메뉴 건너뛰기




Volumn 287, Issue 1, 2010, Pages 13-22

Neopterin, a prognostic marker in human malignancies

Author keywords

Cancer; Macrophages; Neopterin; Prognosis

Indexed keywords

CYTOKINE; GAMMA INTERFERON; NEOPTERIN; REACTIVE OXYGEN METABOLITE; TRYPTOPHAN;

EID: 72049127518     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2009.05.008     Document Type: Review
Times cited : (136)

References (132)
  • 1
    • 0029924107 scopus 로고    scopus 로고
    • Human tumor antigens recognized by T-lymphocytes
    • Boon T., and van der Bruggen P. Human tumor antigens recognized by T-lymphocytes. J. Exp. Med. 183 (1996) 725-729
    • (1996) J. Exp. Med. , vol.183 , pp. 725-729
    • Boon, T.1    van der Bruggen, P.2
  • 2
    • 34248173331 scopus 로고    scopus 로고
    • Indoleamine 2,3-dioxygenase and tumor-induced tolerance
    • Munn D.H., and Mellor A.L. Indoleamine 2,3-dioxygenase and tumor-induced tolerance. J. Clin. Invest. 117 (2007) 1147-1154
    • (2007) J. Clin. Invest. , vol.117 , pp. 1147-1154
    • Munn, D.H.1    Mellor, A.L.2
  • 3
    • 33747179266 scopus 로고    scopus 로고
    • Antitumoral activity of interferon-gamma involved in impaired immune function in cancer patients
    • Brandacher G., Winkler C., Schroecksnadel K., Margreiter R., and Fuchs D. Antitumoral activity of interferon-gamma involved in impaired immune function in cancer patients. Curr. Drug Metab. 7 (2006) 599-612
    • (2006) Curr. Drug Metab. , vol.7 , pp. 599-612
    • Brandacher, G.1    Winkler, C.2    Schroecksnadel, K.3    Margreiter, R.4    Fuchs, D.5
  • 4
    • 0031900886 scopus 로고    scopus 로고
    • Lineage-negative human leukocyte antigen-DR+ cells with the phenotype of undifferentiated dendritic cells in patients with carcinoma of the abdomen and pelvis
    • Melichar B., Savary C., Kudelka A.P., Verschraegen C., Kavanagh J.J., Edwards C.L., Platsoucas C.D., and Freedman R.S. Lineage-negative human leukocyte antigen-DR+ cells with the phenotype of undifferentiated dendritic cells in patients with carcinoma of the abdomen and pelvis. Clin. Cancer Res. 4 (1998) 799-809
    • (1998) Clin. Cancer Res. , vol.4 , pp. 799-809
    • Melichar, B.1    Savary, C.2    Kudelka, A.P.3    Verschraegen, C.4    Kavanagh, J.J.5    Edwards, C.L.6    Platsoucas, C.D.7    Freedman, R.S.8
  • 5
    • 0036005884 scopus 로고    scopus 로고
    • The roles of IFN gamma in protection against tumor development and cancer immunoediting
    • Ikeda H., Old L.J., and Schreiber R.D. The roles of IFN gamma in protection against tumor development and cancer immunoediting. Cytokine Growth Factor Rev. 13 (2002) 95-109
    • (2002) Cytokine Growth Factor Rev. , vol.13 , pp. 95-109
    • Ikeda, H.1    Old, L.J.2    Schreiber, R.D.3
  • 6
    • 0028809178 scopus 로고
    • Gene transfer as cancer therapy
    • Dranoff G., and Mulligan R.C. Gene transfer as cancer therapy. Adv. Immunol. 58 (1995) 417-454
    • (1995) Adv. Immunol. , vol.58 , pp. 417-454
    • Dranoff, G.1    Mulligan, R.C.2
  • 9
    • 0021203824 scopus 로고
    • Biopterin cofactor biosynthesis: GTP cyclohydrolase, neopterin and biopterin in tissues and body fluids of mammalian species
    • Duch D.S., Bowers S.W., Woolf J.H., and Nichol C.A. Biopterin cofactor biosynthesis: GTP cyclohydrolase, neopterin and biopterin in tissues and body fluids of mammalian species. Life Sci. 35 (1984) 1895-1901
    • (1984) Life Sci. , vol.35 , pp. 1895-1901
    • Duch, D.S.1    Bowers, S.W.2    Woolf, J.H.3    Nichol, C.A.4
  • 12
    • 0042162960 scopus 로고    scopus 로고
    • Potential role of immune system activation associated production of neopterin derivatives in humans
    • Hoffmann G., Wirleitner B., and Fuchs D. Potential role of immune system activation associated production of neopterin derivatives in humans. Inflammation Res. 52 (2003) 313-321
    • (2003) Inflammation Res. , vol.52 , pp. 313-321
    • Hoffmann, G.1    Wirleitner, B.2    Fuchs, D.3
  • 17
    • 0033608872 scopus 로고    scopus 로고
    • Levels of serum neopterin are increased in pancreatic cancer patients and correlate with the prognosis
    • Birk D., Gansauge F., Gansauge S., Schwarz A., and Beger H.G. Levels of serum neopterin are increased in pancreatic cancer patients and correlate with the prognosis. Eur. J. Med. Res. 4 (1999) 156-160
    • (1999) Eur. J. Med. Res. , vol.4 , pp. 156-160
    • Birk, D.1    Gansauge, F.2    Gansauge, S.3    Schwarz, A.4    Beger, H.G.5
  • 19
    • 0014047941 scopus 로고
    • Neopterin: isolation from human urine
    • Sakurai A., and Goto M. Neopterin: isolation from human urine. J. Biochem. 61 (1967) 142-145
    • (1967) J. Biochem. , vol.61 , pp. 142-145
    • Sakurai, A.1    Goto, M.2
  • 20
    • 0018623785 scopus 로고
