Localisation of endothelin B receptor variants to plasma membrane microdomains and its effects on downstream signalling

Molecular Membrane Biology

Volumn 26, Issue 5-7, 2009, Pages 279-292

  Grossmann, Solveig ^a,d   Higashiyama, Shigeki ^c   Oksche, Alexander ^b,e   Schaefer, Michael ^a   Tannert, Astrid ^a  

^a Unversitaet Leipzig   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^c EHIME UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^d LEIBNIZ INSTITUT FÜR MOLEKULARE PHARMAKOLOGIE   (Germany)

^e MUNDIPHARMA GMBH   (Germany)

Author keywords

Caveolae; Ectodomain shedding; Endothelin B receptor; Epidermal growth factor receptor transactivation; Total internal reflection fluorescence microscopy

Indexed keywords

AMPHIREGULIN; BETACELLULIN; ENDOTHELIN B RECEPTOR; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIREGULIN; HEPARIN BINDING EPIDERMAL GROWTH FACTOR; HYBRID PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; TRANSFORMING GROWTH FACTOR ALPHA;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BIOACCUMULATION; CAVEOLA; CELL MEMBRANE; CELL STRAIN COS7; CELL STRAIN HEK293; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENZYME INDUCTION; ENZYME PHOSPHORYLATION; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN GLYCOSYLATION; PROTEIN LOCALIZATION; PROTEIN VARIANT; SIGNAL TRANSDUCTION; TOTAL INTERNAL REFLECTION FLUORESCENCE MICROSCOPY; TRANSACTIVATION;

ANIMALS; CAVEOLAE; CAVEOLIN 1; CAVEOLIN 2; CELL LINE; CERCOPITHECUS AETHIOPS; COS CELLS; HUMANS; MEMBRANE MICRODOMAINS; MICROSCOPY, FLUORESCENCE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MUTAGENESIS, SITE-DIRECTED; MUTATION; PHOSPHORYLATION; RECEPTOR, ENDOTHELIN B; RECEPTOR, EPIDERMAL GROWTH FACTOR; SIGNAL TRANSDUCTION;

EID: 71849110871     PISSN: 09687688     EISSN: 14645203     Source Type: Journal    
DOI: 10.1080/09687680903191682     Document Type: Article

References (45)

