Growth factor receptors, lipid rafts and caveolae: An evolving story

Biochimica et Biophysica Acta - Molecular Cell Research

Volumn 1746, Issue 3, 2005, Pages 260-273

  Pike, Linda J ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Caveola; Cholesterol; EGF receptor; Growth factor; Insulin receptor; Lipid raft

Indexed keywords

CAVEOLIN; CAVEOLIN 1; CHOLESTEROL; EPIDERMAL GROWTH FACTOR RECEPTOR; GROWTH FACTOR RECEPTOR; INSULIN RECEPTOR; LIPID; PHOSPHOTRANSFERASE; PROTEIN TYROSINE KINASE; STRUCTURAL PROTEIN; VASCULOTROPIN RECEPTOR;

CAVEOLA; ENZYME ACTIVITY; HUMAN; KNOCKOUT GENE; LIPID MEMBRANE; LIPID RAFT; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN LOCALIZATION; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; CAVEOLAE; CAVEOLIN 1; CELL MEMBRANE; CHOLESTEROL; HUMANS; MEMBRANE MICRODOMAINS; MODELS, BIOLOGICAL; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTORS, GROWTH FACTOR;

EID: 29244452619     PISSN: 01674889     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbamcr.2005.05.005     Document Type: Review

References (140)

1. D.A. Brown, and E. London Structure and function of sphingolipid- and cholesterol-rich membrane rafts J. Biol. Chem. 275 2000 17221 17224
2. D.A. Brown, and J.K. Rose Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface Cell 68 1992 533 544
3. S. Ilangumaran, S. Arni, G. van Echten-Deckert, B. Borisch, and D.C. Hoessli Microdomain-dependent regulation of lck and fyn protein-tyrosine kinases in T-lymphocyte plasma membranes Mol. Biol. Cell 10 1999 891 905
4. K. Roper, D. Corbeil, and W.B. Huttner Retention of prominin in microvilli reveals distinct cholesterol-based lipid microdomains in the apical plasma membrane Nat. Cell Biol. 2 2000 582 592
5. T.A. Slimane, G. Trugnan, S.C.D. van Izendoorn, and D. Hoekstra Raft-mediated trafficking of apical resident proteins occurs in both direct and transcytotic pathways in polarized hepatic cells: role of distinct lipid microdomains Mol. Biol. Cell 14 2003 611 624
6. E.J. Smart, Y.-S. Ying, C. Mineo, and R.G.W. Anderson A detergent-free method for purifying caveolae membrane from tissue culture cells Proc. Natl. Acad. Sci. U. S. A. 92 1995 10104 10108
7. J.L. Macdonald, L.J. Pike, A simplified method for the preparation of detergent-free lipid rafts, J. Lipid Res.. 46 (in press).
8. K.G. Rothberg, J.E. Heuser, W.C. Donzell, Y.-S. Ying, J.R. Glenney, and R.G.W. Anderson Caveolin, a protein component of caveolae membrane coats Cell 68 1992 673 682
9. N. Madore, K.L. Smith, C.H. Graham, A. Jen, K. Brady, S. Hall, and R. Morris Functionally different GPI proteins are organized in different domains on the neuronal surface EMBO J. 18 1999 6917 6926
10. C. Gomez-Mouton, J.L. Abad, E. Mira, R.A. Lacalle, E. Gallardo, S. Jimenez-Baranda, I. Illa, A. Bernad, and S. Manes Segregation of leading edge and uropod components into specific rafts during T cell polarization Proc. Natl. Acad. Sci. U. S. A. 98 2001 9642 9647
11. M. Bagnat, and K. Simons Cell surface polarization during yeast mating Proc. Natl. Acad. Sci. U. S. A. 99 2002 14183 14188
12. J.B. Helms, and C. Zurzolo Lipids as targeting signals: lipid rafts and intracellular trafficking Traffic 5 2004 247 254
13. R.G. Parton, and A.A. Richards Lipid rafts and caveolae as portals for endocytosis: new insights and common mechanisms Traffic 4 2003 724 738
14. K. Simons, and D. Toomre Lipid rafts and signal transduction Nat. Rev., Mol. Cell Biol. 1 2000 31 41
15. E.J. Smart, G.A. Graf, M.A. McNiven, W.C. Sessa, J.A. Engelman, P.E. Scherer, T. Okamoto, and M.P. Lisanti Caveolins, liquid-ordered domains, and signal transduction Mol. Cell. Biol. 19 1999 7289 7304
