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Volumn 16, Issue 1, 2006, Pages 240-252

Neopterin as an indicator of immune activation and prognosis in patients with gynecological malignancies

Author keywords

Cervical carcinoma; Endometrial carcinoma; Epithelial ovarian carcinoma; Immunotherapy; Neopterin

Indexed keywords

BIOCHEMICAL MARKER; CYTOKINE; ERYTHROPOIETIN; FERRITIN; GAMMA INTERFERON; GRANULOCYTE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HEMOGLOBIN; INTERLEUKIN 2; IRON; NEOPTERIN; TRYPTOPHAN; ZINC;

EID: 33645337897     PISSN: 1048891X     EISSN: 15251438     Source Type: Journal    
DOI: 10.1111/j.1525-1438.2006.00294.x     Document Type: Review
Times cited : (92)

References (134)
  • 1
    • 0033485743 scopus 로고    scopus 로고
    • Identification of an IL-10 producing HLA-DR-negative monocyte subset in the malignant ascites of patients with ovarian carcinoma that inhibits cytokine protein expression and proliferation of autologous T cells
    • Loercher AE Nash MA Kavanagh JJ Platsoucas CD Freedman RS. Identification of an IL-10 producing HLA-DR-negative monocyte subset in the malignant ascites of patients with ovarian carcinoma that inhibits cytokine protein expression and proliferation of autologous T cells. J Immunol 1999 163 6251 60.
    • (1999) J Immunol , vol.163 , pp. 6251-60
    • Loercher, A.E.1    Nash, M.A.2    Kavanagh, J.J.3    Platsoucas, C.D.4    Freedman, R.S.5
  • 2
    • 17044446935 scopus 로고    scopus 로고
    • HLA class I expression on human ovarian carcinoma cells correlates with T-cell infiltration in vivo and T-cell expansion in vitro in low concentrations of recombinant interleukin-2
    • Kooi S Zhang HZ Patenia R et al. HLA class I expression on human ovarian carcinoma cells correlates with T-cell infiltration in vivo and T-cell expansion in vitro in low concentrations of recombinant interleukin-2. Cell Immunol 1996 174 116 28.
    • (1996) Cell Immunol , vol.174 , pp. 116-28
    • Kooi, S.1    Zhang, H.Z.2    Patenia, R.3
  • 3
    • 0031900886 scopus 로고    scopus 로고
    • Lineage-negative human leukocyte antigen-DR+ cells with the phenotype of undifferentiated dendritic cells in patients with carcinoma of the abdomen and pelvis
    • Melichar B Savary C Kudelka AP et al. Lineage-negative human leukocyte antigen-DR+ cells with the phenotype of undifferentiated dendritic cells in patients with carcinoma of the abdomen and pelvis. Clin Cancer Res 1998 4 799 809.
    • (1998) Clin Cancer Res , vol.4 , pp. 799-809
    • Melichar, B.1    Savary, C.2    Kudelka, A.P.3
  • 4
    • 0033983424 scopus 로고    scopus 로고
    • Expression of costimulatory molecules CD80 and CD86 and their receptors CD28, CTLA-4 on malignant ascites CD3+ tumor infiltrating lymphocytes (TIL) from patients with ovarian and other types of peritoneal carcinomatosis
    • Melichar B Nash MA Lenzi R Platsoucas CD Freedman RS. Expression of costimulatory molecules CD80 and CD86 and their receptors CD28, CTLA-4 on malignant ascites CD3+ tumor infiltrating lymphocytes (TIL) from patients with ovarian and other types of peritoneal carcinomatosis. Clin Exp Immunol 2000 119 19 27.
    • (2000) Clin Exp Immunol , vol.119 , pp. 19-27
    • Melichar, B.1    Nash, M.A.2    Lenzi, R.3    Platsoucas, C.D.4    Freedman, R.S.5
  • 5
    • 0030583236 scopus 로고    scopus 로고
    • Collagenase and dispase enzymes disrupt lymphocyte surface molecules
    • Abuzakouk M Feighery C O'Farrelly C. Collagenase and dispase enzymes disrupt lymphocyte surface molecules. J Immunol Methods 1996 194 211 6.
    • (1996) J Immunol Methods , vol.194 , pp. 211-6
    • Abuzakouk, M.1    Feighery, C.2    O'Farrelly, C.3
  • 7
    • 0020000298 scopus 로고
    • The phenomenon of the acute phase response
    • Kushner I. The phenomenon of the acute phase response. Ann N Y Acad Sci 1982 389 39 48.
    • (1982) Ann N Y Acad Sci , vol.389 , pp. 39-48
    • Kushner, I.1
  • 8
    • 0033545342 scopus 로고    scopus 로고
    • Acute-phase proteins and other systemic responses to inflammation
    • Gabay C Kushner I. Acute-phase proteins and other systemic responses to inflammation. N Engl J Med 1999 340 448 53.
    • (1999) N Engl J Med , vol.340 , pp. 448-53
    • Gabay, C.1    Kushner, I.2
  • 9
    • 0024308582 scopus 로고
    • Neopterin as marker for activation of cellular immunity: Immunologic basis and clinical application
    • Wachter H Fuchs D Hausen A Reibnegger G Werner ER. Neopterin as marker for activation of cellular immunity: immunologic basis and clinical application. Adv Clin Chem 1989 27 81 141.
    • (1989) Adv Clin Chem , vol.27 , pp. 81-141
    • Wachter, H.1    Fuchs, D.2    Hausen, A.3    Reibnegger, G.4    Werner, E.R.5
  • 10
    • 0022439453 scopus 로고
    • Renal excretion of neopterin and biopterin in patients with malignant melanoma and Hodgkin's disease
    • Zitko M Andrysek O Cernovska I Vasickova M. Renal excretion of neopterin and biopterin in patients with malignant melanoma and Hodgkin's disease. Neoplasma 1986 33 387 91.
    • (1986) Neoplasma , vol.33 , pp. 387-91
    • Zitko, M.1    Andrysek, O.2    Cernovska, I.3    Vasickova, M.4
  • 11
    • 0027468337 scopus 로고
    • Elevated levels of oncopterin, N2-(3-aminopropyl)biopterin, a new pterin compound, in urine from patients with solid and blood cancers
    • Ogiwara S Hidaka H Sugimoto T et al. Elevated levels of oncopterin, N2-(3-aminopropyl)biopterin, a new pterin compound, in urine from patients with solid and blood cancers. J Biochem 1993 113 1 3.
    • (1993) J Biochem , vol.113 , pp. 1-3
    • Ogiwara, S.1    Hidaka, H.2    Sugimoto, T.3
  • 12
    • 0014047941 scopus 로고
    • Neopterin: Isolation from human urine
    • Sakurai A Goto M. Neopterin: isolation from human urine. J Biochem 1967 61 142 5.
    • (1967) J Biochem , vol.61 , pp. 142-5
    • Sakurai, A.1    Goto, M.2
  • 13
    • 0018623785 scopus 로고
    • Erhöhte Ausscheidung von Neopterin im Harn von Patienten mit malignen Tumoren und mit Viruserkrankungen
    • Wachter H Hausen A Grassmayr K. Erhöhte Ausscheidung von Neopterin im Harn von Patienten mit malignen Tumoren und mit Viruserkrankungen. Hoppe Seylers Z Physiol Chem 1979 360 1957 60.
    • (1979) Hoppe Seylers Z Physiol Chem , vol.360 , pp. 1957-60
    • Wachter, H.1    Hausen, A.2    Grassmayr, K.3
  • 14
    • 0021264311 scopus 로고
    • Immune response-associated production of neopterin. Release from macrophages primarily under control of interferon-gamma
    • Huber C Batchelor JR Fuchs D et al. Immune response-associated production of neopterin. Release from macrophages primarily under control of interferon-gamma. J Exp Med 1984 160 310 6.
