Endothelin-1 in atherosclerosis and other vasculopathies

Canadian Journal of Physiology and Pharmacology

Volumn 81, Issue 6, 2003, Pages 578-587

  Bousette, Nicolas ^a   Giaid, Adel ^a  

^a MONTREAL GENERAL HOSPITAL   (Canada)

Author keywords

ECE 1; Human; Mitogenic; Receptors; Vasoactive

Indexed keywords

ANGIOTENSIN; BOSENTAN; ENDOTHELIN 1; ENDOTHELIN A RECEPTOR ANTAGONIST; ENDOTHELIN B RECEPTOR ANTAGONIST; ENDOTHELIN RECEPTOR ANTAGONIST; LOW DENSITY LIPOPROTEIN; REACTIVE OXYGEN METABOLITE; THROMBIN;

AGING; ATHEROSCLEROSIS; CARDIOVASCULAR SYSTEM; CELL ADHESION; CLINICAL TRIAL; CORRELATION ANALYSIS; DRUG MEGADOSE; ENDOTHELIUM CELL; FACE EDEMA; HEADACHE; HUMAN; HYPERTROPHY; IMMUNOREACTIVITY; ISCHEMIC HEART DISEASE; LIVER TOXICITY; MACROPHAGE; MITOGENESIS; NEUTROPHIL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PULMONARY HYPERTENSION; REVIEW; SIDE EFFECT; SMOOTH MUSCLE FIBER; TERATOGENESIS; THROMBOCYTE AGGREGATION; VASCULAR DISEASE; VASOCONSTRICTION;

ANIMALS; ARTERIOSCLEROSIS; ASPARTIC ENDOPEPTIDASES; ENDOTHELIN-1; HUMANS; METALLOENDOPEPTIDASES; VASCULAR DISEASES;

EID: 0038300770     PISSN: 00084212     EISSN: None     Source Type: Journal    
DOI: 10.1139/y03-010     Document Type: Review

References (78)