16. L.J. Pike Lipid rafts: bringing order to chaos J. Lipid Res. 44 2003 655 667
17. A. Ullrich, L. Coussens, J.S. Hayflick, T.J. Dull, A. Gray, A.W. Tam, J. Lee, Y. Yarden, T.A. Libermann, J. Schlessinger, J. Downward, E.L.V. Mayes, N. Whittle, N.D. Waterfield, and P.H. Seeburg Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells. Nature 309 1984 418 425
18. Y. Yarden, and J. Schlessinger Self-phosphorylation of epidermal growth factor receptor: evidence for a model of intermolecular allosteric activation Biochemistry 26 1987 1434 1442
19. Y. Yarden, and J. Schlessinger Epidermal growth factor induces rapid, reversible aggregation of the purified epidermal growth factor receptor Biochemistry 26 1987 1443 1451
20. J.M. Tavare, and K. Siddle Mutational analysis of insulin receptor function: consensus and controversy Biochim. Biophys. Acta 1178 1993 21 39
21. C.C. Yip, and P. Ottensmeyer Three-dimensional structural interactions of insulin and its receptor J. Biol. Chem. 278 2003 27329 28332
22. Y.H. Lee, and M.F. White Insulin receptor substrate proteins and diabetes Arch. Pharmacal Res. 27 2004 361 370
23. A.M. Johnston, L. Pirola, and E. Van Obberghen Molecular mechanisms of insulin receptor substrate protein-mediated modulation of insulin signalling FEBS Lett. 546 2003 32 36
24. M.F. White IRS proteins and the common path to diabetes Am. J. Physiol: Endocrinol. Metab. 283 2002 E413 E422
25. H. Kouhara, Y.R. Hadari, T. Spivak-Kroizman, J. Schilling, D. Bar-Sagi, I. Lax, and J. Schlessinger A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway Cell 89 1997 693 702
26. Y.R. Hadari, H. Kouhara, I. Lax, and J. Schlessinger Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation Mol. Cell. Biol. 18 1998 3966 3973
27. S.H. Ong, G.R. Guy, Y.R. Hadai, S. Laks, N. Gotoh, J. Schlessinger, and I. Lax FRS2 proteins recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptors Mol. Cell. Biol. 20 2000 979 989
28. J. Gustavsson, S. Parpal, M. Karlsson, C. Ramsing, H. Thorm, M. Borg, M. Lindroth, K.H. Peterson, K.-E. Magnusson, and P. Stralfors Localization of the insulin receptor in caveolae of adipocyte plasma membrane FASEB J. 13 1999 1961 1971
29. L.J. Pike, and L. Casey Localization and turnover of phosphatidylinositol 4,5-bisphosphate in caveolin-enriched membrane domains J. Biol. Chem. 271 1996 26453 26456
30. L.J. Foster, C.L. de Hoog, and M. Mann Unbiased quantitative proteomics of lipid rafts reveals high specificity for signaling factors Proc. Natl. Acad. Sci. U. S. A. 100 2003 5813 5818
31. J. Blonder, M.L. Hale, D.A. Lucas, C.F. Schaefer, L.-R. Yu, T.P. Conrads, H.J. Issaq, B.G. Stiles, and T.D. Veenstra Proteomic analysis of detergent-resistant membrane rafts Electrophoresis 25 2004 1307 1318
32. N. Li, A.R.E. Shaw, N. Zhang, A. Mak, and L. Li Lipid raft proteomics: analysis of in-solution digest of sodium, dodecyl sulfate-solubilized lipid raft proteins by liquid chromatography-matrix-assisted laser desorption/ionization tandem mass spectrometry Proteomics 4 2004 3156 3166
33. P.D. von Haller, S. Donohoe, D.R. Goodlett, R. Aebersold, and J.D. Watts Mass spectrometric characterization of proteins extracted from Jurkat T cell detergent-resistant membrane domains Proteomics 1 2001 1010 1021
34. T. Nebl, K.N. Pestonjamasp, J.D. Leszyk, J.L. Crowley, S.W. Oh, and E.J. Luna Proteomic analysis of a detergent-resistant membrane skeleton from neutrophil plasma membranes J. Biol. Chem. 277 2002 43399 43409