    • Increased urinary excretion of neopterin in patients with malignant tumors and with virus diseases
    • Wachter H., Hausen A., and Grassmayr K. Increased urinary excretion of neopterin in patients with malignant tumors and with virus diseases. Hoppe Seyler's Z. Physiol. Chem. 360 (1979) 1957-1960
    • (1979) Hoppe Seyler's Z. Physiol. Chem. , vol.360 , pp. 1957-1960
    • Wachter, H.1    Hausen, A.2    Grassmayr, K.3
  • 22
    • 0025236440 scopus 로고
    • Tetrahydrobiopterin biosynthetic activities in human macrophages fibroblasts, THP-1, and T 24 cells. GTP-cyclohydrolase I is stimulated by interferon-gamma, and 6-pyruvoyl tetrahydropterin synthase and sepiapterin reductase are constitutively present
    • Werner E.R., Werner-Felmayer G., Fuchs D., Hausen A., Reibnegger G., Yim J.J., Pfleiderer W., and Wachter H. Tetrahydrobiopterin biosynthetic activities in human macrophages fibroblasts, THP-1, and T 24 cells. GTP-cyclohydrolase I is stimulated by interferon-gamma, and 6-pyruvoyl tetrahydropterin synthase and sepiapterin reductase are constitutively present. J. Biol. Chem. 265 (1990) 3189-3192
    • (1990) J. Biol. Chem. , vol.265 , pp. 3189-3192
    • Werner, E.R.1    Werner-Felmayer, G.2    Fuchs, D.3    Hausen, A.4    Reibnegger, G.5    Yim, J.J.6    Pfleiderer, W.7    Wachter, H.8
  • 23
    • 0034726703 scopus 로고    scopus 로고
    • Oxidation of 7,8-dihydroneopterin by hypochlorous acid yields neopterin
    • Widner B., Mayr C., Wirleitner B., and Fuchs D. Oxidation of 7,8-dihydroneopterin by hypochlorous acid yields neopterin. Biochem. Biophys. Res. Commun. 275 (2000) 307-311
    • (2000) Biochem. Biophys. Res. Commun. , vol.275 , pp. 307-311
    • Widner, B.1    Mayr, C.2    Wirleitner, B.3    Fuchs, D.4
  • 24
    • 0035065831 scopus 로고    scopus 로고
    • Protection of erythrocytes by the macrophage synthesized antioxidant 7,8 dihydroneopterin
    • Gieseg S.P., Maghzal G., and Glubb D. Protection of erythrocytes by the macrophage synthesized antioxidant 7,8 dihydroneopterin. Free Radical Res. 34 (2001) 123-136
    • (2001) Free Radical Res. , vol.34 , pp. 123-136
    • Gieseg, S.P.1    Maghzal, G.2    Glubb, D.3
  • 25
    • 0026653881 scopus 로고
    • Neopterin release from human endothelial cells is triggered by interferon-gamma
    • Andert S.E., Griesmacher A., Zuckermann A., and Müller M.M. Neopterin release from human endothelial cells is triggered by interferon-gamma. Clin. Exp. Immunol. 88 (1992) 555-558
    • (1992) Clin. Exp. Immunol. , vol.88 , pp. 555-558
    • Andert, S.E.1    Griesmacher, A.2    Zuckermann, A.3    Müller, M.M.4
  • 26
    • 0026625694 scopus 로고
    • Different lymphoid cell populations produce varied levels of neopterin, beta 2-microglobulin and soluble IL-2, receptor when stimulated with IL-2 interferon-gamma or tumour necrosis factor-alpha
    • Hofmann B., Bass H., Nishanian P., Faisal M., Figlin R.A., Sarna G.P., and Fahey J.L. Different lymphoid cell populations produce varied levels of neopterin, beta 2-microglobulin and soluble IL-2, receptor when stimulated with IL-2 interferon-gamma or tumour necrosis factor-alpha. Clin. Exp. Immunol. 88 (1992) 548-554
    • (1992) Clin. Exp. Immunol. , vol.88 , pp. 548-554
    • Hofmann, B.1    Bass, H.2    Nishanian, P.3    Faisal, M.4    Figlin, R.A.5    Sarna, G.P.6    Fahey, J.L.7
  • 28
    • 0029559933 scopus 로고
    • Nitric oxide formation as predictive parameter for acute graft-versus-host disease after human allogeneic bone marrow transplantation
    • Weiss G., Schwaighofer H., Herold M., Nachbaur D., Wachter H., Niederwieser D., and Werner E.R. Nitric oxide formation as predictive parameter for acute graft-versus-host disease after human allogeneic bone marrow transplantation. Transplantation 60 (1995) 1239-1244
    • (1995) Transplantation , vol.60 , pp. 1239-1244
    • Weiss, G.1    Schwaighofer, H.2    Herold, M.3    Nachbaur, D.4    Wachter, H.5    Niederwieser, D.6    Werner, E.R.7
  • 29
    • 0021162101 scopus 로고
    • Use of monoclonal antibodies as sensitive and specific probes for biologically active human gamma-interferon
    • Chang T.W., McKinney S., Liu V., Kung P.C., Vilcek J., and Le J. Use of monoclonal antibodies as sensitive and specific probes for biologically active human gamma-interferon. Proc. Natl. Acad. Sci. USA 81 (1984) 5219-5222
    • (1984) Proc. Natl. Acad. Sci. USA , vol.81 , pp. 5219-5222
    • Chang, T.W.1    McKinney, S.2    Liu, V.3    Kung, P.C.4    Vilcek, J.5    Le, J.6
  • 30
    • 0026071233 scopus 로고
    • Lymphokine-activated killer cells, natural killer cells and cytokines
    • Perussia B. Lymphokine-activated killer cells, natural killer cells and cytokines. Curr. Opin. Immunol. 3 (1991) 49-55
