Auclair M, Maachi M, Capeau J, Caron M (2003) Chronic interleukin-6 (IL-6) treatment increased IL-6 secretion and induced insulin resistance in adipocyte: prevention by rosiglitazone. Biochem Biophys Res Commun 311:372-379
-
(2003)
Biochem Biophys Res Commun
, vol.311
, pp. 372-379
-
-
Lagathu, C.1
Bastard, J.P.2
Auclair, M.3
Maachi, M.4
Capeau, J.5
Caron, M.6
-
64
-
-
0242268894
-
Chronic exposure to interleukin-6 causes hepatic insulin resistance in mice
-
Klover PJ, Zimmers TA, Koniaris LG, Mooney RA (2003) Chronic exposure to interleukin-6 causes hepatic insulin resistance in mice. Diabetes 52:2784-2789
-
(2003)
Diabetes
, vol.52
, pp. 2784-2789
-
-
Klover, P.J.1
Zimmers, T.A.2
Koniaris, L.G.3
Mooney, R.A.4
-
65
-
-
0023257911
-
Effect of endotoxin-induced monokines on glucose metabolism in the muscle cell line L6
-
Lee MD, Zentella A, Vine W, Pekala PH, Cerami A (1987) Effect of endotoxin-induced monokines on glucose metabolism in the muscle cell line L6. Proc Natl Acad Sci USA 84:2590-2594
-
(1987)
Proc Natl Acad Sci USA
, vol.84
, pp. 2590-2594
-
-
Lee, M.D.1
Zentella, A.2
Vine, W.3
Pekala, P.H.4
Cerami, A.5
-
67
-
-
0033944531
-
Effect of proinflammatory interleukins on jejunal nutrient transport
-
Hardin J, Kroeker K, Chung B, Gall DG (2000) Effect of proinflammatory interleukins on jejunal nutrient transport. Gut 47:184-191
-
(2000)
Gut
, vol.47
, pp. 184-191
-
-
Hardin, J.1
Kroeker, K.2
Chung, B.3
Gall, D.G.4
-
68
-
-
0035892752
-
Cytokine regulation of facilitated glucose transport in human articular chondrocytes
-
Shikhman AR, Brinson DC, Valbracht J, Lotz MK (2001) Cytokine regulation of facilitated glucose transport in human articular chondrocytes. J Immunol 167:7001-7008
-
(2001)
J Immunol
, vol.167
, pp. 7001-7008
-
-
Shikhman, A.R.1
Brinson, D.C.2
Valbracht, J.3
Lotz, M.K.4
-
69
-
-
0029857542
-
Comparison of the effects of insulin, PDGF, interleukin-6, and interferon-gamma on glucose transport in 3T3-L1 cells: Lack of cross-talk between tyrosine kinase receptors and JAK/STAT pathways
-
Huppertz C, Schwartz C, Becker W, Horn F, Heinrich PC, Joost HG (1996) Comparison of the effects of insulin, PDGF, interleukin-6, and interferon-gamma on glucose transport in 3T3-L1 cells: lack of cross-talk between tyrosine kinase receptors and JAK/STAT pathways. Diabetologia 39:1432-1439
-
(1996)
Diabetologia
, vol.39
, pp. 1432-1439
-
-
Huppertz, C.1
Schwartz, C.2
Becker, W.3
Horn, F.4
Heinrich, P.C.5
Joost, H.G.6
-
70
-
-
0037459090
-
Adiponectin gene expression and secretion is inhibited by interleukin-6 in 3T3-L1 adipocytes
-
Fasshauer M, Kralisch S, Klier M et al. (2003) Adiponectin gene expression and secretion is inhibited by interleukin-6 in 3T3-L1 adipocytes. Biochem Biophys Res Commun 301:1045-1050
-
(2003)
Biochem Biophys Res Commun
, vol.301
, pp. 1045-1050
-
-
Fasshauer, M.1
Kralisch, S.2
Klier, M.3
-
71
-
-
0035855625
-
The anti-apoptotic role of interleukin-6 in human cervical cancer is mediated by up-regulation of Mcl-1 through a PI 3-K/Akt pathway
-
Wei LH, Kuo ML, Chen CA et al. (2001) The anti-apoptotic role of interleukin-6 in human cervical cancer is mediated by up-regulation of Mcl-1 through a PI 3-K/Akt pathway. Oncogene 20:5799-5809
-
(2001)
Oncogene
, vol.20
, pp. 5799-5809
-
-
Wei, L.H.1
Kuo, M.L.2
Chen, C.A.3