35. J. Liu, P. Oh, T. Horner, R.A. Rogers, and J.E. Schnitzer Organized endothelial cell surface signal transduction in caveolae distinct from glycosylphosphatidylinositol-anchored protein microdomains J. Biol. Chem. 272 1997 7211 7222
36. C. Mineo, G.N. Gill, and R.G.W. Anderson Regulated migration of epidermal growth factor receptor from caveolae J. Biol. Chem. 274 1999 30636 30643
37. H. Huo, X. Guo, S. Hong, M. Jiang, X. Liu, and K. Liao Lipid rafts/caveolae are essential for insulin-like growth factor-1 receptor signaling during 3T3-L1 preadipocyte differentiation induction J. Biol. Chem. 278 2003 11561 11569
38. C.-S. Huang, J. Zhou, A.K. Feng, C.C. Lynch, J. Klumperman, S.J. DeArmond, and W.C. Mobley Nerve growth factor signaling in caveolae-like domains at the plasma membrane J. Biol. Chem. 274 1999 36707 36714
39. C. Mineo, G.L. James, E.J. Smart, and R.G.W. Anderson Localization of epidermal growth factor-stimulated Ras/Raf-1 interaction to caveolae membrane J. Biol. Chem. 271 1996 11930 11935
40. T. Ringerike, F.D. Glystad, F.O. Levy, I.H. Madshus, and E. Stang Cholesterol is important in control of EGF receptor kinase activity but EGF receptors are not concentrated in caveolae J. Cell. Sci. 115 2002 1331 1340
41. K. Roepstorff, P. Thomsen, K. Sandvig, and B. van Deurs Sequestration of EGF receptors in non-caveolar lipid rafts inhibits ligand binding J. Biol. Chem. 277 2002 18954 18960
42. S.V. Matveev, and E.J. Smart Heterologous densensitization of EGF Receptors and PDGF receptors by sequestration in caveolae Am. J. Physiol., Cell Physiol. 282 2002 C935 C946
43. M. Karlsson, H. Thorn, A. Danielsson, K.G. Stenkula, A. Ost, J. Gustavsson, F.H. Nystrom, and P. Stralfors Colocalization of insulin receptor and insulin receptor substrate-1 to caveolae in primary human adipocytes Eur. J. Biochem. 271 2004 2471 2479
44. R.P. Souto, G. Vallega, J. Wharton, J. Vinten, J. Tranum-Jensen, and P.F. Pilch Immunopurification and characterization of rat adipocyte caveolae suggest their dissociation from insulin signaling J. Biol. Chem. 278 2003 18321 18329
45. S. Vainio, S. Heino, J.-E. Mansson, P. Fredman, E. Kuismanen, O. Vaarala, and E. Ikonen Dynamic association of human insulin receptor with lipid rafts in cells lacking caveolae EMBO Rep. 3 2002 95 100
46. P. Liu, Y. Ying, Y.-G. Ko, and R.G.W. Anderson Localization of platelet-derived growth factor-stimulated phosphorylation cascade to caveolae J. Biol. Chem. 271 1996 10299 10303
47. S. Peiro, J.X. Comella, C. Enrich, D. Martin-Zanca, and N. Rocamora PC12 cells have caveolae that contain TrkA J. Biol. Chem. 275 2000 37846 37852
48. A. Davy, C. Feuerstein, and S.M. Robbins Signaling within a caveolae-like membrane microdomain in human neuroblastoma cells in response to fibroblast growth factor J. Neurochem. 74 2000 676 683
49. C.L. Chu, J.A. Buczek-Thomas, and M.A. Nugent Heparan sulphate proteoglycans modulate fibroblast growth factor-2 binding through a lipid raft-mediated mechanism Biochem. J. 379 2004 331 341
50. P.E. Gleizes, J. Noaillac-Depeyre, M.A. Dupont, and N. Gas Basic fibroblast growth factor (FGF-2) is addressed to caveolae after binding to the plasma membrane of BHK cells Eur. J. Cell Biol. 71 1996 144 153
51. M.S. Ridyard, and S.M. Robbins Fibroblast growth factor-2-induced signaling through lipid raft-associate fibroblast growth factor receptor substrate 2 (FRS2) J. Biol. Chem. 278 2003 13803 13809
52. S. Moffett, D.A. Brown, and M.E. Linder Lipid-dependent targeting of G proteins into rafts J. Biol. Chem. 275 2000 2191 2198
53. P. Scheiffele, M.G. Roth, and K. Simons Interaction of influenza virus haemagglutinin with sphingolipid-cholesterol membrane domains via its transmembrane domain EMBO J. 16 1997 5501 5508
