Synthesis and in vivo evaluation of novel PET radioligands for imaging the endothelin-A receptor

Journal of Nuclear Medicine

Volumn 49, Issue 9, 2008, Pages 1529-1536

  Mathews, William B ^a   Murugesan, Natesan ^b   Xia, Jinsong ^a   Scheffel, Ursula ^a   Hilton, John ^a   Ravert, Hayden T ^a   Dannals, Robert F ^a   Szabo, Zsolt ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BRISTOL MYERS SQUIBB   (United States)

Author keywords

11C; 18F; Antagonist; Endothelin; PET

Indexed keywords

CARBON 11 METHYL IODIDE; CARBON 11(N [[2 [[(4,5 DIMETHYL 3 ISOXAZOLYL)AMINO]SULFONYL] 4 (2 OXAZOLYL)[1,1 BIPHENYL] 2 YL]METHYL] N,1 METHYLINDOLECARBOXAMIDE; ENDOTHELIN A RECEPTOR; ENDOTHELIN A RECEPTOR ANTAGONIST; FLUORINE 18; FLUORINE 18 (N [[2 [[(4,5 DIMETHYL 3 ISOXAZOLYL)AMINO]SULFONYL] 4 (2 OXAZOLYL)[1,1 BIPHENYL] 2 YL]METHYL] N,4 FLUOROBENZAMIDE); FLUORINE 18 FLUORIDE; METHYL IODIDE; N [[2 [[(4,5 DIMETHYL 3 ISOXAZOLYL)AMINO]SULFONYL] 4 (2 OXAZOLYL)[1,1 BIPHENYL] 2 YL]METHYL] N 3 3 TRIMETHYLBUTANAMIDE; RADIOLIGAND; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BABOON; DEPROTECTION REACTION; DRUG ACTIVITY; DRUG BINDING; DRUG DISTRIBUTION; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG UPTAKE; HEART MUSCLE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; ISOTOPE LABELING; KIDNEY; LIVER; LUNG; MALE; MOUSE; MOUSE STRAIN; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RADIOACTIVITY; VEIN;

ANIMALS; CARBON RADIOISOTOPES; FLUORINE RADIOISOTOPES; ISOTOPE LABELING; LIGANDS; MALE; METABOLIC CLEARANCE RATE; MICE; MOLECULAR PROBE TECHNIQUES; ORGAN SPECIFICITY; OXAZOLES; PAPIO; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; RECEPTOR, ENDOTHELIN A; SULFONAMIDES; TISSUE DISTRIBUTION;

EID: 51349106524     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: 10.2967/jnumed.108.051565     Document Type: Article

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