-
72
-
-
0036445584
-
The phosphotidyl inositol 3-kinase/Akt signal pathway is involved in interleukin-6-mediated Mcl-1 upregulation and anti-apoptosis activity in basal cell carcinoma cells
-
Jee SH, Chiu HC, Tsai TF et al. (2002) The phosphotidyl inositol 3-kinase/Akt signal pathway is involved in interleukin-6-mediated Mcl-1 upregulation and anti-apoptosis activity in basal cell carcinoma cells. J Invest Dermatol 119:1121-1127
-
(2002)
J Invest Dermatol
, vol.119
, pp. 1121-1127
-
-
Jee, S.H.1
Chiu, H.C.2
Tsai, T.F.3
-
73
-
-
0033551802
-
Interleukin-6 inhibits transforming growth factor-beta-induced apoptosis through the phosphatidylinositol 3-kinase/Akt and signal transducers and activators of transcription 3 pathways
-
Chen RH, Chang MC, Su YH, Tsai YT, Kuo ML (1999) Interleukin-6 inhibits transforming growth factor-beta-induced apoptosis through the phosphatidylinositol 3-kinase/Akt and signal transducers and activators of transcription 3 pathways. J Biol Chem 274:23013-23019
-
(1999)
J Biol Chem
, vol.274
, pp. 23013-23019
-
-
Chen, R.H.1
Chang, M.C.2
Su, Y.H.3
Tsai, Y.T.4
Kuo, M.L.5
-
74
-
-
0031596597
-
Interleukin 1beta and interleukin 6, but not tumor necrosis factor alpha, inhibit insulin-stimulated glycogen synthesis in rat hepatocytes
-
Kanemaki T, Kitade H, Kaibori M et al. (1998) Interleukin 1beta and interleukin 6, but not tumor necrosis factor alpha, inhibit insulin-stimulated glycogen synthesis in rat hepatocytes. Hepatology 27:1296-1303
-
(1998)
Hepatology
, vol.27
, pp. 1296-1303
-
-
Kanemaki, T.1
Kitade, H.2
Kaibori, M.3
-
75
-
-
0036327970
-
Impairment of insulin signaling in human skeletal muscle cells by co-culture with human adipocytes
-
Dietze D, Koenen M, Rohrig K, Horikoshi H, Hauner H, Eckel J (2002) Impairment of insulin signaling in human skeletal muscle cells by co-culture with human adipocytes. Diabetes 51:2369-2376
-
(2002)
Diabetes
, vol.51
, pp. 2369-2376
-
-
Dietze, D.1
Koenen, M.2
Rohrig, K.3
Horikoshi, H.4
Hauner, H.5
Eckel, J.6
-
76
-
-
0041548173
-
Interleukin-6 gene polymorphism and insulin sensitivity
-
Fernandez-Real JM, Broch M, Vendrell J et al. (2000) Interleukin-6 gene polymorphism and insulin sensitivity. Diabetes 49:517-520
-
(2000)
Diabetes
, vol.49
, pp. 517-520
-
-
Fernandez-Real, J.M.1
Broch, M.2
Vendrell, J.3
-
77
-
-
0038353486
-
Promoter polymorphisms of the TNF-alpha (G-308A) and IL-6 (C-174G) genes predict the conversion from impaired glucose tolerance to type 2 diabetes: The Finnish Diabetes Prevention Study
-
Kubaszek A, Pihlajamaki J, Komarovski V et al. (2003) Promoter polymorphisms of the TNF-alpha (G-308A) and IL-6 (C-174G) genes predict the conversion from impaired glucose tolerance to type 2 diabetes: the Finnish Diabetes Prevention Study. Diabetes 52:1872-1876
-
(2003)
Diabetes
, vol.52
, pp. 1872-1876
-
-
Kubaszek, A.1
Pihlajamaki, J.2
Komarovski, V.3
-
78
-
-
0037849948
-
The interleukin-6 (-174) G/C promoter polymorphism is associated with type-2 diabetes mellitus in Native Americans and Caucasians
-
Vozarova B, Fernandez-Real JM, Knowler WC et al. (2003) The interleukin-6 (-174) G/C promoter polymorphism is associated with type-2 diabetes mellitus in Native Americans and Caucasians. Hum Genet 112:409-413
-
(2003)
Hum Genet
, vol.112
, pp. 409-413
-
-
Vozarova, B.1
