-
1
-
-
34047115205
-
Functional integration of hepatocytes derived from human mesenchymal stem cells into mouse livers
-
DOI 10.1136/gut.2005.090050
-
I Aurich LP Mueller H Aurich J Luetzkendorf K Tisljar MM Dollinger W Schormann J Walldorf JG Hengstler WE Fleig B Christ 2007 Functional integration of hepatocytes derived from human mesenchymal stem cells into mouse livers Gut 56 3 405 415 10.1136/gut.2005.090050 1:CAS:528:DC%2BD2sXksVCqs7w%3D 16928726 (Pubitemid 46579773)
-
(2007)
Gut
, vol.56
, Issue.3
, pp. 405-415
-
-
Aurich, I.1
Mueller, L.P.2
Aurich, H.3
Luetzkendorf, J.4
Tisljar, K.5
Dollinger, M.M.6
Schormann, W.7
Walldorf, J.8
Hengstler, J.G.9
Fleig, W.E.10
Christ, B.11
-
2
-
-
59849114291
-
Most cited articles in the archives of toxicology: The debate about possibilities and limitations of in vitro toxicity tests and replacement of in vivo studies
-
10.1007/s00204-008-0379-6 1:CAS:528:DC%2BD1cXhtlCju73P 18987845
-
HM Bolt JG Hengstler 2008 Most cited articles in the archives of toxicology: the debate about possibilities and limitations of in vitro toxicity tests and replacement of in vivo studies Arch Toxicol 82 12 881 883 10.1007/s00204-008-0379-6 1:CAS:528:DC%2BD1cXhtlCju73P 18987845
-
(2008)
Arch Toxicol
, vol.82
, Issue.12
, pp. 881-883
-
-
Bolt, H.M.1
Hengstler, J.G.2
-
3
-
-
38349130790
-
The past and the future of toxicology
-
10.1007/s00204-007-0269-3 1:CAS:528:DC%2BD1cXps1ansA%3D%3D 18057915
-
HM Bolt JG Hengstler 2008 The past and the future of toxicology Arch Toxicol 82 1 1 3 10.1007/s00204-007-0269-3 1:CAS:528:DC%2BD1cXps1ansA%3D%3D 18057915
-
(2008)
Arch Toxicol
, vol.82
, Issue.1
, pp. 1-3
-
-
Bolt, H.M.1
Hengstler, J.G.2
-
4
-
-
2942606042
-
Carcinogenicity categorization of chemicals - New aspects to be considered in a European perspective
-
DOI 10.1016/j.toxlet.2004.04.004, PII S0378427404002103
-
HM Bolt H Foth JG Hengstler GH Degen 2004 Carcinogenicity categorization of chemicals-new aspects to be considered in a European perspective Toxicol Lett 151 1 29 41 10.1016/j.toxlet.2004.04.004 1:CAS:528:DC%2BD2cXks1Wnsbc%3D 15177638 (Pubitemid 38739025)
-
(2004)
Toxicology Letters
, vol.151
, Issue.1
, pp. 29-41
-
-
Bolt, H.M.1
Foth, H.2
Hengstler, J.G.3
Degen, G.H.4
-
6
-
-
27744497021
-
Use of the dog as non-rodent test species in the safety testing schedule associated with the registration of crop and plant protection products (pesticides): Present status
-
DOI 10.1007/s00204-005-0678-0
-
RJ Box H Spielmann 2005 Use of the dog as non-rodent test species in the safety testing schedule associated with the registration of crop and plant protection products (pesticides): present status Arch Toxicol 79 615 626 10.1007/s00204-005-0678-0 1:CAS:528:DC%2BD2MXht1SmtbrI 15940470 (Pubitemid 41622189)
-
(2005)
Archives of Toxicology
, vol.79
, Issue.11
, pp. 615-626
-
-
Box, R.J.1
Spielmann, H.2
-
7
-
-
34548742815
-
Fate of extrahepatic human stem and precursor cells after transplantation into mouse livers
-
DOI 10.1002/hep.21745
-
M Brulport W Schormann A Bauer M Hermes C Elsner FJ Hammersen W Beerheide D Spitkovsky W Härtig A Nussler LC Horn J Edelmann O Pelz-Ackermann J Petersen M Kamprad M von Mach A Lupp H Zulewski JG Hengstler 2007 Fate of extrahepatic human stem and precursor cells after transplantation into mouse livers Hepatology 46 3 861 870 10.1002/hep.21745 17668884 (Pubitemid 47436132)
-
(2007)
Hepatology
, vol.46
, Issue.3
, pp. 861-870
-
-
Brulport, M.1
Schormann, W.2
Bauer, A.3
Hermes, M.4
Elsner, C.5
Hammersen, F.J.6
Beerheide, W.7
Spitkovsky, D.8
Hartig, W.9
Nussler, A.10
Horn, L.C.11
Edelmann, J.12
Pelz-Ackermann, O.13
Petersen, J.14
Kamprad, M.15
Von Mach, M.16
Lupp, A.17
Zulewski, H.18
Hengstler, J.G.19
-
8
-
-
60149088848
-
Origins and mechanisms of miRNAs and siRNAs
-
10.1016/j.cell.2009.01.035 1:CAS:528:DC%2BD1MXkvFGksb0%3D 19239886
-
RW Carthew EJ Sontheimer 2009 Origins and mechanisms of miRNAs and siRNAs Cell 136 4 642 655 10.1016/j.cell.2009.01.035 1:CAS:528:DC%2BD1MXkvFGksb0%3D 19239886
-
(2009)
Cell
, vol.136
, Issue.4
, pp. 642-655
-
-
Carthew, R.W.1
Sontheimer, E.J.2
-
9
-
-
40649111338
-
Non-coding RNAs, epigenetics and complexity