1. Aliev, G., Smith, M.A., Turmaine, M., Neal, M.L., Zimina, T.V., Friedland, R.P., Perry, G., LaManna, J.C., and Burnstock, G. 2001. Atherosclerotic lesions are associated with increased immunoreactivity for inducible nitric oxide synthase and endothelin-1 in thoracic aortic intimal cells of hyperlipidemic Watanabe rabbits. Exp. Mol. Pathol. 71(1): 40-54.
2. Alon, R., Kassner, P.D., Carr, M.W., Finger, E.B., Hemler, M.E., and Springer, T.A. 1995. The integrin VLA-4 supports tethering and rolling in flow on VCAM-1. J. Cell. Biol. 128(6): 1243-1253.
3. Arai, M., Yoguchi, A., Iso, T., Takahashi, T., Imai, S., Murata, K., and Suzuki, T. 1995. Endothelin-1 and its binding sites are upregulated in pressure overload cardiac hypertrophy. Am. J. Physiol. 268(5 Pt. 2): H2084-H2091.
4. Babaei, S., Picard, P., Ravandi, A., Monge, J.C., Lee, T.C., Cernacek, P., and Stewart, D.J. 2000. Blockade of endothelin receptors markedly reduces atherosclerosis in LDL receptor deficient mice: role of endothelin in macrophage foam cell formation. Cardiovasc. Res. 48(1): 158-167.
5. Bacon, C.R., Cary, N.R., and Davenport, A.P. 1996. Endothelin peptide and receptors in human atherosclerotic coronary artery and aorta. Circ. Res. 79(4): 794-801.
6. Berkenboom, G., Giot, C., Unger, P., Vachiery, J.L., Antoine, M., and LeClerc, J.L. 1995. Plasma endothelin and early coronary endothelial dysfunction in recipients of a cardiac transplant. Am. Heart J. 129(6): 1178-1184.
7. A-receptor antagonist, attenuates hypoxic pulmonary hypertension in rats. Am. J. Physiol. 266(4 Pt. 2): H1327-H1331.
8. Boulanger, C.M., Tanner, F.C., Bea, M.L., Hahn, A.W., Werner, A., and Luscher, T.F. 1992. Oxidized low density lipoproteins induce mRNA expression and release of endothelin from human and porcine endothelium. Circ. Res. 70(6): 1191-1197.
9. Coughlin, S.R. 1999. How the protease thrombin talks to cells. Proc. Natl. Acad. Sci. U.S.A. 96(20): 11 023-11 027.
10. Cozza, E.N., Chiou, S., and Gomez-Sanchez, C.E. 1992. Endothelin-1 potentiation of angiotensin II stimulation of aldosterone production. Am. J. Physiol. 262(1 Pt. 2): R85-R89.
11. A-receptor antagonist prevents and reverses chronic hypoxia-induced pulmonary hypertension in rat. Am. J. Physiol. 269(5 Pt. 1): L690-L697.
12. Dimmeler, S., Haendeler, J., Galle, J., and Zeiher, A.M. 1997. Oxidized low-density lipoprotein induces apoptosis of human endothelial cells by activation of CPP32-like proteases. A mechanistic clue to the 'response to injury' hypothesis. Circulation, 95(7): 1760-1763.
13. Duerrschmidt, N., Wippich, N., Goettsch, W., Broemme, H.J., and Morawietz, H. 2000. Endothelin-1 induces NAD(P)H oxidase in human endothelial cells. Biochem. Biophys. Res. Commun. 269(3): 713-717.
14. Eto, M., Barandier, C., Rathgeb, L., Kozai, T., Joch, H., Yang, Z., and Luscher, T.F. 2001. Thrombin suppresses endothelial nitric oxide synthase and upregulates endothelin-converting enzyme-1 expression by distinct pathways: role of Rho/ROCK and mitogen-activated protein kinase. Circ. Res. 89(7): 583-590.
15. Fattinger, K., Funk, C., Pantze, M., Weber, C., Reichen, J., Stieger, B., and Meier, P.J. 2001. The endothelin antagonist bosentan inhibits the canalicular bile salt export pump: a potential mechanism for hepatic adverse reactions. Clin. Pharmacol. Ther. 69(4): 223-231.
16. Filippatos, G.S., Gangopadhyay, N., Lalude, O., Parameswaran, N., Said, S.I., Spielman, W., and Uhal, B.D. 2001. Regulation of apoptosis by vasoactive peptides. Am. J. Physiol. Lung Cell. Mol. Physiol. 281(4): L749-L761.