    • (1984) J Exp Med , vol.160 , pp. 310-6
    • Huber, C.1    Batchelor, J.R.2    Fuchs, D.3
  • 15
    • 0022909292 scopus 로고
    • Interferon-gamma enhances biosynthesis of pterins in peripheral blood mononuclear cells by induction of GTP-cyclohydrolase I activity
    • Schoedon G Troppmair J Adolf G Huber C Niederwieser A. Interferon-gamma enhances biosynthesis of pterins in peripheral blood mononuclear cells by induction of GTP-cyclohydrolase I activity. J Interferon Res 1986 6 697 703.
    • (1986) J Interferon Res , vol.6 , pp. 697-703
    • Schoedon, G.1    Troppmair, J.2    Adolf, G.3    Huber, C.4    Niederwieser, A.5
  • 16
    • 0025236440 scopus 로고
    • Tetrahydrobiopterin biosynthetic activities in human macrophages, fibroblasts, THP-1, and T24 cell
    • Werner ER Werner-Felmayer G Fuchs D et al. Tetrahydrobiopterin biosynthetic activities in human macrophages, fibroblasts, THP-1, and T24 cell. J Biol Chem 1990 265 3189 92.
    • (1990) J Biol Chem , vol.265 , pp. 3189-92
    • Werner, E.R.1    Werner-Felmayer, G.2    Fuchs, D.3
  • 17
    • 0042569095 scopus 로고    scopus 로고
    • Low tetrahydrobiopterin biosynthetic capacity of human monocytes is caused by exon skipping in 6-pyruvoyl tetrahydropterin synthase
    • Leitner KL Meyer M Leimbacher W et al. Low tetrahydrobiopterin biosynthetic capacity of human monocytes is caused by exon skipping in 6-pyruvoyl tetrahydropterin synthase. Biochem J 2003 373 681 8.
    • (2003) Biochem J , vol.373 , pp. 681-8
    • Leitner, K.L.1    Meyer, M.2    Leimbacher, W.3
  • 18
    • 0024849614 scopus 로고
    • Urinary neopterin concentrations vs total neopterin for clinical utility
    • Fuchs D Milstien S Kramer A et al. Urinary neopterin concentrations vs total neopterin for clinical utility. Clin Chem 1989 35 2305 7.
    • (1989) Clin Chem , vol.35 , pp. 2305-7
    • Fuchs, D.1    Milstien, S.2    Kramer, A.3
  • 19
    • 0026653881 scopus 로고
    • Neopterin release from human endothelial cells is triggered by interferon-gamma
    • Andert SE Greismacher A Zuckermann A Muller MM. Neopterin release from human endothelial cells is triggered by interferon-gamma. Clin Exp Immunol 1992 88 555 8.
    • (1992) Clin Exp Immunol , vol.88 , pp. 555-8
    • Andert, S.E.1    Greismacher, A.2    Zuckermann, A.3    Muller, M.M.4
  • 20
    • 0026625694 scopus 로고
    • Different lymphoid cell populations produce varied levels of neopterin, beta2-microglobulin and soluble IL-2 receptor when stimulated with IL-2, interferon-gamma or tumor necrosis factor-alpha
    • Hofmann B Bass H Nishanian P et al. Different lymphoid cell populations produce varied levels of neopterin, beta2-microglobulin and soluble IL-2 receptor when stimulated with IL-2, interferon-gamma or tumor necrosis factor-alpha. Clin Exp Immunol 1992 88 548 54.
    • (1992) Clin Exp Immunol , vol.88 , pp. 548-54
    • Hofmann, B.1    Bass, H.2    Nishanian, P.3
  • 21
    • 0028142448 scopus 로고
    • Interferon-gamma stimulates neopterin release from cultured kidney epithelial cells
    • Mountabarrik A Takahara S Nakanishi I et al. Interferon-gamma stimulates neopterin release from cultured kidney epithelial cells. Scand J Immunol 1994 39 27 30.
    • (1994) Scand J Immunol , vol.39 , pp. 27-30
    • Mountabarrik, A.1    Takahara, S.2    Nakanishi, I.3
  • 22
    • 0024269609 scopus 로고
    • In-vitro and in-vivo studies on the induction of neopterin biosynthesis by cytokines, alloantigens and lipopolysaccharide (LPS)
    • Troppmair J Nachbaur K Herold M et al. In-vitro and in-vivo studies on the induction of neopterin biosynthesis by cytokines, alloantigens and lipopolysaccharide (LPS). Clin Exp Immunol 1988 74 392 7.
    • (1988) Clin Exp Immunol , vol.74 , pp. 392-7
    • Troppmair, J.1    Nachbaur, K.2    Herold, M.3
  • 23
    • 0034878784 scopus 로고    scopus 로고
    • CD4+ T-lymphocytopenia and systemic immune activation in patients with primary and secondary liver tumours
    • Melichar B Touskova M Solichova D Kralickova P Kopecky O. CD4+ T-lymphocytopenia and systemic immune activation in patients with primary and secondary liver tumours. Scand J Clin Lab Invest 2001 61 363 70.
    • (2001) Scand J Clin Lab Invest , vol.61 , pp. 363-70
    • Melichar, B.1    Touskova, M.2    Solichova, D.3    Kralickova, P.4    Kopecky, O.5
  • 24
    • 17544396862 scopus 로고    scopus 로고
    • The phenotype of ascitic fluid lymphocytes in patients with ovarian carcinoma and other primaries
    • Melichar B Touskova M Tosner J Kopecky O. The phenotype of ascitic fluid lymphocytes in patients with ovarian carcinoma and other primaries. Onkologie 2001 24 156 60.
    • (2001) Onkologie , vol.24 , pp. 156-60
    • Melichar, B.1    Touskova, M.2    Tosner, J.3    Kopecky, O.4
  • 25
    • 0027447381 scopus 로고
    • Interferon-gamma: A key immunoregulatory lymphokine
    • Williams JG Jurkovich GJ Maier RV. Interferon-gamma: a key immunoregulatory lymphokine. J Surg Res 1993 54 79 93.
    • (1993) J Surg Res , vol.54 , pp. 79-93
    • Williams, J.G.1    Jurkovich, G.J.2    Maier, R.V.3
  • 26
    • 45549115941 scopus 로고
    • Neopterin as a marker for activated cell mediated immunity: Application in HIV infection
    • Fuchs D Hausen A Reibnegger G et al. Neopterin as a marker for activated cell mediated immunity: application in HIV infection. Immunol Today 1988 9 150 5.
    • (1988) Immunol Today , vol.9 , pp. 150-5
    • Fuchs, D.1    Hausen, A.2    Reibnegger, G.3
  • 27
    • 0025328972 scopus 로고
    • Neopterin formation and tryptophan degradation by a human myelomonocytic cell line (THP-1) upon cytokine treatment
    • Werner-Felmayer G Werner ER Fuchs D et al. Neopterin formation and tryptophan degradation by a human myelomonocytic cell line (THP-1) upon cytokine treatment. Cancer Res 1990 90 2863 7.
    • (1990) Cancer Res , vol.90 , pp. 2863-7
    • Werner-Felmayer, G.1    Werner, E.R.2    Fuchs, D.3
  • 28
    • 0023925937 scopus 로고
    • Selective induction of mononuclear phagocytes to produce neopterin by interferons
    • Bitterlich G Szabo G Werner ER et al. Selective induction of mononuclear phagocytes to produce neopterin by interferons. Immunobiology 1988 176 228 35.
    • (1988) Immunobiology , vol.176 , pp. 228-35
    • Bitterlich, G.1    Szabo, G.2    Werner, E.R.3
  • 29
    • 0025861749 scopus 로고
    • Posttransplant neopterin excretion in renal allograft recipients - A reliable diagnostic aid for acute rejection and a predictive marker of long-term graft survival
    • Reibnegger G Aichberger C Fuchs D et al. Posttransplant neopterin excretion in renal allograft recipients - a reliable diagnostic aid for acute rejection and a predictive marker of long-term graft survival. Transplantation 1991 52 58 63.
    • (1991) Transplantation , vol.52 , pp. 58-63
    • Reibnegger, G.1    Aichberger, C.2    Fuchs, D.3
  • 30
    • 0028371358 scopus 로고
    • Increased urinary neopterin in acute myocardial infarction
    • Melichar B Gregor J Solichova D et al. Increased urinary neopterin in acute myocardial infarction. Clin Chem 1994 40 338 9.
