Cadmium, cobalt and lead cause stress response, cell cycle deregulation and increased steroid as well as xenobiotic metabolism in primary normal human bronchial epithelial cells which is coordinated by at least nine transcription factors

Archives of Toxicology

Volumn 82, Issue 8, 2008, Pages 513-524

  Glahn, Felix ^a   Schmidt Heck, Wolfgang ^b   Zellmer, Sebastian ^c   Guthke, Reinhard ^b   Wiese, Jan ^a   Golka, Klaus ^d   Hergenröder, Roland ^e   Degen, Gisela H ^d   Lehmann, Thomas ^f   Hermes, Matthias ^d   Schormann, Wiebke ^d   Brulport, Marc ^d   Bauer, Alexander ^d   Bedawy, Essam ^d   Gebhardt, Rolf ^c   Hengstler, Jan G ^d   Foth, Heidi ^a  

^a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^b HANS KNÖLL INSTITUTE   (Germany)

^c UNIVERSITY OF LEIPZIG   (Germany)

^d LEIBNIZ RESEARCH CENTRE FOR WORKING ENVIRONMENT AND HUMAN FACTORS   (Germany)

^e LEIBNIZ INSTITUT FÜR ANALYTISCHE WISSENSCHAFTEN ISAS E V   (Germany)

^f Translational Centre for Regenerative Medicine   (Germany)

Author keywords

Cadmium; Cell cycle; Cobalt; Gene array; Lead; Metabolism; Normal human bronchial epithelial cells; Stress response; Transcription factors

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; CADMIUM; COBALT; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; GA BINDING PROTEIN; LEAD; OCTAMER TRANSCRIPTION FACTOR 1; PURINE; PYRIMIDINE; SERUM RESPONSE FACTOR; STEROID; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR ELK 1; TRANSCRIPTION FACTOR HIC 1; TRANSCRIPTION FACTOR TGIF; TRANSCRIPTION FACTOR YY1;

ARTICLE; BRONCHUS MUCOSA; CELL CYCLE REGULATION; CONTROLLED STUDY; EPITHELIUM CELL; GLUTATHIONE METABOLISM; HUMAN; HUMAN CELL; NORMAL HUMAN; PRIORITY JOURNAL; PURINE METABOLISM; PYRIMIDINE METABOLISM; STEROID METABOLISM; UPREGULATION; XENOBIOTIC STRESS;

20-HYDROXYSTEROID DEHYDROGENASES; AGED; CADMIUM COMPOUNDS; CELL CYCLE; CELLS, CULTURED; COBALT; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; EPITHELIAL CELLS; FEMALE; GENE EXPRESSION REGULATION; HUMANS; HYDROXYSTEROID DEHYDROGENASES; LEAD; MALE; MIDDLE AGED; OCCUPATIONAL EXPOSURE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OXIDATIVE STRESS; RESPIRATORY MUCOSA; STEROIDS; SULFATES; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 48749124037     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00204-008-0331-9     Document Type: Article

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