    • (1991) Curr. Opin. Immunol. , vol.3 , pp. 49-55
    • Perussia, B.1
  • 31
    • 0028960040 scopus 로고
    • Cytokine-induced differentiation of precursor mouse CD8+ T cells into cytotoxic CD8+ T cells secreting Th1 or Th2 cytokines
    • Sad S., Marcotte R., and Mosmann T.R. Cytokine-induced differentiation of precursor mouse CD8+ T cells into cytotoxic CD8+ T cells secreting Th1 or Th2 cytokines. Immunity 2 (1995) 271-279
    • (1995) Immunity , vol.2 , pp. 271-279
    • Sad, S.1    Marcotte, R.2    Mosmann, T.R.3
  • 32
    • 0027066967 scopus 로고
    • The role of neopterin as a monitor of cellular immune activation in transplantation, inflammatory, infectious, and malignant diseases
    • Fuchs D., Weiss G., Reibnegger G., and Wachter H. The role of neopterin as a monitor of cellular immune activation in transplantation, inflammatory, infectious, and malignant diseases. Crit. Rev. Clin. Lab. Sci. 29 (1992) 307-341
    • (1992) Crit. Rev. Clin. Lab. Sci. , vol.29 , pp. 307-341
    • Fuchs, D.1    Weiss, G.2    Reibnegger, G.3    Wachter, H.4
  • 34
    • 0025819142 scopus 로고
    • Increased endogenous interferon-gamma and neopterin correlate with increased degradation of tryptophan in human immunodeficiency virus type 1 infection
    • Fuchs D., Moeller A.A., Reibnegger G., Werner E.R., Werner-Felmayer G., Dierich M.P., and Wachter H. Increased endogenous interferon-gamma and neopterin correlate with increased degradation of tryptophan in human immunodeficiency virus type 1 infection. Immunol. Lett. 28 (1991) 207-211
    • (1991) Immunol. Lett. , vol.28 , pp. 207-211
    • Fuchs, D.1    Moeller, A.A.2    Reibnegger, G.3    Werner, E.R.4    Werner-Felmayer, G.5    Dierich, M.P.6    Wachter, H.7
  • 35
    • 0026884189 scopus 로고
    • Changes of serum neopterin, beta 2-microglobulin and interferon-gamma in patients with chronic hepatitis C treated with interferon-alpha 2b
    • Fuchs D., Norkrans G., Wejstal R., Reibnegger G., Weiss G., Weiland O., Schvarcz R., Fryden A., and Wachter H. Changes of serum neopterin, beta 2-microglobulin and interferon-gamma in patients with chronic hepatitis C treated with interferon-alpha 2b. Eur. J. Med. 1 (1992) 196-200
    • (1992) Eur. J. Med. , vol.1 , pp. 196-200
    • Fuchs, D.1    Norkrans, G.2    Wejstal, R.3    Reibnegger, G.4    Weiss, G.5    Weiland, O.6    Schvarcz, R.7    Fryden, A.8    Wachter, H.9
  • 37
    • 0033066772 scopus 로고    scopus 로고
    • Modulation of neopterin formation and tryptophan degradation by Th1- and Th2-derived cytokines in human monocytic cells
    • Weiss G., Murr C., Zoller H., Haun M., Widner B., Ludescher C., and Fuchs D. Modulation of neopterin formation and tryptophan degradation by Th1- and Th2-derived cytokines in human monocytic cells. Clin. Exp. Immunol. 116 (1999) 435-440
    • (1999) Clin. Exp. Immunol. , vol.116 , pp. 435-440
    • Weiss, G.1    Murr, C.2    Zoller, H.3    Haun, M.4    Widner, B.5    Ludescher, C.6    Fuchs, D.7
  • 38
    • 0024460738 scopus 로고
    • Tumour necrosis factor-alpha and lipopolysaccharide enhance interferon-induced tryptophan degradation and pteridine synthesis in human cells
    • Werner-Felmayer G., Werner E.R., Fuchs D., Hausen A., Reibnegger G., and Wachter H. Tumour necrosis factor-alpha and lipopolysaccharide enhance interferon-induced tryptophan degradation and pteridine synthesis in human cells. Biol. Chem. Hoppe Seyler 370 (1989) 1063-1069
    • (1989) Biol. Chem. Hoppe Seyler , vol.370 , pp. 1063-1069
    • Werner-Felmayer, G.1    Werner, E.R.2    Fuchs, D.3    Hausen, A.4    Reibnegger, G.5    Wachter, H.6
  • 40
  • 41
    • 0028178876 scopus 로고
    • Commercial enzyme-linked immunosorbent assay for neopterin detection in blood donations compared with RIA and HPLC
    • Mayersbach P., Augustin R., Schennach H., Schoenitzer D., Werner E.R., Wachter H., and Reibnegger G. Commercial enzyme-linked immunosorbent assay for neopterin detection in blood donations compared with RIA and HPLC. Clin. Chem. 40 (1994) 265-266
    • (1994) Clin. Chem. , vol.40 , pp. 265-266
    • Mayersbach, P.1    Augustin, R.2    Schennach, H.3    Schoenitzer, D.4    Werner, E.R.5    Wachter, H.6    Reibnegger, G.7
  • 45
    • 0022991358 scopus 로고
    • Peroxide and pteridine: a hypothesis on the regulation of macrophage antimicrobial activity by interferon gamma
    • Nathan C.F. Peroxide and pteridine: a hypothesis on the regulation of macrophage antimicrobial activity by interferon gamma. Interferon 7 (1986) 125-143
    • (1986) Interferon , vol.7 , pp. 125-143
    • Nathan, C.F.1
  • 46
    • 0032782906 scopus 로고    scopus 로고
    • Increased neopterin concentrations in patients with cancer: indicator of oxidative stress?