    • (1994) Clin Chem , vol.40 , pp. 338-9
    • Melichar, B.1    Gregor, J.2    Solichova, D.3
  • 31
    • 0026325938 scopus 로고
    • Neopterin, a marker of cell-mediated immune activation in human pregnancy
    • Fuith LC Fuchs D Hausen A et al. Neopterin, a marker of cell-mediated immune activation in human pregnancy. Int J Fertil 1991 36 372 5.
    • (1991) Int J Fertil , vol.36 , pp. 372-5
    • Fuith, L.C.1    Fuchs, D.2    Hausen, A.3
  • 32
    • 0027392935 scopus 로고
    • Neopterin and prognosis in patients with adenocarcinoma of the colon
    • Weiss G Kronberger P Conrad F et al. Neopterin and prognosis in patients with adenocarcinoma of the colon. Cancer Res 1993 53 260 5.
    • (1993) Cancer Res , vol.53 , pp. 260-5
    • Weiss, G.1    Kronberger, P.2    Conrad, F.3
  • 33
    • 0027421542 scopus 로고
    • The prognostic value of nuclear roundness and neopterin in ovarian cancer
    • Marth C Weger E Muller-Holzner E et al. The prognostic value of nuclear roundness and neopterin in ovarian cancer. Eur J Cancer 1993 29A 1863 8.
    • (1993) Eur J Cancer , vol.29 , pp. 1863-8
    • Marth, C.1    Weger, E.2    Muller-Holzner, E.3
  • 34
    • 0022633961 scopus 로고
    • Neopterin as a prognostic indicator in patients with carcinoma of the uterine cervix
    • Reibnegger G Bichler AH Dapunt O et al. Neopterin as a prognostic indicator in patients with carcinoma of the uterine cervix. Cancer Res 1986 46 950 5.
    • (1986) Cancer Res , vol.46 , pp. 950-5
    • Reibnegger, G.1    Bichler, A.H.2    Dapunt, O.3
  • 35
    • 0034448094 scopus 로고    scopus 로고
    • Serum neopterin levels in renal cell carcinoma
    • Yoshida N Ikemoto S Narita K et al. Serum neopterin levels in renal cell carcinoma. Pteridines 2000 11 133 6.
    • (2000) Pteridines , vol.11 , pp. 133-6
    • Yoshida, N.1    Ikemoto, S.2    Narita, K.3
  • 36
    • 0031183798 scopus 로고    scopus 로고
    • IL-6 is a survival prognostic factor in renal cell carcinoma
    • Thiounn N Pages F Flam T et al. IL-6 is a survival prognostic factor in renal cell carcinoma. Immunol Lett 1997 58 121 4.
    • (1997) Immunol Lett , vol.58 , pp. 121-4
    • Thiounn, N.1    Pages, F.2    Flam, T.3
  • 37
    • 0032738333 scopus 로고    scopus 로고
    • Neopterin is an independent prognostic variable in females with breast cancer
    • Murr C Berant A Widschwendter M et al. Neopterin is an independent prognostic variable in females with breast cancer. Clin Chem 1999 45 1998 2004.
    • (1999) Clin Chem , vol.45 , pp. 1998-2004
    • Murr, C.1    Berant, A.2    Widschwendter, M.3
  • 38
    • 0019778250 scopus 로고
    • Urinary neopterin as marker for haematological neoplasias
    • Hausen A Fuchs D Grunewald K et al. Urinary neopterin as marker for haematological neoplasias. Clin Chim Acta 1981 117 297 305.
    • (1981) Clin Chim Acta , vol.117 , pp. 297-305
    • Hausen, A.1    Fuchs, D.2    Grunewald, K.3
  • 40
    • 0028041417 scopus 로고
    • Urinary neopterin excretion in colorectal cancer
    • Melichar B Jandik P Solichova D et al. Urinary neopterin excretion in colorectal cancer. Onkologie 1994 17 434 6.
    • (1994) Onkologie , vol.17 , pp. 434-6
    • Melichar, B.1    Jandik, P.2    Solichova, D.3
  • 41
    • 0027418494 scopus 로고
    • Neopterin modulates toxicity mediated by reactive oxygen and chloride species
    • Weiss G Fuchs D Hausen A et al. Neopterin modulates toxicity mediated by reactive oxygen and chloride species. FEBS Lett 1993 321 89 92.
    • (1993) FEBS Lett , vol.321 , pp. 89-92
    • Weiss, G.1    Fuchs, D.2    Hausen, A.3
  • 42
    • 0028153944 scopus 로고
    • Enhancement of hydrogen peroxide-induced luminol-dependent chemiluminescence by neopterin depends on the presence of iron chelator complexes
    • Murr C Fuchs D Gossler W et al. Enhancement of hydrogen peroxide-induced luminol-dependent chemiluminescence by neopterin depends on the presence of iron chelator complexes. FEBS Lett 1994 338 223 6.
    • (1994) FEBS Lett , vol.338 , pp. 223-6
    • Murr, C.1    Fuchs, D.2    Gossler, W.3
  • 44
    • 0027248803 scopus 로고
    • Inhibitory effect of neopterin on NADPH-dependent superoxide-generating oxidase of rat peritoneal macrophages
    • Kojima S Nomura T Icho T et al. Inhibitory effect of neopterin on NADPH-dependent superoxide-generating oxidase of rat peritoneal macrophages. FEBS Lett 1993 329 125 8.
    • (1993) FEBS Lett , vol.329 , pp. 125-8
    • Kojima, S.1    Nomura, T.2    Icho, T.3
  • 45
    • 0027874440 scopus 로고
    • Inhibitory effects of 5,6,7,8-tetrahydroneopterin on adriamycin-induced cardiotoxicity
    • Kojima S Icho T Hayashi M et al. Inhibitory effects of 5,6,7,8-tetrahydroneopterin on adriamycin-induced cardiotoxicity. J Pharmacol Exp Ther 1993 266 1699 704.
    • (1993) J Pharmacol Exp Ther , vol.266 , pp. 1699-704
    • Kojima, S.1    Icho, T.2    Hayashi, M.3
  • 46
    • 0026035117 scopus 로고
    • Inflammation and oxidative stress in carcinogenesis
    • Cerutti PA Trump BF. Inflammation and oxidative stress in carcinogenesis. Cancer Cells 1991 3 1 7.
    • (1991) Cancer Cells , vol.3 , pp. 1-7
    • Cerutti, P.A.1    Trump, B.F.2
  • 47
    • 0029918901 scopus 로고    scopus 로고
    • Role of oxygen free radicals in cancer development
    • Dreher D Junod AF. Role of oxygen free radicals in cancer development. Eur J Cancer 1996 32A 30 8.
    • (1996) Eur J Cancer , vol.32 , pp. 30-8
    • Dreher, D.1    Junod, A.F.2
  • 48
    • 0028946916 scopus 로고
    • Effect of neopterin and 7, 8-dihydroneopterin on tumor necrosis factor-a induced programmed cell death
    • Baier-Bitterlich G Fuchs D Murr C et al. Effect of neopterin and 7, 8-dihydroneopterin on tumor necrosis factor-a induced programmed cell death. FEBS Lett 1995 364 234 8.
    • (1995) FEBS Lett , vol.364 , pp. 234-8
    • Baier-Bitterlich, G.1    Fuchs, D.2    Murr, C.3
  • 49
    • 0030592784 scopus 로고    scopus 로고
    • Neopterin and 7,8-dihydroneopterin induce apoptosis in the rat alveolar epithelial cell line L2
    • Schobersberger W Hoffmann G Hobisch-Hagen P et al. Neopterin and 7,8-dihydroneopterin induce apoptosis in the rat alveolar epithelial cell line L2. FEBS Lett 1996 397 263 8.
    • (1996) FEBS Lett , vol.397 , pp. 263-8
    • Schobersberger, W.1    Hoffmann, G.2    Hobisch-Hagen, P.3
  • 50
    • 0028048065 scopus 로고
    • Neopterin derivatives together with cyclic guanosine monophosphate induce c-fos gene expression
    • Uberall F Werner-Felmayer G Schubert C et al. Neopterin derivatives together with cyclic guanosine monophosphate induce c-fos gene expression. FEBS Lett 1994 352 11 4.