54. M.S. Bretscher, and S. Munro Cholesterol and the Golgi apparatus Science 261 1993 1280 1281
55. P. Scheiffele, J. Peranen, and K. Simons N-glycans as apical sorting signals in epithelial cells Nature 378 1995 96 98
56. A. Kundu, R.T. Avalos, C.M. Sanderson, and D.P. Nayak Transmembrane domain of influenza virus neuraminidase, a type III protein, possesses an apical sorting signal in polarized MDCK cells J. Virol. 70 1996 6508 6515
57. A.J. Crossthwaite, T. Seebacher, N. Masada, A. Ciruela, K. Dufraux, J.E. Schultz, and D.M.F. Cooper The cytosolic domains of Ca2+-sensitive adenylyl cyclases dictate their targeting to plasma membrane lipid rafts J. Biol. Chem. 280 2005 6380 6391
58. A. Kimura, C.A. Baumann, S.-H. Chiang, and A.R. Saltiel The sorbin homology domain: a motif for the targeting of proteins to lipid rafts Proc. Natl. Acad. Sci. U. S. A. 98 2001 9098 9103
59. M. Yamabhai, and R.G.W. Anderson Second cysteine-rich region of EGFR contains targeting information for caveolae/rafts J. Biol. Chem. 277 2002 24843 24846
60. J. Couet, S. Li, T. Okamoto, T. Ikezu, and M.P. Lisanti Identification of peptide and protein ligands for the caveolin-scaffolding domain J. Biol. Chem. 272 1997 6525 6533
61. J. Couet, M. Sargiacomo, and M.P. Lisanti Interaction of a receptor tyrosine kinase, EGF-R, with caveolins. caveolin binding negatively regulates tyrosine and serine/threonine kinase activities J. Biol. Chem. 272 1997 30429 30438
62. R. Ravichandran, and S. Divakar Inclusion of ring A of cholesterol inside the β-cyclodextrin cavity: evidence from oxidation reactions and structural studies J. Incl. Phenom. Mol. Recognit. Chem. 30 1998 253 270
63. J.E. Schnitzer, P. Oh, E. Pinney, and J. Allard Filipin-sensitive caveolae-mediated transport in endothelium: reduced transcytosis, scavenger endocytosis, and capillary permeability of select macromolecules J. Cell Biol. 127 1994 1217 1232
64. T. Furuchi, and R.G.W. Anderson Cholesterol depletion of caveolae causes hyperactivation of extracellular signal-related kinase (ERK) J. Biol. Chem. 273 1998 21099 21104
65. L. Liscum, and J.J. Klansek Niemann-pick disease type C Cur. Opin. Lipidol. 9 1998 131 135
66. L.J. Pike, and L. Casey Cholesterol levels modulate EGF receptor-mediated signaling by altering receptor function and trafficking Biochemistry 41 2002 10315 10322
67. E.J. Westover, D.F. Covey, H.L. Brockman, R.E. Brown, and L.J. Pike Cholesterol depletion results in site-specific increases in EGF receptor phosphorylation due to membrane level effects: studies with cholesterol enantiomers J. Biol. Chem. 278 2003 51125 51133
68. Y. Okabayashi, Y. Kido, T. Okutani, Y. Sugimoto, K. Sakaguchi, and M. Kasuga Tyrosines 1148 and 1173 of activated human epidermal growth factor receptors are binding sites of shc in intact cells J. Biol. Chem. 269 1994 18674 18678
69. A.G. Batzer, D. Rotin, J.M. Urena, E.Y. Skolnik, and J. Schlessinger Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor Mol. Cell. Biol. 14 1994 5192 5201
70. G. Levkowitz, H. Waterman, S.A. Ettenberg, M. Katz, A.Y. Tsygankov, I. Alroy, S. Lavi, K. Iwai, Y. Reiss, A. Ciechanover, S. Lipkowitz, and Y. Yarden Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1 Mol. Cell 4 1999 1029 1040
71. M.-C. Maa, T.-Z. Leu, D.J. McCarley, R.C. Schatzman, and S.J. Parsons Potentiation of epidermal growth factor receptor-mediated oncogenesis by c-Src: implications for the etiology of multiple human cancers Proc. Natl. Acad. Sci. U. S. A. 92 1995 6981 6985
72. P.-Y. Wang, P. Liu, J. Weng, E. Sontag, and R.G.W. Anderson A cholesterol-regulated PP2A/HePTP complex with dual specificity ERK 1/2 phosphatase activity EMBO J. 22 2003 2658 2667