1. Kedzierski RM, Yanagisawa M. 2001. Endothelin system: The double-edged sword in health and disease. Annu Rev Pharmacol Toxicol 41:851-876.
2. Maguire JJ, Davenport AP. 1995. ETA receptor-mediated constrictor responses to endothelin peptides in human blood vessels in vitro. Br J Pharmacol 115:191-197.
3. Roubert P, Gillard-Roubert V, Pourmarin L, Cornet S, Guilmard C, Plas P, Pirotzky E, Chabrier PE, Braquet P. 1994. Endothelin receptor subtypes A and B are up-regulated in an experimental model of acute renal failure. Mol Pharmacol 45:182-188.
4. Dagassan PH, Breu V, Clozel M, Künzli A, Vogt P, Turina M, Kiowski W, Clozel J-P. 1996. Up-regulation of endothe-lin-B receptors in atherosclerotic human coronary arteries. J Cardiovasc Pharmacol 27:147-153.
5. Wackenfors A, Emilson M, Ingemansson R, Hortobagyi T, Szok D, Tajti J, Vecsei L, Edvinsson L, Malmsjo M. 2004. Ischemic heart disease induce upregulation of endothelin receptor mRNA in human coronary arteries. Eur J Pharmacol 484:103-109. (Pubitemid 38068539)
6. Akiyama N, Hiraoka O, Fujii Y, Terashima H, Satoh M, Wada K, Furuichi Y. 1992. Biotin derivatives of endothelin: Utilization for affinity purification of endothelin receptor. Protein Expr Purif 3:427-433
7. Kochl R, Alken M, Rutz C, Krause G, Oksche A, Rosenthal W, Schulein R. 2002. The signal peptide of the G protein-coupled human endothelin B receptor is necessary for translocation of the N-terminal tail across the endoplasmic reticulum membrane. J Biol Chem 277:16131-16138.
8. Grantcharova E, Furkert J, Reusch HP, Krell HW, Papsdorf G, Beyermann M, Schulein R, Rosenthal W, Oksche A. 2002. The extracellular N terminus of the endothelin B (ETB) receptor is cleaved by a metalloprotease in an agonist-dependent process. J Biol Chem 277:43933-43941.
9. Grantcharova E, Reusch HP, Beyermann M, Rosenthal W, Oksche A. 2006. Endothelin A and endothelin B receptors differ in their ability to stimulate ERK1/2 activation. Exp Biol Med (Maywood) 231:757-760.
10. Grantcharova E, Reusch HP, Grossmann S, Eichhorst J, Krell HW, Beyermann M, Rosenthal W, Oksche A. 2006. N-terminal proteolysis of the endothelin B receptor abolishes its ability to induce EGF receptor transactivation and contractile protein expression in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 26:1288-1296.
11. Prenzel N, Zwick E, Daub H, Leserer M, Abraham R, Wallasch C, Ullrich A. 1999. EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF. Nature 402:884-888.
12. Kurzchalia TV, Dupree P, Monier S. 1994. VIP21-caveolin, a protein of the trans-Golgi network and caveolae. FEBS Lett 346:88-91.
13. Lisanti MP, Tang Z, Scherer PE, Kübler E, Koleske AJ, Sargiacomo M. 1995. Caveolae, transmembrane signalling and cellular transformation. Mol Membr Biol 12:121-124
14. Kurzchalia TV, Parton RG. 1999. Membrane microdomains and caveolae. Curr Opin Cell Biol 11:424-431.
15. Teixeira A, Chaverot N, Schroder C, Strosberg AD, Cour-aud PO, Cazaubon S. 1999. Requirement of caveolae microdomains in extracellular signal-regulated kinase and focal adhesion kinase activation induced by endothelin-1 in primary astrocytes. J Neurochem 72:120-128.
16. Yamaguchi T, Murata Y, Fujiyoshi Y, Doi T 2003. Regulated interaction of endothelin B receptor with caveo-lin-1. Eur J Biochem 270:1816-1827.
17. Oksche A, Boese G, Horstmeyer A, Furkert J, Beyermann M, Bienert M, Rosenthal W. 2000. Late endosomal/lysoso-mal targeting and lack of recycling of the ligand-occupied endothelin B receptor. Mol Pharmacol 57:1104-1113.
18. Guzzi F, Zanchetta D, Cassoni P, Guzzi V, Francolini M, Parenti M, Chini B. 2002. Localization of the human oxytocin receptor in caveolin-1 enriched domains turns the receptor-mediated inhibition of cell growth into a proliferative response. Oncogene 21:1658-1667.
19. Smart EJ, Ying Y, Mineo C, Anderson RGW. 1995. A detergent-free method for purifying caveolae membrane from tissue culture cells. PNAS 92:10104-10108.
20. Tokumaru S, Higashiyama S, Endo T, Nakagawa T, Miyagawa Ji, Yamamori K, Hanakawa Y, Ohmoto H, Yoshino K, Shirakata Y, Matsuzawa Y, Hashimoto K, Taniguchi N. 2000. Ectodomain shedding of epidermal growth factor receptor ligands is required for keratinocyte migration in cutaneous wound healing. J Cell Biol 151: 209-220.
21. Sahin U, Weskamp G, Kelly K, Zhou HM, Higashiyama S, Peschon J, Hartmann D, Saftig P, Blobel CP. 2004. Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands. J Cell Biol 164:769-779.
22. Sahin U, Weskamp G, Zheng Y, Chesneau V, Horiuchi K, Blobel CP. 2006. A sensitive method to monitor ectodomain shedding of ligands of the epidermal growth factor receptor. Methods Mol Biol 327:99-113.