    • (1994) FEBS Lett , vol.352 , pp. 11-4
    • Uberall, F.1    Werner-Felmayer, G.2    Schubert, C.3
  • 51
    • 0027302433 scopus 로고
    • Protective effects of tetrahydroneopterin against free radical-induced injury
    • Icho T Kojima S Shinohara N et al. Protective effects of tetrahydroneopterin against free radical-induced injury. Biochem Pharmacol 1993 45 1953 8.
    • (1993) Biochem Pharmacol , vol.45 , pp. 1953-8
    • Icho, T.1    Kojima, S.2    Shinohara, N.3
  • 52
    • 0023250888 scopus 로고
    • Induction of nitrite/nitrate synthesis in murine macrophages by BCG infection, lymphokines or interferon-gamma
    • Stuehr DJ Marletta MA. Induction of nitrite/nitrate synthesis in murine macrophages by BCG infection, lymphokines or interferon-gamma. J Immunol 1987 139 518 25.
    • (1987) J Immunol , vol.139 , pp. 518-25
    • Stuehr, D.J.1    Marletta, M.A.2
  • 53
    • 0025630533 scopus 로고
    • Tetrahydrobiopterin-dependent formation of nitrite and nitrate in murine fibroblasts
    • Werner-Felmayer G Werner ER Fuchs D et al. Tetrahydrobiopterin-dependent formation of nitrite and nitrate in murine fibroblasts. J Exp Med 1990 172 1599 607.
    • (1990) J Exp Med , vol.172 , pp. 1599-607
    • Werner-Felmayer, G.1    Werner, E.R.2    Fuchs, D.3
  • 54
    • 0029592781 scopus 로고
    • On the expression of nitric oxide synthase by human macrophages. Why no NO?
    • Albina JE. On the expression of nitric oxide synthase by human macrophages. Why no NO? J Leukoc Biol 1995 58 643 9.
    • (1995) J Leukoc Biol , vol.58 , pp. 643-9
    • Albina, J.E.1
  • 55
    • 0028215982 scopus 로고
    • Nitric oxide synthase activity in human gynecological cancer
    • Thomsen LL Lawton FG Knowles RG et al. Nitric oxide synthase activity in human gynecological cancer. Cancer Res 1994 54 1352 4.
    • (1994) Cancer Res , vol.54 , pp. 1352-4
    • Thomsen, L.L.1    Lawton, F.G.2    Knowles, R.G.3
  • 56
    • 0029133539 scopus 로고
    • Human mononuclear phagocyte inducible nitric oxide synthase (iNOS): Analysis of iNOS mRNA, iNOS protein, biopterin, and nitric oxide production by blood monocytes and peritoneal macrophages
    • Weinberg JB Misukonis MA Shami PJ et al. Human mononuclear phagocyte inducible nitric oxide synthase (iNOS): analysis of iNOS mRNA, iNOS protein, biopterin, and nitric oxide production by blood monocytes and peritoneal macrophages. Blood 1995 86 1184 95.
    • (1995) Blood , vol.86 , pp. 1184-95
    • Weinberg, J.B.1    Misukonis, M.A.2    Shami, P.J.3
  • 57
    • 0024584020 scopus 로고
    • Nitric oxide. a macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells
    • Stuehr DJ Nathan CF. Nitric oxide. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells. J Exp Med 1989 169 1543 55.
    • (1989) J Exp Med , vol.169 , pp. 1543-55
    • Stuehr, D.J.1    Nathan, C.F.2
  • 59
    • 0025945515 scopus 로고
    • Nitrogen oxide levels in patients after trauma and during sepsis
    • Ochoa JB Udekwu AO Billiar TR et al. Nitrogen oxide levels in patients after trauma and during sepsis. Ann Surg 1991 214 621 6.
    • (1991) Ann Surg , vol.214 , pp. 621-6
    • Ochoa, J.B.1    Udekwu, A.O.2    Billiar, T.R.3
  • 60
  • 61
    • 0026684595 scopus 로고
    • Increased circulating nitrogen oxides after human tumor immunotherapy: Correlation with toxic hemodynamic changes
    • Ochoa JB Curti B Peitzman AB et al. Increased circulating nitrogen oxides after human tumor immunotherapy: correlation with toxic hemodynamic changes. J Natl Cancer Inst 1992 84 864 7.
    • (1992) J Natl Cancer Inst , vol.84 , pp. 864-7
    • Ochoa, J.B.1    Curti, B.2    Peitzman, A.B.3
  • 62
    • 18844483161 scopus 로고    scopus 로고
    • Clinical and biological effects of intraperitoneal injections of recombinant interferon-gamma and recombinant interleukin-2 with or without tumor-infiltrating lymphocytes in patients with ovarian or peritoneal carcinomatosis
    • Freedman RS Kudelka AP Kavanagh JJ et al. Clinical and biological effects of intraperitoneal injections of recombinant interferon-gamma and recombinant interleukin-2 with or without tumor-infiltrating lymphocytes in patients with ovarian or peritoneal carcinomatosis. Clin Cancer Res 2000 6 2268 78.
    • (2000) Clin Cancer Res , vol.6 , pp. 2268-78
    • Freedman, R.S.1    Kudelka, A.P.2    Kavanagh, J.J.3
  • 63
    • 0037500853 scopus 로고    scopus 로고
    • Intraperitoneal fluid neopterin, nitrate, and tryptophan after regional administration of interleukin-12
    • Melichar B Lenzi R Rosenblum M et al. Intraperitoneal fluid neopterin, nitrate, and tryptophan after regional administration of interleukin-12. J Immunother 2003 26 270 6.
    • (2003) J Immunother , vol.26 , pp. 270-6
    • Melichar, B.1    Lenzi, R.2    Rosenblum, M.3
  • 64
    • 4344663790 scopus 로고    scopus 로고
    • RINF-gamma-mediated growth suppression of platinum-sensitive and -resistant ovarian tumor cell lines not dependent upon arginase inhibition
    • Melichar B Hu W Patenia R et al. rINF-gamma-mediated growth suppression of platinum-sensitive and -resistant ovarian tumor cell lines not dependent upon arginase inhibition. J Transl Med 2003 1 5.
    • (2003) J Transl Med , vol.1 , pp. 5
    • Melichar, B.1    Hu, W.2    Patenia, R.3
  • 65
    • 0032420785 scopus 로고    scopus 로고
    • Growth inhibitory effects of aromatic fatty acids on ovarian tumor cell lines
    • Melichar B Ferrandina G Verschraegen CF et al. Growth inhibitory effects of aromatic fatty acids on ovarian tumor cell lines. Clin Cancer Res 1998 4 3069 76.
    • (1998) Clin Cancer Res , vol.4 , pp. 3069-76
    • Melichar, B.1    Ferrandina, G.2    Verschraegen, C.F.3
  • 66
    • 0142137237 scopus 로고    scopus 로고
    • Evidence for a tumor immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase
    • Uyttenhove C Pilotte L Theate I et al. Evidence for a tumor immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase. Nat Med 2003 9 1269 74.
    • (2003) Nat Med , vol.9 , pp. 1269-74
    • Uyttenhove, C.1    Pilotte, L.2    Theate, I.3
  • 67
    • 0033066772 scopus 로고    scopus 로고
    • Modulation of neopterin formation and tryptophan degradation by Th1- and Th2-derived cytokines in human monocytic cells
    • Weiss G Murr C Zoller H et al. Modulation of neopterin formation and tryptophan degradation by Th1- and Th2-derived cytokines in human monocytic cells. Clin Exp Immunol 1999 116 435 40.
    • (1999) Clin Exp Immunol , vol.116 , pp. 435-40
    • Weiss, G.1    Murr, C.2    Zoller, H.3
  • 68
    • 0028916297 scopus 로고
    • Reciprocal regulation of the nitric oxide synthase/arginase balance in mouse bone marrow-derived macrophages by TH1 and TH2 cytokines
    • Modolell M Corraliza IM Link F Soler G Eichman K. Reciprocal regulation of the nitric oxide synthase/arginase balance in mouse bone marrow-derived macrophages by TH1 and TH2 cytokines. Eur J Immunol 1995 25 1101 4.
