Synthesis, in vitro pharmacology and biodistribution studies of new PD 156707-derived ETA receptor radioligands

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 6, 2006, Pages 1910-1917

  Höltke, Carsten ^a   Law, Marilyn P ^a   Wagner, Stefan ^a   Breyholz, Hans Jörg ^a   Kopka, Klaus ^a,b   Bremer, Christoph ^a,b   Levkau, Bodo ^c   Schober, Otmar ^a   Schäfers, Michael ^a,b  

^a UNIVERSITY HOSPITAL MÜNSTER   (Germany)

^b UNIVERSITY OF MÜNSTER   (Germany)

^c UNIVERSITY HOSPITAL ESSEN   (Germany)

Author keywords

Biodistribution studies; Endothelin receptor antagonists; Radioiodination; SPECT

Indexed keywords

1,3 BENZODIOXOLE DERIVATIVE; 3 BENZO[1,3]DIOXOL 5 YL 5 HYDROXY 5 (4 BENZYLOXYPHENYL) 4 (3,4,5 TRIMETHOXYBENZYL) 5H FURAN 2 ONE; 3 BENZO[1,3]DIOXOL 5 YL 5 HYDROXY 5 (4 HYDROXY 3 IODOPHENYL) 4 (3,4,5 TRIMETHOXYBENZYL) 5H FURAN 2 ONE; 3 BENZO[1,3]DIOXOL 5 YL 5 HYDROXY 5 (4 HYDROXY 3 IODOPHENYL) 4 (3,4,5 TRIMETHOXYBENZYL) 5H FURAN 2 ONE I 123; 3 BENZO[1,3]DIOXOL 5 YL 5 HYDROXY 5 (4 HYDROXY 3 IODOPHENYL) 4 (3,4,5 TRIMETHOXYBENZYL) 5H FURAN 2 ONE I 125; 3 BENZO[1,3]DIOXOL 5 YL 5 HYDROXY 5 (4 HYDROXYPHENYL) 4 (3,4,5 TRIMETHOXYBENZYL) 5H FURAN 2 ONE; 4 (4 METHOXYPHENYL) 2 (3,4 METHYLENEDIOXYPHENYL) 4 OXO 3 (3,4,5 TRIMETHOXYBENZYL) 2 BUTENOIC ACID; ENDOTHELIN 1; ENDOTHELIN A RECEPTOR; ENDOTHELIN A RECEPTOR ANTAGONIST; PD 164333; PD 169390; RADIOLIGAND; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG POTENCY; DRUG SYNTHESIS; DRUG TISSUE LEVEL; DRUG UPTAKE; HEART SCINTISCANNING; IN VITRO STUDY; IN VIVO STUDY; ISOTOPE LABELING; MALE; MOUSE; NONHUMAN; RADIOIODINATION; RECEPTOR DENSITY; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY;

ANIMALS; CELLS, CULTURED; DIOXOLES; IODINE RADIOISOTOPES; LIGANDS; MICE; MICROSOMES; RECEPTOR, ENDOTHELIN A;

ANIMALIA;

EID: 32044453984     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.10.039     Document Type: Article

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