    • Murr C., Fuith L.C., Widner B., Wirleitner B., Baier-Bitterlich G., and Fuchs D. Increased neopterin concentrations in patients with cancer: indicator of oxidative stress?. Anticancer Res. 19 (1999) 1721-1728
    • (1999) Anticancer Res. , vol.19 , pp. 1721-1728
    • Murr, C.1    Fuith, L.C.2    Widner, B.3    Wirleitner, B.4    Baier-Bitterlich, G.5    Fuchs, D.6
  • 48
    • 0023898932 scopus 로고
    • The ras gene family and human carcinogenesis
    • Bos J.L. The ras gene family and human carcinogenesis. Mutat. Res. 195 (1988) 255-271
    • (1988) Mutat. Res. , vol.195 , pp. 255-271
    • Bos, J.L.1
  • 50
    • 0028048065 scopus 로고
    • Neopterin derivatives together with cyclic guanosine monophosphate induce c-fos gene expression
    • Überall F., Werner-Felmayer G., Schubert C., Grunicke H.H., Wachter H., and Fuchs D. Neopterin derivatives together with cyclic guanosine monophosphate induce c-fos gene expression. FEBS Lett. 352 (1994) 11-14
    • (1994) FEBS Lett. , vol.352 , pp. 11-14
    • Überall, F.1    Werner-Felmayer, G.2    Schubert, C.3    Grunicke, H.H.4    Wachter, H.5    Fuchs, D.6
  • 51
    • 0025852479 scopus 로고
    • Modulation of transcription factor NF-kappa B binding activity by oxidation-reduction in vitro
    • Toledano M.B., and Leonard W.J. Modulation of transcription factor NF-kappa B binding activity by oxidation-reduction in vitro. Proc. Natl. Acad. Sci. USA 88 (1991) 4328-4332
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 4328-4332
    • Toledano, M.B.1    Leonard, W.J.2
  • 56
    • 12144251006 scopus 로고    scopus 로고
    • D. St. John's wort (Hypericum perforatum) counteracts cytokine-induced tryptophan catabolism in vitro
    • Winkler C C., Wirleitner B., Schroecksnadel K., Schennach H., and Mur E. D. St. John's wort (Hypericum perforatum) counteracts cytokine-induced tryptophan catabolism in vitro. Biol. Chem. 385 (2004) 1197-1202
    • (2004) Biol. Chem. , vol.385 , pp. 1197-1202
    • Winkler C, C.1    Wirleitner, B.2    Schroecksnadel, K.3    Schennach, H.4    Mur, E.5
  • 57
    • 33645337897 scopus 로고    scopus 로고
    • Neopterin as an indicator of immune activation and prognosis in patients with gynecological malignancies
    • Melichar B., Solichova D., and Freedman R.S. Neopterin as an indicator of immune activation and prognosis in patients with gynecological malignancies. Int. J. Gynecol. Cancer 16 (2006) 240-252
    • (2006) Int. J. Gynecol. Cancer , vol.16 , pp. 240-252
    • Melichar, B.1    Solichova, D.2    Freedman, R.S.3
  • 60
    • 3342896373 scopus 로고    scopus 로고
    • A research on the level of urine neopterin to see if it may provide a vital clue for a provisional diagnosis of breast cancer in menopausal women
    • Bayram M., Bayram O., Boyunaga H., and Ozer G. A research on the level of urine neopterin to see if it may provide a vital clue for a provisional diagnosis of breast cancer in menopausal women. Maturitas 48 (2004) 432-437
    • (2004) Maturitas , vol.48 , pp. 432-437
    • Bayram, M.1    Bayram, O.2    Boyunaga, H.3    Ozer, G.4
  • 63
    • 0026328009 scopus 로고
    • Predictive value of interleukin-6 and neopterin in patients with multiple myeloma
    • Reibnegger G., Krainer M., Herold M., Ludwig H., Wachter H., and Huber H. Predictive value of interleukin-6 and neopterin in patients with multiple myeloma. Cancer Res. 51 (1991) 6250-6253
    • (1991) Cancer Res. , vol.51 , pp. 6250-6253
    • Reibnegger, G.1    Krainer, M.2    Herold, M.3    Ludwig, H.4    Wachter, H.5    Huber, H.6
  • 64
  • 65
    • 0023736398 scopus 로고
    • Prognostic significance of urinary neopterin levels in patients with hepatocellular carcinoma
    • Kawasaki H., Watanabe H., Yamada S., Watanabe K., and Suyama A. Prognostic significance of urinary neopterin levels in patients with hepatocellular carcinoma. Tohoku J. Exp. Med. 155 (1988) 311-318
    • (1988) Tohoku J. Exp. Med. , vol.155 , pp. 311-318
    • Kawasaki, H.1    Watanabe, H.2    Yamada, S.3    Watanabe, K.4    Suyama, A.5
  • 67
    • 0027066967 scopus 로고
    • The role of neopterin as a monitor of cellular activation in transplantation, inflammatory, infectious and malignant disease
    • Fuchs D D., Weiss G., Reibnegger G., and Wachter H. The role of neopterin as a monitor of cellular activation in transplantation, inflammatory, infectious and malignant disease. Crit. Rev. Clin. Chem. 29 (1992) 307-341
    • (1992) Crit. Rev. Clin. Chem. , vol.29 , pp. 307-341
    • Fuchs D, D.1    Weiss, G.2    Reibnegger, G.3    Wachter, H.4
  • 68
    • 0025328972 scopus 로고
    • Neopterin formation and tryptophan degradation by a human myelomonocytic cell line (THP-1) upon cytokine treatment