    • (1995) Eur J Immunol , vol.25 , pp. 1101-4
    • Modolell, M.1    Corraliza, I.M.2    Link, F.3    Soler, G.4    Eichman, K.5
  • 69
    • 0020048438 scopus 로고
    • Urinary neopterin excretion in patients with genital cancer
    • Bichler A Fuchs D Hausen A et al. Urinary neopterin excretion in patients with genital cancer. Clin Biochem 1982 15 38 40.
    • (1982) Clin Biochem , vol.15 , pp. 38-40
    • Bichler, A.1    Fuchs, D.2    Hausen, A.3
  • 70
    • 0020580466 scopus 로고
    • Measurement of urinary neopterin in normal pregnant and non-pregnant women and in women with benign and malignant genital tract neoplasms
    • Bichler A Fuchs D Hausen A et al. Measurement of urinary neopterin in normal pregnant and non-pregnant women and in women with benign and malignant genital tract neoplasms. Arch Gynecol 1983 233 121 30.
    • (1983) Arch Gynecol , vol.233 , pp. 121-30
    • Bichler, A.1    Fuchs, D.2    Hausen, A.3
  • 71
    • 0020656490 scopus 로고
    • Significance of urinary neopterin in gynecological oncology: Follow-up of patients with ovarian cancer
    • Hetzel H Bichler A Fuchs D et al. Significance of urinary neopterin in gynecological oncology: follow-up of patients with ovarian cancer. Cancer Detect Prev 1983 6 263 6.
    • (1983) Cancer Detect Prev , vol.6 , pp. 263-6
    • Hetzel, H.1    Bichler, A.2    Fuchs, D.3
  • 72
    • 0023617545 scopus 로고
    • Clinical significance of neopterin for prognosis and follow-up in ovarian cancer
    • Reibnegger G Hetzel H Fuchs D et al. Clinical significance of neopterin for prognosis and follow-up in ovarian cancer. Cancer Res 1987 47 4977 81.
    • (1987) Cancer Res , vol.47 , pp. 4977-81
    • Reibnegger, G.1    Hetzel, H.2    Fuchs, D.3
  • 73
    • 0023270832 scopus 로고
    • Erste Erfahrungen mit Neopterinbestimmungen im Urin von Frauen mit Genital- und Mammatumoren
    • Bartel U Rabe H Schulz-Pinkus M. Erste Erfahrungen mit Neopterinbestimmungen im Urin von Frauen mit Genital- und Mammatumoren. Zentrabl Gynakol 1987 109 1226 32.
    • (1987) Zentrabl Gynakol , vol.109 , pp. 1226-32
    • Bartel, U.1    Rabe, H.2    Schulz-Pinkus, M.3
  • 74
    • 0024259609 scopus 로고
    • The significance of neopterin determination as a tumour marker in ovarian cancer
    • Szarka G Pulay T Csomor S Tran-Phoung-Mai Schumann B. The significance of neopterin determination as a tumour marker in ovarian cancer. Acta Chir Hung 1988 29 359 64.
    • (1988) Acta Chir Hung , vol.29 , pp. 359-64
    • Szarka, G.1    Pulay, T.2    Csomor, S.3    Tran-Phoung-Mai4    Schumann, B.5
  • 75
    • 0024953510 scopus 로고
    • Evaluation of seven different tumour markers for the establishment of tumour marker panels in gynecologic malignancies
    • Avall Lundqvist E Nordstrom L Sjovall K Eneroth P. Evaluation of seven different tumour markers for the establishment of tumour marker panels in gynecologic malignancies. Eur J Gynaecol Oncol 1989 10 395 405.
    • (1989) Eur J Gynaecol Oncol , vol.10 , pp. 395-405
    • Avall Lundqvist, E.1    Nordstrom, L.2    Sjovall, K.3    Eneroth, P.4
  • 76
    • 0025117699 scopus 로고
    • Urinary neopterin excretion in patients with uterine sarcoma
    • Fuith LC Fuchs D Hausen A et al. Urinary neopterin excretion in patients with uterine sarcoma. Cancer 1990 65 1228 31.
    • (1990) Cancer , vol.65 , pp. 1228-31
    • Fuith, L.C.1    Fuchs, D.2    Hausen, A.3
  • 77
    • 0028211730 scopus 로고
    • Elevated serum levels of neopterin and soluble interleukin-2 receptor in patients with ovarian cancer
    • Gadducci A Ferdeghini M Malagnino G et al. Elevated serum levels of neopterin and soluble interleukin-2 receptor in patients with ovarian cancer. Gynecol Oncol 1994 52 386 91.
    • (1994) Gynecol Oncol , vol.52 , pp. 386-91
    • Gadducci, A.1    Ferdeghini, M.2    Malagnino, G.3
  • 79
    • 0030715628 scopus 로고    scopus 로고
    • High serum levels of soluble CD44 variant isoform v5 are associated with favourable clinical outcome in ovarian cancer
    • Zeimet AG Windschwendter M Uhl-Steidl M et al. High serum levels of soluble CD44 variant isoform v5 are associated with favourable clinical outcome in ovarian cancer. Br J Cancer 1997 76 1646 51.
    • (1997) Br J Cancer , vol.76 , pp. 1646-51
    • Zeimet, A.G.1    Windschwendter, M.2    Uhl-Steidl, M.3
  • 80
    • 0028952585 scopus 로고
    • Cervical intraepithelial neoplasia is not associated with elevated serum neopterin levels
    • Strickler HD Escoffery C Rattray C et al. Cervical intraepithelial neoplasia is not associated with elevated serum neopterin levels. Cancer Epidemiol Biomarkers Prev 1995 4 295 8.
    • (1995) Cancer Epidemiol Biomarkers Prev , vol.4 , pp. 295-8
    • Strickler, H.D.1    Escoffery, C.2    Rattray, C.3
  • 81
    • 0027254767 scopus 로고
    • Association between increased urinary neopterin concentrations in women with gynaecological cancer
    • Melichar B Zeimet A Artner-Dworzak E et al. Association between increased urinary neopterin concentrations in women with gynaecological cancer. TumorDiagn Ther 1993 14 110 2.
    • (1993) TumorDiagn Ther , vol.14 , pp. 110-2
    • Melichar, B.1    Zeimet, A.2    Artner-Dworzak, E.3
  • 82
    • 0025035940 scopus 로고
    • Second-look operation in women with ovarian cancer: I. Concentrations of neopterin in urine and CA125 in serum at second-look laparotomy. Their relationship with prognosis
    • Fuith LC Dapunt O Hetzel H Reibnegger G Wachter H. Second-look operation in women with ovarian cancer: I. Concentrations of neopterin in urine and CA125 in serum at second-look laparotomy. Their relationship with prognosis. TumorDiagn Ther 1990 11 147 51.
    • (1990) TumorDiagn Ther , vol.11 , pp. 147-51
    • Fuith, L.C.1    Dapunt, O.2    Hetzel, H.3    Reibnegger, G.4    Wachter, H.5
  • 83
    • 0033984006 scopus 로고    scopus 로고
    • The use of paclitaxel and cisplatin in a patient with epithelial ovarian cancer and human immunodeficiency virus
    • Knox SN Robinson JB Im DD Logan L Rosenheim NB. The use of paclitaxel and cisplatin in a patient with epithelial ovarian cancer and human immunodeficiency virus. Gynecol Oncol 2000 76 118 22.
    • (2000) Gynecol Oncol , vol.76 , pp. 118-22
    • Knox, S.N.1    Robinson, J.B.2    Im, D.D.3    Logan, L.4    Rosenheim, N.B.5
  • 84
    • 0028957471 scopus 로고
    • Effect of combination chemotherapy with cisplatin and cyclophosphamide on human immunodeficiency virus type-1 surrogate markers in a patient with advanced epithelial ovarian cancer
    • Fishman DA Viscarello RR Cass I Schwartz PE. Effect of combination chemotherapy with cisplatin and cyclophosphamide on human immunodeficiency virus type-1 surrogate markers in a patient with advanced epithelial ovarian cancer. Gynecol Oncol 1995 57 105 8.