Fernandez-Real, J.M.2
Knowler, W.C.3
-
80
-
-
0030782520
-
Dose-dependent effects of recombinant human interleukin-6 on glucose regulation
-
Tsigos C, Papanicolaou DA, Kyrou I, Defensor R, Mitsiadis CS, Chrousos GP (1997) Dose-dependent effects of recombinant human interleukin-6 on glucose regulation. J Clin Endocrinol Metab 82:4167-4170
-
(1997)
J Clin Endocrinol Metab
, vol.82
, pp. 4167-4170
-
-
Tsigos, C.1
Papanicolaou, D.A.2
Kyrou, I.3
Defensor, R.4
Mitsiadis, C.S.5
Chrousos, G.P.6
-
81
-
-
0037101934
-
Metabolic effects of interleukin-6 in human splanchnic and adipose tissue
-
Lyngso D, Simonsen L, Bulow J (2002) Metabolic effects of interleukin-6 in human splanchnic and adipose tissue. J Physiol 543:379-386
-
(2002)
J Physiol
, vol.543
, pp. 379-386
-
-
Lyngso, D.1
Simonsen, L.2
Bulow, J.3
-
82
-
-
0036152683
-
Interleukin-6-deficient mice develop mature-onset obesity
-
Wallenius V, Wallenius K, Ahren B et al. (2002) Interleukin-6-deficient mice develop mature-onset obesity. Nat Med 8:75-79
-
(2002)
Nat Med
, vol.8
, pp. 75-79
-
-
Wallenius, V.1
Wallenius, K.2
Ahren, B.3
-
83
-
-
0036295573
-
Intracerebroventricular interleukin-6 treatment decreases body fat in rats
-
Wallenius K, Wallenius V, Sunter D, Dickson SL, Jansson JO (2002) Intracerebroventricular interleukin-6 treatment decreases body fat in rats. Biochem Biophys Res Commun 293:560-565
-
(2002)
Biochem Biophys Res Commun
, vol.293
, pp. 560-565
-
-
Wallenius, K.1
Wallenius, V.2
Sunter, D.3
Dickson, S.L.4
Jansson, J.O.5
-
84
-
-
0025934803
-
Altered transcriptional regulation of phosphoenolpyruvate carboxykinase in rats following endotoxin treatment
-
Hill M, McCallum R (1991) Altered transcriptional regulation of phosphoenolpyruvate carboxykinase in rats following endotoxin treatment. J Clin Invest 88:811-816
-
(1991)
J Clin Invest
, vol.88
, pp. 811-816
-
-
Hill, M.1
McCallum, R.2
-
85
-
-
0028152932
-
Inhibition by recombinant human interleukin-6 of the glucagon-dependent induction of phosphoenolpyruvate carboxy-kinase and of the insulin-dependent induction of glucokinase gene expression in cultured rat hepatocytes: Regulation of gene transcription and messenger RNA degradation
-
Christ B, Nath A, Heinrich PC, Jungermann K (1994) Inhibition by recombinant human interleukin-6 of the glucagon-dependent induction of phosphoenolpyruvate carboxy-kinase and of the insulin-dependent induction of glucokinase gene expression in cultured rat hepatocytes: regulation of gene transcription and messenger RNA degradation. Hepatology 20:1577-1583
-
(1994)
Hepatology
, vol.20
, pp. 1577-1583
-
-
Christ, B.1
Nath, A.2
Heinrich, P.C.3
Jungermann, K.4
-
86
-
-
0028929156
-
Interleukin-6 stimulates hepatic triglyceride secretion in rats
-
Nonogaki K, Fuller GM, Fuentes NL et al. (1995) Interleukin-6 stimulates hepatic triglyceride secretion in rats. Endocrinology 136:2143-2149
-
(1995)
Endocrinology
, vol.136
, pp. 2143-2149
-
-
Nonogaki, K.1
Fuller, G.M.2
Fuentes, N.L.3
-
87
-
-
0028674174
-
Endocrine and carbohydrate responses to interleukin-6 in vivo
-
Stith RD, Luo J (1994) Endocrine and carbohydrate responses to interleukin-6 in vivo. Circ Shock 44:210-215
-
(1994)
Circ Shock
, vol.44
, pp. 210-215
-
-
Stith, R.D.1
Luo, J.2
-
88
-
-
3042721664
-