    • Werner-Felmayer G., Werner E.R., Fuchs D., Hausen A., Reibnegger G., and Wachter H. Neopterin formation and tryptophan degradation by a human myelomonocytic cell line (THP-1) upon cytokine treatment. Cancer Res. 50 (1990) 2863-2867
    • (1990) Cancer Res. , vol.50 , pp. 2863-2867
    • Werner-Felmayer, G.1    Werner, E.R.2    Fuchs, D.3    Hausen, A.4    Reibnegger, G.5    Wachter, H.6
  • 69
    • 0034528154 scopus 로고    scopus 로고
    • Inflammation marker 7,8-dihydroneopterin induces apoptosis of neurons and glial cells - potential contribution to neurodegenerative processes
    • Speth C., Stoeckl G., Fuchs D., Wirleitner B., Widner B., Würzner R., Mohsenipour I., and Dierich M.P. Inflammation marker 7,8-dihydroneopterin induces apoptosis of neurons and glial cells - potential contribution to neurodegenerative processes. Immunobiology 202 (2000) 460-476
    • (2000) Immunobiology , vol.202 , pp. 460-476
    • Speth, C.1    Stoeckl, G.2    Fuchs, D.3    Wirleitner, B.4    Widner, B.5    Würzner, R.6    Mohsenipour, I.7    Dierich, M.P.8
  • 71
    • 33845920042 scopus 로고    scopus 로고
    • Decreased serum tryptophan concentration predicts poor prognosis in malignant melanoma patients
    • Weinlich G., Murr C., Richardsen L., Winkler C., and Fuchs D. Decreased serum tryptophan concentration predicts poor prognosis in malignant melanoma patients. Dermatology 214 (2007) 8-14
    • (2007) Dermatology , vol.214 , pp. 8-14
    • Weinlich, G.1    Murr, C.2    Richardsen, L.3    Winkler, C.4    Fuchs, D.5
  • 72
    • 0025944659 scopus 로고
    • Relationship between interferon-gamma, indoleamine 2,3-dioxygenase, and tryptophan catabolism
    • Taylor M.W., and Feng G.S. Relationship between interferon-gamma, indoleamine 2,3-dioxygenase, and tryptophan catabolism. FASEB J. 5 (1991) 2516-2522
    • (1991) FASEB J. , vol.5 , pp. 2516-2522
    • Taylor, M.W.1    Feng, G.S.2
  • 73
    • 0024994054 scopus 로고
    • Decreased serum tryptophan in patients with HIV-1 infection correlates with increased serum neopterin and with neurologic/psychiatric symptoms
    • Fuchs D., Moeller A.A., Reibnegger G., Stoeckle E., Werner E.R., and Wachter H. Decreased serum tryptophan in patients with HIV-1 infection correlates with increased serum neopterin and with neurologic/psychiatric symptoms. J. Acquir. Immune Defic. Syndr. 3 (1990) 873-876
    • (1990) J. Acquir. Immune Defic. Syndr. , vol.3 , pp. 873-876
    • Fuchs, D.1    Moeller, A.A.2    Reibnegger, G.3    Stoeckle, E.4    Werner, E.R.5    Wachter, H.6
  • 75
    • 0037024439 scopus 로고    scopus 로고
    • Serum tryptophan decrease correlates with immune activation and impaired quality of life in colorectal cancer
    • Huang A., Fuchs D., Widner B., Glover C., Henderson D.C., and Allen-Mersh T.G. Serum tryptophan decrease correlates with immune activation and impaired quality of life in colorectal cancer. Br. J. Cancer 86 (2002) 1691-1696
    • (2002) Br. J. Cancer , vol.86 , pp. 1691-1696
    • Huang, A.1    Fuchs, D.2    Widner, B.3    Glover, C.4    Henderson, D.C.5    Allen-Mersh, T.G.6
  • 76
    • 0000056144 scopus 로고
    • Interferon gamma blocks the growth of Toxoplasma gondii in human fibroblasts by inducing the host cells to degrade tryptophan
    • Pfefferkorn E.R. Interferon gamma blocks the growth of Toxoplasma gondii in human fibroblasts by inducing the host cells to degrade tryptophan. Proc. Natl. Acad. Sci. USA 81 (1984) 908-912
    • (1984) Proc. Natl. Acad. Sci. USA , vol.81 , pp. 908-912
    • Pfefferkorn, E.R.1
  • 77
    • 0034176031 scopus 로고    scopus 로고
    • Indoleamine 2,3-dioxygenase production by human dendritic cells results in the inhibition of T-cell proliferation
    • Hwu P., Du M.X., Lapointe R., Do M., Taylor M.W., and Young H.A. Indoleamine 2,3-dioxygenase production by human dendritic cells results in the inhibition of T-cell proliferation. J. Immunol. 164 (2000) 3596-3599
    • (2000) J. Immunol. , vol.164 , pp. 3596-3599
    • Hwu, P.1    Du, M.X.2    Lapointe, R.3    Do, M.4    Taylor, M.W.5    Young, H.A.6
  • 80
    • 0038215374 scopus 로고    scopus 로고
    • Tolerance, DCs and tryptophan: much ado about IDO
    • Grohmann U., Fallarino F., and Puccetti P. Tolerance, DCs and tryptophan: much ado about IDO. Trends Immunol. 24 (2003) 242-248
    • (2003) Trends Immunol. , vol.24 , pp. 242-248
    • Grohmann, U.1    Fallarino, F.2    Puccetti, P.3
  • 82
    • 0024317795 scopus 로고
    • Parallel induction of tetrahydrobiopterin biosynthesis and indoleamine 2,3-dioxygenase activity in human cells and cell lines by interferon-gamma
    • Werner E.R., Werner-Felmayer G., Fuchs D., Hausen A., Reibnegger G., and Wachter H. Parallel induction of tetrahydrobiopterin biosynthesis and indoleamine 2,3-dioxygenase activity in human cells and cell lines by interferon-gamma. Biochem. J. 262 (1989) 861-866
    • (1989) Biochem. J. , vol.262 , pp. 861-866
