PET-compatible endothelin receptor radioligands: Synthesis and first in vitro and in vivo studies

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 20, 2009, Pages 7197-7208

  Höltke, Carsten ^a   Law, Marilyn P ^a   Wagner, Stefan ^a   Kopka, Klaus ^a,b   Faust, Andreas ^a   Breyholz, Hans Jörg ^a   Schober, Otmar ^a   Bremer, Christoph ^a,b   Riemann, Burkhard ^a   Schäfers, Michael ^b  

^a UNIVERSITY HOSPITAL MÜNSTER   (Germany)

^b UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

Binding studies; Biodistribution studies; Endothelin axis; PET imaging; Radiofluorination

Indexed keywords

4 (4 METHOXYPHENYL) 2 (3,4 METHYLENEDIOXYPHENYL) 4 OXO 3 (3,4,5 TRIMETHOXYBENZYL) 2 BUTENOIC ACID; 4 (4 METHOXYPHENYL) 2 (3,4 METHYLENEDIOXYPHENYL) 4 OXO 3 (3,4,5 TRIMETHOXYBENZYL) 2 BUTENOIC ACID FLUORINE F 18; ENDOTHELIN A RECEPTOR; FLUORINE 18; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; DRUG DISTRIBUTION; DRUG METABOLISM; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; EX VIVO STUDY; FEMALE; IN VITRO STUDY; IN VIVO STUDY; ISOTOPE LABELING; MALE; MOUSE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; RAT;

ANIMALS; DIOXOLES; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MICE; POSITRON-EMISSION TOMOGRAPHY; RATS; RECEPTORS, ENDOTHELIN; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

MUS; RATTUS;

EID: 71749086032     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.08.058     Document Type: Article

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