-
10.1016/j.gene.2007.12.008 1:CAS:528:DC%2BD1cXitlWksb0%3D 18226475
-
FF Costa 2008 Non-coding RNAs, epigenetics and complexity Gene 410 9 17 10.1016/j.gene.2007.12.008 1:CAS:528:DC%2BD1cXitlWksb0%3D 18226475
-
(2008)
Gene
, vol.410
, pp. 9-17
-
-
Costa, F.F.1
-
10
-
-
48549091046
-
Methylation mediated silencing of MicroRNA-1 gene and its role in hepatocellular carcinogenesis
-
10.1158/0008-5472.CAN-07-6655 1:CAS:528:DC%2BD1cXnvFOqtLg%3D 18593903
-
J Datta H Kutay MW Nasser GJ Nuovo B Wang S Majumder CG Liu S Volinia CM Croce TD Schmittgen K Ghoshal ST Jacob 2008 Methylation mediated silencing of MicroRNA-1 gene and its role in hepatocellular carcinogenesis Cancer Res 68 5049 5058 10.1158/0008-5472.CAN-07-6655 1:CAS:528:DC%2BD1cXnvFOqtLg%3D 18593903
-
(2008)
Cancer Res
, vol.68
, pp. 5049-5058
-
-
Datta, J.1
Kutay, H.2
Nasser, M.W.3
Nuovo, G.J.4
Wang, B.5
Majumder, S.6
Liu, C.G.7
Volinia, S.8
Croce, C.M.9
Schmittgen, T.D.10
Ghoshal, K.11
Jacob, S.T.12
-
11
-
-
45849092557
-
Developments in industrial and occupational toxicology: REACH, toxicogenomics, mycotoxins, lead, asbestos, boron, bitumen, deletions polymorphisms and SNP interactions: Meeting report of the 16th EUROTOX training and discussion session
-
10.1007/s00204-008-0315-9 1:CAS:528:DC%2BD1cXnsVSqsbk%3D 18493747
-
GH Degen JG Hengstler 2008 Developments in industrial and occupational toxicology: REACH, toxicogenomics, mycotoxins, lead, asbestos, boron, bitumen, deletions polymorphisms and SNP interactions: meeting report of the 16th EUROTOX training and discussion session Arch Toxicol 82 7 483 487 10.1007/s00204-008- 0315-9 1:CAS:528:DC%2BD1cXnsVSqsbk%3D 18493747
-
(2008)
Arch Toxicol
, vol.82
, Issue.7
, pp. 483-487
-
-
Degen, G.H.1
Hengstler, J.G.2
-
12
-
-
34547752505
-
Gene expression analyses of the liver in rats treated with oxfendazole
-
DOI 10.1007/s00204-007-0190-9
-
Y Dewa J Nishimura M Muguruma S Matsumoto M Takahashi M Jin K Mitsumori 2007 Gene expression analyses of the liver in rats treated with oxfendazole Arch Toxicol 81 9 647 654 10.1007/s00204-007-0190-9 1:CAS:528:DC%2BD2sXosFarsbs%3D 17340121 (Pubitemid 47228767)
-
(2007)
Archives of Toxicology
, vol.81
, Issue.9
, pp. 647-654
-
-
Dewa, Y.1
Nishimura, J.2
Muguruma, M.3
Matsumoto, S.4
Takahashi, M.5
Jin, M.6
Mitsumori, K.7
-
13
-
-
0142177156
-
Directive 2003/15/EC of the European parliament and of the council of 27 February 2003 amending council directive 76/768/EEC on the approximation of the laws of the member states relating to cosmetic products
-
11 March
-
Directive 2003/15/EC of the European parliament and of the council of 27 February 2003 amending council directive 76/768/EEC on the approximation of the laws of the member states relating to cosmetic products. Official Journal L066, 26-35, 11 March 2003
-
(2003)
Official Journal
, vol.L066
, pp. 26-35
-
-
-
14
-
-
43749116510
-
Some molecular descriptors for non-specific chromosomal genotoxicity based on hydrophobic interactions
-
10.1007/s00204-007-0256-8 1:CAS:528:DC%2BD1cXlvVCgt7k%3D 17992515
-
SB Dorn GH Degen HM Bolt J van der Louw FA van Acker DJ van den Dobbelsteen JP Lommerse 2008 Some molecular descriptors for non-specific chromosomal genotoxicity based on hydrophobic interactions Arch Toxicol 82 5 333 338 10.1007/s00204-007-0256-8 1:CAS:528:DC%2BD1cXlvVCgt7k%3D 17992515
-
(2008)
Arch Toxicol
, vol.82
, Issue.5
, pp. 333-338
-
-
Dorn, S.B.1
Degen, G.H.2
Bolt, H.M.3
Van Der Louw, J.4
Van Acker, F.A.5
Van Den Dobbelsteen, D.J.6
Lommerse, J.P.7
-
15
-
-
2642531973
-
Epigenetics in human disease and prospects for epigenetic therapy
-
DOI 10.1038/nature02625
-
G Egger G Liang A Aparicio PA Jones 2004 Epigenetics in human disease and prospects for epigenetic therapy Nature 429 457 463 10.1038/nature02625 1:CAS:528:DC%2BD2cXkt1Onsb0%3D 15164071 (Pubitemid 38715140)
-
(2004)
Nature
, vol.429
, Issue.6990
, pp. 457-463
-
-
Egger, G.1
Liang, G.2
Aparicio, A.3
Jones, P.A.4
-
16
-
-
42949131684
-
The epigenetics of adult (somatic) stem cells
-
1:CAS:528:DC%2BD1cXmsFegtL8%3D 18540823
-
KJ Eilertsen Z Floyd JM Gimble 2008 The epigenetics of adult (somatic) stem cells Crit Rev Eukaryot Gene Expr 18 3 189 206 1:CAS:528: DC%2BD1cXmsFegtL8%3D 18540823