    • (1995) Gynecol Oncol , vol.57 , pp. 105-8
    • Fishman, D.A.1    Viscarello, R.R.2    Cass, I.3    Schwartz, P.E.4
  • 85
    • 0024409856 scopus 로고
    • Neopterin concentrations in cerebrospinal fluid and serum of individuals infected with HIV-1
    • Fuchs D Chiodi F Albert J et al. Neopterin concentrations in cerebrospinal fluid and serum of individuals infected with HIV-1. AIDS 1989 3 285 8.
    • (1989) AIDS , vol.3 , pp. 285-8
    • Fuchs, D.1    Chiodi, F.2    Albert, J.3
  • 86
    • 0025164684 scopus 로고
    • Increased neopterin concentration in saliva of patients with HIV-1 infection
    • Reibnegger G Fuchs D Zangerle R Wachter H. Increased neopterin concentration in saliva of patients with HIV-1 infection. Clin Chem 1990 36 1379 80.
    • (1990) Clin Chem , vol.36 , pp. 1379-80
    • Reibnegger, G.1    Fuchs, D.2    Zangerle, R.3    Wachter, H.4
  • 87
    • 0026855912 scopus 로고
    • Distinct distributions of D-erythro-neopterin in arteries and veins and its recovery by an enterohepatic circulation
    • Weiss G Glaser K Kronberger P et al. Distinct distributions of D-erythro-neopterin in arteries and veins and its recovery by an enterohepatic circulation. Biol Chem Hoppe Seyler 1992 373 289 94.
    • (1992) Biol Chem Hoppe Seyler , vol.373 , pp. 289-94
    • Weiss, G.1    Glaser, K.2    Kronberger, P.3
  • 88
    • 0027391802 scopus 로고
    • Biliary and urinary neopterin concentrations in monitoring liver-allograft recipients
    • Hausen A Aichberger C Konigsrainer A et al. Biliary and urinary neopterin concentrations in monitoring liver-allograft recipients. Clin Chem 1993 39 45 7.
    • (1993) Clin Chem , vol.39 , pp. 45-7
    • Hausen, A.1    Aichberger, C.2    Konigsrainer, A.3
  • 90
    • 0027749496 scopus 로고
    • Spontaneous bacterial peritonitis is associated with high levels of interleukin-6 and its secondary mediators in ascitic fluid
    • Propst T Propst A Herold M et al. Spontaneous bacterial peritonitis is associated with high levels of interleukin-6 and its secondary mediators in ascitic fluid. Eur J Clin Invest 1993 23 832 6.
    • (1993) Eur J Clin Invest , vol.23 , pp. 832-6
    • Propst, T.1    Propst, A.2    Herold, M.3
  • 91
    • 0024563152 scopus 로고
    • Tumormarker und immunomodulatorische Substanzen im Aszites - Ihre Wertigkeit als Screening und Diagnoseparameter
    • Satz N Joller-Jemelka HI Grob PJ et al. Tumormarker und immunomodulatorische Substanzen im Aszites - Ihre Wertigkeit als Screening und Diagnoseparameter. Schweiz Med Wochenschr 1989 119 762 5.
    • (1989) Schweiz Med Wochenschr , vol.119 , pp. 762-5
    • Satz, N.1    Joller-Jemelka, H.I.2    Grob, P.J.3
  • 92
    • 0036197888 scopus 로고    scopus 로고
    • Immunology of the peritoneal cavity: Relevance for host-tumor relation
    • Melichar B Freedman RS. Immunology of the peritoneal cavity: relevance for host-tumor relation. Int J Gynecol Cancer 2002 12 3 17.
    • (2002) Int J Gynecol Cancer , vol.12 , pp. 3-17
    • Melichar, B.1    Freedman, R.S.2
  • 93
    • 0023766008 scopus 로고
    • Ascitic fluid in malignancy-related ascites
    • Runyon BA Hoefs JC Morgan TR. Ascitic fluid in malignancy-related ascites. Hepatology 1988 8 1104 9.
    • (1988) Hepatology , vol.8 , pp. 1104-9
    • Runyon, B.A.1    Hoefs, J.C.2    Morgan, T.R.3
  • 94
    • 0029799303 scopus 로고    scopus 로고
    • Increased concentrations of neopterin in plasma, ascites and ovarian cyst fluid in malignant tumours compared with benign ovarial tumours
    • Haeger M Swahn M Hahlin M Horvath G Bengtsson A. Increased concentrations of neopterin in plasma, ascites and ovarian cyst fluid in malignant tumours compared with benign ovarial tumours. Anticancer Res 1996 16 3189 92.
    • (1996) Anticancer Res , vol.16 , pp. 3189-92
    • Haeger, M.1    Swahn, M.2    Hahlin, M.3    Horvath, G.4    Bengtsson, A.5
  • 95
    • 1242316943 scopus 로고    scopus 로고
    • Phenotype and antitumor activity of ascitic fluid monocytes in patients with ovarian carcinoma
    • Melichar B Savary CA Patenia R et al. Phenotype and antitumor activity of ascitic fluid monocytes in patients with ovarian carcinoma. Int J Gynecol Cancer 2003 13 435 43.
    • (2003) Int J Gynecol Cancer , vol.13 , pp. 435-43
    • Melichar, B.1    Savary, C.A.2    Patenia, R.3
  • 96
    • 0031804713 scopus 로고    scopus 로고
    • Ascitic interleukin-12 is an independent prognostic factor in ovarian cancer
    • Zeimet AG Widschwendter M Knabbe C et al. Ascitic interleukin-12 is an independent prognostic factor in ovarian cancer. J Clin Oncol 1998 16 1861 8.
    • (1998) J Clin Oncol , vol.16 , pp. 1861-8
    • Zeimet, A.G.1    Widschwendter, M.2    Knabbe, C.3
  • 97
    • 0027092457 scopus 로고
    • Prolonged interferon-gamma application by subcutaneous infusion in cancer patients: Differential response of serum CD14, neopterin, and monocyte HLA class I and II antigens
    • Landmann R Ludwig C Wesp M et al. Prolonged interferon-gamma application by subcutaneous infusion in cancer patients: differential response of serum CD14, neopterin, and monocyte HLA class I and II antigens. J Interferon Res 1992 12 103 11.
    • (1992) J Interferon Res , vol.12 , pp. 103-11
    • Landmann, R.1    Ludwig, C.2    Wesp, M.3
  • 98
    • 0025947683 scopus 로고
    • The in vivo immunomodulatory effects of recombinant interferon gamma plus recombinant tumor necrosis factor-alpha
    • Urba WJ Kopp WC Clark JW et al. The in vivo immunomodulatory effects of recombinant interferon gamma plus recombinant tumor necrosis factor-alpha. J Clin Oncol 1991 9 1831 9.
    • (1991) J Clin Oncol , vol.9 , pp. 1831-9
    • Urba, W.J.1    Kopp, W.C.2    Clark, J.W.3
  • 99
    • 0024958713 scopus 로고
    • Effects of interferon-alpha on macrophage activation in patients with ovarian carcinoma and cervical dysplasia
    • Fuith LC Fuchs D Hausen A et al. Effects of interferon-alpha on macrophage activation in patients with ovarian carcinoma and cervical dysplasia. J Clin Lab Immunol 1989 29 65 9.
    • (1989) J Clin Lab Immunol , vol.29 , pp. 65-9
    • Fuith, L.C.1    Fuchs, D.2    Hausen, A.3
  • 100
    • 0028244915 scopus 로고
    • Elevation de la neopterine apres traitement par le facteur stimulant des colonies granulo-macrophagiques (GM-CSF)
    • Melichar B Solichova D Jebavy L. Elevation de la neopterine apres traitement par le facteur stimulant des colonies granulo-macrophagiques (GM-CSF). Presse Med 1994 23 581.