73. L.J. Pike, and J.M. Miller Cholesterol depletion de-localizes PIP2 and inhibits hormone-stimulated phosphatidylinositol turnover J. Biol. Chem. 273 1998 22298 22304
74. H. Thorn, K.G. Stenkula, M. Karlsson, U. Ortegren, F.H. Nystrom, J. Gustavsson, and P. Stralfors Cell surface orifices of caveolae and localization of caveolin to the necks of caveolae in adipocytes Mol. Biol. Cell 14 2003 3967 3976
75. S. Parpal, M. Karlsson, H. Thorn, and P. Stralfors Cholesterol depletion disrupts caveolae and insulin receptor signaling for metabolic control via insulin receptor substrate-1, but not for mitogen-activated protein kinase control J. Biol. Chem. 276 2001 9670 9678
76. M. Murata, J. Peranen, R. Schreiner, F. Wieland, T.V. Kurzchalia, and K. Simons VIP21/caveolin is a cholesterol-binding protein Proc. Natl. Acad. Sci. U. S. A. 92 1995 10339 10343
77. A.R. Saltiel, and J.E. Pessin Insulin signaling in microdomains of the plasma membrane Traffic 4 2003 711 716
78. A.R. Saltiel, and J.E. Pessin Insulin signaling pathways in time and space Trends Cell Biol. 12 2002 65 71
79. J. Liu, A. Kimura, C.A. Baumann, and A.R. Saltiel APS facilitates c-Cbl tyrosine phosphorylation and GLUT4 translocation in response to insulin in 3T3-L1 adipocytes Mol. Cell. Biol. 22 2002 3599 3609
80. C.A.P. Joazeiro, S.S. Wing, H.-K. Huang, J.D. Leverson, T. Hunter, and Y.-C. Liu The tyrosine kinase negative regulator c-Cbl as a RING-type E2-dependent ubiquitin-protein ligase Science 286 1999 309 312
81. V. Ribon, and A.R. Saltiel Insulin stimulates tyrosine phosphorylation of the proto-oncogene c-Cbl in 3T3-L1 adipocytes Biochem. J. 324 1997 839 845
82. C.A. Baumann, V. Ribon, M. Kanzaki, d.C. Thurmond, S. Mora, S. Shigematsu, P.E. Bickel, J.E. Pessin, and A.R. Saltiel CAP defines a second signalling pathway required for insulin-stimulated glucose transport Nature 407 2000 202 207
83. S.-H. Chiang, C.A. Baumann, M. Kanzaki, D.C. Thurmond, R.T. Watson, C.L. Neudauer, I.g. Macara, J.E. Pessin, and A.R. Saltiel Insulin-stimulated GLUT4 translocation requires the CAP-dependent activation of TC10 Nature 410 2001 944 948
84. J.F. Hancock, A.I. Magee, J.E. Childs, and C.J. Marshall All ras proteins are polyisoprenylated but only some are palmitoylated Cell 57 1989 1167 1177
85. R.T. Watson, S. Shigematsu, S.-H. Chiang, S. Mora, M. Kanzaki, I.G. Macara, A.R. Saltiel, and J.E. Pessin Lipid raft microdomain compartmentalization of TC10 is required for insulin signaling and GLUT4 translocation J. Cell Biol. 154 2001 829 840
86. P. Aspenstrom, A. Fransson, and J. Saras Rho GTPases have diverse effects on the organization of the actin filament system Biochem. J. 377 2004 327 337
87. P. Mitra, X. Zheng, and M.P. Czech RNAi-based analysis of CAP, Cbl and CrkII function in the regulation of GLUT4 by insulin J. Biol. Chem. 279 2004 37431 37435
88. P. Liu, Y.-S. Ying, and R.G.W. Anderson Platelet-derived growth factor activates mitogen-activated protein kinase in isolated caveolae Proc. Natl. Acad. Sci. U. S. A. 94 1997 13666 13670
89. T.F. McGuire, S.J. Corey, and S.M. Sebti Lovastatin inhibits platelet-derived growth factor (PDGF) stimulation of phosphatidylinositol 3-kinase activity as well as association of p85 subunit to tyrosine- phosphorylated PDGF receptor J. Biol. Chem. 268 1993 22227 22230
90. C.J. Marshall Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation Cell 80 1995 179 185
91. M.-S. Qiu, and S.H. Green PC12 cell neuronal differentiation is associated with prolonged p21Ras activity and consequent prolonged ERK activity Neuron 9 1992 705 717