-
(2008)
Crit Rev Eukaryot Gene Expr
, vol.18
, Issue.3
, pp. 189-206
-
-
Eilertsen, K.J.1
Floyd, Z.2
Gimble, J.M.3
-
17
-
-
33747312640
-
Molecular mechanisms underlying the dedifferentiation process of isolated hepatocytes and their cultures
-
DOI 10.2174/138920006778017759
-
G Elaut T Henkens P Papeleu S Snykers M Vinken T Vanhaecke V Rogiers 2006 Molecular mechanisms underlying the dedifferentiation process of isolated hepatocytes and their cultures Curr Drug Metab 7 6 629 660 10.2174/ 138920006778017759 1:CAS:528:DC%2BD28XmvV2mtLk%3D 16918317 (Pubitemid 44234347)
-
(2006)
Current Drug Metabolism
, vol.7
, Issue.6
, pp. 629-660
-
-
Elaut, G.1
Henkens, T.2
Papeleu, P.3
Snykers, S.4
Vinken, M.5
Vanhaecke, T.6
Rogiers, V.7
-
18
-
-
61449164867
-
Application of toxicogenomics to study mechanisms of genotoxicity and carcinogenicity
-
10.1016/j.toxlet.2008.08.017 1:CAS:528:DC%2BD1MXivVersLk%3D 18822359
-
H Ellinger-Ziegelbauer J Aubrecht JC Kleinjans HJ Ahr 2009 Application of toxicogenomics to study mechanisms of genotoxicity and carcinogenicity Toxicol Lett 186 1 36 44 10.1016/j.toxlet.2008.08.017 1:CAS:528:DC%2BD1MXivVersLk%3D 18822359
-
(2009)
Toxicol Lett
, vol.186
, Issue.1
, pp. 36-44
-
-
Ellinger-Ziegelbauer, H.1
Aubrecht, J.2
Kleinjans, J.C.3
Ahr, H.J.4
-
20
-
-
71449119088
-
-
EU Commission Regulation (EC) No761/2009 of 23 July 2009 amending, for the purpose of its adaptation to technical progress, Regulation (EC) No 440/2008 laying down test methods pursuant to regulation (EC) No 1907/2006 of the European parliament and of the council on the registration, evaluation, authorisation and restriction of chemicals (REACH) Official Journal L220, 24/08/2009
-
EU (2009a) B.46. In vitro skin irritation: Reconstructed Human Epidermis Model Test. Commission Regulation (EC) No761/2009 of 23 July 2009 amending, for the purpose of its adaptation to technical progress, Regulation (EC) No 440/2008 laying down test methods pursuant to regulation (EC) No 1907/2006 of the European parliament and of the council on the registration, evaluation, authorisation and restriction of chemicals (REACH) Official Journal L220, 24/08/2009, 24-31
-
(2009)
B.46. in Vitro Skin Irritation: Reconstructed Human Epidermis Model Test
, pp. 24-31
-
-
-
21
-
-
71449127569
-
-
EU Commission regulation (EC) No 761/2009 of 23 July 2009 amending, for the purpose of its adaptation to technical progress, Regulation (EC) No 440/2008 laying down test methods pursuant to Regulation (EC) No 1907/2006 of the European Parliament and of the Council on the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH) Official Journal L220, 24/08/2009
-
EU (2009b) B.42. Skin sensitisation: local lymph node assay. Commission regulation (EC) No 761/2009 of 23 July 2009 amending, for the purpose of its adaptation to technical progress, Regulation (EC) No 440/2008 laying down test methods pursuant to Regulation (EC) No 1907/2006 of the European Parliament and of the Council on the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH) Official Journal L220, 24/08/2009, 414-419
-
(2009)
B.42. Skin Sensitisation: Local Lymph Node Assay
, pp. 414-419
-
-
-
24
-
-
71449120961
-
-
FP7-Health-2010-Alternative-Testing consultationdate29/09/200 9
-
FP7-Health-2010-Alternative-Testing; http://cordis.europa.eu/fp7/dc/ index.cfm?fuseaction=UserSite.CooperationDetailsCallPage&call-id=280 ; consultation date 29/09/2009
-
-
-
-
25
-
-
33846023317
-
Concise review: Epigenetic mechanisms contribute to pluripotency and cell lineage determination of embryonic stem cells
-
DOI 10.1634/stemcells.2006-0383
-
Q Gan T Yoshida OG McDonald GK Owens 2007 Concise review: epigenetic mechanisms contribute to pluripotency and cell lineage determination of embryonic stem cells Stem Cells 25 1 2 9 10.1634/stemcells.2006-0383 1:CAS:528:DC%2BD2sXhvVGjsLg%3D 17023513 (Pubitemid 46052969)
-
(2007)
Stem Cells
, vol.25
, Issue.1
, pp. 2-9
-
-
Gan, Q.1
Yoshida, T.2
McDonald, O.G.3
Owens, G.K.4
-
26
-
-
0035086548
-
The use of dogs as second species in regulatory testing of pesticides. Part II: Subacute, subchronic and chronic studies in the dog