    • (1994) Presse Med , vol.23 , pp. 581
    • Melichar, B.1    Solichova, D.2    Jebavy, L.3
  • 101
    • 0028225335 scopus 로고
    • Increased production of immune activation marker neopterin by colony-stimulating factors in gynecological cancer patients
    • Marth C Weiss G Koza A et al. Increased production of immune activation marker neopterin by colony-stimulating factors in gynecological cancer patients. Int J Cancer 1994 58 20 3.
    • (1994) Int J Cancer , vol.58 , pp. 20-3
    • Marth, C.1    Weiss, G.2    Koza, A.3
  • 102
    • 0025916290 scopus 로고
    • Increase in soluble interleukin-2 receptor and neopterin serum levels during immunotherapy of cancer with interleukin-2
    • Lissoni P Tisi E Brivio F et al. Increase in soluble interleukin-2 receptor and neopterin serum levels during immunotherapy of cancer with interleukin-2. Eur J Cancer 1991 27 1014 6.
    • (1991) Eur J Cancer , vol.27 , pp. 1014-6
    • Lissoni, P.1    Tisi, E.2    Brivio, F.3
  • 103
    • 0034917186 scopus 로고    scopus 로고
    • Randomized multicenter phase II trial of subcutaneous recombinant human interleukin-12 versus interferon-a2a for patients with advanced renal cell carcinoma
    • Motzer RJ Rakhit A Thompson JA et al. Randomized multicenter phase II trial of subcutaneous recombinant human interleukin-12 versus interferon-a2a for patients with advanced renal cell carcinoma. J Interferon Cytokine Res 2001 21 257 63.
    • (2001) J Interferon Cytokine Res , vol.21 , pp. 257-63
    • Motzer, R.J.1    Rakhit, A.2    Thompson, J.A.3
  • 104
    • 0022478367 scopus 로고
    • Induction of macrophage tumoricidal activity by granulocyte-macrophage colony-stimulating factor
    • Grabstein KH Urdal DL Tushinsky RJ et al. Induction of macrophage tumoricidal activity by granulocyte-macrophage colony-stimulating factor. Science 1986 232 506 8.
    • (1986) Science , vol.232 , pp. 506-8
    • Grabstein, K.H.1    Urdal, D.L.2    Tushinsky, R.J.3
  • 105
    • 0024416645 scopus 로고
    • Die intraperitoneale Instillation von Interferon-gamma zur Behandlung des refraktaren Ovarialkarzinoms
    • Marth C Mull R Gastl G et al. Die intraperitoneale Instillation von Interferon-gamma zur Behandlung des refraktaren Ovarialkarzinoms. Geburtshilfe Frauenheilkd 1989 49 987 91.
    • (1989) Geburtshilfe Frauenheilkd , vol.49 , pp. 987-91
    • Marth, C.1    Mull, R.2    Gastl, G.3
  • 106
    • 0035901090 scopus 로고    scopus 로고
    • Inflammation and cancer: Back to Virchow?
    • Balkwill F Mantovani A. Inflammation and cancer: back to Virchow? Lancet 2001 357 539 45.
    • (2001) Lancet , vol.357 , pp. 539-45
    • Balkwill, F.1    Mantovani, A.2
  • 107
    • 0031709864 scopus 로고    scopus 로고
    • Tumor-induced immune dysfunction: The macrophage connection
    • Elgert KD Alleva DG Mullins DW. Tumor-induced immune dysfunction: the macrophage connection. J Leukoc Biol 1998 64 275 90.
    • (1998) J Leukoc Biol , vol.64 , pp. 275-90
    • Elgert, K.D.1    Alleva, D.G.2    Mullins, D.W.3
  • 108
    • 0028083246 scopus 로고
    • Tumor-induced regulation of suppressor macrophage nitric oxide and TNF-alpha production. Role of tumor-derived IL-10, TGF-beta, and prostaglandin e
    • Alleva DG Burger CJ Elgert KD. Tumor-induced regulation of suppressor macrophage nitric oxide and TNF-alpha production. Role of tumor-derived IL-10, TGF-beta, and prostaglandin E. J Immunol 1994 153 1674 86.
    • (1994) J Immunol , vol.153 , pp. 1674-86
    • Alleva, D.G.1    Burger, C.J.2    Elgert, K.D.3
  • 109
    • 0029017886 scopus 로고
    • CD69+ and HLA-DR+ activation antigens on peripheral blood lymphocyte populations in metastatic breast and ovarian cancer patients: Correlations with survival following active specific immunotherapy
    • Yacyshyn MBB Poppema S Berg A et al. CD69+ and HLA-DR+ activation antigens on peripheral blood lymphocyte populations in metastatic breast and ovarian cancer patients: correlations with survival following active specific immunotherapy. Int J Cancer 1995 61 470 4.
    • (1995) Int J Cancer , vol.61 , pp. 470-4
    • Yacyshyn, M.B.B.1    Poppema, S.2    Berg, A.3
  • 110
    • 0025082092 scopus 로고
    • Analysis of T helper and suppressor lymphocyte subsets in relation to the clinical stage of solid neoplasms
    • Tancini G Barni S Rescaldani R et al. Analysis of T helper and suppressor lymphocyte subsets in relation to the clinical stage of solid neoplasms. Oncology 1990 47 381 4.
    • (1990) Oncology , vol.47 , pp. 381-4
    • Tancini, G.1    Barni, S.2    Rescaldani, R.3
  • 112
    • 0024263910 scopus 로고
    • Neopterin estimation compared with the ratio of T-cell subpopulations in persons infected with human immunodeficiency virus-1
    • Fuchs D Banekovich M Hausen A et al. Neopterin estimation compared with the ratio of T-cell subpopulations in persons infected with human immunodeficiency virus-1. Clin Chem 1988 34 2415 7.
    • (1988) Clin Chem , vol.34 , pp. 2415-7
    • Fuchs, D.1    Banekovich, M.2    Hausen, A.3
  • 113
    • 0028912254 scopus 로고
    • Apoptosis occurs predominantly in bystander cells and not in productively infected cells of HIV- and SIV-infected lymph nodes
    • Finkel TH Tudor-Williams G Banda NK et al. Apoptosis occurs predominantly in bystander cells and not in productively infected cells of HIV- and SIV-infected lymph nodes. Nat Med 1995 1 129 34.
    • (1995) Nat Med , vol.1 , pp. 129-34
    • Finkel, T.H.1    Tudor-Williams, G.2    Banda, N.K.3
  • 114
    • 0029034517 scopus 로고
    • Analysis of apoptosis in lymph nodes of HIV-infected persons. Intensity of apoptosis correlates with the general state of activation of the lymphoid tissue and not with stage of disease or viral burden
    • Muro-Cacho CA Pantaleo G Fauci AS. Analysis of apoptosis in lymph nodes of HIV-infected persons. Intensity of apoptosis correlates with the general state of activation of the lymphoid tissue and not with stage of disease or viral burden. J Immunol 1995 154 5555 66.
    • (1995) J Immunol , vol.154 , pp. 5555-66
    • Muro-Cacho, C.A.1    Pantaleo, G.2    Fauci, A.S.3
  • 115
    • 0032927310 scopus 로고    scopus 로고
    • Mechanisms of apoptosis in T cells from patients with renal cell carcinoma
    • Uzzo RG Rayman P Kolenko V et al. Mechanisms of apoptosis in T cells from patients with renal cell carcinoma. Clin Cancer Res 1999 5 1219 29.
    • (1999) Clin Cancer Res , vol.5 , pp. 1219-29
    • Uzzo, R.G.1    Rayman, P.2    Kolenko, V.3
  • 116
    • 0030944017 scopus 로고    scopus 로고
    • Chronic immune stimulation, oxidative stress, and apoptosis in HIV infection
    • Baier-Bitterlich G Fuchs D Wachter H. Chronic immune stimulation, oxidative stress, and apoptosis in HIV infection. Biochem Pharmacol 1997 53 755 63.
    • (1997) Biochem Pharmacol , vol.53 , pp. 755-63
    • Baier-Bitterlich, G.1    Fuchs, D.2    Wachter, H.3
  • 117
    • 0037527725 scopus 로고    scopus 로고
    • Induction of apoptosis in human blood T cells by 7,8-dihydroneopterin: The difference between healthy controls and patients with systemic lupus erythematosus
    • Wirleitner B Obermoser G Bock G et al. Induction of apoptosis in human blood T cells by 7,8-dihydroneopterin: the difference between healthy controls and patients with systemic lupus erythematosus. Clin Immunol 2003 107 152 9.