92. S.-C. Kao, R.K. Jaiswal, W. Kolch, and G.E. Landreth Identification of the mechanisms regulating the differential activation of the MAPK cascade by epidermal growth factor and nerve growth factor in PC12 cells J. Biol. Chem. 276 2001 18169 18177
93. A.M. Fra, E. Williamson, K. Simons, and R.G. Parton De novo formation of caveolae in lymphocytes by expression of VIP21-caveolin Proc. Natl. Acad. Sci. U. S. A. 92 1995 8655 8659
94. P.E. Scherer, T. Okamoto, M. Chun, I. Nishimoto, H.F. Lodish, and M.P. Lisanti Identification, sequence, and expression of caveolin-2 defines a caveolin gene family Proc. Natl. Acad. Sci. U. S. A. 93 1996 131 135
95. R. Mora, V.L. Bonilha, A. Marmorstein, P.E. Scherer, D. Brown, M.P. Lisanti, and E. Rodriguez-Boulan Caveolin-2 localizes to the Golgi complex but redistributes to plasma membrane, caveolae, and rafts when co-expressed with caveolin-1 J. Biol. Chem. 274 1999 25708 25717
96. I. Parolini, M. Sargiacomo, F. Galbiati, G. Rizzo, F. Grignani, J.A. Engelman, T. Okamoto, T. Ikezu, P.E. Scherer, R. Mora, E. Rodrigues-Boulan, C. Peschle, and M.P. Lisanti Expression of caveolin-1 is required for the transport of caveolin-2 to the plasma membrane J. Biol. Chem. 274 1999 25718 25725
97. Z. Tang, P.E. Scherer, T. Okamoto, K. Song, C. Chu, D.S. Kohtz, I. Nishimoto, H.F. Lodish, and M.P. Lisanti Molecular cloning of caveolin-3, a novel member of the caveolin gene family expressed predominantly in muscle J. Biol. Chem. 271 1996 2255 2261
98. R.G. Parton, M. Way, N. Zorzi, and E. Stang Caveolin-3 associates with developing T-tubules during muscle differentiation J. Cell Biol. 136 1997 137 154
99. M. Yamamoto, Y. Toya, C. Schwencke, M.P. Lisanti, M.G. Myers Jr., and Y. Ishikawa Caveolin is an activator of insulin receptor signaling J. Biol. Chem. 273 1998 26962 26968
100. T.R. Bilderback, V.-R. Gazula, M.P. Lisanti, and R.T. Dobrowsky Caveolin interacts with TrkA and p75 NTR and regulates neurotrophin signaling pathways J. Biol. Chem. 274 1999 247 263
101. M. Yamamoto, Y. Toya, R.A. Jensen, and Y. Ishikawa Caveolin is an inhibitor of platelet-derived growth factor receptor signaling Exp. Cell Res. 247 1999 380 388
102. N. Oka, Y. Yamamoto, C. Schwencke, J.-I. Kawabe, T. Ebina, S. Ohno, J. Couet, M.P. Lisanti, and Y. Ishikawa Caveolin interaction with protein kinase c isoenzyme-dependent regulation of kinase activity by the caveolin scaffolding domain peptide J. Biol. Chem. 272 1997 33416 33421
103. B. Razani, C.S. Rubin, and M.P. Lisanti Regulation of cAMP-mediated signal transduction via interaction of caveolins with the catalytic subunit of protein kinase A J. Biol. Chem. 274 1999 26353 26360
104. C.V. Carman, M.P. Lisanti, and J.L. Benovic Regulation of G protein-coupled receptor kinases by caveolin J. Biol. Chem. 274 1999 8858 8864
105. S. Li, J. Couet, and M.P. Lisanti Src tyrosine kinases, Gα subunits, and H-ras share a common membrane-anchored scaffolding protein, caveolin J. Biol. Chem. 271 1996 29182 29190
106. S. Li, T. Okamoto, M. Chun, M. Sargiacomo, J.E. Casanova, S.H. Hansen, I. Nishimoto, and M.P. Lisanti Evidence for a regulated interaction between heterotrimeric G proteins and caveolin J. Biol. Chem. 270 1995 15693 15701
107. K.S. Song, S. Li, T. Okamoto, L.A. Quilliam, M. Sargiacomo, and M.P. Lisanti Co-purification and direct interaction of ras with caveolin, an integral membrane protein of caveolae microdomains J. Biol. Chem. 271 1996 9690 9697
108. Y. Toya, C. Schwencke, J. Couet, M.P. Lisanti, and Y. Ishikawa Inhibition of adenylyl cyclase by caveolin peptides Endocrinology 139 1998 2025 2031