Interleukin-6 is a novel factor mediating glucose homeostasis during skeletal muscle contraction
-
Febbraio MA, Hiscock N, Sacchetti M, Fischer CP, Pedersen BK (2004) Interleukin-6 is a novel factor mediating glucose homeostasis during skeletal muscle contraction. Diabetes 53:1643-1648
-
(2004)
Diabetes
, vol.53
, pp. 1643-1648
-
-
Febbraio, M.A.1
Hiscock, N.2
Sacchetti, M.3
Fischer, C.P.4
Pedersen, B.K.5
-
89
-
-
0024312875
-
High interleukin-6 serum levels and increased production by leucocytes in alcoholic liver cirrhosis. Correlation with IgA serum levels and lymphokines production
-
Deviere J, Content J, Denys C et al. (1989) High interleukin-6 serum levels and increased production by leucocytes in alcoholic liver cirrhosis. Correlation with IgA serum levels and lymphokines production. Clin Exp Immunol 77:221-225
-
(1989)
Clin Exp Immunol
, vol.77
, pp. 221-225
-
-
Deviere, J.1
Content, J.2
Denys, C.3
-
90
-
-
0026021473
-
Effects of cytokines on the liver
-
Andus T, Bauer J, Gerok W (1991) Effects of cytokines on the liver. Hepatology 13:364-375
-
(1991)
Hepatology
, vol.13
, pp. 364-375
-
-
Andus, T.1
Bauer, J.2
Gerok, W.3
-
91
-
-
0035861013
-
Cytokines and type 2 diabetes mellitus
-
Dovio A, Angeli A (2001) Cytokines and type 2 diabetes mellitus. JAMA 286:2233
-
(2001)
JAMA
, vol.286
, pp. 2233
-
-
Dovio, A.1
Angeli, A.2
-
92
-
-
0035211501
-
Autocrine up-regulation of glucocorticoid receptors by interleukin-6 in human osteoblast-like cells
-
Dovio A, Masera RG, Sartori ML, Racca S, Angeli A (2001) Autocrine up-regulation of glucocorticoid receptors by interleukin-6 in human osteoblast-like cells. Calcif Tissue Int 69:293-298
-
(2001)
Calcif Tissue Int
, vol.69
, pp. 293-298
-
-
Dovio, A.1
Masera, R.G.2
Sartori, M.L.3
Racca, S.4
Angeli, A.5
-
93
-
-
0034947869
-
Mammalian target of rapamycin pathway regulates insulin signaling via subcellular redistribution of insulin receptor substrate 1 and integrates nutritional signals and metabolic signals of insulin
-
Takano A, Usui I, Haruta T et al. (2001) Mammalian target of rapamycin pathway regulates insulin signaling via subcellular redistribution of insulin receptor substrate 1 and integrates nutritional signals and metabolic signals of insulin. Mol Cell Biol 21:5050-5062
-
(2001)
Mol Cell Biol
, vol.21
, pp. 5050-5062
-
-
Takano, A.1
Usui, I.2
Haruta, T.3
-
94
-
-
0035851205
-
Amino acid and insulin signaling via the mTOR/p70 S6 kinase pathway. A negative feedback mechanism leading to insulin resistance in skeletal muscle cells
-
Tremblay F, Marette A (2001) Amino acid and insulin signaling via the mTOR/p70 S6 kinase pathway. A negative feedback mechanism leading to insulin resistance in skeletal muscle cells. J Biol Chem 276:38052-38060
-
(2001)
J Biol Chem
, vol.276
, pp. 38052-38060
-
-
Tremblay, F.1
Marette, A.2
-
95
-
-
0344686538
-
MAP kinases and mTOR mediate insulin-induced phosphorylation of Insulin Receptor Substrate-1 on serine residues 307, 612 and 632
-
Gual P, Gremeaux T, Gonzalez T, Le Marchand-Brustel Y, Tanti JF (2003) MAP kinases and mTOR mediate insulin-induced phosphorylation of Insulin Receptor Substrate-1 on serine residues 307, 612 and 632. Diabetologia 46:1532-1542
-
(2003)
Diabetologia
, vol.46
, pp. 1532-1542
-
-
Gual, P.1
Gremeaux, T.2
Gonzalez, T.3
Le Marchand-Brustel, Y.4
Tanti, J.F.5
|