-
DOI 10.1007/s002040000195
-
U Gerbracht H Spielmann 2001 The use of dogs as second species in regulatory testing of pesticides. Part II: subacute, subchronic and chronic studies in the dog Arch Toxicol 75 1 21 10.1007/s002040000195 11368059 (Pubitemid 32247235)
-
(2001)
Archives of Toxicology
, vol.75
, Issue.1
, pp. 1-21
-
-
Spielmann, H.1
Gerbracht, U.2
-
27
-
-
48749124037
-
Cadmium, cobalt and lead cause stress response, cell cycle deregulation and increased steroid as well as xenobiotic metabolism in primary normal human bronchial epithelial cells which is coordinated by at least nine transcription factors
-
10.1007/s00204-008-0331-9 1:CAS:528:DC%2BD1cXpt12rs7k%3D 18654764
-
F Glahn W Schmidt-Heck S Zellmer R Guthke J Wiese K Golka R Hergenröder GH Degen T Lehmann M Hermes W Schormann M Brulport A Bauer E Bedawy R Gebhardt JG Hengstler H Foth 2008 Cadmium, cobalt and lead cause stress response, cell cycle deregulation and increased steroid as well as xenobiotic metabolism in primary normal human bronchial epithelial cells which is coordinated by at least nine transcription factors Arch Toxicol 82 8 513 524 10.1007/s00204-008-0331-9 1:CAS:528:DC%2BD1cXpt12rs7k%3D 18654764
-
(2008)
Arch Toxicol
, vol.82
, Issue.8
, pp. 513-524
-
-
Glahn, F.1
Schmidt-Heck, W.2
Zellmer, S.3
Guthke, R.4
Wiese, J.5
Golka, K.6
Hergenröder, R.7
Degen, G.H.8
Lehmann, T.9
Hermes, M.10
Schormann, W.11
Brulport, M.12
Bauer, A.13
Bedawy, E.14
Gebhardt, R.15
Hengstler, J.G.16
Foth, H.17
-
28
-
-
33244490008
-
Generation of human hepatocytes by stem cell technology: Definition of the hepatocyte
-
10.1517/17425255.1.1.61 1:CAS:528:DC%2BD2MXmvVGhs70%3D 16922653
-
JG Hengstler M Brulport W Schormann A Bauer M Hermes AK Nussler F Fandrich M Ruhnke H Ungefroren L Griffin E Bockamp F Oesch MA von Mach 2005 Generation of human hepatocytes by stem cell technology: definition of the hepatocyte Expert Opin Drug Metab Toxicol 1 1 61 74 10.1517/17425255.1.1.61 1:CAS:528:DC%2BD2MXmvVGhs70%3D 16922653
-
(2005)
Expert Opin Drug Metab Toxicol
, vol.1
, Issue.1
, pp. 61-74
-
-
Hengstler, J.G.1
Brulport, M.2
Schormann, W.3
Bauer, A.4
Hermes, M.5
Nussler, A.K.6
Fandrich, F.7
Ruhnke, M.8
Ungefroren, H.9
Griffin, L.10
Bockamp, E.11
Oesch, F.12
Von MacH, M.A.13
-
29
-
-
33845902230
-
Trichostatin A, a critical factor in maintaining the functional differentiation of primary cultured rat hepatocytes
-
DOI 10.1016/j.taap.2006.10.012, PII S0041008X06003723
-
T Henkens P Papeleu G Elaut M Vinken V Rogiers T Vanhaecke 2007 Trichostatin A, a critical factor in maintaining the functional differentiation of primary cultures rat hepatocytes Toxicol Appl Pharmacol 218 64 71 10.1016/j.taap.2006.10.012 1:CAS:528:DC%2BD2sXitl2htg%3D%3D 17125810 (Pubitemid 46026840)
-
(2007)
Toxicology and Applied Pharmacology
, vol.218
, Issue.1
, pp. 64-71
-
-
Henkens, T.1
Papeleu, P.2
Elaut, G.3
Vinken, M.4
Rogiers, V.5
Vanhaecke, T.6
-
30
-
-
34548698676
-
Derivation of GMP raw materials for use in regenerative medicine: HESC-based therapies, progress toward clinical application
-
DOI 10.1038/sj.clpt.6100321, PII 6100321
-
ZA Hewitt KJ Amps HD Moore 2007 Derivation of GMP raw materials for use in regenerative medicine: hESC-based therapies, progress toward clinical application Clin Pharmacol Ther 82 4 448 452 10.1038/sj.clpt.6100321 1:STN:280:DC%2BD2srjsFSisg%3D%3D 17687270 (Pubitemid 47414351)
-
(2007)
Clinical Pharmacology and Therapeutics
, vol.82
, Issue.4
, pp. 448-452
-
-
Hewitt, Z.A.1
Amps, K.J.2
Moore, H.D.3
-
31
-
-
34247596870
-
4
-
DOI 10.1016/j.cbi.2007.01.010, PII S000927970700018X
-
S Höhme JG Hengstler M Brulport M Schäfer A Bauer R Gebhardt D Drasdo 2007 Mathematical modelling of liver regeneration after intoxication with CCl(4) Chem Biol Interact 168 1 74 93 10.1016/j.cbi.2007.01.010 17442287 (Pubitemid 46671421)
-
(2007)
Chemico-Biological Interactions
, vol.168
, Issue.1
, pp. 74-93
-
-
Hohme, S.1
Hengstler, J.G.2
Brulport, M.3
Schafer, M.4
Bauer, A.5
Gebhardt, R.6
Drasdo, D.7
-
32
-
-
34249085274
-
How can structural similarity analysis help in category formation?