109. B. Razani, J.A. Engelman, X.B. Wang, W. Schubert, X.L. Zhang, C.B. Marks, F. Macaluso, R.G. Russell, M. Li, R.G. Pestell, D. Di Vizio, H. Hou, B. Kneitz, G. Lagaud, G.J. Christ, W. Edelmann, and M.P. Lisanti Caveolin-1 null mice are viable but show evidence of hyperproliferative and vascular abnormalities J. Biol. Chem. 275 2001 38121 38138
110. M. Drab, P. Verkade, M. Elger, M. Kasper, M. Lohn, B. Lauterbach, J. Menne, C. Lindschau, F. Mende, F.C. Luft, A. Schedl, H. Haller, and T.V. Kurzchalia Loss of caveolae, vascular dysfunction, and pulmonary defects in caveolin-1 gene-disrupted mice Science 293 2001 2449 2452
111. L. Citores, D. Khnykin, V. Sorensen, J. Wesche, O. Klingenberg, A. Wiedlocha, and S. Olsnes Modulation of intracellular transport of acidic fibroblast growth factor by mutations in the cytoplasmic receptor domain J. Cell. Sci. 114 2001 1677 1689
112. F.H. Nystrom, H. Chen, L.N. Cong, Y. Li, and M.J. Quon Caveolin-1 interacts with the insulin receptor and can differentially modulate insulin signaling in transfected Cos-7 cells and rat adipose cells Mol. Endocrinol. 13 1999 2013 2024
113. A.W. Cohen, D.S. Park, S.E. Woodman, T.M. Williams, M. Chandra, J. Shirani, A. Preira de Souza, R.N. Kitsis, R.G. Russell, L.M. Weiss, B. Tang, L.A. Jelicks, S.M. Factor, V. Shtutin, H.B. Tanowitz, and M.P. Lisanti Caveolin-1 null mice develop cardiac hypertrophy with hyperactivation of p42/44 MAP kinase in cardiac fibroblasts Am. J. Physiol.: Cell Physiol. 284 2003 C457 C474
114. Y.-Y. Zhao, Y. Liu, R.-V. Stan, L. Fan, Y. Gu, N. Dalton, P.-H. Chu, K. Peterson, J. Ross, and K.R. Chien Defects in caveolin-1 cause dilated cardiomyopathy and pulmonary hypertension in knockout mice Proc. Natl. Acad. Sci. U. S. A. 99 2002 11375 11380
115. A.W. Cohen, B. Razani, X.B. Wang, T.P. Combs, T.M. Williams, P.E. Scherer, and M.P. Lisanti Caveolin-deficient mice show insulin resistance and defective insulin receptor protein expression in adipose tissue Am. J. Physiol.: Cell Physiol. 285 2003 C222 C235
116. B. Razani, T.P. Combs, X.B. Wang, P.G. Frank, D.S. Park, R.G. Russell, M. Li, B. Tang, L.A. Jelicks, P.E. Scherer, and M.P. Lisanti Caveolin-1-deficient mice are lean, resistant to diet-induced obesity, and show hypertriglyceridemia with adipocyte abnormalities J. Biol. Chem. 277 2002 8635 8647
117. D.S. Park, A.W. Cohen, P.G. Frank, B. Razani, H. Lee, T.M. Williams, M. Chandra, J. Shirani, A.P. De Souza, B. Tang, L.A. Jelicks, S.M. Factor, L.M. Weiss, H.B. Tanowitz, and M.P. Lisanti Caveolin-null (-/-) mice show dramatic reductions in life span Biochemistry 42 2003 15124 15131
118. J. Oshikawa, K. Otsu, Y. Toya, T. Tsunematsu, R. Hankins, J.-I. Kawabe, S. Minamisawa, S. Umemura, Y. Hagiwara, and Y. Ishikawa Insulin resistance in skeletal muscles of caveolin-3-null mice Proc. Natl. Acad. Sci. U. S. A. 101 2004 12670 12675
119. E. Gonzalez, A. Nagiel, A.J. Lin, D.E. Golan, and T. Michel Small interfering RNA-mediated down-regulation of caveolin-1 differentially modulates signaling pathways in endothelial cells J. Biol. Chem. 279 2004 40659 40669
120. A.J. Koleske, D. Baltimore, and M.P. Lisanti Reduction of caveolin and caveolae in oncogenically transformed cells Proc. Natl. Acad. Sci. U. S. A. 92 1995 1381 1385
121. J.A. Engelman, C.C. Wykoff, S. Yasuhara, K.S. Song, T. Okamoto, and M.P. Lisanti Recombinant expression of caveolin-1 in oncogenically transformed cells abrogates anchorage-independent growth J. Biol. Chem. 272 1997 16374 16381
122. B.L. Trigatti, R.G.W. Anderson, and G.E. Gerber Identification of caveolin-1 as a fatty acid binding protein Biochem. Biophys. Res. Commun. 255 1999 34 39