17. Flowers, M.A., Wang, Y., Stewart, R.J., Patel, B., and Marsden, P.A. 1995. Reciprocal regulation of endothelin-1 and endothelial constitutive NOS in proliferating endothelial cells. Am. J. Physiol. 269(6 Pt. 2): H1988-H1997.
18. Forbes, R.D., Cernacek, P., Zheng, S., Gomersall, M., and Guttmann, R.D. 1996. Increased endothelin expression in a rat cardiac allograft model of chronic vascular rejection. Transplantation, 61(5): 791-797.
19. Fukuchi, M., and Giaid, A. 1998. Expression of endothelin-1 and endothelin-converting enzyme-1 mRNAs and proteins in failing human hearts. J. Cardiovasc. Pharmacol. 31(Suppl. 1): S421-S423.
20. Fukuchi, M., and Giaid, A. 1999. Endothelial expression of endothelial nitric oxide synthase and endothelin-1 in human coronary artery disease. Specific reference to underlying lesion. Lab. Invest. 79(6): 659-670.
21. Fukuroda, T., Kobayashi, M., Ozaki, S., Yano, M., Miyauchi, T., Onizuka, M., Sugishita, Y., Goto, K., and Nishikibe, M. 1994. Endothelin receptor subtypes in human versus rabbit pulmonary arteries. J. Appl. Physiol. 76(5): 1976-1982.
22. Geng, J.G., Bevilacqua, M.P., Moore, K.L., McIntyre, T.M., Prescott, S.M., Kim, J.M., Bliss, G.A., Zimmerman, G.A., and McEver, R.P. 1990. Rapid neutrophil adhesion to activated endothelium mediated by GMP-140. Nature (London), 343(6260): 757-760.
23. Giaid, A., Yanagisawa, M., Langleben, D., Michel, R.P., Levy, R., Shennib, H., Kimura, S., Masaki, T., Duguid, W.P., and Stewart, D.J. 1993. Expression of endothelin-1 in the lungs of patients with pulmonary hypertension. N. Engl. J. Med. 328(24): 1732-1739.
24. Giaid, A., Saleh, D., Yanagisawa, M., and Forbes, R.D. 1995. Endothelin-1 immunoreactivity and mRNA in the transplanted human heart. Transplantation, 59(9): 1308-1313.
25. Goettsch, W., Lattmann, T., Amann, K., Szibor, M., Morawietz, H., Munter, K., Muller, S.P., Shaw, S., and Barton, M. 2001. Increased expression of endothelin-1 and inducible nitric oxide synthase isoform II in aging arteries in vivo: implications for atherosclerosis. Biochem. Biophys. Res. Commun. 280(3): 908-913.
26. Guarda, E., Katwa, L.C., Myers, P.R., Tyagi, S.C., and Weber, K.T. 1993. Effects of endothelins on collagen turnover in cardiac fibroblasts. Cardiovasc. Res. 27(12): 2130-2134.
27. Haug, C., Schmid-Kotsas, A., Zorn, U., Schuett, S., Gross, H.J., Gruenert, A., and Bachem, M.G. 2001. Endothelin-1 synthesis and endothelin b receptor expression in human coronary artery smooth muscle cells and monocyte-derived macrophages is upregulated by low density lipoproteins. J. Mol. Cell Cardiol. 33(9): 1701-1712.
28. Hocher, B., George, I., Rebstock, J., Bauch, A., Schwarz, A., Neumayer, H.H., and Bauer, C. 1999. Endothelin system-dependent cardiac remodeling in renovascular hypertension. Hypertension, 33(3): 816-822.
29. Ihling, C., Szombathy, T., Bohrmann, B., Brockhaus, M., Schaefer, H.E., and Loeffler, B.M. 2001. Coexpression of endothelin-converting enzyme-1 and endothelin-1 in different stages of human atherosclerosis. Circulation, 104(8): 864-869.
30. Imai, T., Hirata, Y., Emori, T., Yanagisawa, M., Masaki, T., and Marumo, F. 1992. Induction of endothelin-1 gene by angiotensin and vasopressin in endothelial cells. Hypertension, 19(6 Pt. 2): 753-757.