    • Werner, E.R.1    Werner-Felmayer, G.2    Fuchs, D.3    Hausen, A.4    Reibnegger, G.5    Wachter, H.6
  • 83
    • 19344369437 scopus 로고    scopus 로고
    • Tryptophan degradation in patients with gynecological cancer correlates with immune activation
    • Schroecksnadel K., Winkler C., Fuith L.C., and Fuchs D. Tryptophan degradation in patients with gynecological cancer correlates with immune activation. Cancer Lett. 223 (2005) 323-329
    • (2005) Cancer Lett. , vol.223 , pp. 323-329
    • Schroecksnadel, K.1    Winkler, C.2    Fuith, L.C.3    Fuchs, D.4
  • 84
    • 0024835226 scopus 로고
    • Endogenous release of interferon-gamma and diminished response of peripheral blood mononuclear cells to antigenic stimulation
    • Fuchs D., Malkovsky M., Reibnegger G., Werner E.R., Forni G., and Wachter H. Endogenous release of interferon-gamma and diminished response of peripheral blood mononuclear cells to antigenic stimulation. Immunol. Lett. 23 (1989) 103-108
    • (1989) Immunol. Lett. , vol.23 , pp. 103-108
    • Fuchs, D.1    Malkovsky, M.2    Reibnegger, G.3    Werner, E.R.4    Forni, G.5    Wachter, H.6
  • 85
    • 33645878295 scopus 로고    scopus 로고
    • Interferon gamma: a crucial role in the function of induced regulatory T cells in vivo
    • Wood K.J., and Sawitzki B. Interferon gamma: a crucial role in the function of induced regulatory T cells in vivo. Trends Immunol. 27 (2006) 183-187
    • (2006) Trends Immunol. , vol.27 , pp. 183-187
    • Wood, K.J.1    Sawitzki, B.2
  • 88
    • 0030688961 scopus 로고    scopus 로고
    • ABC of palliative care Anorexia, cachexia, and nutrition
    • Bruera E. ABC of palliative care Anorexia, cachexia, and nutrition. Brit. Med. J. 315 (1997) 1219-1222
    • (1997) Brit. Med. J. , vol.315 , pp. 1219-1222
    • Bruera, E.1
  • 89
    • 0032897962 scopus 로고    scopus 로고
    • Wasting in cancer
    • Tisdale M.J. Wasting in cancer. J. Nutr. 129 (1999) 243S-246S
    • (1999) J. Nutr. , vol.129
    • Tisdale, M.J.1
  • 90
    • 0031004362 scopus 로고    scopus 로고
    • Proinflammatory cytokines, nutritional support, and the cachexia syndrome: interactions and therapeutic options
    • Moldawer L.L., and Copeland III E.M. Proinflammatory cytokines, nutritional support, and the cachexia syndrome: interactions and therapeutic options. Cancer 79 (1997) 1828-1839
    • (1997) Cancer , vol.79 , pp. 1828-1839
    • Moldawer, L.L.1    Copeland III, E.M.2
  • 92
    • 0027402767 scopus 로고
    • Weight loss in patients with hematological neoplasias is associated with immune system stimulation
    • Denz H., Orth B., Weiss G., Herrmann R., Huber P., Wachter H., and Fuchs D. Weight loss in patients with hematological neoplasias is associated with immune system stimulation. Clin. Investig. 71 (1993) 37-41
    • (1993) Clin. Investig. , vol.71 , pp. 37-41
    • Denz, H.1    Orth, B.2    Weiss, G.3    Herrmann, R.4    Huber, P.5    Wachter, H.6    Fuchs, D.7
  • 93
    • 0028932245 scopus 로고
    • Decreased serum tryptophan in patients with cancer cachexia correlates with increased serum neopterin
    • Iwagaki H., Hizuta A., Tanaka N., and Orita K. Decreased serum tryptophan in patients with cancer cachexia correlates with increased serum neopterin. Immunol. Invest. 24 (1995) 467-478
    • (1995) Immunol. Invest. , vol.24 , pp. 467-478
    • Iwagaki, H.1    Hizuta, A.2    Tanaka, N.3    Orita, K.4
  • 95
    • 0028278034 scopus 로고
    • Neuropeptide Y in hypothalamic paraventricular nucleus: a center coordinating energy metabolism
    • Billington C.J., Briggs J.E., Harker S., Grace M., and Levine A.S. Neuropeptide Y in hypothalamic paraventricular nucleus: a center coordinating energy metabolism. Am. J. Physiol. 266 (1994) R1765-R1770
    • (1994) Am. J. Physiol. , vol.266
    • Billington, C.J.1    Briggs, J.E.2    Harker, S.3    Grace, M.4    Levine, A.S.5
  • 97
    • 0033567912 scopus 로고    scopus 로고
    • Cancer anorexia-cachexia syndrome: are neuropeptides the key
    • Inui A. Cancer anorexia-cachexia syndrome: are neuropeptides the key. Cancer Res. 59 (1999) 4493-4501
    • (1999) Cancer Res. , vol.59 , pp. 4493-4501
    • Inui, A.1
  • 98
    • 0035883484 scopus 로고    scopus 로고
    • The role of cytokines in cancer-related fatigue
    • Kurzrock R. The role of cytokines in cancer-related fatigue. Cancer 92 (2001) 1684-1688
    • (2001) Cancer , vol.92 , pp. 1684-1688
    • Kurzrock, R.1
  • 99
    • 0027503358 scopus 로고
    • Weight loss in HIV-1 infection is associated with immune activation
    • Zangerle R., Reibnegger G., Wachter H., and Fuchs D. Weight loss in HIV-1 infection is associated with immune activation. AIDS 7 (1993) 175-181
    • (1993) AIDS , vol.7 , pp. 175-181
    • Zangerle, R.1    Reibnegger, G.2    Wachter, H.3    Fuchs, D.4
  • 101
    • 0024564441 scopus 로고