23. Axelrod D. 2003. Total internal reflection fluorescence microscopy in cell biology. Methods Enzymol 361:1-33.
24. Lenz JC, Reusch HP, Albrecht N, Schultz G, Schaefer M. 2001. Ca +-controlled competitive diacylglycerol binding of protein kinase C isoenzymes in living cells. J Cell Biol 159:291-302.
25. Stuurman N, Amodaj N, Vale RD. 2007. Micro-Manager: Open Source software for light microscope imaging. Microscopy Today 15:42-43
26. Reusch HP, Schaefer M, Plum C, Schultz G, Paul M. 2001. GPy mediate differentiation of vascular smooth muscle cells. J Biol Chem 276:19540-19547.
27. Keren O, Sarne Y. 2003. Multiple mechanisms of CB1 cannabinoid receptors regulation. Brain Res 980:197-205.
28. Mayor S, Maxfield FR. 1995. Insolubility and redistribution of GPI-anchored proteins at the cell surface after detergent treatment. Mol Biol Cell 6:929-944.
29. Gimpl G, Gehrig-Burger K. 2007. Cholesterol reporter molecules. Biosci Rep 27:335-358.
30. Ghittoni R, Patrussi L, Pirozzi K, Pellegrini M, Lazzerini PE, Capecchi PL, Laghi Pasini F, Baldari CT 2005. Simvastatin inhibits T-cell activation by selectively impairing the function of Ras superfamily GTPases. FASEB J 19:605-607.
31. Liao JK, Laufs U. 2005. Pleiotropic effects of statins. Annu Rev Pharmacol Toxicol 45:89-118.
32. Tagawa A, Mezzacasa A, Hayer A, Longatti A, Pelkmans L, Helenius A. 2005. Assembly and trafficking of caveolar domains in the cell: Caveolae as stable, cargo-triggered, vesicular transporters. J Cell Biol 170:769-779.
33. Rybin VO, Xu X, Lisanti MP, Steinberg SF. 2000. Differential targeting of beta-adrenergic receptor subtypes and adenylyl cyclase to cardiomyocyte caveolae. A mechanism to functionally regulate the cAMP signaling pathway. J Biol Chem 275:41447-41457
34. Ostrom RS, Gregorian C, Drenan RM, Xiang Y, Regan JW, Insel PA. 2001. Receptor number and caveolar co-localization determine receptor coupling efficiency to adenylyl cyclase. J Biol Chem 276:42063-42069
35. Ostrom RS, Liu X, Head BP, Gregorian C, Seasholtz TM, Insel PA. 2002. Localization of adenylyl cyclase isoforms and g protein-coupled receptors in vascular smooth muscle cells: Expression in caveolin-rich and noncaveolin domains. Mol Pharmacol 62:983-992.
36. Sanderson MP, Abbott CA, Tada H, Senu M, Dempsey PJ, Dunbar AJ. 2006. Hydrogen peroxide and endothelin-1 are novel activators of betacellulin ectodomain shedding. J Cell Biochem 99:609-623.
37. Gschwind A, Hart S, Fischer OM, Ullrich A. 2003. TACE cleavage of proamphiregulin regulates GPCR-induced proliferation and motility of cancer cells. EMBO J 22: 2411-2421.
38. Higashiyama S, Nanba D. 2005. ADAM-mediated ectodomain shedding of HB-EGF in receptor cross-talk. Biochim Biophys Acta 1751:110-117.
39. Mifune M, Ohtsu H, Suzuki H, Nakashima H, Brailoiu E, Dun NJ, Frank GD, Inagami T, Higashiyama S, Thomas WG, Eckhart AD, Dempsey PJ, Eguchi S. 2005. G protein coupling and second messenger generation are indispensable for metalloprotease-dependent, heparin-binding epidermal growth factor shedding through angiotensin II type-1 receptor. J Biol Chem 280:26592-26599.
40. Pike LJ. 2005. Growth factor receptors, lipid rafts and caveolae: An evolving story. Biochimica et Biophysica Acta (BBA)-Molec Cell Res 1746:260-273.
41. Rimoldi V, Reversi A, Taverna E, Rosa P, Francolini M, Cassoni P, Parenti M, Chini B. 2003. Oxytocin receptor elicits different EGFR/MAPK activation patterns depending on its localization in caveolin-1 enriched domains. Oncogene 22:6054-6060.
42. Vichi P, Whelchel A, Knot H, Nelson M, Kolch W, Posada J. 1999. Endothelin-stimulated ERK activation in airway smooth-muscle cells requires calcium influx and Raf activation. Am J Respir Cell Mol Biol 20:99-105.
43. Schinelli S, Zanassi P, Paolillo M, Wang H, Feliciello A, Gallo V. 2001. Stimulation of endothelin B receptors in astrocytes induces cAMP response element-binding protein phosphorylation and c-fos expression via multiple mitogen-activated protein kinase signaling pathways. J Neurosci 21:8842-8853.
44. Cheng CM, Hong HJ, Liu JC, Shih NL, Juan SH, Loh SH, Chan P, Chen JJ, Cheng TH. 2003. Crucial role of extracellular signal-regulated kinase pathway in reactive oxygen species-mediated endothelin-1 gene expression induced by endothelin-1 in rat cardiac fibroblasts. Mol Pharmacol 63:1002-1011.
45. Dschietzig T, Bartsch C, Richter C, Laule M, Baumann G, Stangl K. 2003. Relaxin, a pregnancy hormone, is a functional endothelin-1 antagonist: Attenuation of endothelin-1-mediated vasoconstriction by stimulation of endothelin type-B receptor expression via ERK-1/2 and nuclear factor-kB. Circ Res 92:32-40