31. Iwanaga, Y., Kihara, Y., Hasegawa, K., Inagaki, K., Yoneda, T., Kaburagi, S., Araki, M., and Sasayama, S. 1998. Cardiac endothelin-1 plays a critical role in the functional deterioration of left ventricles during the transition from compensatory hypertrophy to congestive heart failure in salt-sensitive hypertensive rats. Circulation, 98(19): 2065-2073.
32. Johnston, B., Issekutz, T.B., and Kubes, P. 1996. The alpha 4-integrin supports leukocyte rolling and adhesion in chronically inflamed postcapillary venules in vivo. J. Exp. Med. 183(5): 1995-2006.
33. Kahler, J., Ewert, A., Weckmuller, J., Stobbe, S., Mittmann, C., Koster, R., Paul, M., Meinertz, T., and Munzel, T. 2001. Oxidative stress increases endothelin-1 synthesis in human coronary artery smooth muscle cells. J. Cardiovasc. Pharmacol. 38(1): 49-57.
34. Karam, H., Heudes, D., Bruneval, P., Gonzales, M.F., Loffler, B.M., Clozel, M., and Clozel, J.P. 1996. Endothelin antagonism in end-organ damage of spontaneously hypertensive rats. Comparison with angiotensin-converting enzyme inhibition and calcium antagonism. Hypertension, 28(3): 379-385.
35. Katwa, L.C., Guarda, E., and Weber, K.T. 1993. Endothelin receptors in cultured adult rat cardiac fibroblasts. Cardiovasc. Res. 27(12): 2125-2129.
36. Khan, B.V., Parthasarathy, S.S., Alexander, R.W., and Medford, R.M. 1995. Modified low density lipoprotein and its constituents augment cytokine-activated vascular cell adhesion molecule-1 gene expression in human vascular endothelial cells. J. Clin. Invest. 95(3): 1262-1270.
37. Kinlay, S., Behrendt, D., Wainstein, M., Beltrame, J., Fang, J.C., Creager, M.A., Selwyn, A.P., and Ganz, P. 2001. Role of endothelin-1 in the active constriction of human atherosclerotic coronary arteries. Circulation, 104(10): 1114-1118.
38. Kirshbom, P.M., Tsui, S.S., DiBernardo, L.R., Meliones, J.N., Schwinn, D.A., Ungerleider, R.M., and Gaynor, J.W. 1995. Blockade of endothelin-converting enzyme reduces pulmonary hypertension after cardiopulmonary bypass and circulatory arrest. Surgery, 118(2): 440-444. [Discussion pp. 444-445]
39. B receptor-mediated clearance of endothelin-1? Life Sci. 62(2): 185-193.
40. Komuro, I., Kurihara, H., Sugiyama, T., Yoshizumi, M., Takaku, F., and Yazaki, Y. 1988. Endothelin stimulates c-fos and c-myc expression and proliferation of vascular smooth muscle cells. FEBS Lett. 238(2): 249-252.
41. Kowala, M.C. 1997. The role of endothelin in the pathogenesis of atherosclerosis. Adv. Pharmacol. 37: 299-318.
42. Kurihara, H., Yoshizumi, M., Sugiyama, T., Takaku, F., Yanagisawa, M., Masaki, T., Hamaoki, M., Kato, H., and Yazaki, Y. 1989. Transforming growth factor-beta stimulates the expression of endothelin mRNA by vascular endothelial cells. Biochem. Biophys. Res. Commun. 159(3): 1435-1440.
43. Latini, R., Maggioni, A.P., Flather, M., Sleight, P., and Tognoni, G. 1995. ACE inhibitor use in patients with myocardial infarction. Summary of evidence from clinical trials. Circulation, 92(10): 3132-3137.
44. Lehr, H.A., Becker, M., Marklund, S.L., Hubner, C., Arfors, K.E., Kohlschutter, A., and Messmer, K. 1992. Superoxide-dependent stimulation of leukocyte adhesion by oxidatively modified LDL in vivo. Arterioscler. Thromb. 12(7): 824-829.
45. Luscher, T.F., and Barton, M. 2000. Endothelins and endothelin receptor antagonists: therapeutic considerations for a novel class of cardiovascular drugs. Circulation, 102(19): 2434-2440.