    • Cellular immune activation and erythropoiesis in gynaecological cancer
    • Fuith L.C., Fuchs D., Reibnegger G., and Wachter H. Cellular immune activation and erythropoiesis in gynaecological cancer. Lancet 1 (1989) 908
    • (1989) Lancet , vol.1 , pp. 908
    • Fuith, L.C.1    Fuchs, D.2    Reibnegger, G.3    Wachter, H.4
  • 103
  • 104
    • 0026661852 scopus 로고
    • Association between the activation of macrophages changes of iron metabolism and the degree of anaemia in patients with malignant disorders
    • Denz H., Huber P., Landmann R., Orth B., Wachter H., and Fuchs D. Association between the activation of macrophages changes of iron metabolism and the degree of anaemia in patients with malignant disorders. Eur. J. Haematol. 48 (1992) 244-248
    • (1992) Eur. J. Haematol. , vol.48 , pp. 244-248
    • Denz, H.1    Huber, P.2    Landmann, R.3    Orth, B.4    Wachter, H.5    Fuchs, D.6
  • 106
    • 0026760450 scopus 로고
    • Progress in understanding the pathogenesis of the anemia of chronic disease
    • Means Jr. R.T., and Krantz S.B. Progress in understanding the pathogenesis of the anemia of chronic disease. Blood 80 (1992) 1639-1647
    • (1992) Blood , vol.80 , pp. 1639-1647
    • Means Jr., R.T.1    Krantz, S.B.2
  • 107
    • 0028307817 scopus 로고
    • Inhibition of erythropoietin production by cytokines. Implications for the anemia involved in inflammatory states
    • Jelkmann W.E., Fandrey J., Frede S., and Pagel H. Inhibition of erythropoietin production by cytokines. Implications for the anemia involved in inflammatory states. Ann. NY Acad. Sci. 718 (1994) 300-309
    • (1994) Ann. NY Acad. Sci. , vol.718 , pp. 300-309
    • Jelkmann, W.E.1    Fandrey, J.2    Frede, S.3    Pagel, H.4
  • 108
    • 33646577477 scopus 로고    scopus 로고
    • Dysregulated monocyte iron homeostasis and erythropoietin formation in patients with anemia of chronic disease
    • Theurl I., Mattle V., Seifert M., Mariani M., Marth C., and Weiss G. Dysregulated monocyte iron homeostasis and erythropoietin formation in patients with anemia of chronic disease. Blood 107 (2006) 4142-4148
    • (2006) Blood , vol.107 , pp. 4142-4148
    • Theurl, I.1    Mattle, V.2    Seifert, M.3    Mariani, M.4    Marth, C.5    Weiss, G.6
  • 109
    • 0031821059 scopus 로고    scopus 로고
    • Proinflammatory cytokines lowering erythropoietin production
    • Jelkmann W. Proinflammatory cytokines lowering erythropoietin production. J. Interferon Cytokine Res. 18 (1998) 555-559
    • (1998) J. Interferon Cytokine Res. , vol.18 , pp. 555-559
    • Jelkmann, W.1
  • 111
    • 29844439527 scopus 로고    scopus 로고
    • Effects of neopterin on the hematopoietic microenvironment of senescence-accelerated mice (SAM)
    • Kanbe E., Hatta Y., Tsuboi I., Harada T., Koshinaga M., Inoue T., and Aizawa S. Effects of neopterin on the hematopoietic microenvironment of senescence-accelerated mice (SAM). Biol. Pharm. Bull. 29 (2006) 43-48
    • (2006) Biol. Pharm. Bull. , vol.29 , pp. 43-48
    • Kanbe, E.1    Hatta, Y.2    Tsuboi, I.3    Harada, T.4    Koshinaga, M.5    Inoue, T.6    Aizawa, S.7
  • 112
    • 33846136962 scopus 로고    scopus 로고
    • Inflammatory biomarker, neopterin, suppresses B lymphopoiesis for possible facilitation of granulocyte responses, which is severely altered in age-related stromal-cell-impaired mice, SCI/SAM
    • (Maywood)
    • Minami A., Tsuboi I., Harada T., Fukumoto T., Hiramoto M., Koshinaga M., Hirabayashi Y., Kanno J., Inoue T., and Aizawa S. Inflammatory biomarker, neopterin, suppresses B lymphopoiesis for possible facilitation of granulocyte responses, which is severely altered in age-related stromal-cell-impaired mice, SCI/SAM,. Exp. Biol. Med. 23 (2007) 134-145 (Maywood)
    • (2007) Exp. Biol. Med. , vol.23 , pp. 134-145
    • Minami, A.1    Tsuboi, I.2    Harada, T.3    Fukumoto, T.4    Hiramoto, M.5    Koshinaga, M.6    Hirabayashi, Y.7    Kanno, J.8    Inoue, T.9    Aizawa, S.10
  • 113
    • 0029990271 scopus 로고    scopus 로고
    • Interferon-gamma constitutively expressed in the stromal microenvironment of human marrow cultures mediates potent hematopoietic inhibition
    • Selleri C., Maciejewski J.P., Sato T., and Young N.S. Interferon-gamma constitutively expressed in the stromal microenvironment of human marrow cultures mediates potent hematopoietic inhibition. Blood 87 (1996) 4149-4157
    • (1996) Blood , vol.87 , pp. 4149-4157
    • Selleri, C.1    Maciejewski, J.P.2    Sato, T.3    Young, N.S.4
  • 114
    • 0037926880 scopus 로고    scopus 로고
    • Cytokine-mediated regulation of iron transport in human monocytic cells
    • Ludwiczek S., Aigner E., Theurl I., and Weiss G. Cytokine-mediated regulation of iron transport in human monocytic cells. Blood 101 (2003) 4148-4154