    • (2003) Clin Immunol , vol.107 , pp. 152-9
    • Wirleitner, B.1    Obermoser, G.2    Bock, G.3
  • 118
    • 0015513739 scopus 로고
    • Lymphocyte transformation in cancer patients
    • Hagen C Froland A Weberg E. Lymphocyte transformation in cancer patients. Lancet 1972 1 1340.
    • (1972) Lancet , vol.1 , pp. 1340
    • Hagen, C.1    Froland, A.2    Weberg, E.3
  • 119
    • 0014957390 scopus 로고
    • Lymphocyte response to PHA in patients with non-lymphoid tumours
    • Garrioch DB Good RA Gatti RA. Lymphocyte response to PHA in patients with non-lymphoid tumours. Lancet 1970 1 618.
    • (1970) Lancet , vol.1 , pp. 618
    • Garrioch, D.B.1    Good, R.A.2    Gatti, R.A.3
  • 120
    • 0028269721 scopus 로고
    • Selective depression of T-lymphocyte subsets in gastric cancer patients: An implication of immunotherapy
    • Lee WJ Chang KJ Lee CS Chen KM. Selective depression of T-lymphocyte subsets in gastric cancer patients: an implication of immunotherapy. J Surg Oncol 1994 55 165 9.
    • (1994) J Surg Oncol , vol.55 , pp. 165-9
    • Lee, W.J.1    Chang, K.J.2    Lee, C.S.3    Chen, K.M.4
  • 121
    • 0030221608 scopus 로고    scopus 로고
    • Alterations in T cells of cancer-bearers: Whence specificity?
    • Levey DL Srivastava PK. Alterations in T cells of cancer-bearers: whence specificity? Immunol Today 1996 17 365 8.
    • (1996) Immunol Today , vol.17 , pp. 365-8
    • Levey, D.L.1    Srivastava, P.K.2
  • 122
    • 0029987714 scopus 로고    scopus 로고
    • Mitogen-induced lymphocyte proliferation and systemic immune activation in cancer patients
    • Melichar B Jandik P Krejsek J et al. Mitogen-induced lymphocyte proliferation and systemic immune activation in cancer patients. Tumori 1996 82 218 20.
    • (1996) Tumori , vol.82 , pp. 218-20
    • Melichar, B.1    Jandik, P.2    Krejsek, J.3
  • 123
    • 33645374430 scopus 로고    scopus 로고
    • Dendritic cells in ascites associated with peritoneal carcinomatosis
    • Melichar B Savary CA Kudelka AP et al. Dendritic cells in ascites associated with peritoneal carcinomatosis. Proc AACR 1997 38 35 6.
    • (1997) Proc AACR , vol.38 , pp. 35-6
    • Melichar, B.1    Savary, C.A.2    Kudelka, A.P.3
  • 124
    • 0027323998 scopus 로고
    • Dendritic cells freshly isolated from human blood express CD4 and mature into typical immunostimulatory dendritic cells after culture in monocyte-conditioned medium
    • O'Doherty U Steinman RM Peng M et al. Dendritic cells freshly isolated from human blood express CD4 and mature into typical immunostimulatory dendritic cells after culture in monocyte-conditioned medium. J Exp Med 1993 178 1067 78.
    • (1993) J Exp Med , vol.178 , pp. 1067-78
    • O'Doherty, U.1    Steinman, R.M.2    Peng, M.3
  • 125
    • 0021934212 scopus 로고
    • Association between urinary zinc excretion and lymphocyte dysfunction in patients with lung cancer
    • Allen JI Bell E Boosalis MG et al. Association between urinary zinc excretion and lymphocyte dysfunction in patients with lung cancer. Am J Med 1985 79 209 15.
    • (1985) Am J Med , vol.79 , pp. 209-15
    • Allen, J.I.1    Bell, E.2    Boosalis, M.G.3
  • 126
    • 0019978561 scopus 로고
    • Serum zinc levels and urinary zinc excretion in patients with bronchogenic carcinoma. Effects of tumor resection
    • Voyatzoglou V Mountokalakis T Tsata-Voyatzoglou V Koutselenis A Skalkeas G. Serum zinc levels and urinary zinc excretion in patients with bronchogenic carcinoma. Effects of tumor resection. Am J Surg 1982 144 355 8.
    • (1982) Am J Surg , vol.144 , pp. 355-8
    • Voyatzoglou, V.1    Mountokalakis, T.2    Tsata-Voyatzoglou, V.3    Koutselenis, A.4    Skalkeas, G.5
  • 127
    • 0029016497 scopus 로고
    • Increased urinary zinc excretion in cancer patients is linked to immune activation and renal tubular cell dysfunction
    • Melichar B Malir F Jandik P et al. Increased urinary zinc excretion in cancer patients is linked to immune activation and renal tubular cell dysfunction. Biometals 1995 8 205 8.
    • (1995) Biometals , vol.8 , pp. 205-8
    • Melichar, B.1    Malir, F.2    Jandik, P.3
  • 128
    • 0028900799 scopus 로고
    • Association between renal tubular cell dysfunction and increased urinary zinc excretion in cancer patients
    • Melichar B Jandik P Malir F et al. Association between renal tubular cell dysfunction and increased urinary zinc excretion in cancer patients. Scand J Clin Lab Invest 1994 55 149 52.
    • (1994) Scand J Clin Lab Invest , vol.55 , pp. 149-52
    • Melichar, B.1    Jandik, P.2    Malir, F.3
  • 129
    • 0027075199 scopus 로고
    • The role of NAG (N-acetyl-beta-D-glucosaminidase) in the diagnosis of kidney disease including the monitoring of nephrotoxicity
    • Price RG. The role of NAG (N-acetyl-beta-D-glucosaminidase) in the diagnosis of kidney disease including the monitoring of nephrotoxicity. Clin Nephrol 1992 38 S14 9.
    • (1992) Clin Nephrol , vol.38 , pp. 14-9
    • Price, R.G.1
  • 130
    • 0025968321 scopus 로고
    • Immune activation and the anaemia associated with chronic inflammatory disorders
    • Fuchs D Hausen A Reibnegger G et al. Immune activation and the anaemia associated with chronic inflammatory disorders. Eur J Haematol 1991 46 65 70.
    • (1991) Eur J Haematol , vol.46 , pp. 65-70
    • Fuchs, D.1    Hausen, A.2    Reibnegger, G.3
  • 131
    • 0028891726 scopus 로고
    • Pathogenesis of the anemia of chronic disease: A cytokine-mediated anemia
    • Means RT. Pathogenesis of the anemia of chronic disease: a cytokine-mediated anemia. Stem Cells 1995 13 32 7.
    • (1995) Stem Cells , vol.13 , pp. 32-7
    • Means, R.T.1
  • 132
    • 0021356806 scopus 로고
    • Iron withholding: A defence against infection and neoplasia
    • Weinberg ED. Iron withholding: a defence against infection and neoplasia. Physiol Rev 1984 64 65 102.
    • (1984) Physiol Rev , vol.64 , pp. 65-102
    • Weinberg, E.D.1
  • 133
    • 0025552001 scopus 로고
    • Reduction of ferric iron by 7, 8-dihydroneopterin
    • Hausen A Fuchs D Reibnegger G et al. Reduction of ferric iron by 7, 8-dihydroneopterin. Pteridines 1990 2 83 5.
    • (1990) Pteridines , vol.2 , pp. 83-5
    • Hausen, A.1    Fuchs, D.2    Reibnegger, G.3
  • 134
    • 0025250498 scopus 로고
    • Association between neopterin and iron metabolism in cancer patients
    • Wachter H Artner-Dworzak E Fuchs D et al. Association between neopterin and iron metabolism in cancer patients. Tumor Diagn Ther 1990 11 229 32.
    • (1990) Tumor Diagn Ther , vol.11 , pp. 229-32
    • Wachter, H.1    Artner-Dworzak, E.2    Fuchs, D.3


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