46. Macconi, D., Foppolo, M., Paris, S., Noris, M., Aiello, S., Remuzzi, G., and Remuzzi, A. 1995. PAF mediates neutrophil adhesion to thrombin or TNF-stimulated endothelial cells under shear stress. Am. J. Physiol. 269(1 Pt. 1): C42-C47.
47. Maemura, K., Kurihara, H., Morita, T., Oh-hashi, Y., and Yazaki, Y. 1992. Production of endothelin-1 in vascular endothelial cells is regulated by factors associated with vascular injury. Gerontology, 38(Suppl. 1): 29-35.
48. McQuillan, L.P., Leung, G.K., Marsden, P.A., Kostyk, S.K., and Kourembanas, S. 1994. Hypoxia inhibits expression of eNOS via transcriptional and posttranscriptional mechanisms. Am. J. Physiol. 267(5 Pt. 2): H1921-H1927.
49. Molet, S., Furukawa, K., Maghazechi, A., Hamid, Q., and Giaid, A. 2000. Chemokine- and cytokine-induced expression of endothelin 1 and endothelin-converting enzyme 1 in endothelial cells. J. Allergy Clin. Immunol. 105(2 Pt. 1): 333-338.
50. Morawietz, H., Duerrschmidt, N., Niemann, B., Galle, J., Sawamura, T., and Holtz, J. 2001. Induction of the oxLDL receptor LOX-1 by endothelin-1 in human endothelial cells. Biochem. Biophys. Res. Commun. 284(4): 961-965.
51. Morey, A.K., Razandi, M., Pedram, A., Hu, R.M., Prins, B.A., and Levin, E.R. 1998. Oestrogen and progesterone inhibit the stimulated production of endothelin-1. Biochem. J. 330(Pt. 3): 1097-1105.
52. Nelson, J.B., Chan-Tack, K., Hedican, S.P., Magnuson, S.R., Opgenorth, T.J., Bova, G.S., and Simons, J.W. 1996. Endothelin-1 production and decreased endothelin B receptor expression in advanced prostate cancer. Cancer Res. 56(4): 663-668.
53. Oka, K., Sawamura, T., Kikuta, K., Itokawa, S., Kume, N., Kita, T., and Masaki, T. 1998. Lectin-like oxidized low-density lipoprotein receptor 1 mediates phagocytosis of aged/apoptotic cells in endothelial cells. Proc. Natl. Acad. Sci. U.S.A. 95(16): 9535-9540.
54. Oliver, F.J., de la Rubia, G., Feener, E.P., Lee, M.E., Loeken, M.R., Shiba, T., Quertermous, T., and King, G.L. 1991. Stimulation of endothelin-1 gene expression by insulin in endothelial cells. J. Biol. Chem. 266(34): 23 251-23 256.
55. Omland, T., Lie, R.T., Aakvaag, A., Aarsland, T., and Dickstein, K. 1994. Plasma endothelin determination as a prognostic indicator of 1-year mortality after acute myocardial infarction. Circulation, 89(4): 1573-1579.
56. Parissis, J.T., Venetsanou, K.F., Mentzikof, D.G., Kalantzi, M.V., Georgopoulou, M.V., Chrisopoulos, N., and Karas, S.M. 2001. Plasma levels of soluble cellular adhesion molecules in patients with arterial hypertension. Correlations with plasma endothelin-1. Eur. J. Intern. Med. 12(4): 350-356.
57. Perreault, T., and Baribeau, J. 1995. Characterization of endothelin receptors in newborn piglet lung. Am. J. Physiol. 268(4 Pt. 1): L607-L614.
58. A receptor antagonist, reduces neonatal hypoxia-induced pulmonary hypertension in piglets. Pediatr. Res. 50(3): 374-383.
59. Rajagopalan, S., Kurz, S., Munzel, T., Tarpey, M., Freeman, B.A., Griendling, K.K., and Harrison, D.G. 1996. Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation. Contribution to alterations of vasomotor tone. J. Clin. Invest. 97(8): 1916-1923.
60. Rajagopalan, S., Laursen, J.B., Borthayre, A., Kurz, S., Keiser, J., Haleen, S., Giaid, A., and Harrison, D.G. 1997. Role for endothelin-1 in angiotensin II-mediated hypertension. Hypertension, 30(1 Pt. 1): 29-34.
61. Ravalli, S., Szabolcs, M., Albala, A., Michler, R.E., and Cannon, P.J. 1996. Increased immunoreactive endothelin-1 in human transplant coronary artery disease. Circulation, 94(9): 2096-2102.