123. P.E. Fielding, and C.J. Fielding Plasma membrane caveolae mediate the efflux of cellular free cholesterol Biochemistry 34 1995 14288 14292
124. C.J. Fielding, A. Bist, and P.E. Fielding Caveolin mRNA levels are up-regulated by free cholesterol and down-regulated by oxysterols in fibroblast monolayers Proc. Natl. Acad. Sci. U. S. A. 94 1997 3753 3758
125. E.J. Smart, Y.-S. Ying, W.C. Donzell, and R.G.W. Anderson A role for caveolin in transport of cholesterol from endoplasmic reticulum to plasma membrane J. Biol. Chem. 271 1996 29427 29435
126. A. Uittenbogaard, Y.-S. Ying, and E.J. Smart Characterization of a cytosolic heat-shock protein-caveolin chaperone complex. Involvement in cholesterol trafficking J. Biol. Chem. 273 1998 6525 6532
127. S. Roy, R. Luetterforst, A. Harding, A. Apolloni, M. Etheridge, E. Stang, B. Rolls, J.F. Hancock, and R.G. Parton Dominant-negative caveolin inhibits H-ras function by disrupting cholesterol-rich plasma membrane domains Nat. Cell Biol. 1 1999 98 105
128. A. Pol, R. Luetterforst, M.R. Lindsay, S. Heino, E. Ikonen, and R.G. Parton A caveolin dominant negative mutant associates with lipid bodies and induces intracellular cholesterol imbalance J. Cell Biol. 152 2001 1057 1070
129. Y.-N. Kim, G.J. Wiepz, A.G. Guadarrama, and P.J. Bertics Epidermal growth factor-stimulated tyrosine phosphorylation of caveolin-1 J. Biol. Chem. 275 2000 7481 7491
130. H. Lee, D. Volonte, F. Galbiati, P. Iyengar, D.M. Lublin, D.B. Bregman, M.T. Wilson, R. Campos-Gonzalez, B. Bouzahzah, R.G. Pestell, P.E. Scherer, and M.P. Lisanti Constitutive and growth factor-regulated phosphorylation of caveolin-1 occurs at the same site (Tyr-14) in vivo: identification of a c-Src/Cav-1/Grb7 signaling cassette Mol. Endocrinol. 14 2000 1750 1775
131. C.C. Mastick, M.J. Brady, and A.R. Saltiel Insulin stimulates the tyrosine phosphorylation of caveolin J. Cell Biol. 129 1995 1523 1531
132. Y.-N. Kim, P. Dam, and P.J. Bertics Caveolin-1 phosphorylation in human squamous and epidermoid carcinoma cells: dependence on ErbB1 expression and Src activation Exp. Cell Res. 280 2002 134 147
133. C.C. Mastick, and A.R. Saltiel Insulin-stimulated tyrosine phosphorylation of caveolin is specific for the differentiated adipocyte phenotype in 3T3-L1 cells J. Biol. Chem. 272 1997 20706 20714
134. A. Kimura, S. Mora, S. Shigematsu, J.E. Pessin, and A.R. Saltiel The insulin receptor catalyzes the tyrosine phosphorylation of caveolin-1 J. Biol. Chem. 277 2002 30153 30158
135. J.R. Glenney, and L. Zokas Novel tyrosine kinase substrates from Rous Sarcoma virus transformed cells are present in the membrane skeleton J. Cell Biol. 108 1989 2401 2408
136. S. Li, R. Seitz, and M.P. Lisanti Phosphorylation of caveolin by src tyrosine kinases J. Biol. Chem. 271 1996 3863 3868
137. H. Cao, W.E. Courchesne, and C.C. Mastick A phosphotyrosine-dependent protein interaction screen reveals a role for phosphorylation of caveolin-1 on tyrosine 14 J. Biol. Chem. 277 2002 8771 8774
138. W.-Y. Park, J.-S. Park, K.-A. Cho, D.-I. Kim, Y.-G. Ko, J.-S. Seo, and S.C. Park Up-regulation of caveolin attenuates epidermal growth factor signaling in senescent cells J. Biol. Chem. 275 2000 20847 20852
139. P.U. Le, G. Guay, Y. Altschuler, and I.R. Nabi Caveolin-1 is a negative regulator of caveolae-mediated endocytosis to the endoplasmic reticulum J. Biol. Chem. 277 2002 3371 3379
140. W. Schubert, P.G. Frank, B. Razani, D.S. Park, C.-W. Chow, and M.P. Lisanti Caveolae-deficient endothelial cells show defects in the uptake and transport of albumin in vivo J. Biol. Chem. 276 2001 48619 48622