-
DOI 10.1080/10629360701306050, PII 778871248
-
J Jaworska N Nikolova-Jeliazkova 2007 How can structural similarity analysis help in category formation? SAR QSAR Environ Res 18 3-4 195 207 10.1080/10629360701306050 1:CAS:528:DC%2BD2sXlsVeru7w%3D 17514565 (Pubitemid 46789491)
-
(2007)
SAR and QSAR in Environmental Research
, vol.18
, Issue.3-4
, pp. 195-207
-
-
Jaworska, J.1
Nikolova-Jeliazkova, N.2
-
33
-
-
33750795440
-
Primary mouse hepatocytes for systems biology approaches: A standardized in vitro system for modelling of signal transduction pathways
-
U Klingmüller A Bauer S Bohl PJ Nickel K Breitkopf S Dooley S Zellmer C Kern I Merfort T Sparna J Donauer G Walz M Geyer C Kreutz M Hermes F Götschel A Hecht D Walter L Egger K Neubert C Borner M Brulport W Schormann C Sauer F Baumann R Preiss S MacNelly P Godoy E Wiercinska L Ciuclan J Edelmann K Zeilinger M Heinrich UM Zanger R Gebhardt T Maiwald R Heinrich J Timmer F von Weizsäcker JG Hengstler 2006 Primary mouse hepatocytes for systems biology approaches: a standardized in vitro system for modelling of signal transduction pathways Syst Biol (Stevenage) 153 6 433 447
-
(2006)
Syst Biol (Stevenage)
, vol.153
, Issue.6
, pp. 433-447
-
-
Klingmüller, U.1
Bauer, A.2
Bohl, S.3
Nickel, P.J.4
Breitkopf, K.5
Dooley, S.6
Zellmer, S.7
Kern, C.8
Merfort, I.9
Sparna, T.10
Donauer, J.11
Walz, G.12
Geyer, M.13
Kreutz, C.14
Hermes, M.15
Götschel, F.16
Hecht, A.17
Walter, D.18
Egger, L.19
Neubert, K.20
Borner, C.21
Brulport, M.22
Schormann, W.23
Sauer, C.24
Baumann, F.25
Preiss, R.26
MacNelly, S.27
Godoy, P.28
Wiercinska, E.29
Ciuclan, L.30
Edelmann, J.31
Zeilinger, K.32
Heinrich, M.33
Zanger, U.M.34
Gebhardt, R.35
Maiwald, T.36
Heinrich, R.37
Timmer, J.38
Von Weizsäcker, F.39
Hengstler, J.G.40
more..
-
34
-
-
62749109092
-
Toxicity testing in the 21st century: Implications for human health risk assessment
-
10.1111/j.1539-6924.2008.01150.x 19144067
-
D Krewski ME Andersen E Mantus L Zeise 2009 Toxicity testing in the 21st century: implications for human health risk assessment Risk Anal 29 4 474 479 10.1111/j.1539-6924.2008.01150.x 19144067
-
(2009)
Risk Anal
, vol.29
, Issue.4
, pp. 474-479
-
-
Krewski, D.1
Andersen, M.E.2
Mantus, E.3
Zeise, L.4
-
35
-
-
35649018168
-
Determination of major human cytochrome P450s activities in 96-well plates using liquid chromatography tandem mass spectrometry
-
DOI 10.1016/j.tiv.2007.03.022, PII S0887233307001324, Fourteenth International Workshop on In Vitro Toxicology
-
A Lahoz MT Donato L Picazo MJ Gómez-Lechón JV Castell 2007 Determination of major human cytochrome P450 s activities in 96-well plates using liquid chromatography tandem mass spectrometry Toxicol In Vitro 21 7 1247 1252 10.1016/j.tiv.2007.03.022 1:CAS:528:DC%2BD2sXht1GrsL7K 17521862 (Pubitemid 350026238)
-
(2007)
Toxicology in Vitro
, vol.21
, Issue.7
, pp. 1247-1252
-
-
Lahoz, A.1
Donato, M.T.2
Picazo, L.3
Gomez-Lechon, M.J.4
Castell, J.V.5
-
36
-
-
43549114744
-
Alternative methods to safety studies in experimental animals: Role in the risk assessment of chemicals under the new European chemicals legislation (REACH)
-
10.1007/s00204-008-0279-9 1:CAS:528:DC%2BD1cXjvFKgt7c%3D 18322675
-
W Lilienblum W Dekant H Foth T Gebel JG Hengstler R Kahl PJ Kramer H Schweinfurth KM Wollin 2008 Alternative methods to safety studies in experimental animals: role in the risk assessment of chemicals under the new European chemicals legislation (REACH) Arch Toxicol 82 4 211 236 10.1007/s00204-008-0279-9 1:CAS:528:DC%2BD1cXjvFKgt7c%3D 18322675
-
(2008)
Arch Toxicol
, vol.82
, Issue.4
, pp. 211-236
-
-
Lilienblum, W.1
Dekant, W.2
Foth, H.3
Gebel, T.4
Hengstler, J.G.5
Kahl, R.6
Kramer, P.J.7
Schweinfurth, H.8
Wollin, K.M.9
-
37
-
-
39149129618
-