62. Ross, R. 1999. Atherosclerosis is an inflammatory disease. Am. Heart J. 138(5 Pt. 2): S419-S420.
63. Salomon, R.N., Hughes, C.C., Schoen, F.J., Payne, D.D., Pober, J.S., and Libby, P. 1991. Human coronary transplantation-associated arteriosclerosis. Evidence for a chronic immune reaction to activated graft endothelial cells. Am. J. Pathol. 138(4): 791-798.
64. Sanz, M.J., Johnston, B., Issekutz, A., and Kubes, P. 1999. Endothelin-1 causes P-selectin-dependent leukocyte rolling and adhesion within rat mesenteric microvessels. Am. J. Physiol. 277(5 Pt. 2): H1823-H1830.
65. Schiffrin, E.L. 1998. Endothelin and endothelin antagonists in hypertension. J. Hypertens. 16(12 Pt. 2): 1891-1895.
66. Shichiri, M., Kato, H., Marumo, F., and Hirata, Y. 1997. Endothelin-1 as an autocrine/paracrine apoptosis survival factor for endothelial cells. Hypertension, 30(5): 1198-1203.
67. Shichiri, M., Sedivy, J.M., Marumo, F., and Hirata, Y. 1998. Endothelin-1 is a potent survival factor for c-Myc-dependent apoptosis. Mol. Endocrinol. 12(2): 172-180.
68. Springer, T.A. 1994. Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell, 76(2): 301-314.
69. Sung, C.P., Arleth, A.J., Storer, B.L., and Ohlstein, E.H. 1994. Angiotensin type 1 receptors mediate smooth muscle proliferation and endothelin biosynthesis in rat vascular smooth muscle. J. Pharmacol. Exp. Ther. 271(1): 429-437.
70. Tonnessen, T., Lunde, P.K., Giaid, A., Sejersted, O.M., and Christensen, G. 1998. Pulmonary and cardiac expression of preproendothelin-1 mRNA are increased in heart failure after myocardial infarction in rats. Localization of preproendothelin-1 mRNA and endothelin peptide. Cardiovasc. Res. 39(3): 633-643.
71. Wagenvoort, C.A. 1981. Grading of pulmonary vascular lesions - a reappraisal. Histopathology, 5(6): 595-598.
72. Watanabe, T., Suzuki, N., Shimamoto, N., Fujino, M., and Imada, A.S. 1990. Endothelin in myocardial infarction. Nature (London), 344(6262): 114.
73. Wei, C.M., Lerman, A., Rodeheffer, R.J., McGregor, C.G., Brandt, R.R., Wright, S., Heublein, D.M., Kao, P.C., Edwards, W.D., and Burnett, J.C. Jr. 1994. Endothelin in human congestive heart failure. Circulation, 89(4): 1580-1586.
74. Woods, M., Mitchell, J.A., Wood, E.G., Barker, S., Walcot, N.R., Rees, G.M., and Warner, T.D. 1999. Endothelin-1 is induced by cytokines in human vascular smooth muscle cells: evidence for intracellular endothelin-converting enzyme. Mol. Pharmacol. 55(5): 902-909.
75. Wu-Wong, J.R., Chiou, W.J., Dickinson, R., and Opgenorth, T.J. 1997. Endothelin attenuates apoptosis in human smooth muscle cells. Biochem. J. 328(Pt. 3): 733-737.
76. Wu-Wong, J.R., Chiou, W.J., and Wang, J. 2000. Extracellular signal-regulated kinases are involved in the antiapoptotic effect of endothelin-1. J. Pharmacol. Exp. Ther. 293(2): 514-521.
77. Yang, Z., Ruschitzka, F., Rabelink, T.J., Noll, G., Julmy, F., Joch, H., Gafner, V., Aleksic, I., Althaus, U., and Luscher, T.F. 1997. Different effects of thrombin receptor activation on endothelium and smooth muscle cells of human coronary bypass vessels. Implications for venous bypass graft failure. Circulation, 95(7): 1870-1876.
78. Yoshida, H., Quehenberger, O., Kondratenko, N., Green, S., and Steinberg, D. 1998. Minimally oxidized low-density lipoprotein increases expression of scavenger receptor A, CD36, and macrosialin in resident mouse peritoneal macrophages. Arterioscler. Thromb. Vasc. Biol. 18(5): 794-802.