    • (2003) Blood , vol.101 , pp. 4148-4154
    • Ludwiczek, S.1    Aigner, E.2    Theurl, I.3    Weiss, G.4
  • 116
    • 0029055581 scopus 로고
    • Rapid responses to oxidative stress mediated by iron regulatory protein
    • Pantopoulos K., and Hentze M.W. Rapid responses to oxidative stress mediated by iron regulatory protein. EMBO J. 14 (1995) 2917-2924;
    • (1995) EMBO J. , vol.14
    • Pantopoulos, K.1    Hentze, M.W.2
  • 117
    • 0027301897 scopus 로고
    • Biosynthesis of nitric oxide activates iron regulatory factor in macrophages
    • Drapier J.C., Hirling H., Wietzerbin J., Kaldy P., and Kuhn L.C. Biosynthesis of nitric oxide activates iron regulatory factor in macrophages. EMBO J. 12 (1993) 3643-3649
    • (1993) EMBO J. , vol.12 , pp. 3643-3649
    • Drapier, J.C.1    Hirling, H.2    Wietzerbin, J.3    Kaldy, P.4    Kuhn, L.C.5
  • 119
    • 0036071176 scopus 로고    scopus 로고
    • Fatigue and proinflammatory cytokine activity in breast cancer survivors
    • Bower J.E., Ganz P.A., Aziz N., and Fahey J.L. Fatigue and proinflammatory cytokine activity in breast cancer survivors. Psychosom. Med. 64 (2002) 604-611
    • (2002) Psychosom. Med. , vol.64 , pp. 604-611
    • Bower, J.E.1    Ganz, P.A.2    Aziz, N.3    Fahey, J.L.4
  • 121
  • 122
    • 0028265462 scopus 로고
    • Role of serotonin in the pathophysiology of depression: focus on the serotonin transporter
    • Owens M.J., and Nemeroff C.B. Role of serotonin in the pathophysiology of depression: focus on the serotonin transporter. Clin. Chem. 40 (1994) 288-295
    • (1994) Clin. Chem. , vol.40 , pp. 288-295
    • Owens, M.J.1    Nemeroff, C.B.2
  • 124
    • 0036982779 scopus 로고    scopus 로고
    • Tryptophan metabolites as scavengers of reactive oxygen and chlorine species
    • Weiss G G., Diez-Ruiz A A., Murr C C., Theurl I I., and Fuchs D. Tryptophan metabolites as scavengers of reactive oxygen and chlorine species. Pteridines 13 (2002) 140-144
    • (2002) Pteridines , vol.13 , pp. 140-144
    • Weiss G, G.1    Diez-Ruiz A, A.2    Murr C, C.3    Theurl I, I.4    Fuchs, D.5
  • 125
    • 0028670087 scopus 로고
    • Increased neopterin and interferon-gamma secretion and lower availability of L-tryptophan in major depression: further evidence for an immune response
    • Maes M., Scharpe S., Meltzer H.Y., Okayli G., Bosmans E., D'Hondt P., Vanden Bossche B.V., and Cosyns P. Increased neopterin and interferon-gamma secretion and lower availability of L-tryptophan in major depression: further evidence for an immune response. Psychiatry Res. 54 (1994) 143-160
    • (1994) Psychiatry Res. , vol.54 , pp. 143-160
    • Maes, M.1    Scharpe, S.2    Meltzer, H.Y.3    Okayli, G.4    Bosmans, E.5    D'Hondt, P.6    Vanden Bossche, B.V.7    Cosyns, P.8
  • 127
    • 0032424283 scopus 로고    scopus 로고
    • Differential pharmacology of newer antidepressants
    • DeVane C.L. Differential pharmacology of newer antidepressants. J. Clin. Psychiatry 59 Suppl. 20 (1998) 85-93
    • (1998) J. Clin. Psychiatry , vol.59 , Issue.SUPPL. 20 , pp. 85-93
    • DeVane, C.L.1
  • 128
  • 130
    • 53949089621 scopus 로고    scopus 로고
    • Serum phenylalanine concentrations in patients with ovarian carcinoma correlate with concentrations of immune activation markers and of isoprostane-8
    • Neurauter G., Grahmann A.V., Klieber M., Zeimet A., Ledochowski M., Sperner-Unterweger B., and Fuchs D. Serum phenylalanine concentrations in patients with ovarian carcinoma correlate with concentrations of immune activation markers and of isoprostane-8. Cancer Lett. 272 (2008) 141-147
    • (2008) Cancer Lett. , vol.272 , pp. 141-147
    • Neurauter, G.1    Grahmann, A.V.2    Klieber, M.3    Zeimet, A.4    Ledochowski, M.5    Sperner-Unterweger, B.6    Fuchs, D.7
  • 131
    • 0035139983 scopus 로고    scopus 로고
    • Danger signals: SOS to the immune system
    • Gallucci S., and Matzinger P. Danger signals: SOS to the immune system. Curr. Opin. Immunol. 13 (2001) 114-119
    • (2001) Curr. Opin. Immunol. , vol.13 , pp. 114-119
    • Gallucci, S.1    Matzinger, P.2
  • 132
    • 58549116694 scopus 로고    scopus 로고
    • Inverse association between serum concentrations of neopterin and antioxidants in patients with and without angiographic coronary artery disease
    • Murr C., Schroecksnadel K., Winklhofer-Roob B.M., Mangge H., Boehm B.O., Winkelmann B.R., Maerz W., and Fuchs D. Inverse association between serum concentrations of neopterin and antioxidants in patients with and without angiographic coronary artery disease. Atherosclerosis 202 (2009) 543-549
    • (2009) Atherosclerosis , vol.202 , pp. 543-549
    • Murr, C.1    Schroecksnadel, K.2    Winklhofer-Roob, B.M.3    Mangge, H.4    Boehm, B.O.5    Winkelmann, B.R.6    Maerz, W.7    Fuchs, D.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.