Application of PBPK modeling in support of the derivation of toxicity reference values for 1, 1, 1-trichloroethane
-
10.1016/j.yrtph.2007.12.001 1:CAS:528:DC%2BD1cXitVaqt7k%3D 18226845
-
Y Lu S Rieth M Lohitnavy J Dennison H El-Masri HA Barton J Bruckner RS Yang 2008 Application of PBPK modeling in support of the derivation of toxicity reference values for 1, 1, 1-trichloroethane Regul Toxicol Pharmacol 50 2 249 260 10.1016/j.yrtph.2007.12.001 1:CAS:528:DC%2BD1cXitVaqt7k%3D 18226845
-
(2008)
Regul Toxicol Pharmacol
, vol.50
, Issue.2
, pp. 249-260
-
-
Lu, Y.1
Rieth, S.2
Lohitnavy, M.3
Dennison, J.4
El-Masri, H.5
Barton, H.A.6
Bruckner, J.7
Yang, R.S.8
-
38
-
-
48049110892
-
Epigenetic regulation of stem cell fate
-
10.1093/hmg/ddn149 1:CAS:528:DC%2BD1cXoslCms7o%3D 18632693
-
VV Lunyak MG Rosenfeld 2008 Epigenetic regulation of stem cell fate Hum Mol Genet 17 R1 R28 R36 10.1093/hmg/ddn149 1:CAS:528:DC%2BD1cXoslCms7o%3D 18632693
-
(2008)
Hum Mol Genet
, vol.17
, Issue.R1
-
-
Lunyak, V.V.1
Rosenfeld, M.G.2
-
39
-
-
33847795004
-
In silico identification of NF-kappaB-regulated genes in pancreatic beta-cells
-
DOI 10.1186/1471-2105-8-55
-
N Naamane J van Helden DL Eizirik 2007 In silico identification of NF-kappaB-regulated genes in pancreatic beta-cells BMC Bioinformatics 8 55 10.1186/1471-2105-8-55 17302974 (Pubitemid 46389844)
-
(2007)
BMC Bioinformatics
, vol.8
, pp. 55
-
-
Naamane, N.1
Van Helden, J.2
Eizirik, D.L.3
-
40
-
-
54549091125
-
Systems biology: Metabonomics
-
10.1038/4551054a 1:CAS:528:DC%2BD1cXht1yju7zN
-
JK Nicholson JC Lindon 2008 Systems biology: metabonomics Nature 23 455 7216 1054 1056 10.1038/4551054a 1:CAS:528:DC%2BD1cXht1yju7zN
-
(2008)
Nature 23
, vol.455
, Issue.7216
, pp. 1054-1056
-
-
Nicholson, J.K.1
Lindon, J.C.2
-
41
-
-
71449090709
-
-
Regulation (EC) No 1907/2006 of the European parliament and of the council of 18 December 2006 concerning the registration, evaluation, authorisation and restriction of chemicals (REACH), establishing a European chemicals agency, amending directive 1999/45/EC and repealing council regulation (EEC) No 793/93 and commission regulation (EC) No 1488/94 as well as council directive 76/769/EEC and commission directives 91/155/EEC, 93/67/EEC, 93/105/EC and 2000/21/EC. Official Journal L396, 1-849, 30 December 2006. L136, 3-280, 29 May
-
Regulation (EC) No 1907/2006 of the European parliament and of the council of 18 December 2006 concerning the registration, evaluation, authorisation and restriction of chemicals (REACH), establishing a European chemicals agency, amending directive 1999/45/EC and repealing council regulation (EEC) No 793/93 and commission regulation (EC) No 1488/94 as well as council directive 76/769/EEC and commission directives 91/155/EEC, 93/67/EEC, 93/105/EC and 2000/21/EC. Official Journal L396, 1-849, 30 December 2006. Corrigendum in Official Journal L136, 3-280, 29 May 2007
-
(2007)
Corrigendum in Official Journal
-
-
-
44
-
-
71449094997
-
-
OECD (version 7.6) on "In vitro skin irritation: reconstructed human epidermis (RhE) test method". Organization for Economic Cooperation and Development, Paris. Adopted 9 September 2009
-
OECD (2009a) Draft test guideline (version 7.6) on "In vitro skin irritation: reconstructed human epidermis (RhE) test method". Organization for Economic Cooperation and Development, Paris. Adopted 9 September 2009
-
(2009)
Draft Test Guideline
-
-
-
46
-
-
51749119926
-
Local kinetics and dynamics of xenobiotics
-
10.1080/10408440802194931 1:CAS:528:DC%2BD1cXhtFajt7vL 18686076
-
O Pelkonen J Kapitulnik U Gundert-Remy AR Boobis A Stockis 2008 Local kinetics and dynamics of xenobiotics Crit Rev Toxicol 38 8 697 720 10.1080/10408440802194931 1:CAS:528:DC%2BD1cXhtFajt7vL 18686076
-
(2008)
Crit Rev Toxicol
