Preparation of 1-(3-aminobenzo[d]isoxazol-5-yl)-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-ones as potent, selective, and efficacious inhibitors of coagulation factor Xa

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 19, 2006, Pages 5176-5182

  Li, Yun Long ^a   Fevig, John M ^a   Cacciola, Joseph ^a   Buriak Jr , Joseph ^a   Rossi, Karen A ^a   Jona, Janan ^a   Knabb, Robert M ^a   Luettgen, Joseph M ^a   Wong, Pancras C ^a   Bai, Stephen A ^a   Wexler, Ruth R ^a   Lam, Patrick Y S ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

Anticoagulants; Antithrombotic agents; Bicyclic core; Factor Xa inhibitors; Pyrazole; Pyrazolo 4,3 d pyrimidin 7(6H) ones

Indexed keywords

BLOOD CLOTTING FACTOR 10A INHIBITOR; ISOXAZOLE DERIVATIVE; PYRIMIDINE DERIVATIVE; RAZAXABAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG BINDING; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG DETERMINATION; DRUG EFFICACY; DRUG HALF LIFE; DRUG METABOLISM; DRUG POTENCY; DRUG SELECTIVITY; DRUG STABILITY; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; NONHUMAN; PH MEASUREMENT; STRUCTURE ACTIVITY RELATION; THROMBOGENESIS; THROMBOSIS;

ANTICOAGULANTS; FACTOR XA; HUMANS; PYRIMIDINONES; SERINE PROTEINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; THROMBOEMBOLISM;

EID: 33747351727     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.07.002     Document Type: Article

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