Assessment of heat-sensitive thiophosphate protecting groups in the development of thermolytic DNA oligonucleotide prodrugs

Tetrahedron

Volumn 66, Issue 1, 2010, Pages 68-79

  Ausín, Cristina ^a   Kauffman, Jon S ^b   Duff, Robert J ^b   Shivaprasad, Shankaramma ^b   Beaucage, Serge L ^a  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^b Lancaster Laboratories   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL DERIVATIVE; CPG OLIGODEOXYNUCLEOTIDE; PHOSPHOROTHIOIC ACID DERIVATIVE;

ARTICLE; CHEMICAL REACTION; DEPROTECTION REACTION; DNA SEQUENCE; DRUG DESIGN; DRUG SYNTHESIS; HEAT SENSITIVITY; NUCLEOTIDE SEQUENCE; OLIGONUCLEOTIDE THERAPY; PRIORITY JOURNAL; REACTION ANALYSIS;

EID: 70549105974     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tet.2009.10.096     Document Type: Article

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