, vol.38
, Issue.8
, pp. 697-720
-
-
Pelkonen, O.1
Kapitulnik, J.2
Gundert-Remy, U.3
Boobis, A.R.4
Stockis, A.5
-
47
-
-
33847388440
-
Metabonomics in pharmaceutical discovery and development
-
DOI 10.1021/pr060535c
-
DG Robertson MD Reily JD Baker 2007 Metabonomics in pharmaceutical discovery and development J Proteome Res 6 2 526 539 10.1021/pr060535c 1:CAS:528:DC%2BD28XhtlCitbzI 17269709 (Pubitemid 46340156)
-
(2007)
Journal of Proteome Research
, vol.6
, Issue.2
, pp. 526-539
-
-
Robertson, D.G.1
Reily, M.D.2
Baker, J.D.3
-
48
-
-
54849442447
-
Strategic applications of toxicogenomics in early drug discovery
-
10.1016/j.coph.2008.07.011 1:CAS:528:DC%2BD1cXhtlaqsLjK 18760379
-
TP Ryan JL Stevens GE Thomas 2008 Strategic applications of toxicogenomics in early drug discovery Curr Opin Pharmacol 8 5 654 660 10.1016/j.coph.2008.07.011 1:CAS:528:DC%2BD1cXhtlaqsLjK 18760379
-
(2008)
Curr Opin Pharmacol
, vol.8
, Issue.5
, pp. 654-660
-
-
Ryan, T.P.1
Stevens, J.L.2
Thomas, G.E.3
-
49
-
-
47349124275
-
What does systems biology mean for drug development?
-
DOI 10.2174/092986708784638843
-
A Schrattenholz V Soskić 2008 What does systems biology mean for drug development? Curr Med Chem 15 15 1520 1528 10.2174/092986708784638843 1:CAS:528:DC%2BD1cXnsVyhsL0%3D 18537627 (Pubitemid 351997783)
-
(2008)
Current Medicinal Chemistry
, vol.15
, Issue.15
, pp. 1520-1528
-
-
Schrattenholz, A.1
Soskic, V.2
-
50
-
-
59849100943
-
Primary rat hepatocytes as in vitro system for gene expression studies: Comparison of sandwich, matrigel and 2D cultures
-
10.1007/s00204-008-0375-x 1:CAS:528:DC%2BD1cXhtlCju7zO 18987846
-
M Schug T Heise A Bauer D Storm M Blaszkewicz E Bedawy M Brulport B Geppert M Hermes W Föllmann K Rapp L Maccoux W Schormann KE Appel A Oberemm U Gundert-Remy JG Hengstler 2008 Primary rat hepatocytes as in vitro system for gene expression studies: comparison of sandwich, matrigel and 2D cultures Arch Toxicol 82 12 923 931 10.1007/s00204-008-0375-x 1:CAS:528:DC%2BD1cXhtlCju7zO 18987846
-
(2008)
Arch Toxicol
, vol.82
, Issue.12
, pp. 923-931
-
-
Schug, M.1
Heise, T.2
Bauer, A.3
Storm, D.4
Blaszkewicz, M.5
Bedawy, E.6
Brulport, M.7
Geppert, B.8
Hermes, M.9
Föllmann, W.10
Rapp, K.11
MacCoux, L.12
Schormann, W.13
Appel, K.E.14
Oberemm, A.15
Gundert-Remy, U.16
Hengstler, J.G.17
-
51
-
-
84934434193
-
Applications of toxicogenomics to nonclinical drug development: Regulatory science considerations
-
1:CAS:528:DC%2BD1cXosFGnsL0%3D 18449491
-
FD Sistare JJ Degeorge 2008 Applications of toxicogenomics to nonclinical drug development: regulatory science considerations Methods Mol Biol 460 239 261 1:CAS:528:DC%2BD1cXosFGnsL0%3D 18449491
-
(2008)
Methods Mol Biol
, vol.460
, pp. 239-261
-
-
Sistare, F.D.1
Degeorge, J.J.2
-
52
-
-
33751401356
-
Sequential exposure to cytokines reflecting embryogenesis: The key for in vitro differentiation of adult bone marrow stem cells into functional hepatocyte-like cells
-
10.1093/toxsci/kfl058
-
S Snykers T Vanhaecke P Papeleu A Luttun Y Jiang Y Vander Heyden C Verfaillie V Rogiers 2007 Sequential exposure to cytokines reflecting embryogenesis: the key for in vitro differentiation of adult bone marrow stem cells into functional hepatocyte-like cells Toxicol Sci 94 2 330 341 10.1093/toxsci/kfl058
-
(2007)
Toxicol Sci
, vol.94
, Issue.2
, pp. 330-341
-
-
Snykers, S.1
Vanhaecke, T.2
Papeleu, P.3
Luttun, A.4
Jiang, Y.5
Vander Heyden, Y.6
Verfaillie, C.7
Rogiers, V.8
-
53
-
-
34247231009
-
Chromatin remodeling agent trichostatin A: A key-factor in the hepatic differentiation of human mesenchymal stem cells derived of adult bone marrow
-
DOI 10.1186/1471-213X-7-24
-
