The use of dogs as second species in regulatory testing of pesticides. Part II: Subacute, subchronic and chronic studies in the dog

Archives of Toxicology

Volumn 75, Issue 1, 2001, Pages 1-21

  Spielmann, Horst ^a   Gerbracht, Ulrich ^a  

^a FEDERAL INSTITUTE FOR RISK ASSESSMENT   (Germany)

Author keywords

Chronic toxicity studies; Dog; Interspecies comparison; Pesticides; Regulatory testing

Indexed keywords

FUNGICIDE; HERBICIDE; INSECTICIDE; PESTICIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOG; ENZYME ACTIVITY; MEDICAL RESEARCH; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; SPECIES DIFFERENCE; TOXICITY TESTING; TOXICOLOGICAL PARAMETERS; VETERINARY MEDICINE;

ANIMALS; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GERMANY; GOVERNMENT AGENCIES; MALE; NO-OBSERVED-ADVERSE-EFFECT LEVEL; ORGAN SPECIFICITY; PESTICIDES; RATS; RETROSPECTIVE STUDIES; SPECIES SPECIFICITY; TIME FACTORS; TOXICITY TESTS;

ANIMALIA; CANIS FAMILIARIS; RODENTIA;

EID: 0035086548     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002040000195     Document Type: Article

References (10)

1. Significance of the dog as 'second animal species' in toxicity testing for establishing the 'lowest no-toxic-effect level'
2. The use of dogs as second species in regulatory testing of pesticides. I. Interspecies comparison
3. A review of the Japanese pharmaceutical manufacturers association database currently established to examine retrospectively the value of long-term animal toxicity studies
4. The use of the dog in toxicity test on pharmaceutical compounds
5. The value of information generated by long-term toxicity studies in the dog for the non-clinical safety assessment of pharmaceutical compounds
6. The concept of multispecies testing in industrial toxicology