S Snykers T Vanhaecke A De Becker P Papeleu M Vinken I Van Riet V Rogiers 2007 Chromatin remodelling agent trichostatin A: a key-factor in the hepatic differentiation of human mesenchymal stem cells derived of adult bone marrow BMC Dev Biol 7 24 10.1186/1471-213X-7-24 17407549 (Pubitemid 46624379)
-
(2007)
BMC Developmental Biology
, vol.7
, pp. 24
-
-
Snykers, S.1
Vanhaecke, T.2
De Becker, A.3
Papeleu, P.4
Vinken, M.5
Van Riet, I.6
Rogiers, V.7
-
54
-
-
45849134870
-
Family 1 uridine-5-diphosphate glucuronosyltransferases (UGT1A): From Gilbert's syndrome to genetic organization and variability
-
10.1007/s00204-008-0314-x 1:CAS:528:DC%2BD1cXnsVSqsbg%3D 18491077
-
CP Strassburg TO Lankisch MP Manns U Ehmer 2008 Family 1 uridine-5-diphosphate glucuronosyltransferases (UGT1A): from Gilbert's syndrome to genetic organization and variability Arch Toxicol 82 7 415 433 10.1007/s00204-008-0314-x 1:CAS:528:DC%2BD1cXnsVSqsbg%3D 18491077
-
(2008)
Arch Toxicol
, vol.82
, Issue.7
, pp. 415-433
-
-
Strassburg, C.P.1
Lankisch, T.O.2
Manns, M.P.3
Ehmer, U.4
-
55
-
-
34447550088
-
Gene expression profiling in lung tissues from rats exposed to formaldehyde
-
DOI 10.1007/s00204-007-0182-9
-
D Sul H Kim E Oh S Phark E Cho S Choi HS Kang EM Kim KW Hwang WW Jung 2007 Gene expression profiling in lung tissues from rats exposed to formaldehyde Arch Toxicol 81 8 589 597 10.1007/s00204-007-0182-9 1:CAS:528: DC%2BD2sXnsl2gt7g%3D 17285311 (Pubitemid 47077060)
-
(2007)
Archives of Toxicology
, vol.81
, Issue.8
, pp. 589-597
-
-
Sul, D.1
Kim, H.2
Oh, E.3
Phark, S.4
Cho, E.5
Choi, S.6
Kang, H.-S.7
Kim, E.-M.8
Hwang, K.-W.9
Jung, W.-W.10
-
56
-
-
38849109564
-
Detection of early signals of hepatotoxicity by gene expression profiling studies with cultures of metabolically competent human hepatocytes
-
DOI 10.1007/s00204-007-0234-1
-
T Thum J Borlak 2008 Detection of early signals of hepatotoxicity by gene expression profiling studies with cultures of metabolically competent human hepatocytes Arch Toxicol 82 2 89 101 10.1007/s00204-007-0234-1 1:CAS:528:DC%2BD1cXhtFWquro%3D 17851650 (Pubitemid 351187672)
-
(2008)
Archives of Toxicology
, vol.82
, Issue.2
, pp. 89-101
-
-
Thum, T.1
Borlak, J.2
-
57
-
-
0002121557
-
Issues relating to the release of proprietary information and data for use in the validation of alternative methods. the report and recommendations of ECVAM workshop 27
-
M Todd B Garthoff W Bernhardt G Bodé S Farr C Lumley M Pieters V Rogiers U Sauer H Spielmann J Straus L Warngard 1998 Issues relating to the release of proprietary information and data for use in the validation of alternative methods. The report and recommendations of ECVAM workshop 27 ATLA 26 13 20
-
(1998)
ATLA
, vol.26
, pp. 13-20
-
-
Todd, M.1
Garthoff, B.2
Bernhardt, W.3
Bodé, G.4
Farr, S.5
Lumley, C.6
Pieters, M.7
Rogiers, V.8
Sauer, U.9
Spielmann, H.10
Straus, J.11
Warngard, L.12
-
58
-
-
34547539880
-
Biomarkers, metabonomics, and drug development: Can inborn errors of metabolism help in understanding drug toxicity?
-
DOI 10.1208/aapsj0903031, 31
-
S Vangala A Tonelli 2007 Biomarkers, metabonomics, and drug development: can inborn errors of metabolism help in understanding drug toxicity? AAPS J 9 3 E284 E297 10.1208/aapsj0903031 1:CAS:528:DC%2BD2sXhtVOntbrN 17915830 20 (Pubitemid 47177141)
-
(2007)
AAPS Journal
, vol.9
, Issue.3
-
-
Vangala, S.1
Tonelli, A.2
-
59
-
-
33744804024
-
Histone deacetylase inhibitors as potent modulators of cellular contacts
-
DOI 10.2174/138945006777435281
-
M Vinken P Papeleu V Rogiers T Vanhaecke 2006 Histone deacetylase inhibitors as potent modulators of cellular contacts Curr Drug Targets 7 773 787 10.2174/138945006777435281 1:CAS:528:DC%2BD28XlvVOlur0%3D 16787179 (Pubitemid 43827273)
-
(2006)
Current Drug Targets
, vol.7
, Issue.6
, pp. 773-787
-
-
Vinken, M.1
Peggy, P.2
Vera, R.3
Tamara, V.4
|